Amino acid dipepetide frequency for Pontibacter ummariensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.584AlaAla: 7.584 ± 0.086
0.725AlaCys: 0.725 ± 0.023
4.164AlaAsp: 4.164 ± 0.049
5.28AlaGlu: 5.28 ± 0.064
3.869AlaPhe: 3.869 ± 0.048
6.272AlaGly: 6.272 ± 0.075
1.412AlaHis: 1.412 ± 0.03
4.621AlaIle: 4.621 ± 0.061
4.334AlaLys: 4.334 ± 0.058
8.542AlaLeu: 8.542 ± 0.082
1.985AlaMet: 1.985 ± 0.04
3.201AlaAsn: 3.201 ± 0.046
3.165AlaPro: 3.165 ± 0.052
3.45AlaGln: 3.45 ± 0.046
3.519AlaArg: 3.519 ± 0.05
4.996AlaSer: 4.996 ± 0.064
4.597AlaThr: 4.597 ± 0.08
5.866AlaVal: 5.866 ± 0.068
0.911AlaTrp: 0.911 ± 0.021
3.206AlaTyr: 3.206 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.566CysAla: 0.566 ± 0.023
0.136CysCys: 0.136 ± 0.009
0.347CysAsp: 0.347 ± 0.015
0.408CysGlu: 0.408 ± 0.016
0.359CysPhe: 0.359 ± 0.013
0.638CysGly: 0.638 ± 0.022
0.182CysHis: 0.182 ± 0.011
0.422CysIle: 0.422 ± 0.016
0.332CysLys: 0.332 ± 0.015
0.776CysLeu: 0.776 ± 0.022
0.17CysMet: 0.17 ± 0.011
0.311CysAsn: 0.311 ± 0.013
0.384CysPro: 0.384 ± 0.02
0.29CysGln: 0.29 ± 0.012
0.351CysArg: 0.351 ± 0.016
0.53CysSer: 0.53 ± 0.021
0.408CysThr: 0.408 ± 0.017
0.465CysVal: 0.465 ± 0.015
0.08CysTrp: 0.08 ± 0.006
0.275CysTyr: 0.275 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
3.925AspAla: 3.925 ± 0.058
0.334AspCys: 0.334 ± 0.014
2.156AspAsp: 2.156 ± 0.037
3.498AspGlu: 3.498 ± 0.047
2.776AspPhe: 2.776 ± 0.042
3.469AspGly: 3.469 ± 0.07
0.873AspHis: 0.873 ± 0.025
3.284AspIle: 3.284 ± 0.047
3.445AspLys: 3.445 ± 0.051
5.163AspLeu: 5.163 ± 0.059
1.24AspMet: 1.24 ± 0.028
2.299AspAsn: 2.299 ± 0.034
2.19AspPro: 2.19 ± 0.039
1.754AspGln: 1.754 ± 0.035
2.47AspArg: 2.47 ± 0.042
2.618AspSer: 2.618 ± 0.042
2.627AspThr: 2.627 ± 0.038
3.573AspVal: 3.573 ± 0.048
0.792AspTrp: 0.792 ± 0.024
2.516AspTyr: 2.516 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
6.036GluAla: 6.036 ± 0.074
0.31GluCys: 0.31 ± 0.015
3.349GluAsp: 3.349 ± 0.051
6.008GluGlu: 6.008 ± 0.077
2.308GluPhe: 2.308 ± 0.037
4.659GluGly: 4.659 ± 0.056
1.474GluHis: 1.474 ± 0.029
3.593GluIle: 3.593 ± 0.055
4.643GluLys: 4.643 ± 0.058
6.776GluLeu: 6.776 ± 0.081
1.554GluMet: 1.554 ± 0.031
3.142GluAsn: 3.142 ± 0.039
2.197GluPro: 2.197 ± 0.041
3.609GluGln: 3.609 ± 0.062
3.588GluArg: 3.588 ± 0.054
3.018GluSer: 3.018 ± 0.045
3.282GluThr: 3.282 ± 0.045
5.367GluVal: 5.367 ± 0.063
0.778GluTrp: 0.778 ± 0.021
2.133GluTyr: 2.133 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.32PheAla: 3.32 ± 0.047
0.379PheCys: 0.379 ± 0.016
2.512PheAsp: 2.512 ± 0.042
2.723PheGlu: 2.723 ± 0.04
2.252PhePhe: 2.252 ± 0.044
3.267PheGly: 3.267 ± 0.051
0.823PheHis: 0.823 ± 0.023
2.56PheIle: 2.56 ± 0.043
2.442PheLys: 2.442 ± 0.043
4.454PheLeu: 4.454 ± 0.066
1.033PheMet: 1.033 ± 0.026
2.173PheAsn: 2.173 ± 0.039
1.669PhePro: 1.669 ± 0.029
1.457PheGln: 1.457 ± 0.031
2.154PheArg: 2.154 ± 0.032
3.297PheSer: 3.297 ± 0.051
2.822PheThr: 2.822 ± 0.039
3.069PheVal: 3.069 ± 0.046
0.61PheTrp: 0.61 ± 0.024
1.928PheTyr: 1.928 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
5.293GlyAla: 5.293 ± 0.073
0.6GlyCys: 0.6 ± 0.019
3.441GlyAsp: 3.441 ± 0.052
4.414GlyGlu: 4.414 ± 0.06
3.452GlyPhe: 3.452 ± 0.047
5.232GlyGly: 5.232 ± 0.082
1.353GlyHis: 1.353 ± 0.031
4.565GlyIle: 4.565 ± 0.053
4.8GlyLys: 4.8 ± 0.052
6.876GlyLeu: 6.876 ± 0.077
1.791GlyMet: 1.791 ± 0.04
3.258GlyAsn: 3.258 ± 0.056
1.925GlyPro: 1.925 ± 0.032
2.681GlyGln: 2.681 ± 0.048
3.148GlyArg: 3.148 ± 0.047
4.254GlySer: 4.254 ± 0.06
4.291GlyThr: 4.291 ± 0.063
5.151GlyVal: 5.151 ± 0.069
0.996GlyTrp: 0.996 ± 0.029
3.103GlyTyr: 3.103 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
1.372HisAla: 1.372 ± 0.028
0.19HisCys: 0.19 ± 0.011
0.914HisAsp: 0.914 ± 0.027
1.199HisGlu: 1.199 ± 0.025
1.058HisPhe: 1.058 ± 0.023
1.351HisGly: 1.351 ± 0.031
0.591HisHis: 0.591 ± 0.023
1.135HisIle: 1.135 ± 0.027
0.987HisLys: 0.987 ± 0.021
2.166HisLeu: 2.166 ± 0.037
0.45HisMet: 0.45 ± 0.015
0.917HisAsn: 0.917 ± 0.024
1.145HisPro: 1.145 ± 0.026
0.87HisGln: 0.87 ± 0.025
0.969HisArg: 0.969 ± 0.022
1.1HisSer: 1.1 ± 0.026
1.11HisThr: 1.11 ± 0.026
1.346HisVal: 1.346 ± 0.03
0.269HisTrp: 0.269 ± 0.012
0.954HisTyr: 0.954 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
4.881IleAla: 4.881 ± 0.064
0.491IleCys: 0.491 ± 0.016
3.109IleAsp: 3.109 ± 0.042
3.507IleGlu: 3.507 ± 0.056
2.24IlePhe: 2.24 ± 0.042
4.234IleGly: 4.234 ± 0.053
1.043IleHis: 1.043 ± 0.03
3.29IleIle: 3.29 ± 0.049
3.306IleLys: 3.306 ± 0.048
5.099IleLeu: 5.099 ± 0.057
1.12IleMet: 1.12 ± 0.027
2.736IleAsn: 2.736 ± 0.039
2.596IlePro: 2.596 ± 0.041
2.018IleGln: 2.018 ± 0.035
2.857IleArg: 2.857 ± 0.041
3.831IleSer: 3.831 ± 0.054
3.412IleThr: 3.412 ± 0.049
3.697IleVal: 3.697 ± 0.051
0.579IleTrp: 0.579 ± 0.019
1.989IleTyr: 1.989 ± 0.039
0.0IleXaa: 0.0 ± 0.0
Lys
5.277LysAla: 5.277 ± 0.064
0.265LysCys: 0.265 ± 0.014
3.245LysAsp: 3.245 ± 0.052
4.766LysGlu: 4.766 ± 0.065
1.84LysPhe: 1.84 ± 0.034
4.273LysGly: 4.273 ± 0.05
1.262LysHis: 1.262 ± 0.03
2.985LysIle: 2.985 ± 0.042
3.904LysLys: 3.904 ± 0.067
5.74LysLeu: 5.74 ± 0.059
1.394LysMet: 1.394 ± 0.031
2.577LysAsn: 2.577 ± 0.045
2.621LysPro: 2.621 ± 0.039
2.644LysGln: 2.644 ± 0.04
2.957LysArg: 2.957 ± 0.046
2.993LysSer: 2.993 ± 0.042
3.011LysThr: 3.011 ± 0.044
4.471LysVal: 4.471 ± 0.065
0.642LysTrp: 0.642 ± 0.02
2.308LysTyr: 2.308 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
8.226LeuAla: 8.226 ± 0.077
0.859LeuCys: 0.859 ± 0.021
4.978LeuAsp: 4.978 ± 0.059
6.443LeuGlu: 6.443 ± 0.076
4.664LeuPhe: 4.664 ± 0.071
6.561LeuGly: 6.561 ± 0.067
2.156LeuHis: 2.156 ± 0.04
5.254LeuIle: 5.254 ± 0.07
6.029LeuLys: 6.029 ± 0.066
11.878LeuLeu: 11.878 ± 0.146
2.292LeuMet: 2.292 ± 0.04
4.598LeuAsn: 4.598 ± 0.055
4.73LeuPro: 4.73 ± 0.059
5.158LeuGln: 5.158 ± 0.075
4.937LeuArg: 4.937 ± 0.058
6.807LeuSer: 6.807 ± 0.08
5.538LeuThr: 5.538 ± 0.063
6.856LeuVal: 6.856 ± 0.078
1.049LeuTrp: 1.049 ± 0.029
3.775LeuTyr: 3.775 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.102MetAla: 2.102 ± 0.04
0.131MetCys: 0.131 ± 0.008
1.117MetAsp: 1.117 ± 0.027
1.503MetGlu: 1.503 ± 0.029
0.794MetPhe: 0.794 ± 0.025
1.568MetGly: 1.568 ± 0.036
0.483MetHis: 0.483 ± 0.018
1.191MetIle: 1.191 ± 0.028
1.644MetLys: 1.644 ± 0.033
2.429MetLeu: 2.429 ± 0.041
0.579MetMet: 0.579 ± 0.023
1.071MetAsn: 1.071 ± 0.023
1.118MetPro: 1.118 ± 0.027
1.126MetGln: 1.126 ± 0.028
1.202MetArg: 1.202 ± 0.027
1.3MetSer: 1.3 ± 0.029
1.09MetThr: 1.09 ± 0.03
1.533MetVal: 1.533 ± 0.034
0.208MetTrp: 0.208 ± 0.011
0.622MetTyr: 0.622 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.253AsnAla: 3.253 ± 0.043
0.305AsnCys: 0.305 ± 0.013
2.061AsnAsp: 2.061 ± 0.044
2.665AsnGlu: 2.665 ± 0.044
2.088AsnPhe: 2.088 ± 0.041
3.239AsnGly: 3.239 ± 0.059
0.845AsnHis: 0.845 ± 0.023
2.857AsnIle: 2.857 ± 0.04
2.644AsnLys: 2.644 ± 0.042
4.52AsnLeu: 4.52 ± 0.062
1.023AsnMet: 1.023 ± 0.027
2.282AsnAsn: 2.282 ± 0.041
2.463AsnPro: 2.463 ± 0.044
1.682AsnGln: 1.682 ± 0.037
2.36AsnArg: 2.36 ± 0.034
2.668AsnSer: 2.668 ± 0.049
2.669AsnThr: 2.669 ± 0.047
2.9AsnVal: 2.9 ± 0.05
0.634AsnTrp: 0.634 ± 0.018
2.14AsnTyr: 2.14 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
3.892ProAla: 3.892 ± 0.054
0.237ProCys: 0.237 ± 0.013
2.724ProAsp: 2.724 ± 0.047
3.674ProGlu: 3.674 ± 0.048
1.966ProPhe: 1.966 ± 0.033
2.873ProGly: 2.873 ± 0.044
0.86ProHis: 0.86 ± 0.022
2.066ProIle: 2.066 ± 0.036
2.077ProLys: 2.077 ± 0.034
3.99ProLeu: 3.99 ± 0.042
0.876ProMet: 0.876 ± 0.025
1.84ProAsn: 1.84 ± 0.035
1.261ProPro: 1.261 ± 0.031
1.722ProGln: 1.722 ± 0.035
1.461ProArg: 1.461 ± 0.035
2.372ProSer: 2.372 ± 0.035
2.234ProThr: 2.234 ± 0.04
3.509ProVal: 3.509 ± 0.055
0.485ProTrp: 0.485 ± 0.019
1.729ProTyr: 1.729 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.667GlnAla: 3.667 ± 0.052
0.205GlnCys: 0.205 ± 0.012
2.196GlnAsp: 2.196 ± 0.036
3.728GlnGlu: 3.728 ± 0.053
1.458GlnPhe: 1.458 ± 0.032
2.695GlnGly: 2.695 ± 0.046
1.064GlnHis: 1.064 ± 0.025
1.998GlnIle: 1.998 ± 0.033
2.606GlnLys: 2.606 ± 0.043
4.497GlnLeu: 4.497 ± 0.071
0.927GlnMet: 0.927 ± 0.026
1.904GlnAsn: 1.904 ± 0.038
1.777GlnPro: 1.777 ± 0.033
2.793GlnGln: 2.793 ± 0.058
2.086GlnArg: 2.086 ± 0.038
1.88GlnSer: 1.88 ± 0.036
2.022GlnThr: 2.022 ± 0.038
3.32GlnVal: 3.32 ± 0.052
0.437GlnTrp: 0.437 ± 0.015
1.566GlnTyr: 1.566 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
3.272ArgAla: 3.272 ± 0.048
0.273ArgCys: 0.273 ± 0.014
2.407ArgAsp: 2.407 ± 0.035
3.44ArgGlu: 3.44 ± 0.051
2.311ArgPhe: 2.311 ± 0.04
2.741ArgGly: 2.741 ± 0.045
1.049ArgHis: 1.049 ± 0.025
2.954ArgIle: 2.954 ± 0.045
3.05ArgLys: 3.05 ± 0.047
5.011ArgLeu: 5.011 ± 0.063
1.287ArgMet: 1.287 ± 0.028
2.378ArgAsn: 2.378 ± 0.038
1.807ArgPro: 1.807 ± 0.035
2.321ArgGln: 2.321 ± 0.041
2.341ArgArg: 2.341 ± 0.04
2.543ArgSer: 2.543 ± 0.041
2.413ArgThr: 2.413 ± 0.039
3.273ArgVal: 3.273 ± 0.046
0.616ArgTrp: 0.616 ± 0.02
2.113ArgTyr: 2.113 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
4.382SerAla: 4.382 ± 0.054
0.608SerCys: 0.608 ± 0.018
2.877SerAsp: 2.877 ± 0.042
3.431SerGlu: 3.431 ± 0.049
3.234SerPhe: 3.234 ± 0.044
4.593SerGly: 4.593 ± 0.052
1.1SerHis: 1.1 ± 0.025
3.561SerIle: 3.561 ± 0.047
3.206SerLys: 3.206 ± 0.041
6.184SerLeu: 6.184 ± 0.075
1.344SerMet: 1.344 ± 0.028
2.526SerAsn: 2.526 ± 0.046
2.638SerPro: 2.638 ± 0.041
2.093SerGln: 2.093 ± 0.035
2.776SerArg: 2.776 ± 0.043
3.969SerSer: 3.969 ± 0.06
3.293SerThr: 3.293 ± 0.05
4.1SerVal: 4.1 ± 0.053
0.741SerTrp: 0.741 ± 0.022
2.569SerTyr: 2.569 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
4.847ThrAla: 4.847 ± 0.083
0.382ThrCys: 0.382 ± 0.015
2.96ThrAsp: 2.96 ± 0.048
3.39ThrGlu: 3.39 ± 0.043
2.64ThrPhe: 2.64 ± 0.037
4.598ThrGly: 4.598 ± 0.061
1.007ThrHis: 1.007 ± 0.022
3.247ThrIle: 3.247 ± 0.047
2.625ThrLys: 2.625 ± 0.045
5.512ThrLeu: 5.512 ± 0.058
1.02ThrMet: 1.02 ± 0.025
2.245ThrAsn: 2.245 ± 0.044
2.74ThrPro: 2.74 ± 0.044
1.88ThrGln: 1.88 ± 0.039
2.198ThrArg: 2.198 ± 0.038
3.32ThrSer: 3.32 ± 0.056
3.167ThrThr: 3.167 ± 0.057
4.25ThrVal: 4.25 ± 0.072
0.702ThrTrp: 0.702 ± 0.02
2.294ThrTyr: 2.294 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
5.983ValAla: 5.983 ± 0.072
0.603ValCys: 0.603 ± 0.021
3.573ValAsp: 3.573 ± 0.047
4.629ValGlu: 4.629 ± 0.058
3.11ValPhe: 3.11 ± 0.048
4.666ValGly: 4.666 ± 0.061
1.319ValHis: 1.319 ± 0.031
3.849ValIle: 3.849 ± 0.053
4.079ValLys: 4.079 ± 0.052
7.637ValLeu: 7.637 ± 0.069
1.599ValMet: 1.599 ± 0.03
3.177ValAsn: 3.177 ± 0.05
3.354ValPro: 3.354 ± 0.047
2.944ValGln: 2.944 ± 0.043
3.354ValArg: 3.354 ± 0.046
4.595ValSer: 4.595 ± 0.059
3.996ValThr: 3.996 ± 0.064
5.504ValVal: 5.504 ± 0.071
0.804ValTrp: 0.804 ± 0.021
2.737ValTyr: 2.737 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.909TrpAla: 0.909 ± 0.027
0.098TrpCys: 0.098 ± 0.008
0.668TrpAsp: 0.668 ± 0.023
0.754TrpGlu: 0.754 ± 0.024
0.532TrpPhe: 0.532 ± 0.02
0.841TrpGly: 0.841 ± 0.025
0.305TrpHis: 0.305 ± 0.015
0.581TrpIle: 0.581 ± 0.02
0.66TrpLys: 0.66 ± 0.023
1.337TrpLeu: 1.337 ± 0.032
0.331TrpMet: 0.331 ± 0.016
0.574TrpAsn: 0.574 ± 0.019
0.412TrpPro: 0.412 ± 0.016
0.626TrpGln: 0.626 ± 0.021
0.628TrpArg: 0.628 ± 0.019
0.689TrpSer: 0.689 ± 0.02
0.591TrpThr: 0.591 ± 0.019
0.852TrpVal: 0.852 ± 0.026
0.194TrpTrp: 0.194 ± 0.011
0.448TrpTyr: 0.448 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.911TyrAla: 2.911 ± 0.04
0.299TyrCys: 0.299 ± 0.013
2.204TyrAsp: 2.204 ± 0.039
2.365TyrGlu: 2.365 ± 0.037
1.993TyrPhe: 1.993 ± 0.035
2.851TyrGly: 2.851 ± 0.05
0.89TyrHis: 0.89 ± 0.026
2.024TyrIle: 2.024 ± 0.04
2.364TyrLys: 2.364 ± 0.044
4.201TyrLeu: 4.201 ± 0.057
0.794TyrMet: 0.794 ± 0.022
2.089TyrAsn: 2.089 ± 0.036
1.658TyrPro: 1.658 ± 0.033
1.707TyrGln: 1.707 ± 0.032
2.244TyrArg: 2.244 ± 0.041
2.443TyrSer: 2.443 ± 0.05
2.453TyrThr: 2.453 ± 0.046
2.409TyrVal: 2.409 ± 0.041
0.506TyrTrp: 0.506 ± 0.018
1.8TyrTyr: 1.8 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5129 proteins (1702560 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski