Amino acid dipepetide frequency for Aquimarina spongiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.923AlaAla: 3.923 ± 0.069	0.507AlaCys: 0.507 ± 0.019	3.2AlaAsp: 3.2 ± 0.058	3.649AlaGlu: 3.649 ± 0.054	3.275AlaPhe: 3.275 ± 0.052	3.963AlaGly: 3.963 ± 0.07	1.084AlaHis: 1.084 ± 0.027	5.333AlaIle: 5.333 ± 0.073	4.426AlaLys: 4.426 ± 0.06	5.879AlaLeu: 5.879 ± 0.078	1.428AlaMet: 1.428 ± 0.03	3.413AlaAsn: 3.413 ± 0.05	1.959AlaPro: 1.959 ± 0.052	2.465AlaGln: 2.465 ± 0.043	1.961AlaArg: 1.961 ± 0.038	4.071AlaSer: 4.071 ± 0.059	3.806AlaThr: 3.806 ± 0.075	3.734AlaVal: 3.734 ± 0.055	0.594AlaTrp: 0.594 ± 0.019	2.466AlaTyr: 2.466 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.417CysAla: 0.417 ± 0.017	0.102CysCys: 0.102 ± 0.008	0.416CysAsp: 0.416 ± 0.019	0.419CysGlu: 0.419 ± 0.015	0.412CysPhe: 0.412 ± 0.016	0.576CysGly: 0.576 ± 0.022	0.156CysHis: 0.156 ± 0.011	0.595CysIle: 0.595 ± 0.021	0.487CysLys: 0.487 ± 0.016	0.661CysLeu: 0.661 ± 0.023	0.145CysMet: 0.145 ± 0.009	0.43CysAsn: 0.43 ± 0.018	0.328CysPro: 0.328 ± 0.016	0.231CysGln: 0.231 ± 0.013	0.21CysArg: 0.21 ± 0.012	0.577CysSer: 0.577 ± 0.024	0.468CysThr: 0.468 ± 0.023	0.442CysVal: 0.442 ± 0.017	0.066CysTrp: 0.066 ± 0.007	0.318CysTyr: 0.318 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.667AspAla: 3.667 ± 0.05	0.423AspCys: 0.423 ± 0.016	3.2AspAsp: 3.2 ± 0.058	3.495AspGlu: 3.495 ± 0.053	3.727AspPhe: 3.727 ± 0.053	4.051AspGly: 4.051 ± 0.086	1.198AspHis: 1.198 ± 0.029	4.606AspIle: 4.606 ± 0.057	3.82AspLys: 3.82 ± 0.06	5.357AspLeu: 5.357 ± 0.059	1.048AspMet: 1.048 ± 0.025	3.25AspAsn: 3.25 ± 0.056	2.244AspPro: 2.244 ± 0.055	2.488AspGln: 2.488 ± 0.039	2.146AspArg: 2.146 ± 0.035	3.176AspSer: 3.176 ± 0.045	3.231AspThr: 3.231 ± 0.048	3.556AspVal: 3.556 ± 0.051	0.812AspTrp: 0.812 ± 0.024	2.67AspTyr: 2.67 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	4.21GluAla: 4.21 ± 0.062	0.334GluCys: 0.334 ± 0.014	3.891GluAsp: 3.891 ± 0.061	5.448GluGlu: 5.448 ± 0.083	2.917GluPhe: 2.917 ± 0.043	3.873GluGly: 3.873 ± 0.051	1.196GluHis: 1.196 ± 0.028	5.644GluIle: 5.644 ± 0.059	5.541GluLys: 5.541 ± 0.078	6.217GluLeu: 6.217 ± 0.082	1.501GluMet: 1.501 ± 0.03	4.363GluAsn: 4.363 ± 0.062	1.543GluPro: 1.543 ± 0.034	2.492GluGln: 2.492 ± 0.047	2.536GluArg: 2.536 ± 0.04	3.291GluSer: 3.291 ± 0.045	3.596GluThr: 3.596 ± 0.052	4.521GluVal: 4.521 ± 0.063	0.632GluTrp: 0.632 ± 0.021	2.583GluTyr: 2.583 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	2.971PheAla: 2.971 ± 0.045	0.418PheCys: 0.418 ± 0.016	3.558PheAsp: 3.558 ± 0.053	3.636PheGlu: 3.636 ± 0.049	2.893PhePhe: 2.893 ± 0.05	3.635PheGly: 3.635 ± 0.05	0.822PheHis: 0.822 ± 0.029	3.667PheIle: 3.667 ± 0.055	3.399PheLys: 3.399 ± 0.042	4.669PheLeu: 4.669 ± 0.062	1.09PheMet: 1.09 ± 0.026	3.011PheAsn: 3.011 ± 0.056	1.675PhePro: 1.675 ± 0.033	1.648PheGln: 1.648 ± 0.032	1.828PheArg: 1.828 ± 0.03	3.975PheSer: 3.975 ± 0.057	3.262PheThr: 3.262 ± 0.057	3.237PheVal: 3.237 ± 0.046	0.609PheTrp: 0.609 ± 0.019	2.255PheTyr: 2.255 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.178GlyAla: 4.178 ± 0.082	0.608GlyCys: 0.608 ± 0.021	3.694GlyAsp: 3.694 ± 0.066	3.655GlyGlu: 3.655 ± 0.051	3.771GlyPhe: 3.771 ± 0.056	4.648GlyGly: 4.648 ± 0.085	1.056GlyHis: 1.056 ± 0.024	5.458GlyIle: 5.458 ± 0.063	4.651GlyLys: 4.651 ± 0.055	5.595GlyLeu: 5.595 ± 0.067	1.444GlyMet: 1.444 ± 0.03	3.99GlyAsn: 3.99 ± 0.072	1.481GlyPro: 1.481 ± 0.044	1.956GlyGln: 1.956 ± 0.037	2.176GlyArg: 2.176 ± 0.046	4.102GlySer: 4.102 ± 0.064	4.097GlyThr: 4.097 ± 0.078	4.578GlyVal: 4.578 ± 0.062	0.832GlyTrp: 0.832 ± 0.027	2.955GlyTyr: 2.955 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	0.909HisAla: 0.909 ± 0.023	0.19HisCys: 0.19 ± 0.012	0.867HisAsp: 0.867 ± 0.025	0.957HisGlu: 0.957 ± 0.026	1.18HisPhe: 1.18 ± 0.025	1.06HisGly: 1.06 ± 0.022	0.544HisHis: 0.544 ± 0.018	1.528HisIle: 1.528 ± 0.033	1.261HisLys: 1.261 ± 0.031	1.87HisLeu: 1.87 ± 0.038	0.37HisMet: 0.37 ± 0.015	1.006HisAsn: 1.006 ± 0.027	0.918HisPro: 0.918 ± 0.024	0.873HisGln: 0.873 ± 0.022	0.746HisArg: 0.746 ± 0.023	1.065HisSer: 1.065 ± 0.028	1.057HisThr: 1.057 ± 0.026	0.901HisVal: 0.901 ± 0.026	0.224HisTrp: 0.224 ± 0.01	0.847HisTyr: 0.847 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.587IleAla: 5.587 ± 0.071	0.63IleCys: 0.63 ± 0.018	5.053IleAsp: 5.053 ± 0.061	5.43IleGlu: 5.43 ± 0.06	3.55IlePhe: 3.55 ± 0.056	5.096IleGly: 5.096 ± 0.062	1.53IleHis: 1.53 ± 0.032	5.523IleIle: 5.523 ± 0.073	5.549IleLys: 5.549 ± 0.068	6.939IleLeu: 6.939 ± 0.086	1.299IleMet: 1.299 ± 0.027	4.569IleAsn: 4.569 ± 0.065	3.319IlePro: 3.319 ± 0.045	2.93IleGln: 2.93 ± 0.043	2.758IleArg: 2.758 ± 0.042	5.697IleSer: 5.697 ± 0.061	5.237IleThr: 5.237 ± 0.07	4.701IleVal: 4.701 ± 0.051	0.74IleTrp: 0.74 ± 0.022	2.756IleTyr: 2.756 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.5LysAla: 4.5 ± 0.058	0.309LysCys: 0.309 ± 0.015	4.366LysAsp: 4.366 ± 0.059	6.405LysGlu: 6.405 ± 0.091	2.616LysPhe: 2.616 ± 0.05	4.334LysGly: 4.334 ± 0.062	1.332LysHis: 1.332 ± 0.033	5.826LysIle: 5.826 ± 0.068	6.628LysLys: 6.628 ± 0.084	6.012LysLeu: 6.012 ± 0.07	1.774LysMet: 1.774 ± 0.036	4.832LysAsn: 4.832 ± 0.06	2.12LysPro: 2.12 ± 0.041	2.61LysGln: 2.61 ± 0.046	2.976LysArg: 2.976 ± 0.053	4.175LysSer: 4.175 ± 0.061	4.481LysThr: 4.481 ± 0.056	4.578LysVal: 4.578 ± 0.069	0.718LysTrp: 0.718 ± 0.023	2.89LysTyr: 2.89 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	5.348LeuAla: 5.348 ± 0.065	0.707LeuCys: 0.707 ± 0.021	5.255LeuAsp: 5.255 ± 0.063	6.019LeuGlu: 6.019 ± 0.074	4.827LeuPhe: 4.827 ± 0.066	5.907LeuGly: 5.907 ± 0.071	1.659LeuHis: 1.659 ± 0.039	6.818LeuIle: 6.818 ± 0.08	6.961LeuLys: 6.961 ± 0.084	8.747LeuLeu: 8.747 ± 0.107	1.917LeuMet: 1.917 ± 0.037	5.074LeuAsn: 5.074 ± 0.06	3.459LeuPro: 3.459 ± 0.049	3.625LeuGln: 3.625 ± 0.055	3.285LeuArg: 3.285 ± 0.046	6.873LeuSer: 6.873 ± 0.076	4.963LeuThr: 4.963 ± 0.065	5.426LeuVal: 5.426 ± 0.059	0.874LeuTrp: 0.874 ± 0.024	3.222LeuTyr: 3.222 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.338MetAla: 1.338 ± 0.028	0.125MetCys: 0.125 ± 0.008	1.125MetAsp: 1.125 ± 0.028	1.191MetGlu: 1.191 ± 0.028	0.84MetPhe: 0.84 ± 0.025	1.333MetGly: 1.333 ± 0.035	0.409MetHis: 0.409 ± 0.018	1.676MetIle: 1.676 ± 0.033	2.039MetLys: 2.039 ± 0.034	1.829MetLeu: 1.829 ± 0.035	0.552MetMet: 0.552 ± 0.02	1.308MetAsn: 1.308 ± 0.026	0.739MetPro: 0.739 ± 0.024	0.795MetGln: 0.795 ± 0.021	0.837MetArg: 0.837 ± 0.02	1.279MetSer: 1.279 ± 0.028	1.107MetThr: 1.107 ± 0.026	1.313MetVal: 1.313 ± 0.032	0.146MetTrp: 0.146 ± 0.009	0.739MetTyr: 0.739 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.693AsnAla: 3.693 ± 0.056	0.463AsnCys: 0.463 ± 0.02	3.447AsnAsp: 3.447 ± 0.057	3.67AsnGlu: 3.67 ± 0.056	3.075AsnPhe: 3.075 ± 0.052	4.129AsnGly: 4.129 ± 0.075	1.13AsnHis: 1.13 ± 0.025	4.482AsnIle: 4.482 ± 0.059	3.831AsnLys: 3.831 ± 0.059	5.027AsnLeu: 5.027 ± 0.065	1.192AsnMet: 1.192 ± 0.024	3.753AsnAsn: 3.753 ± 0.067	2.745AsnPro: 2.745 ± 0.054	2.435AsnGln: 2.435 ± 0.046	2.311AsnArg: 2.311 ± 0.036	3.668AsnSer: 3.668 ± 0.056	4.165AsnThr: 4.165 ± 0.055	3.439AsnVal: 3.439 ± 0.054	0.783AsnTrp: 0.783 ± 0.028	2.651AsnTyr: 2.651 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	1.894ProAla: 1.894 ± 0.051	0.225ProCys: 0.225 ± 0.014	2.338ProAsp: 2.338 ± 0.046	2.895ProGlu: 2.895 ± 0.049	1.821ProPhe: 1.821 ± 0.033	2.119ProGly: 2.119 ± 0.052	0.567ProHis: 0.567 ± 0.021	2.724ProIle: 2.724 ± 0.047	2.521ProLys: 2.521 ± 0.043	2.903ProLeu: 2.903 ± 0.043	0.674ProMet: 0.674 ± 0.02	2.322ProAsn: 2.322 ± 0.049	0.925ProPro: 0.925 ± 0.034	1.2ProGln: 1.2 ± 0.024	0.99ProArg: 0.99 ± 0.028	2.216ProSer: 2.216 ± 0.042	2.019ProThr: 2.019 ± 0.043	2.428ProVal: 2.428 ± 0.045	0.347ProTrp: 0.347 ± 0.015	1.34ProTyr: 1.34 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	1.998GlnAla: 1.998 ± 0.036	0.217GlnCys: 0.217 ± 0.012	1.935GlnAsp: 1.935 ± 0.034	2.892GlnGlu: 2.892 ± 0.052	1.782GlnPhe: 1.782 ± 0.032	2.145GlnGly: 2.145 ± 0.042	0.703GlnHis: 0.703 ± 0.018	2.826GlnIle: 2.826 ± 0.045	3.231GlnLys: 3.231 ± 0.055	3.654GlnLeu: 3.654 ± 0.047	0.813GlnMet: 0.813 ± 0.023	2.506GlnAsn: 2.506 ± 0.046	1.205GlnPro: 1.205 ± 0.027	1.754GlnGln: 1.754 ± 0.036	1.366GlnArg: 1.366 ± 0.029	2.162GlnSer: 2.162 ± 0.039	2.035GlnThr: 2.035 ± 0.039	2.079GlnVal: 2.079 ± 0.041	0.474GlnTrp: 0.474 ± 0.02	1.522GlnTyr: 1.522 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.06ArgAla: 2.06 ± 0.032	0.221ArgCys: 0.221 ± 0.012	1.915ArgAsp: 1.915 ± 0.033	2.237ArgGlu: 2.237 ± 0.04	2.097ArgPhe: 2.097 ± 0.035	2.022ArgGly: 2.022 ± 0.04	0.596ArgHis: 0.596 ± 0.019	3.212ArgIle: 3.212 ± 0.046	2.828ArgLys: 2.828 ± 0.047	3.348ArgLeu: 3.348 ± 0.046	0.902ArgMet: 0.902 ± 0.024	2.232ArgAsn: 2.232 ± 0.041	1.091ArgPro: 1.091 ± 0.026	1.17ArgGln: 1.17 ± 0.029	1.418ArgArg: 1.418 ± 0.035	2.211ArgSer: 2.211 ± 0.043	2.01ArgThr: 2.01 ± 0.037	2.263ArgVal: 2.263 ± 0.039	0.447ArgTrp: 0.447 ± 0.018	1.655ArgTyr: 1.655 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	3.614SerAla: 3.614 ± 0.046	0.698SerCys: 0.698 ± 0.021	3.506SerAsp: 3.506 ± 0.049	4.048SerGlu: 4.048 ± 0.05	3.867SerPhe: 3.867 ± 0.058	4.72SerGly: 4.72 ± 0.066	1.037SerHis: 1.037 ± 0.028	5.305SerIle: 5.305 ± 0.059	4.762SerLys: 4.762 ± 0.069	5.873SerLeu: 5.873 ± 0.064	1.265SerMet: 1.265 ± 0.029	3.903SerAsn: 3.903 ± 0.057	2.126SerPro: 2.126 ± 0.044	2.143SerGln: 2.143 ± 0.038	2.193SerArg: 2.193 ± 0.041	4.415SerSer: 4.415 ± 0.067	3.636SerThr: 3.636 ± 0.049	3.874SerVal: 3.874 ± 0.052	0.791SerTrp: 0.791 ± 0.025	2.96SerTyr: 2.96 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	3.748ThrAla: 3.748 ± 0.068	0.354ThrCys: 0.354 ± 0.018	3.382ThrAsp: 3.382 ± 0.057	3.481ThrGlu: 3.481 ± 0.049	3.137ThrPhe: 3.137 ± 0.049	4.15ThrGly: 4.15 ± 0.091	1.094ThrHis: 1.094 ± 0.03	5.194ThrIle: 5.194 ± 0.067	3.906ThrLys: 3.906 ± 0.051	5.448ThrLeu: 5.448 ± 0.064	0.995ThrMet: 0.995 ± 0.026	3.46ThrAsn: 3.46 ± 0.064	2.717ThrPro: 2.717 ± 0.055	2.179ThrGln: 2.179 ± 0.038	1.818ThrArg: 1.818 ± 0.031	4.056ThrSer: 4.056 ± 0.055	3.886ThrThr: 3.886 ± 0.067	3.944ThrVal: 3.944 ± 0.073	0.627ThrTrp: 0.627 ± 0.027	2.58ThrTyr: 2.58 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	4.097ValAla: 4.097 ± 0.064	0.473ValCys: 0.473 ± 0.018	3.777ValAsp: 3.777 ± 0.054	3.717ValGlu: 3.717 ± 0.05	3.514ValPhe: 3.514 ± 0.048	3.829ValGly: 3.829 ± 0.052	1.088ValHis: 1.088 ± 0.027	4.944ValIle: 4.944 ± 0.06	3.953ValLys: 3.953 ± 0.063	6.12ValLeu: 6.12 ± 0.075	1.294ValMet: 1.294 ± 0.028	3.498ValAsn: 3.498 ± 0.053	2.182ValPro: 2.182 ± 0.038	2.017ValGln: 2.017 ± 0.033	2.098ValArg: 2.098 ± 0.042	4.51ValSer: 4.51 ± 0.056	3.89ValThr: 3.89 ± 0.074	4.38ValVal: 4.38 ± 0.056	0.634ValTrp: 0.634 ± 0.022	2.384ValTyr: 2.384 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.582TrpAla: 0.582 ± 0.019	0.107TrpCys: 0.107 ± 0.008	0.66TrpAsp: 0.66 ± 0.024	0.706TrpGlu: 0.706 ± 0.018	0.575TrpPhe: 0.575 ± 0.023	0.724TrpGly: 0.724 ± 0.024	0.229TrpHis: 0.229 ± 0.012	0.812TrpIle: 0.812 ± 0.025	0.831TrpLys: 0.831 ± 0.023	0.965TrpLeu: 0.965 ± 0.028	0.326TrpMet: 0.326 ± 0.014	0.713TrpAsn: 0.713 ± 0.022	0.245TrpPro: 0.245 ± 0.013	0.428TrpGln: 0.428 ± 0.017	0.461TrpArg: 0.461 ± 0.019	0.702TrpSer: 0.702 ± 0.024	0.608TrpThr: 0.608 ± 0.025	0.673TrpVal: 0.673 ± 0.02	0.176TrpTrp: 0.176 ± 0.012	0.489TrpTyr: 0.489 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.401TyrAla: 2.401 ± 0.044	0.344TyrCys: 0.344 ± 0.015	2.58TyrAsp: 2.58 ± 0.043	2.379TyrGlu: 2.379 ± 0.039	2.382TyrPhe: 2.382 ± 0.044	2.612TyrGly: 2.612 ± 0.046	0.946TyrHis: 0.946 ± 0.022	2.719TyrIle: 2.719 ± 0.05	2.855TyrLys: 2.855 ± 0.053	3.853TyrLeu: 3.853 ± 0.059	0.69TyrMet: 0.69 ± 0.023	2.455TyrAsn: 2.455 ± 0.039	1.449TyrPro: 1.449 ± 0.032	1.861TyrGln: 1.861 ± 0.04	1.822TyrArg: 1.822 ± 0.036	2.513TyrSer: 2.513 ± 0.039	2.604TyrThr: 2.604 ± 0.051	2.333TyrVal: 2.333 ± 0.043	0.487TyrTrp: 0.487 ± 0.019	1.921TyrTyr: 1.921 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4714 proteins (1614774 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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