Amino acid dipepetide frequency for Streptococcus satellite phage Javan243

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.408AlaCys: 0.408 ± 0.318
4.078AlaAsp: 4.078 ± 0.967
6.933AlaGlu: 6.933 ± 2.205
2.447AlaPhe: 2.447 ± 0.815
3.67AlaGly: 3.67 ± 1.25
0.0AlaHis: 0.0 ± 0.0
5.71AlaIle: 5.71 ± 1.471
5.71AlaLys: 5.71 ± 1.478
3.67AlaLeu: 3.67 ± 0.949
2.447AlaMet: 2.447 ± 0.86
3.263AlaAsn: 3.263 ± 0.751
1.631AlaPro: 1.631 ± 0.445
1.223AlaGln: 1.223 ± 0.497
3.67AlaArg: 3.67 ± 1.109
2.447AlaSer: 2.447 ± 0.819
4.078AlaThr: 4.078 ± 1.664
3.67AlaVal: 3.67 ± 1.335
0.0AlaTrp: 0.0 ± 0.0
4.078AlaTyr: 4.078 ± 1.658
0.0AlaXaa: 0.0 ± 0.0
Cys
0.408CysAla: 0.408 ± 0.397
0.0CysCys: 0.0 ± 0.0
0.408CysAsp: 0.408 ± 0.4
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.408CysLys: 0.408 ± 0.318
0.408CysLeu: 0.408 ± 0.4
0.0CysMet: 0.0 ± 0.0
0.816CysAsn: 0.816 ± 0.636
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.408CysArg: 0.408 ± 0.374
0.0CysSer: 0.0 ± 0.0
1.223CysThr: 1.223 ± 0.871
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.408CysTyr: 0.408 ± 0.41
0.0CysXaa: 0.0 ± 0.0
Asp
0.816AspAla: 0.816 ± 0.516
0.816AspCys: 0.816 ± 0.563
2.855AspAsp: 2.855 ± 0.928
2.447AspGlu: 2.447 ± 0.947
3.67AspPhe: 3.67 ± 1.086
1.223AspGly: 1.223 ± 0.693
1.223AspHis: 1.223 ± 0.809
5.71AspIle: 5.71 ± 2.063
6.117AspLys: 6.117 ± 1.252
6.525AspLeu: 6.525 ± 1.557
2.039AspMet: 2.039 ± 0.645
2.039AspAsn: 2.039 ± 0.761
1.631AspPro: 1.631 ± 0.585
1.631AspGln: 1.631 ± 0.954
2.855AspArg: 2.855 ± 0.825
2.447AspSer: 2.447 ± 1.349
4.078AspThr: 4.078 ± 1.45
3.263AspVal: 3.263 ± 1.064
0.816AspTrp: 0.816 ± 0.44
6.117AspTyr: 6.117 ± 1.354
0.0AspXaa: 0.0 ± 0.0
Glu
6.117GluAla: 6.117 ± 1.44
0.0GluCys: 0.0 ± 0.0
4.078GluAsp: 4.078 ± 0.8
4.894GluGlu: 4.894 ± 1.449
3.67GluPhe: 3.67 ± 1.297
2.447GluGly: 2.447 ± 0.927
0.816GluHis: 0.816 ± 0.479
4.486GluIle: 4.486 ± 1.35
8.972GluLys: 8.972 ± 2.369
9.788GluLeu: 9.788 ± 2.181
1.223GluMet: 1.223 ± 0.59
4.894GluAsn: 4.894 ± 1.267
2.447GluPro: 2.447 ± 1.619
2.855GluGln: 2.855 ± 1.194
4.078GluArg: 4.078 ± 1.35
4.894GluSer: 4.894 ± 1.174
4.078GluThr: 4.078 ± 1.321
4.894GluVal: 4.894 ± 1.462
2.039GluTrp: 2.039 ± 0.691
4.486GluTyr: 4.486 ± 1.124
0.0GluXaa: 0.0 ± 0.0
Phe
2.447PheAla: 2.447 ± 0.808
0.408PheCys: 0.408 ± 0.318
4.894PheAsp: 4.894 ± 1.056
2.855PheGlu: 2.855 ± 0.942
1.631PhePhe: 1.631 ± 0.827
2.039PheGly: 2.039 ± 0.903
0.816PheHis: 0.816 ± 0.432
4.486PheIle: 4.486 ± 1.039
2.447PheLys: 2.447 ± 0.76
3.67PheLeu: 3.67 ± 1.396
0.408PheMet: 0.408 ± 0.363
2.447PheAsn: 2.447 ± 1.175
0.816PhePro: 0.816 ± 0.609
3.263PheGln: 3.263 ± 1.006
1.631PheArg: 1.631 ± 0.815
2.855PheSer: 2.855 ± 0.943
3.263PheThr: 3.263 ± 1.005
1.223PheVal: 1.223 ± 0.697
0.408PheTrp: 0.408 ± 0.318
2.447PheTyr: 2.447 ± 0.926
0.0PheXaa: 0.0 ± 0.0
Gly
2.855GlyAla: 2.855 ± 1.279
0.816GlyCys: 0.816 ± 0.747
2.855GlyAsp: 2.855 ± 1.157
3.67GlyGlu: 3.67 ± 1.026
2.447GlyPhe: 2.447 ± 1.068
2.039GlyGly: 2.039 ± 0.836
0.816GlyHis: 0.816 ± 0.747
3.263GlyIle: 3.263 ± 0.799
4.078GlyLys: 4.078 ± 1.176
3.67GlyLeu: 3.67 ± 2.17
0.408GlyMet: 0.408 ± 0.394
1.631GlyAsn: 1.631 ± 0.933
0.0GlyPro: 0.0 ± 0.0
1.631GlyGln: 1.631 ± 0.974
2.039GlyArg: 2.039 ± 0.636
0.816GlySer: 0.816 ± 0.486
2.447GlyThr: 2.447 ± 1.157
3.263GlyVal: 3.263 ± 1.58
0.816GlyTrp: 0.816 ± 0.636
3.263GlyTyr: 3.263 ± 1.281
0.0GlyXaa: 0.0 ± 0.0
His
1.631HisAla: 1.631 ± 1.081
0.0HisCys: 0.0 ± 0.0
0.816HisAsp: 0.816 ± 0.568
1.223HisGlu: 1.223 ± 0.692
0.408HisPhe: 0.408 ± 0.318
0.816HisGly: 0.816 ± 0.8
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
0.408HisLys: 0.408 ± 0.375
1.631HisLeu: 1.631 ± 0.791
0.0HisMet: 0.0 ± 0.0
1.631HisAsn: 1.631 ± 0.785
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
1.223HisSer: 1.223 ± 0.678
2.447HisThr: 2.447 ± 0.869
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.631HisTyr: 1.631 ± 0.813
0.0HisXaa: 0.0 ± 0.0
Ile
4.486IleAla: 4.486 ± 1.13
0.0IleCys: 0.0 ± 0.0
4.894IleAsp: 4.894 ± 1.502
7.749IleGlu: 7.749 ± 2.604
4.486IlePhe: 4.486 ± 1.26
2.447IleGly: 2.447 ± 0.881
0.0IleHis: 0.0 ± 0.0
6.117IleIle: 6.117 ± 1.277
7.341IleLys: 7.341 ± 1.175
6.525IleLeu: 6.525 ± 1.517
1.223IleMet: 1.223 ± 0.874
4.486IleAsn: 4.486 ± 0.932
4.486IlePro: 4.486 ± 1.372
1.631IleGln: 1.631 ± 0.703
1.223IleArg: 1.223 ± 0.614
6.117IleSer: 6.117 ± 1.429
4.894IleThr: 4.894 ± 1.452
3.263IleVal: 3.263 ± 0.875
0.0IleTrp: 0.0 ± 0.0
2.447IleTyr: 2.447 ± 0.684
0.0IleXaa: 0.0 ± 0.0
Lys
6.933LysAla: 6.933 ± 2.013
0.0LysCys: 0.0 ± 0.0
4.894LysAsp: 4.894 ± 1.394
10.196LysGlu: 10.196 ± 1.986
1.223LysPhe: 1.223 ± 0.504
4.486LysGly: 4.486 ± 1.387
1.223LysHis: 1.223 ± 0.953
7.749LysIle: 7.749 ± 2.329
11.419LysLys: 11.419 ± 2.898
8.564LysLeu: 8.564 ± 1.878
2.447LysMet: 2.447 ± 1.3
6.933LysAsn: 6.933 ± 1.514
5.71LysPro: 5.71 ± 1.21
4.486LysGln: 4.486 ± 1.568
6.117LysArg: 6.117 ± 1.563
4.486LysSer: 4.486 ± 1.134
4.894LysThr: 4.894 ± 1.495
5.71LysVal: 5.71 ± 1.069
0.816LysTrp: 0.816 ± 0.522
1.631LysTyr: 1.631 ± 0.815
0.0LysXaa: 0.0 ± 0.0
Leu
6.117LeuAla: 6.117 ± 1.898
0.0LeuCys: 0.0 ± 0.0
4.894LeuAsp: 4.894 ± 1.412
10.604LeuGlu: 10.604 ± 2.519
4.486LeuPhe: 4.486 ± 1.507
3.67LeuGly: 3.67 ± 1.325
0.0LeuHis: 0.0 ± 0.0
6.525LeuIle: 6.525 ± 2.046
9.38LeuLys: 9.38 ± 2.45
8.564LeuLeu: 8.564 ± 1.909
3.263LeuMet: 3.263 ± 0.946
3.67LeuAsn: 3.67 ± 1.473
4.078LeuPro: 4.078 ± 1.291
4.078LeuGln: 4.078 ± 1.015
2.855LeuArg: 2.855 ± 0.715
6.117LeuSer: 6.117 ± 1.184
6.117LeuThr: 6.117 ± 1.129
5.71LeuVal: 5.71 ± 1.483
0.408LeuTrp: 0.408 ± 0.374
4.486LeuTyr: 4.486 ± 1.219
0.0LeuXaa: 0.0 ± 0.0
Met
2.447MetAla: 2.447 ± 0.942
0.0MetCys: 0.0 ± 0.0
0.816MetAsp: 0.816 ± 0.499
2.447MetGlu: 2.447 ± 0.806
0.816MetPhe: 0.816 ± 0.743
1.223MetGly: 1.223 ± 0.489
0.0MetHis: 0.0 ± 0.0
0.816MetIle: 0.816 ± 0.484
2.039MetLys: 2.039 ± 0.729
2.855MetLeu: 2.855 ± 1.159
0.0MetMet: 0.0 ± 0.0
3.263MetAsn: 3.263 ± 1.087
0.816MetPro: 0.816 ± 0.44
0.0MetGln: 0.0 ± 0.0
0.816MetArg: 0.816 ± 0.486
0.816MetSer: 0.816 ± 0.451
4.078MetThr: 4.078 ± 1.298
0.408MetVal: 0.408 ± 0.318
0.408MetTrp: 0.408 ± 0.41
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.039AsnAla: 2.039 ± 1.034
0.0AsnCys: 0.0 ± 0.0
2.447AsnAsp: 2.447 ± 1.204
5.71AsnGlu: 5.71 ± 1.459
0.816AsnPhe: 0.816 ± 0.82
5.302AsnGly: 5.302 ± 0.937
1.631AsnHis: 1.631 ± 0.616
2.855AsnIle: 2.855 ± 0.744
4.078AsnLys: 4.078 ± 1.179
3.67AsnLeu: 3.67 ± 1.155
2.447AsnMet: 2.447 ± 0.961
4.078AsnAsn: 4.078 ± 1.064
2.039AsnPro: 2.039 ± 0.955
1.223AsnGln: 1.223 ± 0.57
3.263AsnArg: 3.263 ± 1.175
1.631AsnSer: 1.631 ± 0.436
1.223AsnThr: 1.223 ± 0.723
4.078AsnVal: 4.078 ± 0.841
0.0AsnTrp: 0.0 ± 0.0
3.263AsnTyr: 3.263 ± 1.022
0.0AsnXaa: 0.0 ± 0.0
Pro
2.039ProAla: 2.039 ± 0.78
0.0ProCys: 0.0 ± 0.0
1.223ProAsp: 1.223 ± 0.657
2.855ProGlu: 2.855 ± 1.025
2.855ProPhe: 2.855 ± 1.255
0.0ProGly: 0.0 ± 0.0
0.408ProHis: 0.408 ± 0.419
2.447ProIle: 2.447 ± 0.808
4.894ProLys: 4.894 ± 1.087
3.67ProLeu: 3.67 ± 1.122
0.0ProMet: 0.0 ± 0.0
2.855ProAsn: 2.855 ± 1.551
1.223ProPro: 1.223 ± 0.74
1.631ProGln: 1.631 ± 0.927
2.855ProArg: 2.855 ± 1.062
0.816ProSer: 0.816 ± 0.467
3.263ProThr: 3.263 ± 0.81
2.039ProVal: 2.039 ± 0.813
0.408ProTrp: 0.408 ± 0.318
1.631ProTyr: 1.631 ± 0.945
0.0ProXaa: 0.0 ± 0.0
Gln
4.486GlnAla: 4.486 ± 1.554
0.0GlnCys: 0.0 ± 0.0
2.855GlnAsp: 2.855 ± 1.245
3.263GlnGlu: 3.263 ± 0.719
1.631GlnPhe: 1.631 ± 0.565
2.039GlnGly: 2.039 ± 1.128
0.0GlnHis: 0.0 ± 0.0
1.631GlnIle: 1.631 ± 0.725
4.078GlnLys: 4.078 ± 1.132
5.302GlnLeu: 5.302 ± 1.208
0.408GlnMet: 0.408 ± 0.375
1.223GlnAsn: 1.223 ± 0.573
0.408GlnPro: 0.408 ± 0.374
3.263GlnGln: 3.263 ± 1.021
0.816GlnArg: 0.816 ± 0.467
1.631GlnSer: 1.631 ± 0.57
1.631GlnThr: 1.631 ± 0.636
2.855GlnVal: 2.855 ± 1.041
0.408GlnTrp: 0.408 ± 0.41
2.039GlnTyr: 2.039 ± 0.758
0.0GlnXaa: 0.0 ± 0.0
Arg
4.894ArgAla: 4.894 ± 1.097
0.816ArgCys: 0.816 ± 0.615
2.039ArgAsp: 2.039 ± 0.743
3.263ArgGlu: 3.263 ± 1.288
2.855ArgPhe: 2.855 ± 1.032
1.223ArgGly: 1.223 ± 0.841
1.223ArgHis: 1.223 ± 0.5
3.263ArgIle: 3.263 ± 1.147
4.486ArgLys: 4.486 ± 2.045
3.263ArgLeu: 3.263 ± 1.38
0.408ArgMet: 0.408 ± 0.374
1.631ArgAsn: 1.631 ± 0.795
0.816ArgPro: 0.816 ± 0.636
1.631ArgGln: 1.631 ± 0.935
2.855ArgArg: 2.855 ± 0.853
2.039ArgSer: 2.039 ± 0.729
3.67ArgThr: 3.67 ± 1.053
2.855ArgVal: 2.855 ± 0.929
0.408ArgTrp: 0.408 ± 0.527
1.631ArgTyr: 1.631 ± 0.695
0.0ArgXaa: 0.0 ± 0.0
Ser
2.039SerAla: 2.039 ± 0.678
0.0SerCys: 0.0 ± 0.0
3.67SerAsp: 3.67 ± 1.346
3.263SerGlu: 3.263 ± 1.115
1.223SerPhe: 1.223 ± 0.637
2.855SerGly: 2.855 ± 0.806
1.223SerHis: 1.223 ± 0.628
4.486SerIle: 4.486 ± 0.979
6.117SerLys: 6.117 ± 1.206
4.894SerLeu: 4.894 ± 1.344
0.408SerMet: 0.408 ± 0.4
1.631SerAsn: 1.631 ± 0.927
2.447SerPro: 2.447 ± 0.819
2.855SerGln: 2.855 ± 1.75
1.631SerArg: 1.631 ± 0.999
1.223SerSer: 1.223 ± 0.745
2.447SerThr: 2.447 ± 0.755
2.855SerVal: 2.855 ± 0.897
1.631SerTrp: 1.631 ± 0.675
4.486SerTyr: 4.486 ± 1.298
0.0SerXaa: 0.0 ± 0.0
Thr
4.078ThrAla: 4.078 ± 1.454
0.0ThrCys: 0.0 ± 0.0
3.263ThrAsp: 3.263 ± 1.25
4.078ThrGlu: 4.078 ± 1.244
6.117ThrPhe: 6.117 ± 1.619
3.263ThrGly: 3.263 ± 0.909
0.816ThrHis: 0.816 ± 0.422
6.117ThrIle: 6.117 ± 1.856
5.302ThrLys: 5.302 ± 0.916
6.117ThrLeu: 6.117 ± 1.147
2.447ThrMet: 2.447 ± 0.921
0.0ThrAsn: 0.0 ± 0.0
3.67ThrPro: 3.67 ± 1.129
3.263ThrGln: 3.263 ± 1.178
2.447ThrArg: 2.447 ± 0.721
3.263ThrSer: 3.263 ± 0.896
2.039ThrThr: 2.039 ± 1.077
3.67ThrVal: 3.67 ± 1.317
0.408ThrTrp: 0.408 ± 0.4
2.447ThrTyr: 2.447 ± 1.493
0.0ThrXaa: 0.0 ± 0.0
Val
3.67ValAla: 3.67 ± 0.753
0.408ValCys: 0.408 ± 0.318
4.078ValAsp: 4.078 ± 1.282
2.447ValGlu: 2.447 ± 1.012
0.816ValPhe: 0.816 ± 0.451
1.631ValGly: 1.631 ± 0.512
1.223ValHis: 1.223 ± 0.8
2.039ValIle: 2.039 ± 0.509
5.302ValLys: 5.302 ± 1.017
6.117ValLeu: 6.117 ± 1.331
1.223ValMet: 1.223 ± 0.638
2.855ValAsn: 2.855 ± 0.891
3.263ValPro: 3.263 ± 1.528
1.223ValGln: 1.223 ± 0.937
2.855ValArg: 2.855 ± 0.977
5.302ValSer: 5.302 ± 2.21
5.71ValThr: 5.71 ± 1.202
3.263ValVal: 3.263 ± 1.266
0.0ValTrp: 0.0 ± 0.0
2.447ValTyr: 2.447 ± 0.801
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.816TrpAsp: 0.816 ± 0.617
1.223TrpGlu: 1.223 ± 0.759
0.408TrpPhe: 0.408 ± 0.375
0.0TrpGly: 0.0 ± 0.0
0.408TrpHis: 0.408 ± 0.318
0.408TrpIle: 0.408 ± 0.318
0.0TrpLys: 0.0 ± 0.0
2.447TrpLeu: 2.447 ± 0.726
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.408TrpPro: 0.408 ± 0.318
0.408TrpGln: 0.408 ± 0.318
0.408TrpArg: 0.408 ± 0.318
0.816TrpSer: 0.816 ± 0.432
0.0TrpThr: 0.0 ± 0.0
0.816TrpVal: 0.816 ± 0.467
0.0TrpTrp: 0.0 ± 0.0
0.408TrpTyr: 0.408 ± 0.318
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.631TyrAla: 1.631 ± 0.723
0.816TyrCys: 0.816 ± 0.522
2.447TyrAsp: 2.447 ± 0.844
2.039TyrGlu: 2.039 ± 1.057
2.447TyrPhe: 2.447 ± 1.084
2.447TyrGly: 2.447 ± 0.903
2.039TyrHis: 2.039 ± 0.897
5.71TyrIle: 5.71 ± 1.071
7.749TyrLys: 7.749 ± 1.761
3.67TyrLeu: 3.67 ± 0.915
2.855TyrMet: 2.855 ± 1.06
2.447TyrAsn: 2.447 ± 1.178
1.223TyrPro: 1.223 ± 1.201
3.67TyrGln: 3.67 ± 0.982
2.447TyrArg: 2.447 ± 0.818
2.447TyrSer: 2.447 ± 0.739
1.223TyrThr: 1.223 ± 0.499
2.039TyrVal: 2.039 ± 0.868
0.0TyrTrp: 0.0 ± 0.0
0.408TyrTyr: 0.408 ± 0.419
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 17 proteins (2453 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski