Amino acid dipepetide frequency for Chitinophaga cymbidii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.849AlaAla: 8.849 ± 0.091
0.813AlaCys: 0.813 ± 0.02
4.734AlaAsp: 4.734 ± 0.053
4.758AlaGlu: 4.758 ± 0.059
3.814AlaPhe: 3.814 ± 0.051
7.085AlaGly: 7.085 ± 0.074
1.407AlaHis: 1.407 ± 0.027
4.914AlaIle: 4.914 ± 0.057
4.042AlaLys: 4.042 ± 0.057
7.734AlaLeu: 7.734 ± 0.083
2.035AlaMet: 2.035 ± 0.035
3.494AlaAsn: 3.494 ± 0.049
3.239AlaPro: 3.239 ± 0.043
3.25AlaGln: 3.25 ± 0.044
3.746AlaArg: 3.746 ± 0.042
4.971AlaSer: 4.971 ± 0.055
4.64AlaThr: 4.64 ± 0.075
5.76AlaVal: 5.76 ± 0.06
1.131AlaTrp: 1.131 ± 0.027
3.302AlaTyr: 3.302 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.527CysAla: 0.527 ± 0.019
0.146CysCys: 0.146 ± 0.009
0.365CysAsp: 0.365 ± 0.015
0.368CysGlu: 0.368 ± 0.017
0.414CysPhe: 0.414 ± 0.016
0.636CysGly: 0.636 ± 0.018
0.197CysHis: 0.197 ± 0.011
0.559CysIle: 0.559 ± 0.017
0.408CysLys: 0.408 ± 0.016
0.755CysLeu: 0.755 ± 0.02
0.221CysMet: 0.221 ± 0.011
0.355CysAsn: 0.355 ± 0.014
0.314CysPro: 0.314 ± 0.014
0.217CysGln: 0.217 ± 0.01
0.42CysArg: 0.42 ± 0.017
0.488CysSer: 0.488 ± 0.016
0.468CysThr: 0.468 ± 0.017
0.431CysVal: 0.431 ± 0.014
0.103CysTrp: 0.103 ± 0.007
0.349CysTyr: 0.349 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.631AspAla: 4.631 ± 0.057
0.34AspCys: 0.34 ± 0.014
2.558AspAsp: 2.558 ± 0.05
3.282AspGlu: 3.282 ± 0.043
2.7AspPhe: 2.7 ± 0.039
4.226AspGly: 4.226 ± 0.064
1.105AspHis: 1.105 ± 0.027
3.743AspIle: 3.743 ± 0.044
3.126AspLys: 3.126 ± 0.046
4.618AspLeu: 4.618 ± 0.05
1.31AspMet: 1.31 ± 0.024
2.52AspAsn: 2.52 ± 0.039
2.572AspPro: 2.572 ± 0.042
1.769AspGln: 1.769 ± 0.03
2.572AspArg: 2.572 ± 0.038
2.737AspSer: 2.737 ± 0.045
2.647AspThr: 2.647 ± 0.045
3.645AspVal: 3.645 ± 0.045
0.833AspTrp: 0.833 ± 0.022
2.359AspTyr: 2.359 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
4.817GluAla: 4.817 ± 0.055
0.322GluCys: 0.322 ± 0.014
2.935GluAsp: 2.935 ± 0.044
3.817GluGlu: 3.817 ± 0.058
2.096GluPhe: 2.096 ± 0.033
3.8GluGly: 3.8 ± 0.046
1.197GluHis: 1.197 ± 0.03
3.618GluIle: 3.618 ± 0.047
4.538GluLys: 4.538 ± 0.056
5.416GluLeu: 5.416 ± 0.07
1.568GluMet: 1.568 ± 0.03
2.926GluAsn: 2.926 ± 0.04
1.89GluPro: 1.89 ± 0.036
2.668GluGln: 2.668 ± 0.041
3.031GluArg: 3.031 ± 0.048
2.592GluSer: 2.592 ± 0.04
2.907GluThr: 2.907 ± 0.036
3.854GluVal: 3.854 ± 0.044
0.752GluTrp: 0.752 ± 0.019
2.08GluTyr: 2.08 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.381PheAla: 3.381 ± 0.045
0.399PheCys: 0.399 ± 0.015
2.617PheAsp: 2.617 ± 0.038
2.457PheGlu: 2.457 ± 0.033
2.241PhePhe: 2.241 ± 0.043
3.321PheGly: 3.321 ± 0.05
0.945PheHis: 0.945 ± 0.023
2.865PheIle: 2.865 ± 0.036
2.075PheLys: 2.075 ± 0.029
4.056PheLeu: 4.056 ± 0.047
1.172PheMet: 1.172 ± 0.026
2.518PheAsn: 2.518 ± 0.04
1.895PhePro: 1.895 ± 0.03
1.381PheGln: 1.381 ± 0.024
2.718PheArg: 2.718 ± 0.039
3.682PheSer: 3.682 ± 0.05
3.154PheThr: 3.154 ± 0.041
2.626PheVal: 2.626 ± 0.04
0.62PheTrp: 0.62 ± 0.018
1.97PheTyr: 1.97 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
5.551GlyAla: 5.551 ± 0.062
0.645GlyCys: 0.645 ± 0.025
3.6GlyAsp: 3.6 ± 0.045
3.733GlyGlu: 3.733 ± 0.04
3.502GlyPhe: 3.502 ± 0.044
5.495GlyGly: 5.495 ± 0.072
1.403GlyHis: 1.403 ± 0.03
5.121GlyIle: 5.121 ± 0.05
5.192GlyLys: 5.192 ± 0.061
6.425GlyLeu: 6.425 ± 0.07
2.013GlyMet: 2.013 ± 0.037
3.978GlyAsn: 3.978 ± 0.059
1.904GlyPro: 1.904 ± 0.037
2.577GlyGln: 2.577 ± 0.041
3.487GlyArg: 3.487 ± 0.044
4.513GlySer: 4.513 ± 0.059
4.609GlyThr: 4.609 ± 0.073
4.738GlyVal: 4.738 ± 0.061
1.169GlyTrp: 1.169 ± 0.023
3.412GlyTyr: 3.412 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.569HisAla: 1.569 ± 0.035
0.226HisCys: 0.226 ± 0.011
0.932HisAsp: 0.932 ± 0.025
1.011HisGlu: 1.011 ± 0.028
1.197HisPhe: 1.197 ± 0.025
1.219HisGly: 1.219 ± 0.025
0.635HisHis: 0.635 ± 0.021
1.385HisIle: 1.385 ± 0.029
0.889HisLys: 0.889 ± 0.025
1.954HisLeu: 1.954 ± 0.034
0.44HisMet: 0.44 ± 0.015
0.93HisAsn: 0.93 ± 0.023
1.263HisPro: 1.263 ± 0.029
0.788HisGln: 0.788 ± 0.02
1.05HisArg: 1.05 ± 0.025
1.054HisSer: 1.054 ± 0.025
1.193HisThr: 1.193 ± 0.027
1.085HisVal: 1.085 ± 0.026
0.302HisTrp: 0.302 ± 0.012
0.943HisTyr: 0.943 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.449IleAla: 5.449 ± 0.059
0.629IleCys: 0.629 ± 0.02
3.461IleAsp: 3.461 ± 0.045
3.208IleGlu: 3.208 ± 0.04
2.669IlePhe: 2.669 ± 0.041
4.388IleGly: 4.388 ± 0.055
1.261IleHis: 1.261 ± 0.023
3.858IleIle: 3.858 ± 0.055
3.143IleLys: 3.143 ± 0.045
5.25IleLeu: 5.25 ± 0.07
1.291IleMet: 1.291 ± 0.028
3.09IleAsn: 3.09 ± 0.048
3.081IlePro: 3.081 ± 0.043
2.006IleGln: 2.006 ± 0.031
3.969IleArg: 3.969 ± 0.047
4.451IleSer: 4.451 ± 0.051
4.281IleThr: 4.281 ± 0.062
3.838IleVal: 3.838 ± 0.054
0.731IleTrp: 0.731 ± 0.02
2.361IleTyr: 2.361 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
4.948LysAla: 4.948 ± 0.063
0.281LysCys: 0.281 ± 0.013
3.696LysAsp: 3.696 ± 0.047
3.99LysGlu: 3.99 ± 0.061
1.957LysPhe: 1.957 ± 0.035
4.312LysGly: 4.312 ± 0.057
1.062LysHis: 1.062 ± 0.024
3.465LysIle: 3.465 ± 0.049
4.103LysLys: 4.103 ± 0.063
4.82LysLeu: 4.82 ± 0.051
1.684LysMet: 1.684 ± 0.03
2.774LysAsn: 2.774 ± 0.033
2.483LysPro: 2.483 ± 0.038
2.311LysGln: 2.311 ± 0.031
2.708LysArg: 2.708 ± 0.042
2.838LysSer: 2.838 ± 0.04
3.22LysThr: 3.22 ± 0.04
3.993LysVal: 3.993 ± 0.047
0.79LysTrp: 0.79 ± 0.025
2.325LysTyr: 2.325 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
7.37LeuAla: 7.37 ± 0.073
0.806LeuCys: 0.806 ± 0.021
4.712LeuAsp: 4.712 ± 0.047
5.293LeuGlu: 5.293 ± 0.066
4.287LeuPhe: 4.287 ± 0.052
5.691LeuGly: 5.691 ± 0.064
2.019LeuHis: 2.019 ± 0.034
5.135LeuIle: 5.135 ± 0.062
5.794LeuLys: 5.794 ± 0.065
9.761LeuLeu: 9.761 ± 0.094
2.157LeuMet: 2.157 ± 0.038
4.654LeuAsn: 4.654 ± 0.055
4.708LeuPro: 4.708 ± 0.052
4.625LeuGln: 4.625 ± 0.063
4.793LeuArg: 4.793 ± 0.055
6.316LeuSer: 6.316 ± 0.066
5.353LeuThr: 5.353 ± 0.054
5.477LeuVal: 5.477 ± 0.063
1.02LeuTrp: 1.02 ± 0.026
3.452LeuTyr: 3.452 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
1.988MetAla: 1.988 ± 0.033
0.129MetCys: 0.129 ± 0.008
1.331MetAsp: 1.331 ± 0.022
1.59MetGlu: 1.59 ± 0.026
0.82MetPhe: 0.82 ± 0.02
1.551MetGly: 1.551 ± 0.031
0.515MetHis: 0.515 ± 0.016
1.465MetIle: 1.465 ± 0.033
1.897MetLys: 1.897 ± 0.029
2.463MetLeu: 2.463 ± 0.036
0.656MetMet: 0.656 ± 0.02
1.289MetAsn: 1.289 ± 0.025
1.294MetPro: 1.294 ± 0.022
1.277MetGln: 1.277 ± 0.023
1.329MetArg: 1.329 ± 0.028
1.326MetSer: 1.326 ± 0.024
1.251MetThr: 1.251 ± 0.022
1.377MetVal: 1.377 ± 0.029
0.243MetTrp: 0.243 ± 0.011
0.758MetTyr: 0.758 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
4.086AsnAla: 4.086 ± 0.052
0.324AsnCys: 0.324 ± 0.013
2.51AsnAsp: 2.51 ± 0.041
2.549AsnGlu: 2.549 ± 0.037
2.168AsnPhe: 2.168 ± 0.036
4.28AsnGly: 4.28 ± 0.059
0.831AsnHis: 0.831 ± 0.022
3.624AsnIle: 3.624 ± 0.043
2.642AsnLys: 2.642 ± 0.038
3.989AsnLeu: 3.989 ± 0.049
1.186AsnMet: 1.186 ± 0.025
2.684AsnAsn: 2.684 ± 0.046
2.56AsnPro: 2.56 ± 0.039
1.489AsnGln: 1.489 ± 0.026
2.56AsnArg: 2.56 ± 0.04
2.79AsnSer: 2.79 ± 0.042
3.136AsnThr: 3.136 ± 0.056
3.126AsnVal: 3.126 ± 0.049
0.744AsnTrp: 0.744 ± 0.02
2.259AsnTyr: 2.259 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
4.621ProAla: 4.621 ± 0.057
0.237ProCys: 0.237 ± 0.01
3.055ProAsp: 3.055 ± 0.043
3.238ProGlu: 3.238 ± 0.052
2.023ProPhe: 2.023 ± 0.036
3.827ProGly: 3.827 ± 0.048
0.816ProHis: 0.816 ± 0.021
1.858ProIle: 1.858 ± 0.035
1.795ProLys: 1.795 ± 0.031
3.812ProLeu: 3.812 ± 0.046
0.881ProMet: 0.881 ± 0.022
1.744ProAsn: 1.744 ± 0.031
1.576ProPro: 1.576 ± 0.035
1.647ProGln: 1.647 ± 0.029
1.687ProArg: 1.687 ± 0.029
2.441ProSer: 2.441 ± 0.036
1.842ProThr: 1.842 ± 0.034
4.076ProVal: 4.076 ± 0.056
0.552ProTrp: 0.552 ± 0.017
1.727ProTyr: 1.727 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.058GlnAla: 3.058 ± 0.043
0.226GlnCys: 0.226 ± 0.011
1.741GlnAsp: 1.741 ± 0.032
2.386GlnGlu: 2.386 ± 0.043
1.721GlnPhe: 1.721 ± 0.029
2.286GlnGly: 2.286 ± 0.04
1.062GlnHis: 1.062 ± 0.024
2.107GlnIle: 2.107 ± 0.035
2.071GlnLys: 2.071 ± 0.035
4.361GlnLeu: 4.361 ± 0.052
0.949GlnMet: 0.949 ± 0.023
1.772GlnAsn: 1.772 ± 0.028
2.015GlnPro: 2.015 ± 0.035
2.74GlnGln: 2.74 ± 0.05
2.017GlnArg: 2.017 ± 0.035
2.089GlnSer: 2.089 ± 0.031
2.122GlnThr: 2.122 ± 0.032
2.56GlnVal: 2.56 ± 0.034
0.554GlnTrp: 0.554 ± 0.018
1.728GlnTyr: 1.728 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
3.26ArgAla: 3.26 ± 0.041
0.29ArgCys: 0.29 ± 0.013
2.494ArgAsp: 2.494 ± 0.035
3.157ArgGlu: 3.157 ± 0.046
2.683ArgPhe: 2.683 ± 0.038
2.761ArgGly: 2.761 ± 0.037
1.089ArgHis: 1.089 ± 0.026
3.616ArgIle: 3.616 ± 0.046
3.397ArgLys: 3.397 ± 0.05
4.939ArgLeu: 4.939 ± 0.058
1.429ArgMet: 1.429 ± 0.027
2.935ArgAsn: 2.935 ± 0.043
1.922ArgPro: 1.922 ± 0.032
2.381ArgGln: 2.381 ± 0.038
2.534ArgArg: 2.534 ± 0.039
2.779ArgSer: 2.779 ± 0.04
2.723ArgThr: 2.723 ± 0.037
2.861ArgVal: 2.861 ± 0.04
0.855ArgTrp: 0.855 ± 0.021
2.456ArgTyr: 2.456 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
5.035SerAla: 5.035 ± 0.056
0.537SerCys: 0.537 ± 0.02
2.793SerAsp: 2.793 ± 0.042
2.754SerGlu: 2.754 ± 0.037
3.258SerPhe: 3.258 ± 0.048
5.169SerGly: 5.169 ± 0.061
1.036SerHis: 1.036 ± 0.022
3.877SerIle: 3.877 ± 0.045
2.777SerLys: 2.777 ± 0.034
6.036SerLeu: 6.036 ± 0.067
1.424SerMet: 1.424 ± 0.026
2.694SerAsn: 2.694 ± 0.043
2.51SerPro: 2.51 ± 0.033
1.866SerGln: 1.866 ± 0.034
3.128SerArg: 3.128 ± 0.043
3.721SerSer: 3.721 ± 0.05
3.432SerThr: 3.432 ± 0.049
4.046SerVal: 4.046 ± 0.048
0.907SerTrp: 0.907 ± 0.024
2.549SerTyr: 2.549 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
5.564ThrAla: 5.564 ± 0.07
0.378ThrCys: 0.378 ± 0.015
3.334ThrAsp: 3.334 ± 0.045
2.806ThrGlu: 2.806 ± 0.039
2.66ThrPhe: 2.66 ± 0.039
5.612ThrGly: 5.612 ± 0.073
0.997ThrHis: 0.997 ± 0.023
3.698ThrIle: 3.698 ± 0.054
2.532ThrLys: 2.532 ± 0.033
5.505ThrLeu: 5.505 ± 0.061
1.119ThrMet: 1.119 ± 0.025
2.432ThrAsn: 2.432 ± 0.044
2.959ThrPro: 2.959 ± 0.047
1.827ThrGln: 1.827 ± 0.037
2.481ThrArg: 2.481 ± 0.038
3.273ThrSer: 3.273 ± 0.059
3.413ThrThr: 3.413 ± 0.054
4.347ThrVal: 4.347 ± 0.075
0.812ThrTrp: 0.812 ± 0.021
2.322ThrTyr: 2.322 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
4.94ValAla: 4.94 ± 0.058
0.567ValCys: 0.567 ± 0.017
3.274ValAsp: 3.274 ± 0.04
3.439ValGlu: 3.439 ± 0.051
3.099ValPhe: 3.099 ± 0.036
3.517ValGly: 3.517 ± 0.051
1.272ValHis: 1.272 ± 0.028
4.474ValIle: 4.474 ± 0.052
4.153ValLys: 4.153 ± 0.054
6.294ValLeu: 6.294 ± 0.062
1.685ValMet: 1.685 ± 0.031
3.534ValAsn: 3.534 ± 0.046
2.961ValPro: 2.961 ± 0.036
2.517ValGln: 2.517 ± 0.033
3.217ValArg: 3.217 ± 0.041
4.302ValSer: 4.302 ± 0.053
4.274ValThr: 4.274 ± 0.069
4.282ValVal: 4.282 ± 0.058
0.766ValTrp: 0.766 ± 0.022
2.543ValTyr: 2.543 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
0.885TrpAla: 0.885 ± 0.024
0.121TrpCys: 0.121 ± 0.008
0.733TrpAsp: 0.733 ± 0.02
0.847TrpGlu: 0.847 ± 0.018
0.584TrpPhe: 0.584 ± 0.019
0.95TrpGly: 0.95 ± 0.027
0.294TrpHis: 0.294 ± 0.014
0.78TrpIle: 0.78 ± 0.02
0.978TrpLys: 0.978 ± 0.024
1.378TrpLeu: 1.378 ± 0.025
0.449TrpMet: 0.449 ± 0.016
0.793TrpAsn: 0.793 ± 0.021
0.461TrpPro: 0.461 ± 0.015
0.681TrpGln: 0.681 ± 0.022
0.687TrpArg: 0.687 ± 0.019
0.744TrpSer: 0.744 ± 0.022
0.771TrpThr: 0.771 ± 0.02
0.742TrpVal: 0.742 ± 0.018
0.274TrpTrp: 0.274 ± 0.011
0.603TrpTyr: 0.603 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.187TyrAla: 3.187 ± 0.044
0.327TyrCys: 0.327 ± 0.012
2.42TyrAsp: 2.42 ± 0.04
2.141TyrGlu: 2.141 ± 0.034
2.199TyrPhe: 2.199 ± 0.031
2.941TyrGly: 2.941 ± 0.046
0.921TyrHis: 0.921 ± 0.024
2.255TyrIle: 2.255 ± 0.034
2.209TyrLys: 2.209 ± 0.036
3.855TyrLeu: 3.855 ± 0.045
0.878TyrMet: 0.878 ± 0.023
2.425TyrAsn: 2.425 ± 0.045
1.845TyrPro: 1.845 ± 0.034
1.547TyrGln: 1.547 ± 0.029
2.426TyrArg: 2.426 ± 0.035
2.445TyrSer: 2.445 ± 0.04
2.633TyrThr: 2.633 ± 0.042
2.244TyrVal: 2.244 ± 0.031
0.599TyrTrp: 0.599 ± 0.017
1.95TyrTyr: 1.95 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5222 proteins (1995864 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski