Amino acid dipepetide frequency for Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.698AlaAla: 9.698 ± 0.195
0.447AlaCys: 0.447 ± 0.022
5.66AlaAsp: 5.66 ± 0.085
4.158AlaGlu: 4.158 ± 0.075
3.276AlaPhe: 3.276 ± 0.057
6.761AlaGly: 6.761 ± 0.116
2.002AlaHis: 2.002 ± 0.047
6.319AlaIle: 6.319 ± 0.081
5.12AlaLys: 5.12 ± 0.088
8.844AlaLeu: 8.844 ± 0.127
2.556AlaMet: 2.556 ± 0.058
4.027AlaAsn: 4.027 ± 0.065
2.806AlaPro: 2.806 ± 0.059
4.412AlaGln: 4.412 ± 0.07
3.256AlaArg: 3.256 ± 0.074
5.179AlaSer: 5.179 ± 0.136
7.097AlaThr: 7.097 ± 0.13
6.864AlaVal: 6.864 ± 0.081
0.917AlaTrp: 0.917 ± 0.033
2.844AlaTyr: 2.844 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.406CysAla: 0.406 ± 0.019
0.051CysCys: 0.051 ± 0.007
0.28CysAsp: 0.28 ± 0.018
0.26CysGlu: 0.26 ± 0.016
0.218CysPhe: 0.218 ± 0.015
0.489CysGly: 0.489 ± 0.024
0.185CysHis: 0.185 ± 0.014
0.253CysIle: 0.253 ± 0.018
0.152CysLys: 0.152 ± 0.013
0.575CysLeu: 0.575 ± 0.027
0.111CysMet: 0.111 ± 0.009
0.17CysAsn: 0.17 ± 0.015
0.2CysPro: 0.2 ± 0.013
0.282CysGln: 0.282 ± 0.018
0.22CysArg: 0.22 ± 0.013
0.286CysSer: 0.286 ± 0.02
0.249CysThr: 0.249 ± 0.018
0.361CysVal: 0.361 ± 0.02
0.076CysTrp: 0.076 ± 0.009
0.223CysTyr: 0.223 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.5AspAla: 4.5 ± 0.081
0.294AspCys: 0.294 ± 0.02
3.571AspAsp: 3.571 ± 0.085
3.458AspGlu: 3.458 ± 0.08
2.659AspPhe: 2.659 ± 0.055
3.607AspGly: 3.607 ± 0.071
1.575AspHis: 1.575 ± 0.045
3.191AspIle: 3.191 ± 0.061
2.666AspLys: 2.666 ± 0.081
5.482AspLeu: 5.482 ± 0.077
1.484AspMet: 1.484 ± 0.042
2.28AspAsn: 2.28 ± 0.058
2.21AspPro: 2.21 ± 0.054
3.257AspGln: 3.257 ± 0.079
2.389AspArg: 2.389 ± 0.053
3.572AspSer: 3.572 ± 1.012
3.035AspThr: 3.035 ± 0.07
3.917AspVal: 3.917 ± 0.061
0.855AspTrp: 0.855 ± 0.031
2.623AspTyr: 2.623 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
3.988GluAla: 3.988 ± 0.061
0.199GluCys: 0.199 ± 0.016
2.287GluAsp: 2.287 ± 0.048
2.068GluGlu: 2.068 ± 0.06
1.67GluPhe: 1.67 ± 0.051
2.006GluGly: 2.006 ± 0.055
1.255GluHis: 1.255 ± 0.03
2.972GluIle: 2.972 ± 0.054
2.612GluLys: 2.612 ± 0.075
5.175GluLeu: 5.175 ± 0.082
1.385GluMet: 1.385 ± 0.043
2.019GluAsn: 2.019 ± 0.044
1.779GluPro: 1.779 ± 0.069
2.968GluGln: 2.968 ± 0.061
2.638GluArg: 2.638 ± 0.061
2.246GluSer: 2.246 ± 0.062
2.923GluThr: 2.923 ± 0.059
3.06GluVal: 3.06 ± 0.059
0.482GluTrp: 0.482 ± 0.026
1.394GluTyr: 1.394 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.288PheAla: 3.288 ± 0.072
0.23PheCys: 0.23 ± 0.017
2.745PheAsp: 2.745 ± 0.068
2.038PheGlu: 2.038 ± 0.049
1.751PhePhe: 1.751 ± 0.052
3.163PheGly: 3.163 ± 0.079
0.788PheHis: 0.788 ± 0.029
2.671PheIle: 2.671 ± 0.065
2.308PheLys: 2.308 ± 0.052
3.258PheLeu: 3.258 ± 0.081
1.082PheMet: 1.082 ± 0.039
2.133PheAsn: 2.133 ± 0.053
1.247PhePro: 1.247 ± 0.033
1.428PheGln: 1.428 ± 0.04
1.299PheArg: 1.299 ± 0.046
2.603PheSer: 2.603 ± 0.058
2.5PheThr: 2.5 ± 0.05
2.993PheVal: 2.993 ± 0.067
0.571PheTrp: 0.571 ± 0.025
1.542PheTyr: 1.542 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
5.25GlyAla: 5.25 ± 0.092
0.461GlyCys: 0.461 ± 0.021
3.265GlyAsp: 3.265 ± 0.066
2.923GlyGlu: 2.923 ± 0.064
2.937GlyPhe: 2.937 ± 0.076
4.287GlyGly: 4.287 ± 0.085
1.631GlyHis: 1.631 ± 0.037
5.28GlyIle: 5.28 ± 0.11
3.678GlyLys: 3.678 ± 0.065
7.129GlyLeu: 7.129 ± 0.121
1.921GlyMet: 1.921 ± 0.046
2.624GlyAsn: 2.624 ± 0.056
1.718GlyPro: 1.718 ± 0.043
3.436GlyGln: 3.436 ± 0.066
2.722GlyArg: 2.722 ± 0.044
3.769GlySer: 3.769 ± 0.062
4.619GlyThr: 4.619 ± 0.089
5.116GlyVal: 5.116 ± 0.099
0.943GlyTrp: 0.943 ± 0.035
2.775GlyTyr: 2.775 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
1.871HisAla: 1.871 ± 0.044
0.144HisCys: 0.144 ± 0.011
1.502HisAsp: 1.502 ± 0.044
1.158HisGlu: 1.158 ± 0.033
1.115HisPhe: 1.115 ± 0.041
1.783HisGly: 1.783 ± 0.051
0.951HisHis: 0.951 ± 0.033
1.242HisIle: 1.242 ± 0.035
0.831HisLys: 0.831 ± 0.035
2.294HisLeu: 2.294 ± 0.054
0.566HisMet: 0.566 ± 0.021
0.924HisAsn: 0.924 ± 0.031
1.138HisPro: 1.138 ± 0.029
1.526HisGln: 1.526 ± 0.043
1.165HisArg: 1.165 ± 0.039
1.084HisSer: 1.084 ± 0.039
1.249HisThr: 1.249 ± 0.035
1.758HisVal: 1.758 ± 0.05
0.377HisTrp: 0.377 ± 0.018
1.091HisTyr: 1.091 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.143IleAla: 6.143 ± 0.103
0.44IleCys: 0.44 ± 0.02
4.008IleAsp: 4.008 ± 0.074
3.097IleGlu: 3.097 ± 0.067
2.552IlePhe: 2.552 ± 0.073
5.183IleGly: 5.183 ± 0.108
1.249IleHis: 1.249 ± 0.041
4.558IleIle: 4.558 ± 0.097
3.626IleLys: 3.626 ± 0.068
5.776IleLeu: 5.776 ± 0.104
1.669IleMet: 1.669 ± 0.045
3.234IleAsn: 3.234 ± 0.054
2.6IlePro: 2.6 ± 0.064
2.624IleGln: 2.624 ± 0.063
2.537IleArg: 2.537 ± 0.071
4.052IleSer: 4.052 ± 0.069
4.507IleThr: 4.507 ± 0.082
4.956IleVal: 4.956 ± 0.092
0.636IleTrp: 0.636 ± 0.033
2.089IleTyr: 2.089 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
4.475LysAla: 4.475 ± 0.078
0.144LysCys: 0.144 ± 0.012
2.625LysAsp: 2.625 ± 0.065
2.213LysGlu: 2.213 ± 0.062
1.593LysPhe: 1.593 ± 0.041
2.496LysGly: 2.496 ± 0.055
1.239LysHis: 1.239 ± 0.043
3.3LysIle: 3.3 ± 0.067
3.192LysLys: 3.192 ± 0.093
5.122LysLeu: 5.122 ± 0.079
1.814LysMet: 1.814 ± 0.048
2.375LysAsn: 2.375 ± 0.057
1.999LysPro: 1.999 ± 0.049
3.301LysGln: 3.301 ± 0.064
2.763LysArg: 2.763 ± 0.054
2.914LysSer: 2.914 ± 0.078
3.79LysThr: 3.79 ± 0.089
3.637LysVal: 3.637 ± 0.057
0.578LysTrp: 0.578 ± 0.028
1.974LysTyr: 1.974 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
10.538LeuAla: 10.538 ± 0.135
0.517LeuCys: 0.517 ± 0.026
5.089LeuAsp: 5.089 ± 0.088
3.571LeuGlu: 3.571 ± 0.061
3.854LeuPhe: 3.854 ± 0.073
6.916LeuGly: 6.916 ± 0.112
1.876LeuHis: 1.876 ± 0.05
6.985LeuIle: 6.985 ± 0.137
5.573LeuLys: 5.573 ± 0.084
9.676LeuLeu: 9.676 ± 0.161
2.685LeuMet: 2.685 ± 0.063
4.755LeuAsn: 4.755 ± 0.076
4.483LeuPro: 4.483 ± 0.07
4.198LeuGln: 4.198 ± 0.078
3.883LeuArg: 3.883 ± 0.07
6.254LeuSer: 6.254 ± 0.107
8.227LeuThr: 8.227 ± 0.112
7.435LeuVal: 7.435 ± 0.114
0.969LeuTrp: 0.969 ± 0.034
2.636LeuTyr: 2.636 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
2.776MetAla: 2.776 ± 0.056
0.108MetCys: 0.108 ± 0.012
1.226MetAsp: 1.226 ± 0.038
0.901MetGlu: 0.901 ± 0.028
0.857MetPhe: 0.857 ± 0.038
1.74MetGly: 1.74 ± 0.056
0.549MetHis: 0.549 ± 0.023
1.956MetIle: 1.956 ± 0.056
1.508MetLys: 1.508 ± 0.037
2.629MetLeu: 2.629 ± 0.064
0.874MetMet: 0.874 ± 0.034
1.239MetAsn: 1.239 ± 0.026
1.222MetPro: 1.222 ± 0.038
1.388MetGln: 1.388 ± 0.044
1.218MetArg: 1.218 ± 0.037
1.604MetSer: 1.604 ± 0.035
2.251MetThr: 2.251 ± 0.054
1.88MetVal: 1.88 ± 0.046
0.221MetTrp: 0.221 ± 0.016
0.633MetTyr: 0.633 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.654AsnAla: 3.654 ± 0.068
0.23AsnCys: 0.23 ± 0.016
2.483AsnAsp: 2.483 ± 0.049
2.182AsnGlu: 2.182 ± 0.049
1.786AsnPhe: 1.786 ± 0.042
3.435AsnGly: 3.435 ± 0.06
1.278AsnHis: 1.278 ± 0.043
2.594AsnIle: 2.594 ± 0.062
1.969AsnLys: 1.969 ± 0.065
4.044AsnLeu: 4.044 ± 0.062
1.167AsnMet: 1.167 ± 0.031
2.108AsnAsn: 2.108 ± 0.058
1.963AsnPro: 1.963 ± 0.046
2.83AsnGln: 2.83 ± 0.06
2.014AsnArg: 2.014 ± 0.054
2.32AsnSer: 2.32 ± 0.054
2.487AsnThr: 2.487 ± 0.06
3.12AsnVal: 3.12 ± 0.07
0.651AsnTrp: 0.651 ± 0.03
1.73AsnTyr: 1.73 ± 0.05
0.0AsnXaa: 0.0 ± 0.0
Pro
3.891ProAla: 3.891 ± 0.064
0.125ProCys: 0.125 ± 0.012
2.379ProAsp: 2.379 ± 0.063
2.447ProGlu: 2.447 ± 0.065
1.572ProPhe: 1.572 ± 0.041
2.264ProGly: 2.264 ± 0.059
0.807ProHis: 0.807 ± 0.024
2.566ProIle: 2.566 ± 0.052
1.894ProLys: 1.894 ± 0.05
3.703ProLeu: 3.703 ± 0.088
0.863ProMet: 0.863 ± 0.037
1.754ProAsn: 1.754 ± 0.052
0.574ProPro: 0.574 ± 0.028
1.844ProGln: 1.844 ± 0.04
1.351ProArg: 1.351 ± 0.039
2.011ProSer: 2.011 ± 0.059
2.997ProThr: 2.997 ± 0.084
3.264ProVal: 3.264 ± 0.073
0.393ProTrp: 0.393 ± 0.021
1.286ProTyr: 1.286 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
5.489GlnAla: 5.489 ± 0.109
0.174GlnCys: 0.174 ± 0.013
2.147GlnAsp: 2.147 ± 0.055
1.849GlnGlu: 1.849 ± 0.046
1.898GlnPhe: 1.898 ± 0.052
2.473GlnGly: 2.473 ± 0.054
1.467GlnHis: 1.467 ± 0.046
3.198GlnIle: 3.198 ± 0.063
2.238GlnLys: 2.238 ± 0.05
6.589GlnLeu: 6.589 ± 0.115
1.204GlnMet: 1.204 ± 0.036
1.951GlnAsn: 1.951 ± 0.05
2.426GlnPro: 2.426 ± 0.064
3.714GlnGln: 3.714 ± 0.1
2.907GlnArg: 2.907 ± 0.057
2.627GlnSer: 2.627 ± 0.063
3.667GlnThr: 3.667 ± 0.081
4.112GlnVal: 4.112 ± 0.07
0.562GlnTrp: 0.562 ± 0.028
1.832GlnTyr: 1.832 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
3.22ArgAla: 3.22 ± 0.07
0.231ArgCys: 0.231 ± 0.017
2.301ArgAsp: 2.301 ± 0.067
2.165ArgGlu: 2.165 ± 0.057
1.917ArgPhe: 1.917 ± 0.04
2.286ArgGly: 2.286 ± 0.054
1.288ArgHis: 1.288 ± 0.033
2.663ArgIle: 2.663 ± 0.059
2.087ArgLys: 2.087 ± 0.066
4.681ArgLeu: 4.681 ± 0.091
1.168ArgMet: 1.168 ± 0.037
1.783ArgAsn: 1.783 ± 0.045
1.734ArgPro: 1.734 ± 0.054
3.04ArgGln: 3.04 ± 0.061
2.445ArgArg: 2.445 ± 0.054
2.009ArgSer: 2.009 ± 0.057
2.359ArgThr: 2.359 ± 0.057
3.057ArgVal: 3.057 ± 0.056
0.526ArgTrp: 0.526 ± 0.025
1.911ArgTyr: 1.911 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
5.14SerAla: 5.14 ± 0.128
0.248SerCys: 0.248 ± 0.015
3.959SerAsp: 3.959 ± 1.029
2.783SerGlu: 2.783 ± 0.076
2.265SerPhe: 2.265 ± 0.047
4.346SerGly: 4.346 ± 0.081
1.33SerHis: 1.33 ± 0.042
3.285SerIle: 3.285 ± 0.074
2.892SerLys: 2.892 ± 0.083
5.684SerLeu: 5.684 ± 0.088
1.493SerMet: 1.493 ± 0.034
2.367SerAsn: 2.367 ± 0.062
1.858SerPro: 1.858 ± 0.048
2.928SerGln: 2.928 ± 0.07
2.486SerArg: 2.486 ± 0.064
4.113SerSer: 4.113 ± 0.183
3.919SerThr: 3.919 ± 0.105
4.016SerVal: 4.016 ± 0.07
0.723SerTrp: 0.723 ± 0.033
2.083SerTyr: 2.083 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
7.038ThrAla: 7.038 ± 0.141
0.28ThrCys: 0.28 ± 0.018
4.157ThrAsp: 4.157 ± 0.091
2.875ThrGlu: 2.875 ± 0.061
2.656ThrPhe: 2.656 ± 0.058
5.056ThrGly: 5.056 ± 0.079
1.382ThrHis: 1.382 ± 0.045
4.804ThrIle: 4.804 ± 0.087
3.62ThrLys: 3.62 ± 0.077
6.664ThrLeu: 6.664 ± 0.097
1.699ThrMet: 1.699 ± 0.043
3.139ThrAsn: 3.139 ± 0.057
3.166ThrPro: 3.166 ± 0.073
2.702ThrGln: 2.702 ± 0.07
2.273ThrArg: 2.273 ± 0.051
4.326ThrSer: 4.326 ± 0.12
6.23ThrThr: 6.23 ± 0.16
5.748ThrVal: 5.748 ± 0.117
0.739ThrTrp: 0.739 ± 0.028
2.371ThrTyr: 2.371 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
7.432ValAla: 7.432 ± 0.102
0.431ValCys: 0.431 ± 0.018
4.281ValAsp: 4.281 ± 0.076
3.028ValGlu: 3.028 ± 0.067
2.761ValPhe: 2.761 ± 0.05
5.07ValGly: 5.07 ± 0.098
1.471ValHis: 1.471 ± 0.04
5.318ValIle: 5.318 ± 0.099
4.008ValLys: 4.008 ± 0.077
7.032ValLeu: 7.032 ± 0.119
1.972ValMet: 1.972 ± 0.038
3.333ValAsn: 3.333 ± 0.068
2.984ValPro: 2.984 ± 0.059
2.996ValGln: 2.996 ± 0.064
2.678ValArg: 2.678 ± 0.057
4.419ValSer: 4.419 ± 0.08
6.097ValThr: 6.097 ± 0.122
5.605ValVal: 5.605 ± 0.08
0.779ValTrp: 0.779 ± 0.029
2.201ValTyr: 2.201 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.743TrpAla: 0.743 ± 0.03
0.07TrpCys: 0.07 ± 0.01
0.523TrpAsp: 0.523 ± 0.024
0.392TrpGlu: 0.392 ± 0.018
0.567TrpPhe: 0.567 ± 0.029
0.73TrpGly: 0.73 ± 0.029
0.397TrpHis: 0.397 ± 0.021
0.694TrpIle: 0.694 ± 0.028
0.396TrpLys: 0.396 ± 0.027
1.814TrpLeu: 1.814 ± 0.051
0.289TrpMet: 0.289 ± 0.015
0.432TrpAsn: 0.432 ± 0.03
0.375TrpPro: 0.375 ± 0.024
0.962TrpGln: 0.962 ± 0.038
0.628TrpArg: 0.628 ± 0.027
0.713TrpSer: 0.713 ± 0.034
0.645TrpThr: 0.645 ± 0.029
0.735TrpVal: 0.735 ± 0.032
0.227TrpTrp: 0.227 ± 0.014
0.416TrpTyr: 0.416 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.704TyrAla: 2.704 ± 0.063
0.22TyrCys: 0.22 ± 0.015
2.137TyrAsp: 2.137 ± 0.051
1.561TyrGlu: 1.561 ± 0.042
1.731TyrPhe: 1.731 ± 0.044
2.393TyrGly: 2.393 ± 0.051
1.052TyrHis: 1.052 ± 0.037
1.684TyrIle: 1.684 ± 0.042
1.174TyrLys: 1.174 ± 0.041
3.952TyrLeu: 3.952 ± 0.061
0.777TyrMet: 0.777 ± 0.029
1.397TyrAsn: 1.397 ± 0.044
1.501TyrPro: 1.501 ± 0.04
2.69TyrGln: 2.69 ± 0.059
2.0TyrArg: 2.0 ± 0.043
1.819TyrSer: 1.819 ± 0.039
2.078TyrThr: 2.078 ± 0.066
2.263TyrVal: 2.263 ± 0.051
0.522TyrTrp: 0.522 ± 0.03
1.525TyrTyr: 1.525 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3088 proteins (934580 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski