Amino acid dipepetide frequency for Prevotella saccharolytica F0055

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.862AlaAla: 5.862 ± 0.119
0.994AlaCys: 0.994 ± 0.04
4.53AlaAsp: 4.53 ± 0.082
4.529AlaGlu: 4.529 ± 0.083
3.552AlaPhe: 3.552 ± 0.082
4.878AlaGly: 4.878 ± 0.083
1.47AlaHis: 1.47 ± 0.044
4.522AlaIle: 4.522 ± 0.078
4.263AlaLys: 4.263 ± 0.077
6.948AlaLeu: 6.948 ± 0.1
1.931AlaMet: 1.931 ± 0.049
3.392AlaAsn: 3.392 ± 0.067
2.339AlaPro: 2.339 ± 0.05
3.274AlaGln: 3.274 ± 0.058
3.43AlaArg: 3.43 ± 0.072
4.054AlaSer: 4.054 ± 0.069
4.103AlaThr: 4.103 ± 0.078
4.863AlaVal: 4.863 ± 0.083
0.83AlaTrp: 0.83 ± 0.031
3.144AlaTyr: 3.144 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.857CysAla: 0.857 ± 0.031
0.235CysCys: 0.235 ± 0.017
0.619CysAsp: 0.619 ± 0.028
0.637CysGlu: 0.637 ± 0.03
0.64CysPhe: 0.64 ± 0.034
0.969CysGly: 0.969 ± 0.038
0.304CysHis: 0.304 ± 0.02
0.937CysIle: 0.937 ± 0.035
0.794CysLys: 0.794 ± 0.036
1.048CysLeu: 1.048 ± 0.037
0.304CysMet: 0.304 ± 0.019
0.632CysAsn: 0.632 ± 0.026
0.46CysPro: 0.46 ± 0.025
0.362CysGln: 0.362 ± 0.023
0.622CysArg: 0.622 ± 0.029
0.712CysSer: 0.712 ± 0.029
0.722CysThr: 0.722 ± 0.029
0.768CysVal: 0.768 ± 0.035
0.168CysTrp: 0.168 ± 0.014
0.539CysTyr: 0.539 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.107AspAla: 4.107 ± 0.077
0.61AspCys: 0.61 ± 0.027
2.684AspAsp: 2.684 ± 0.065
3.626AspGlu: 3.626 ± 0.07
2.915AspPhe: 2.915 ± 0.056
4.13AspGly: 4.13 ± 0.086
0.88AspHis: 0.88 ± 0.032
4.255AspIle: 4.255 ± 0.077
3.946AspLys: 3.946 ± 0.072
4.366AspLeu: 4.366 ± 0.066
1.549AspMet: 1.549 ± 0.041
2.969AspAsn: 2.969 ± 0.056
1.751AspPro: 1.751 ± 0.045
1.188AspGln: 1.188 ± 0.037
2.455AspArg: 2.455 ± 0.059
2.894AspSer: 2.894 ± 0.061
2.946AspThr: 2.946 ± 0.064
3.667AspVal: 3.667 ± 0.069
0.766AspTrp: 0.766 ± 0.033
2.722AspTyr: 2.722 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
4.528GluAla: 4.528 ± 0.086
0.536GluCys: 0.536 ± 0.025
2.795GluAsp: 2.795 ± 0.061
4.106GluGlu: 4.106 ± 0.097
1.997GluPhe: 1.997 ± 0.06
3.654GluGly: 3.654 ± 0.068
1.274GluHis: 1.274 ± 0.046
3.875GluIle: 3.875 ± 0.073
4.578GluLys: 4.578 ± 0.085
5.401GluLeu: 5.401 ± 0.094
1.96GluMet: 1.96 ± 0.055
3.154GluAsn: 3.154 ± 0.06
1.685GluPro: 1.685 ± 0.049
2.734GluGln: 2.734 ± 0.065
3.431GluArg: 3.431 ± 0.065
2.595GluSer: 2.595 ± 0.051
3.283GluThr: 3.283 ± 0.067
3.765GluVal: 3.765 ± 0.068
0.742GluTrp: 0.742 ± 0.029
2.269GluTyr: 2.269 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.231PheAla: 3.231 ± 0.069
0.797PheCys: 0.797 ± 0.029
2.794PheAsp: 2.794 ± 0.058
2.332PheGlu: 2.332 ± 0.058
2.486PhePhe: 2.486 ± 0.059
3.263PheGly: 3.263 ± 0.07
0.933PheHis: 0.933 ± 0.036
3.323PheIle: 3.323 ± 0.062
2.551PheLys: 2.551 ± 0.066
4.006PheLeu: 4.006 ± 0.072
1.202PheMet: 1.202 ± 0.041
2.421PheAsn: 2.421 ± 0.054
1.648PhePro: 1.648 ± 0.041
1.225PheGln: 1.225 ± 0.033
2.035PheArg: 2.035 ± 0.056
3.565PheSer: 3.565 ± 0.067
3.078PheThr: 3.078 ± 0.069
2.951PheVal: 2.951 ± 0.057
0.581PheTrp: 0.581 ± 0.03
2.05PheTyr: 2.05 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
4.402GlyAla: 4.402 ± 0.088
0.937GlyCys: 0.937 ± 0.034
3.365GlyAsp: 3.365 ± 0.065
3.794GlyGlu: 3.794 ± 0.073
3.195GlyPhe: 3.195 ± 0.064
4.665GlyGly: 4.665 ± 0.101
1.305GlyHis: 1.305 ± 0.044
5.149GlyIle: 5.149 ± 0.084
5.121GlyLys: 5.121 ± 0.083
5.648GlyLeu: 5.648 ± 0.076
2.085GlyMet: 2.085 ± 0.049
3.636GlyAsn: 3.636 ± 0.079
1.26GlyPro: 1.26 ± 0.04
2.124GlyGln: 2.124 ± 0.048
3.27GlyArg: 3.27 ± 0.066
4.062GlySer: 4.062 ± 0.078
4.209GlyThr: 4.209 ± 0.076
4.916GlyVal: 4.916 ± 0.085
1.025GlyTrp: 1.025 ± 0.037
3.407GlyTyr: 3.407 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.257HisAla: 1.257 ± 0.042
0.289HisCys: 0.289 ± 0.02
0.985HisAsp: 0.985 ± 0.033
0.997HisGlu: 0.997 ± 0.037
1.184HisPhe: 1.184 ± 0.038
1.194HisGly: 1.194 ± 0.043
0.573HisHis: 0.573 ± 0.033
1.664HisIle: 1.664 ± 0.046
0.978HisLys: 0.978 ± 0.036
2.081HisLeu: 2.081 ± 0.048
0.33HisMet: 0.33 ± 0.019
1.054HisAsn: 1.054 ± 0.039
1.106HisPro: 1.106 ± 0.042
0.755HisGln: 0.755 ± 0.032
1.1HisArg: 1.1 ± 0.036
1.171HisSer: 1.171 ± 0.037
1.323HisThr: 1.323 ± 0.042
1.012HisVal: 1.012 ± 0.032
0.284HisTrp: 0.284 ± 0.017
0.979HisTyr: 0.979 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.195IleAla: 5.195 ± 0.084
0.955IleCys: 0.955 ± 0.032
4.466IleAsp: 4.466 ± 0.08
4.221IleGlu: 4.221 ± 0.071
2.876IlePhe: 2.876 ± 0.054
4.687IleGly: 4.687 ± 0.093
1.29IleHis: 1.29 ± 0.04
4.453IleIle: 4.453 ± 0.083
4.246IleLys: 4.246 ± 0.068
5.603IleLeu: 5.603 ± 0.095
1.423IleMet: 1.423 ± 0.04
3.709IleAsn: 3.709 ± 0.064
2.948IlePro: 2.948 ± 0.064
2.047IleGln: 2.047 ± 0.048
3.481IleArg: 3.481 ± 0.07
4.289IleSer: 4.289 ± 0.08
4.156IleThr: 4.156 ± 0.078
4.38IleVal: 4.38 ± 0.083
0.634IleTrp: 0.634 ± 0.025
2.68IleTyr: 2.68 ± 0.061
0.0IleXaa: 0.0 ± 0.0
Lys
5.081LysAla: 5.081 ± 0.106
0.521LysCys: 0.521 ± 0.028
3.929LysAsp: 3.929 ± 0.079
4.796LysGlu: 4.796 ± 0.087
2.049LysPhe: 2.049 ± 0.055
4.513LysGly: 4.513 ± 0.077
1.344LysHis: 1.344 ± 0.046
4.073LysIle: 4.073 ± 0.064
4.927LysLys: 4.927 ± 0.081
5.235LysLeu: 5.235 ± 0.089
2.075LysMet: 2.075 ± 0.05
3.434LysAsn: 3.434 ± 0.07
2.237LysPro: 2.237 ± 0.048
2.646LysGln: 2.646 ± 0.055
3.348LysArg: 3.348 ± 0.067
3.432LysSer: 3.432 ± 0.06
4.037LysThr: 4.037 ± 0.069
4.186LysVal: 4.186 ± 0.071
0.77LysTrp: 0.77 ± 0.029
2.783LysTyr: 2.783 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
6.363LeuAla: 6.363 ± 0.089
1.315LeuCys: 1.315 ± 0.044
4.514LeuAsp: 4.514 ± 0.073
4.368LeuGlu: 4.368 ± 0.074
4.693LeuPhe: 4.693 ± 0.092
5.458LeuGly: 5.458 ± 0.094
2.049LeuHis: 2.049 ± 0.051
5.527LeuIle: 5.527 ± 0.096
6.045LeuLys: 6.045 ± 0.084
9.213LeuLeu: 9.213 ± 0.149
2.465LeuMet: 2.465 ± 0.056
4.898LeuAsn: 4.898 ± 0.082
4.142LeuPro: 4.142 ± 0.078
3.805LeuGln: 3.805 ± 0.084
4.49LeuArg: 4.49 ± 0.087
6.853LeuSer: 6.853 ± 0.1
5.699LeuThr: 5.699 ± 0.083
5.009LeuVal: 5.009 ± 0.082
0.999LeuTrp: 0.999 ± 0.036
3.787LeuTyr: 3.787 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
2.219MetAla: 2.219 ± 0.055
0.277MetCys: 0.277 ± 0.02
1.259MetAsp: 1.259 ± 0.045
1.455MetGlu: 1.455 ± 0.042
1.049MetPhe: 1.049 ± 0.037
1.86MetGly: 1.86 ± 0.05
0.503MetHis: 0.503 ± 0.026
1.503MetIle: 1.503 ± 0.05
2.396MetLys: 2.396 ± 0.047
2.701MetLeu: 2.701 ± 0.063
0.929MetMet: 0.929 ± 0.036
1.472MetAsn: 1.472 ± 0.037
1.217MetPro: 1.217 ± 0.041
1.238MetGln: 1.238 ± 0.038
1.429MetArg: 1.429 ± 0.043
1.575MetSer: 1.575 ± 0.037
1.369MetThr: 1.369 ± 0.039
1.64MetVal: 1.64 ± 0.053
0.252MetTrp: 0.252 ± 0.017
0.858MetTyr: 0.858 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.847AsnAla: 3.847 ± 0.079
0.499AsnCys: 0.499 ± 0.024
2.739AsnAsp: 2.739 ± 0.061
3.136AsnGlu: 3.136 ± 0.066
2.209AsnPhe: 2.209 ± 0.047
4.184AsnGly: 4.184 ± 0.085
0.981AsnHis: 0.981 ± 0.031
3.98AsnIle: 3.98 ± 0.069
3.358AsnLys: 3.358 ± 0.069
4.392AsnLeu: 4.392 ± 0.077
1.224AsnMet: 1.224 ± 0.033
2.937AsnAsn: 2.937 ± 0.072
2.266AsnPro: 2.266 ± 0.044
1.639AsnGln: 1.639 ± 0.047
2.704AsnArg: 2.704 ± 0.059
2.823AsnSer: 2.823 ± 0.059
3.056AsnThr: 3.056 ± 0.062
3.252AsnVal: 3.252 ± 0.062
0.641AsnTrp: 0.641 ± 0.03
2.352AsnTyr: 2.352 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
2.628ProAla: 2.628 ± 0.063
0.348ProCys: 0.348 ± 0.021
2.373ProAsp: 2.373 ± 0.056
2.644ProGlu: 2.644 ± 0.061
1.908ProPhe: 1.908 ± 0.055
2.28ProGly: 2.28 ± 0.053
0.853ProHis: 0.853 ± 0.032
2.425ProIle: 2.425 ± 0.065
2.109ProLys: 2.109 ± 0.048
3.324ProLeu: 3.324 ± 0.066
1.034ProMet: 1.034 ± 0.032
1.835ProAsn: 1.835 ± 0.054
0.877ProPro: 0.877 ± 0.033
1.659ProGln: 1.659 ± 0.05
1.414ProArg: 1.414 ± 0.05
2.16ProSer: 2.16 ± 0.05
2.371ProThr: 2.371 ± 0.054
2.703ProVal: 2.703 ± 0.059
0.36ProTrp: 0.36 ± 0.022
1.757ProTyr: 1.757 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
2.652GlnAla: 2.652 ± 0.061
0.361GlnCys: 0.361 ± 0.019
1.533GlnAsp: 1.533 ± 0.045
1.991GlnGlu: 1.991 ± 0.054
1.387GlnPhe: 1.387 ± 0.039
2.109GlnGly: 2.109 ± 0.046
0.812GlnHis: 0.812 ± 0.033
2.418GlnIle: 2.418 ± 0.057
2.557GlnLys: 2.557 ± 0.062
3.939GlnLeu: 3.939 ± 0.082
1.129GlnMet: 1.129 ± 0.034
1.901GlnAsn: 1.901 ± 0.048
1.556GlnPro: 1.556 ± 0.046
1.924GlnGln: 1.924 ± 0.053
2.083GlnArg: 2.083 ± 0.051
1.981GlnSer: 1.981 ± 0.052
2.514GlnThr: 2.514 ± 0.054
2.058GlnVal: 2.058 ± 0.05
0.554GlnTrp: 0.554 ± 0.023
1.51GlnTyr: 1.51 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
3.003ArgAla: 3.003 ± 0.062
0.554ArgCys: 0.554 ± 0.026
2.195ArgAsp: 2.195 ± 0.052
2.781ArgGlu: 2.781 ± 0.063
2.504ArgPhe: 2.504 ± 0.056
2.731ArgGly: 2.731 ± 0.066
1.102ArgHis: 1.102 ± 0.038
3.639ArgIle: 3.639 ± 0.066
3.463ArgLys: 3.463 ± 0.074
4.97ArgLeu: 4.97 ± 0.083
1.625ArgMet: 1.625 ± 0.043
2.667ArgAsn: 2.667 ± 0.055
1.709ArgPro: 1.709 ± 0.047
2.071ArgGln: 2.071 ± 0.056
2.67ArgArg: 2.67 ± 0.064
2.576ArgSer: 2.576 ± 0.062
2.728ArgThr: 2.728 ± 0.054
2.843ArgVal: 2.843 ± 0.057
0.768ArgTrp: 0.768 ± 0.031
2.607ArgTyr: 2.607 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
4.484SerAla: 4.484 ± 0.084
0.784SerCys: 0.784 ± 0.034
3.145SerAsp: 3.145 ± 0.066
3.159SerGlu: 3.159 ± 0.062
3.063SerPhe: 3.063 ± 0.065
4.351SerGly: 4.351 ± 0.086
1.141SerHis: 1.141 ± 0.037
4.27SerIle: 4.27 ± 0.084
3.458SerLys: 3.458 ± 0.066
5.726SerLeu: 5.726 ± 0.083
1.524SerMet: 1.524 ± 0.048
2.747SerAsn: 2.747 ± 0.066
2.365SerPro: 2.365 ± 0.049
1.841SerGln: 1.841 ± 0.045
2.574SerArg: 2.574 ± 0.058
3.76SerSer: 3.76 ± 0.074
3.529SerThr: 3.529 ± 0.071
4.255SerVal: 4.255 ± 0.08
0.71SerTrp: 0.71 ± 0.035
2.714SerTyr: 2.714 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
4.611ThrAla: 4.611 ± 0.078
0.628ThrCys: 0.628 ± 0.03
3.778ThrAsp: 3.778 ± 0.066
3.27ThrGlu: 3.27 ± 0.065
3.071ThrPhe: 3.071 ± 0.069
4.43ThrGly: 4.43 ± 0.075
1.214ThrHis: 1.214 ± 0.041
3.957ThrIle: 3.957 ± 0.074
2.981ThrLys: 2.981 ± 0.056
5.974ThrLeu: 5.974 ± 0.091
1.331ThrMet: 1.331 ± 0.044
2.697ThrAsn: 2.697 ± 0.062
2.922ThrPro: 2.922 ± 0.066
2.045ThrGln: 2.045 ± 0.044
2.533ThrArg: 2.533 ± 0.059
3.365ThrSer: 3.365 ± 0.076
3.741ThrThr: 3.741 ± 0.077
3.965ThrVal: 3.965 ± 0.085
0.696ThrTrp: 0.696 ± 0.034
2.703ThrTyr: 2.703 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
4.499ValAla: 4.499 ± 0.077
0.981ValCys: 0.981 ± 0.035
3.581ValAsp: 3.581 ± 0.069
3.696ValGlu: 3.696 ± 0.073
2.979ValPhe: 2.979 ± 0.063
4.284ValGly: 4.284 ± 0.082
1.068ValHis: 1.068 ± 0.038
4.144ValIle: 4.144 ± 0.08
4.228ValLys: 4.228 ± 0.077
5.907ValLeu: 5.907 ± 0.089
1.663ValMet: 1.663 ± 0.048
3.38ValAsn: 3.38 ± 0.063
2.453ValPro: 2.453 ± 0.059
2.088ValGln: 2.088 ± 0.053
3.039ValArg: 3.039 ± 0.059
4.448ValSer: 4.448 ± 0.086
3.599ValThr: 3.599 ± 0.078
4.65ValVal: 4.65 ± 0.086
0.767ValTrp: 0.767 ± 0.03
2.685ValTyr: 2.685 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.886TrpAla: 0.886 ± 0.036
0.17TrpCys: 0.17 ± 0.014
0.635TrpAsp: 0.635 ± 0.029
0.629TrpGlu: 0.629 ± 0.03
0.548TrpPhe: 0.548 ± 0.025
0.976TrpGly: 0.976 ± 0.035
0.269TrpHis: 0.269 ± 0.018
0.743TrpIle: 0.743 ± 0.029
0.838TrpLys: 0.838 ± 0.032
1.2TrpLeu: 1.2 ± 0.041
0.43TrpMet: 0.43 ± 0.025
0.734TrpAsn: 0.734 ± 0.032
0.27TrpPro: 0.27 ± 0.019
0.62TrpGln: 0.62 ± 0.026
0.646TrpArg: 0.646 ± 0.031
0.655TrpSer: 0.655 ± 0.036
0.658TrpThr: 0.658 ± 0.027
0.731TrpVal: 0.731 ± 0.029
0.183TrpTrp: 0.183 ± 0.015
0.495TrpTyr: 0.495 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.195TyrAla: 3.195 ± 0.063
0.538TyrCys: 0.538 ± 0.028
2.505TyrAsp: 2.505 ± 0.064
2.197TyrGlu: 2.197 ± 0.05
2.168TyrPhe: 2.168 ± 0.054
2.96TyrGly: 2.96 ± 0.069
0.954TyrHis: 0.954 ± 0.037
2.882TyrIle: 2.882 ± 0.062
2.581TyrLys: 2.581 ± 0.053
4.009TyrLeu: 4.009 ± 0.071
0.988TyrMet: 0.988 ± 0.038
2.546TyrAsn: 2.546 ± 0.054
1.853TyrPro: 1.853 ± 0.041
1.683TyrGln: 1.683 ± 0.051
2.453TyrArg: 2.453 ± 0.045
2.63TyrSer: 2.63 ± 0.069
2.794TyrThr: 2.794 ± 0.063
2.521TyrVal: 2.521 ± 0.055
0.586TyrTrp: 0.586 ± 0.03
2.092TyrTyr: 2.092 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2553 proteins (834224 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski