Amino acid dipepetide frequency for Alteromonas phage JH01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.401AlaAla: 9.401 ± 1.862
0.76AlaCys: 0.76 ± 0.264
4.7AlaAsp: 4.7 ± 0.61
5.461AlaGlu: 5.461 ± 0.982
3.041AlaPhe: 3.041 ± 0.338
6.014AlaGly: 6.014 ± 0.78
1.935AlaHis: 1.935 ± 0.453
4.286AlaIle: 4.286 ± 0.597
4.769AlaLys: 4.769 ± 0.63
6.428AlaLeu: 6.428 ± 0.736
1.659AlaMet: 1.659 ± 0.356
3.871AlaAsn: 3.871 ± 0.464
4.493AlaPro: 4.493 ± 1.437
4.286AlaGln: 4.286 ± 0.811
3.594AlaArg: 3.594 ± 0.549
4.493AlaSer: 4.493 ± 0.528
6.705AlaThr: 6.705 ± 0.786
5.184AlaVal: 5.184 ± 0.534
0.691AlaTrp: 0.691 ± 0.19
2.35AlaTyr: 2.35 ± 0.337
0.0AlaXaa: 0.0 ± 0.0
Cys
0.622CysAla: 0.622 ± 0.23
0.138CysCys: 0.138 ± 0.105
0.968CysAsp: 0.968 ± 0.232
0.899CysGlu: 0.899 ± 0.325
0.622CysPhe: 0.622 ± 0.278
0.138CysGly: 0.138 ± 0.105
0.207CysHis: 0.207 ± 0.117
0.553CysIle: 0.553 ± 0.163
0.207CysLys: 0.207 ± 0.131
0.484CysLeu: 0.484 ± 0.163
0.276CysMet: 0.276 ± 0.158
0.76CysAsn: 0.76 ± 0.251
1.037CysPro: 1.037 ± 0.29
0.276CysGln: 0.276 ± 0.156
0.829CysArg: 0.829 ± 0.254
1.037CysSer: 1.037 ± 0.382
0.484CysThr: 0.484 ± 0.168
0.76CysVal: 0.76 ± 0.257
0.207CysTrp: 0.207 ± 0.115
0.415CysTyr: 0.415 ± 0.177
0.0CysXaa: 0.0 ± 0.0
Asp
5.253AspAla: 5.253 ± 0.616
0.553AspCys: 0.553 ± 0.157
4.009AspAsp: 4.009 ± 0.442
3.94AspGlu: 3.94 ± 0.475
2.35AspPhe: 2.35 ± 0.476
5.184AspGly: 5.184 ± 0.781
1.313AspHis: 1.313 ± 0.393
4.355AspIle: 4.355 ± 0.694
2.488AspLys: 2.488 ± 0.451
5.253AspLeu: 5.253 ± 0.7
1.244AspMet: 1.244 ± 0.273
3.594AspAsn: 3.594 ± 0.596
3.111AspPro: 3.111 ± 0.526
1.866AspGln: 1.866 ± 0.416
2.488AspArg: 2.488 ± 0.371
3.733AspSer: 3.733 ± 0.596
3.387AspThr: 3.387 ± 0.375
5.392AspVal: 5.392 ± 0.479
0.415AspTrp: 0.415 ± 0.141
2.143AspTyr: 2.143 ± 0.468
0.0AspXaa: 0.0 ± 0.0
Glu
5.945GluAla: 5.945 ± 1.008
0.622GluCys: 0.622 ± 0.255
3.387GluAsp: 3.387 ± 0.448
5.184GluGlu: 5.184 ± 0.828
2.627GluPhe: 2.627 ± 0.453
4.286GluGly: 4.286 ± 0.614
1.866GluHis: 1.866 ± 0.487
4.355GluIle: 4.355 ± 0.675
3.18GluLys: 3.18 ± 0.612
6.152GluLeu: 6.152 ± 0.879
1.521GluMet: 1.521 ± 0.372
3.041GluAsn: 3.041 ± 0.491
1.521GluPro: 1.521 ± 0.396
4.147GluGln: 4.147 ± 1.107
4.009GluArg: 4.009 ± 0.572
3.525GluSer: 3.525 ± 0.619
4.147GluThr: 4.147 ± 0.478
4.908GluVal: 4.908 ± 0.581
1.175GluTrp: 1.175 ± 0.311
3.594GluTyr: 3.594 ± 0.451
0.0GluXaa: 0.0 ± 0.0
Phe
2.419PheAla: 2.419 ± 0.343
0.207PheCys: 0.207 ± 0.14
3.733PheAsp: 3.733 ± 0.508
2.212PheGlu: 2.212 ± 0.361
0.76PhePhe: 0.76 ± 0.238
2.212PheGly: 2.212 ± 0.365
0.346PheHis: 0.346 ± 0.154
2.005PheIle: 2.005 ± 0.414
2.488PheLys: 2.488 ± 0.537
1.59PheLeu: 1.59 ± 0.338
0.76PheMet: 0.76 ± 0.266
2.281PheAsn: 2.281 ± 0.391
1.59PhePro: 1.59 ± 0.343
1.244PheGln: 1.244 ± 0.335
2.005PheArg: 2.005 ± 0.464
2.281PheSer: 2.281 ± 0.592
3.111PheThr: 3.111 ± 0.408
2.143PheVal: 2.143 ± 0.376
0.276PheTrp: 0.276 ± 0.146
1.244PheTyr: 1.244 ± 0.295
0.0PheXaa: 0.0 ± 0.0
Gly
4.839GlyAla: 4.839 ± 0.653
0.691GlyCys: 0.691 ± 0.239
3.802GlyAsp: 3.802 ± 0.52
4.355GlyGlu: 4.355 ± 0.629
2.834GlyPhe: 2.834 ± 0.429
5.046GlyGly: 5.046 ± 0.698
0.484GlyHis: 0.484 ± 0.178
3.594GlyIle: 3.594 ± 0.472
3.525GlyLys: 3.525 ± 0.506
5.599GlyLeu: 5.599 ± 0.65
1.244GlyMet: 1.244 ± 0.258
4.009GlyAsn: 4.009 ± 0.504
0.069GlyPro: 0.069 ± 0.068
2.558GlyGln: 2.558 ± 0.45
3.664GlyArg: 3.664 ± 0.563
4.147GlySer: 4.147 ± 0.759
4.769GlyThr: 4.769 ± 0.61
5.184GlyVal: 5.184 ± 0.596
0.622GlyTrp: 0.622 ± 0.185
2.558GlyTyr: 2.558 ± 0.574
0.0GlyXaa: 0.0 ± 0.0
His
1.59HisAla: 1.59 ± 0.308
0.484HisCys: 0.484 ± 0.194
1.313HisAsp: 1.313 ± 0.384
0.76HisGlu: 0.76 ± 0.285
0.622HisPhe: 0.622 ± 0.21
0.76HisGly: 0.76 ± 0.217
0.276HisHis: 0.276 ± 0.148
0.622HisIle: 0.622 ± 0.237
1.037HisLys: 1.037 ± 0.367
1.659HisLeu: 1.659 ± 0.423
0.207HisMet: 0.207 ± 0.107
0.899HisAsn: 0.899 ± 0.313
0.622HisPro: 0.622 ± 0.186
0.553HisGln: 0.553 ± 0.246
0.968HisArg: 0.968 ± 0.301
1.244HisSer: 1.244 ± 0.275
1.175HisThr: 1.175 ± 0.293
2.212HisVal: 2.212 ± 0.429
0.138HisTrp: 0.138 ± 0.092
1.106HisTyr: 1.106 ± 0.353
0.0HisXaa: 0.0 ± 0.0
Ile
4.493IleAla: 4.493 ± 0.525
0.415IleCys: 0.415 ± 0.204
4.769IleAsp: 4.769 ± 0.547
5.392IleGlu: 5.392 ± 0.431
1.728IlePhe: 1.728 ± 0.369
2.834IleGly: 2.834 ± 0.434
0.899IleHis: 0.899 ± 0.223
2.281IleIle: 2.281 ± 0.405
2.903IleLys: 2.903 ± 0.483
2.765IleLeu: 2.765 ± 0.471
0.968IleMet: 0.968 ± 0.255
3.733IleAsn: 3.733 ± 0.541
1.797IlePro: 1.797 ± 0.308
1.659IleGln: 1.659 ± 0.29
2.765IleArg: 2.765 ± 0.377
3.387IleSer: 3.387 ± 0.596
5.322IleThr: 5.322 ± 0.569
4.355IleVal: 4.355 ± 0.59
0.415IleTrp: 0.415 ± 0.119
1.037IleTyr: 1.037 ± 0.228
0.0IleXaa: 0.0 ± 0.0
Lys
3.802LysAla: 3.802 ± 0.584
0.553LysCys: 0.553 ± 0.19
2.765LysAsp: 2.765 ± 0.43
2.765LysGlu: 2.765 ± 0.625
2.005LysPhe: 2.005 ± 0.411
3.664LysGly: 3.664 ± 0.547
1.521LysHis: 1.521 ± 0.374
3.387LysIle: 3.387 ± 0.477
3.18LysLys: 3.18 ± 0.558
4.216LysLeu: 4.216 ± 0.715
1.244LysMet: 1.244 ± 0.322
2.212LysAsn: 2.212 ± 0.35
2.558LysPro: 2.558 ± 0.399
2.696LysGln: 2.696 ± 0.412
3.664LysArg: 3.664 ± 0.583
3.456LysSer: 3.456 ± 0.481
3.525LysThr: 3.525 ± 0.613
3.871LysVal: 3.871 ± 0.694
0.899LysTrp: 0.899 ± 0.254
2.281LysTyr: 2.281 ± 0.369
0.0LysXaa: 0.0 ± 0.0
Leu
7.12LeuAla: 7.12 ± 0.988
0.829LeuCys: 0.829 ± 0.351
4.977LeuAsp: 4.977 ± 0.524
4.908LeuGlu: 4.908 ± 0.787
2.488LeuPhe: 2.488 ± 0.474
4.493LeuGly: 4.493 ± 0.733
1.037LeuHis: 1.037 ± 0.273
4.078LeuIle: 4.078 ± 0.503
4.424LeuLys: 4.424 ± 0.695
7.604LeuLeu: 7.604 ± 2.714
2.005LeuMet: 2.005 ± 0.544
5.046LeuAsn: 5.046 ± 0.88
3.041LeuPro: 3.041 ± 0.438
3.456LeuGln: 3.456 ± 0.495
5.392LeuArg: 5.392 ± 0.83
5.53LeuSer: 5.53 ± 0.637
4.631LeuThr: 4.631 ± 0.653
8.433LeuVal: 8.433 ± 3.892
0.829LeuTrp: 0.829 ± 0.218
2.696LeuTyr: 2.696 ± 0.458
0.0LeuXaa: 0.0 ± 0.0
Met
2.35MetAla: 2.35 ± 0.409
0.138MetCys: 0.138 ± 0.1
1.037MetAsp: 1.037 ± 0.31
0.76MetGlu: 0.76 ± 0.228
0.346MetPhe: 0.346 ± 0.191
1.106MetGly: 1.106 ± 0.287
0.207MetHis: 0.207 ± 0.115
1.106MetIle: 1.106 ± 0.258
1.244MetLys: 1.244 ± 0.296
2.005MetLeu: 2.005 ± 0.495
0.484MetMet: 0.484 ± 0.343
1.521MetAsn: 1.521 ± 0.332
1.175MetPro: 1.175 ± 0.342
0.76MetGln: 0.76 ± 0.225
1.175MetArg: 1.175 ± 0.325
1.382MetSer: 1.382 ± 0.313
1.313MetThr: 1.313 ± 0.257
1.382MetVal: 1.382 ± 0.321
0.346MetTrp: 0.346 ± 0.176
0.622MetTyr: 0.622 ± 0.231
0.0MetXaa: 0.0 ± 0.0
Asn
4.839AsnAla: 4.839 ± 0.532
0.691AsnCys: 0.691 ± 0.207
3.525AsnAsp: 3.525 ± 0.466
2.972AsnGlu: 2.972 ± 0.42
1.659AsnPhe: 1.659 ± 0.343
4.216AsnGly: 4.216 ± 0.704
1.175AsnHis: 1.175 ± 0.316
2.765AsnIle: 2.765 ± 0.609
2.903AsnLys: 2.903 ± 0.417
3.456AsnLeu: 3.456 ± 0.652
1.175AsnMet: 1.175 ± 0.269
3.456AsnAsn: 3.456 ± 0.615
2.35AsnPro: 2.35 ± 0.485
2.005AsnGln: 2.005 ± 0.415
2.419AsnArg: 2.419 ± 0.598
3.387AsnSer: 3.387 ± 0.481
4.355AsnThr: 4.355 ± 0.642
4.839AsnVal: 4.839 ± 0.587
0.415AsnTrp: 0.415 ± 0.162
1.313AsnTyr: 1.313 ± 0.319
0.0AsnXaa: 0.0 ± 0.0
Pro
4.424ProAla: 4.424 ± 1.478
0.484ProCys: 0.484 ± 0.19
2.419ProAsp: 2.419 ± 0.38
2.834ProGlu: 2.834 ± 0.449
1.382ProPhe: 1.382 ± 0.285
2.35ProGly: 2.35 ± 0.477
0.829ProHis: 0.829 ± 0.261
2.212ProIle: 2.212 ± 0.46
2.005ProLys: 2.005 ± 0.431
2.627ProLeu: 2.627 ± 0.469
1.106ProMet: 1.106 ± 0.327
2.074ProAsn: 2.074 ± 0.463
3.594ProPro: 3.594 ± 1.095
0.829ProGln: 0.829 ± 0.256
1.452ProArg: 1.452 ± 0.294
2.488ProSer: 2.488 ± 0.488
2.834ProThr: 2.834 ± 0.419
2.903ProVal: 2.903 ± 0.558
0.484ProTrp: 0.484 ± 0.167
1.037ProTyr: 1.037 ± 0.268
0.0ProXaa: 0.0 ± 0.0
Gln
3.041GlnAla: 3.041 ± 0.985
0.622GlnCys: 0.622 ± 0.225
1.175GlnAsp: 1.175 ± 0.245
2.903GlnGlu: 2.903 ± 0.639
1.728GlnPhe: 1.728 ± 0.288
2.558GlnGly: 2.558 ± 0.476
0.829GlnHis: 0.829 ± 0.251
2.281GlnIle: 2.281 ± 0.305
2.143GlnLys: 2.143 ± 0.399
4.839GlnLeu: 4.839 ± 0.971
0.899GlnMet: 0.899 ± 0.289
1.452GlnAsn: 1.452 ± 0.419
1.175GlnPro: 1.175 ± 0.299
2.903GlnGln: 2.903 ± 0.66
2.212GlnArg: 2.212 ± 0.313
2.488GlnSer: 2.488 ± 0.474
2.765GlnThr: 2.765 ± 0.662
2.558GlnVal: 2.558 ± 0.491
0.829GlnTrp: 0.829 ± 0.199
2.074GlnTyr: 2.074 ± 0.41
0.0GlnXaa: 0.0 ± 0.0
Arg
4.631ArgAla: 4.631 ± 0.777
0.346ArgCys: 0.346 ± 0.147
3.041ArgAsp: 3.041 ± 0.525
4.631ArgGlu: 4.631 ± 0.686
2.005ArgPhe: 2.005 ± 0.336
2.143ArgGly: 2.143 ± 0.379
0.968ArgHis: 0.968 ± 0.292
3.318ArgIle: 3.318 ± 0.538
3.94ArgLys: 3.94 ± 0.505
4.355ArgLeu: 4.355 ± 0.591
1.521ArgMet: 1.521 ± 0.352
2.488ArgAsn: 2.488 ± 0.44
1.521ArgPro: 1.521 ± 0.314
2.488ArgGln: 2.488 ± 0.677
2.972ArgArg: 2.972 ± 0.537
2.488ArgSer: 2.488 ± 0.408
3.525ArgThr: 3.525 ± 0.456
4.009ArgVal: 4.009 ± 0.496
0.484ArgTrp: 0.484 ± 0.137
1.797ArgTyr: 1.797 ± 0.369
0.0ArgXaa: 0.0 ± 0.0
Ser
3.871SerAla: 3.871 ± 0.567
0.622SerCys: 0.622 ± 0.201
4.078SerAsp: 4.078 ± 0.573
4.424SerGlu: 4.424 ± 0.635
2.419SerPhe: 2.419 ± 0.388
4.631SerGly: 4.631 ± 0.629
0.691SerHis: 0.691 ± 0.177
3.802SerIle: 3.802 ± 0.528
3.802SerLys: 3.802 ± 0.539
5.253SerLeu: 5.253 ± 0.528
0.829SerMet: 0.829 ± 0.227
3.733SerAsn: 3.733 ± 0.719
2.212SerPro: 2.212 ± 0.532
2.005SerGln: 2.005 ± 0.374
3.111SerArg: 3.111 ± 0.396
4.355SerSer: 4.355 ± 0.688
4.493SerThr: 4.493 ± 0.594
4.631SerVal: 4.631 ± 0.731
0.829SerTrp: 0.829 ± 0.279
2.074SerTyr: 2.074 ± 0.475
0.0SerXaa: 0.0 ± 0.0
Thr
6.152ThrAla: 6.152 ± 0.857
1.106ThrCys: 1.106 ± 0.419
3.871ThrAsp: 3.871 ± 0.626
4.839ThrGlu: 4.839 ± 0.784
2.143ThrPhe: 2.143 ± 0.465
4.631ThrGly: 4.631 ± 0.525
1.797ThrHis: 1.797 ± 0.378
3.733ThrIle: 3.733 ± 0.517
3.18ThrLys: 3.18 ± 0.463
7.12ThrLeu: 7.12 ± 0.749
1.106ThrMet: 1.106 ± 0.312
2.765ThrAsn: 2.765 ± 0.394
3.871ThrPro: 3.871 ± 0.609
2.005ThrGln: 2.005 ± 0.461
3.18ThrArg: 3.18 ± 0.5
4.631ThrSer: 4.631 ± 0.449
5.184ThrThr: 5.184 ± 0.954
5.806ThrVal: 5.806 ± 0.971
0.622ThrTrp: 0.622 ± 0.253
2.972ThrTyr: 2.972 ± 0.499
0.0ThrXaa: 0.0 ± 0.0
Val
5.875ValAla: 5.875 ± 0.496
1.175ValCys: 1.175 ± 0.418
5.461ValAsp: 5.461 ± 0.795
6.774ValGlu: 6.774 ± 0.76
2.627ValPhe: 2.627 ± 0.575
3.664ValGly: 3.664 ± 0.521
0.76ValHis: 0.76 ± 0.22
3.18ValIle: 3.18 ± 0.52
4.009ValLys: 4.009 ± 0.619
8.156ValLeu: 8.156 ± 3.77
1.313ValMet: 1.313 ± 0.319
3.94ValAsn: 3.94 ± 0.675
3.249ValPro: 3.249 ± 0.605
3.802ValGln: 3.802 ± 0.574
4.078ValArg: 4.078 ± 0.542
4.769ValSer: 4.769 ± 0.611
5.945ValThr: 5.945 ± 0.612
5.461ValVal: 5.461 ± 0.651
0.553ValTrp: 0.553 ± 0.196
2.212ValTyr: 2.212 ± 0.489
0.0ValXaa: 0.0 ± 0.0
Trp
0.968TrpAla: 0.968 ± 0.259
0.207TrpCys: 0.207 ± 0.153
0.691TrpAsp: 0.691 ± 0.222
0.484TrpGlu: 0.484 ± 0.189
0.207TrpPhe: 0.207 ± 0.103
1.452TrpGly: 1.452 ± 0.376
0.553TrpHis: 0.553 ± 0.2
0.138TrpIle: 0.138 ± 0.101
0.622TrpLys: 0.622 ± 0.213
1.175TrpLeu: 1.175 ± 0.318
0.069TrpMet: 0.069 ± 0.058
0.415TrpAsn: 0.415 ± 0.166
0.069TrpPro: 0.069 ± 0.061
0.346TrpGln: 0.346 ± 0.159
0.622TrpArg: 0.622 ± 0.224
1.175TrpSer: 1.175 ± 0.314
0.553TrpThr: 0.553 ± 0.184
0.691TrpVal: 0.691 ± 0.198
0.415TrpTrp: 0.415 ± 0.137
0.415TrpTyr: 0.415 ± 0.167
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.488TyrAla: 2.488 ± 0.319
0.276TyrCys: 0.276 ± 0.118
2.35TyrAsp: 2.35 ± 0.433
2.696TyrGlu: 2.696 ± 0.347
1.313TyrPhe: 1.313 ± 0.284
2.212TyrGly: 2.212 ± 0.313
0.553TyrHis: 0.553 ± 0.169
1.866TyrIle: 1.866 ± 0.347
2.212TyrLys: 2.212 ± 0.316
2.281TyrLeu: 2.281 ± 0.359
0.76TyrMet: 0.76 ± 0.21
2.627TyrAsn: 2.627 ± 0.344
1.313TyrPro: 1.313 ± 0.313
1.59TyrGln: 1.59 ± 0.306
2.074TyrArg: 2.074 ± 0.437
1.866TyrSer: 1.866 ± 0.354
2.488TyrThr: 2.488 ± 0.504
2.281TyrVal: 2.281 ± 0.457
0.622TyrTrp: 0.622 ± 0.2
2.143TyrTyr: 2.143 ± 0.575
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 58 proteins (14468 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski