Amino acid dipepetide frequency for Corynebacterium frankenforstense DSM 45800

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.732AlaAla: 20.732 ± 0.309
1.067AlaCys: 1.067 ± 0.046
9.01AlaAsp: 9.01 ± 0.139
10.493AlaGlu: 10.493 ± 0.162
3.445AlaPhe: 3.445 ± 0.08
14.015AlaGly: 14.015 ± 0.21
2.738AlaHis: 2.738 ± 0.063
3.88AlaIle: 3.88 ± 0.097
2.992AlaLys: 2.992 ± 0.084
12.107AlaLeu: 12.107 ± 0.161
2.603AlaMet: 2.603 ± 0.059
2.418AlaAsn: 2.418 ± 0.066
5.755AlaPro: 5.755 ± 0.116
3.417AlaGln: 3.417 ± 0.077
9.705AlaArg: 9.705 ± 0.15
5.15AlaSer: 5.15 ± 0.092
6.772AlaThr: 6.772 ± 0.11
12.033AlaVal: 12.033 ± 0.192
1.668AlaTrp: 1.668 ± 0.05
2.307AlaTyr: 2.307 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.982CysAla: 0.982 ± 0.037
0.072CysCys: 0.072 ± 0.013
0.463CysAsp: 0.463 ± 0.031
0.407CysGlu: 0.407 ± 0.029
0.207CysPhe: 0.207 ± 0.019
0.833CysGly: 0.833 ± 0.037
0.173CysHis: 0.173 ± 0.016
0.232CysIle: 0.232 ± 0.023
0.107CysLys: 0.107 ± 0.014
0.578CysLeu: 0.578 ± 0.03
0.118CysMet: 0.118 ± 0.015
0.15CysAsn: 0.15 ± 0.014
0.475CysPro: 0.475 ± 0.029
0.15CysGln: 0.15 ± 0.016
0.453CysArg: 0.453 ± 0.028
0.475CysSer: 0.475 ± 0.029
0.462CysThr: 0.462 ± 0.027
0.565CysVal: 0.565 ± 0.033
0.102CysTrp: 0.102 ± 0.013
0.155CysTyr: 0.155 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
9.143AspAla: 9.143 ± 0.153
0.41AspCys: 0.41 ± 0.025
4.15AspAsp: 4.15 ± 0.095
4.913AspGlu: 4.913 ± 0.091
2.068AspPhe: 2.068 ± 0.058
6.152AspGly: 6.152 ± 0.113
1.342AspHis: 1.342 ± 0.048
2.417AspIle: 2.417 ± 0.063
1.663AspLys: 1.663 ± 0.067
5.943AspLeu: 5.943 ± 0.102
1.257AspMet: 1.257 ± 0.047
1.463AspAsn: 1.463 ± 0.049
4.513AspPro: 4.513 ± 0.098
1.632AspGln: 1.632 ± 0.06
4.4AspArg: 4.4 ± 0.09
3.073AspSer: 3.073 ± 0.074
3.292AspThr: 3.292 ± 0.081
5.458AspVal: 5.458 ± 0.099
0.92AspTrp: 0.92 ± 0.042
1.505AspTyr: 1.505 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
8.092GluAla: 8.092 ± 0.135
0.362GluCys: 0.362 ± 0.027
3.95GluAsp: 3.95 ± 0.081
4.642GluGlu: 4.642 ± 0.101
2.02GluPhe: 2.02 ± 0.062
5.133GluGly: 5.133 ± 0.092
1.835GluHis: 1.835 ± 0.058
3.397GluIle: 3.397 ± 0.079
2.32GluLys: 2.32 ± 0.082
7.387GluLeu: 7.387 ± 0.113
1.372GluMet: 1.372 ± 0.046
1.728GluAsn: 1.728 ± 0.062
3.422GluPro: 3.422 ± 0.081
2.12GluGln: 2.12 ± 0.062
5.357GluArg: 5.357 ± 0.113
2.918GluSer: 2.918 ± 0.072
3.607GluThr: 3.607 ± 0.084
5.615GluVal: 5.615 ± 0.104
0.763GluTrp: 0.763 ± 0.037
1.348GluTyr: 1.348 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
3.763PheAla: 3.763 ± 0.078
0.263PheCys: 0.263 ± 0.022
2.412PheAsp: 2.412 ± 0.061
1.742PheGlu: 1.742 ± 0.059
1.103PhePhe: 1.103 ± 0.049
3.308PheGly: 3.308 ± 0.075
0.658PheHis: 0.658 ± 0.036
1.305PheIle: 1.305 ± 0.052
0.518PheLys: 0.518 ± 0.031
2.877PheLeu: 2.877 ± 0.074
0.54PheMet: 0.54 ± 0.034
0.795PheAsn: 0.795 ± 0.034
1.412PhePro: 1.412 ± 0.053
0.683PheGln: 0.683 ± 0.031
1.757PheArg: 1.757 ± 0.05
1.74PheSer: 1.74 ± 0.052
2.075PheThr: 2.075 ± 0.051
2.398PheVal: 2.398 ± 0.072
0.363PheTrp: 0.363 ± 0.03
0.693PheTyr: 0.693 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
11.233GlyAla: 11.233 ± 0.178
0.757GlyCys: 0.757 ± 0.038
5.407GlyAsp: 5.407 ± 0.105
6.425GlyGlu: 6.425 ± 0.1
3.148GlyPhe: 3.148 ± 0.086
8.177GlyGly: 8.177 ± 0.152
2.165GlyHis: 2.165 ± 0.063
3.677GlyIle: 3.677 ± 0.076
2.622GlyLys: 2.622 ± 0.075
8.997GlyLeu: 8.997 ± 0.135
2.198GlyMet: 2.198 ± 0.06
2.02GlyAsn: 2.02 ± 0.065
4.093GlyPro: 4.093 ± 0.086
2.54GlyGln: 2.54 ± 0.064
6.938GlyArg: 6.938 ± 0.134
4.957GlySer: 4.957 ± 0.105
5.72GlyThr: 5.72 ± 0.11
8.478GlyVal: 8.478 ± 0.121
1.503GlyTrp: 1.503 ± 0.053
2.187GlyTyr: 2.187 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
2.437HisAla: 2.437 ± 0.073
0.16HisCys: 0.16 ± 0.016
1.487HisAsp: 1.487 ± 0.051
1.328HisGlu: 1.328 ± 0.053
0.63HisPhe: 0.63 ± 0.031
2.12HisGly: 2.12 ± 0.072
0.58HisHis: 0.58 ± 0.031
0.737HisIle: 0.737 ± 0.037
0.402HisLys: 0.402 ± 0.026
2.183HisLeu: 2.183 ± 0.065
0.41HisMet: 0.41 ± 0.024
0.532HisAsn: 0.532 ± 0.03
1.575HisPro: 1.575 ± 0.06
0.573HisGln: 0.573 ± 0.031
1.733HisArg: 1.733 ± 0.056
1.017HisSer: 1.017 ± 0.041
1.217HisThr: 1.217 ± 0.042
1.748HisVal: 1.748 ± 0.06
0.31HisTrp: 0.31 ± 0.024
0.5HisTyr: 0.5 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.373IleAla: 5.373 ± 0.094
0.35IleCys: 0.35 ± 0.023
3.155IleAsp: 3.155 ± 0.078
2.545IleGlu: 2.545 ± 0.069
1.288IlePhe: 1.288 ± 0.051
3.78IleGly: 3.78 ± 0.092
0.777IleHis: 0.777 ± 0.038
1.625IleIle: 1.625 ± 0.062
0.932IleLys: 0.932 ± 0.037
3.223IleLeu: 3.223 ± 0.073
0.695IleMet: 0.695 ± 0.034
1.063IleAsn: 1.063 ± 0.046
2.06IlePro: 2.06 ± 0.057
0.917IleGln: 0.917 ± 0.041
2.287IleArg: 2.287 ± 0.066
2.128IleSer: 2.128 ± 0.06
2.54IleThr: 2.54 ± 0.068
3.428IleVal: 3.428 ± 0.081
0.44IleTrp: 0.44 ± 0.03
0.857IleTyr: 0.857 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
3.102LysAla: 3.102 ± 0.098
0.118LysCys: 0.118 ± 0.016
1.44LysAsp: 1.44 ± 0.059
1.465LysGlu: 1.465 ± 0.057
0.697LysPhe: 0.697 ± 0.033
1.925LysGly: 1.925 ± 0.07
0.438LysHis: 0.438 ± 0.028
1.273LysIle: 1.273 ± 0.052
1.363LysLys: 1.363 ± 0.076
2.488LysLeu: 2.488 ± 0.072
0.632LysMet: 0.632 ± 0.032
0.795LysAsn: 0.795 ± 0.043
1.205LysPro: 1.205 ± 0.051
0.693LysGln: 0.693 ± 0.037
1.647LysArg: 1.647 ± 0.054
1.243LysSer: 1.243 ± 0.057
1.517LysThr: 1.517 ± 0.065
2.227LysVal: 2.227 ± 0.074
0.285LysTrp: 0.285 ± 0.021
0.49LysTyr: 0.49 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
13.695LeuAla: 13.695 ± 0.196
0.633LeuCys: 0.633 ± 0.04
6.907LeuAsp: 6.907 ± 0.112
5.332LeuGlu: 5.332 ± 0.099
2.643LeuPhe: 2.643 ± 0.072
8.853LeuGly: 8.853 ± 0.121
1.97LeuHis: 1.97 ± 0.058
4.025LeuIle: 4.025 ± 0.085
2.205LeuLys: 2.205 ± 0.068
8.453LeuLeu: 8.453 ± 0.159
1.747LeuMet: 1.747 ± 0.051
2.112LeuAsn: 2.112 ± 0.06
5.367LeuPro: 5.367 ± 0.105
2.07LeuGln: 2.07 ± 0.056
6.808LeuArg: 6.808 ± 0.121
5.122LeuSer: 5.122 ± 0.104
5.963LeuThr: 5.963 ± 0.106
8.352LeuVal: 8.352 ± 0.133
0.995LeuTrp: 0.995 ± 0.042
1.603LeuTyr: 1.603 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.578MetAla: 2.578 ± 0.075
0.138MetCys: 0.138 ± 0.016
1.067MetAsp: 1.067 ± 0.04
0.885MetGlu: 0.885 ± 0.04
0.63MetPhe: 0.63 ± 0.035
1.585MetGly: 1.585 ± 0.056
0.373MetHis: 0.373 ± 0.024
0.975MetIle: 0.975 ± 0.04
0.552MetLys: 0.552 ± 0.033
1.99MetLeu: 1.99 ± 0.061
0.408MetMet: 0.408 ± 0.028
0.543MetAsn: 0.543 ± 0.031
1.175MetPro: 1.175 ± 0.04
0.542MetGln: 0.542 ± 0.031
1.422MetArg: 1.422 ± 0.051
1.498MetSer: 1.498 ± 0.051
1.625MetThr: 1.625 ± 0.046
1.608MetVal: 1.608 ± 0.06
0.225MetTrp: 0.225 ± 0.021
0.317MetTyr: 0.317 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
2.48AsnAla: 2.48 ± 0.075
0.16AsnCys: 0.16 ± 0.017
1.237AsnAsp: 1.237 ± 0.045
1.343AsnGlu: 1.343 ± 0.049
0.742AsnPhe: 0.742 ± 0.041
1.932AsnGly: 1.932 ± 0.072
0.482AsnHis: 0.482 ± 0.026
0.988AsnIle: 0.988 ± 0.04
0.643AsnLys: 0.643 ± 0.034
2.208AsnLeu: 2.208 ± 0.06
0.547AsnMet: 0.547 ± 0.029
0.612AsnAsn: 0.612 ± 0.036
1.748AsnPro: 1.748 ± 0.057
0.678AsnGln: 0.678 ± 0.039
1.532AsnArg: 1.532 ± 0.052
1.185AsnSer: 1.185 ± 0.047
1.243AsnThr: 1.243 ± 0.053
1.767AsnVal: 1.767 ± 0.054
0.357AsnTrp: 0.357 ± 0.024
0.597AsnTyr: 0.597 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
7.217ProAla: 7.217 ± 0.148
0.247ProCys: 0.247 ± 0.023
3.838ProAsp: 3.838 ± 0.08
5.142ProGlu: 5.142 ± 0.128
1.51ProPhe: 1.51 ± 0.051
5.76ProGly: 5.76 ± 0.122
1.088ProHis: 1.088 ± 0.045
1.425ProIle: 1.425 ± 0.049
1.232ProLys: 1.232 ± 0.055
4.183ProLeu: 4.183 ± 0.099
0.965ProMet: 0.965 ± 0.04
1.083ProAsn: 1.083 ± 0.045
1.752ProPro: 1.752 ± 0.062
1.47ProGln: 1.47 ± 0.051
3.268ProArg: 3.268 ± 0.077
2.163ProSer: 2.163 ± 0.065
2.888ProThr: 2.888 ± 0.072
5.187ProVal: 5.187 ± 0.096
0.7ProTrp: 0.7 ± 0.037
1.0ProTyr: 1.0 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
3.427GlnAla: 3.427 ± 0.077
0.14GlnCys: 0.14 ± 0.014
1.352GlnAsp: 1.352 ± 0.05
1.435GlnGlu: 1.435 ± 0.056
0.793GlnPhe: 0.793 ± 0.037
1.892GlnGly: 1.892 ± 0.056
0.455GlnHis: 0.455 ± 0.031
1.333GlnIle: 1.333 ± 0.052
0.722GlnLys: 0.722 ± 0.036
2.92GlnLeu: 2.92 ± 0.076
0.63GlnMet: 0.63 ± 0.033
0.687GlnAsn: 0.687 ± 0.034
1.278GlnPro: 1.278 ± 0.047
0.93GlnGln: 0.93 ± 0.044
2.008GlnArg: 2.008 ± 0.066
1.113GlnSer: 1.113 ± 0.05
1.348GlnThr: 1.348 ± 0.049
2.365GlnVal: 2.365 ± 0.066
0.428GlnTrp: 0.428 ± 0.028
0.507GlnTyr: 0.507 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
8.887ArgAla: 8.887 ± 0.127
0.38ArgCys: 0.38 ± 0.024
4.413ArgAsp: 4.413 ± 0.111
5.312ArgGlu: 5.312 ± 0.109
2.21ArgPhe: 2.21 ± 0.062
5.867ArgGly: 5.867 ± 0.103
1.677ArgHis: 1.677 ± 0.058
3.043ArgIle: 3.043 ± 0.064
1.747ArgLys: 1.747 ± 0.068
7.085ArgLeu: 7.085 ± 0.14
1.743ArgMet: 1.743 ± 0.052
1.492ArgAsn: 1.492 ± 0.052
3.693ArgPro: 3.693 ± 0.091
1.968ArgGln: 1.968 ± 0.075
6.872ArgArg: 6.872 ± 0.157
3.213ArgSer: 3.213 ± 0.071
4.105ArgThr: 4.105 ± 0.094
5.727ArgVal: 5.727 ± 0.121
1.082ArgTrp: 1.082 ± 0.041
1.573ArgTyr: 1.573 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
6.013SerAla: 6.013 ± 0.101
0.327SerCys: 0.327 ± 0.025
2.913SerAsp: 2.913 ± 0.079
2.977SerGlu: 2.977 ± 0.077
1.628SerPhe: 1.628 ± 0.053
5.615SerGly: 5.615 ± 0.117
1.025SerHis: 1.025 ± 0.038
1.777SerIle: 1.777 ± 0.052
1.167SerLys: 1.167 ± 0.043
4.42SerLeu: 4.42 ± 0.104
1.072SerMet: 1.072 ± 0.044
0.993SerAsn: 0.993 ± 0.038
2.548SerPro: 2.548 ± 0.063
1.228SerGln: 1.228 ± 0.057
3.48SerArg: 3.48 ± 0.087
2.525SerSer: 2.525 ± 0.074
3.025SerThr: 3.025 ± 0.078
4.2SerVal: 4.2 ± 0.08
0.807SerTrp: 0.807 ± 0.036
1.092SerTyr: 1.092 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
7.62ThrAla: 7.62 ± 0.127
0.468ThrCys: 0.468 ± 0.026
3.882ThrAsp: 3.882 ± 0.087
3.542ThrGlu: 3.542 ± 0.091
1.72ThrPhe: 1.72 ± 0.05
6.342ThrGly: 6.342 ± 0.101
1.152ThrHis: 1.152 ± 0.042
2.04ThrIle: 2.04 ± 0.068
1.313ThrLys: 1.313 ± 0.056
5.242ThrLeu: 5.242 ± 0.098
1.027ThrMet: 1.027 ± 0.044
1.128ThrAsn: 1.128 ± 0.041
3.64ThrPro: 3.64 ± 0.073
1.317ThrGln: 1.317 ± 0.047
3.717ThrArg: 3.717 ± 0.083
2.89ThrSer: 2.89 ± 0.069
3.545ThrThr: 3.545 ± 0.085
6.438ThrVal: 6.438 ± 0.109
0.732ThrTrp: 0.732 ± 0.033
1.195ThrTyr: 1.195 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
11.748ValAla: 11.748 ± 0.173
0.815ValCys: 0.815 ± 0.035
6.557ValAsp: 6.557 ± 0.111
5.6ValGlu: 5.6 ± 0.097
2.673ValPhe: 2.673 ± 0.073
7.18ValGly: 7.18 ± 0.104
1.977ValHis: 1.977 ± 0.055
3.958ValIle: 3.958 ± 0.078
1.822ValLys: 1.822 ± 0.07
8.692ValLeu: 8.692 ± 0.159
1.567ValMet: 1.567 ± 0.057
2.03ValAsn: 2.03 ± 0.063
4.647ValPro: 4.647 ± 0.082
1.728ValGln: 1.728 ± 0.055
5.875ValArg: 5.875 ± 0.105
4.513ValSer: 4.513 ± 0.082
6.07ValThr: 6.07 ± 0.105
8.465ValVal: 8.465 ± 0.135
1.053ValTrp: 1.053 ± 0.048
1.65ValTyr: 1.65 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
1.59TrpAla: 1.59 ± 0.05
0.107TrpCys: 0.107 ± 0.012
0.715TrpAsp: 0.715 ± 0.035
0.645TrpGlu: 0.645 ± 0.034
0.507TrpPhe: 0.507 ± 0.036
0.9TrpGly: 0.9 ± 0.044
0.33TrpHis: 0.33 ± 0.024
0.615TrpIle: 0.615 ± 0.034
0.322TrpLys: 0.322 ± 0.024
1.617TrpLeu: 1.617 ± 0.052
0.3TrpMet: 0.3 ± 0.025
0.323TrpAsn: 0.323 ± 0.025
0.617TrpPro: 0.617 ± 0.03
0.475TrpGln: 0.475 ± 0.029
1.15TrpArg: 1.15 ± 0.043
0.692TrpSer: 0.692 ± 0.034
0.735TrpThr: 0.735 ± 0.037
1.083TrpVal: 1.083 ± 0.043
0.323TrpTrp: 0.323 ± 0.023
0.307TrpTyr: 0.307 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.195TyrAla: 2.195 ± 0.063
0.185TyrCys: 0.185 ± 0.018
1.362TyrAsp: 1.362 ± 0.048
1.215TyrGlu: 1.215 ± 0.044
0.743TyrPhe: 0.743 ± 0.036
1.873TyrGly: 1.873 ± 0.055
0.443TyrHis: 0.443 ± 0.031
0.742TyrIle: 0.742 ± 0.034
0.402TyrLys: 0.402 ± 0.026
2.262TyrLeu: 2.262 ± 0.071
0.305TyrMet: 0.305 ± 0.022
0.513TyrAsn: 0.513 ± 0.033
1.143TyrPro: 1.143 ± 0.043
0.632TyrGln: 0.632 ± 0.031
1.68TyrArg: 1.68 ± 0.054
1.215TyrSer: 1.215 ± 0.044
1.2TyrThr: 1.2 ± 0.052
1.477TyrVal: 1.477 ± 0.045
0.295TyrTrp: 0.295 ± 0.024
0.532TyrTyr: 0.532 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1801 proteins (600005 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski