Amino acid dipepetide frequency for TM7 phylum sp. oral taxon 346

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.94AlaAla: 9.94 ± 0.292
0.613AlaCys: 0.613 ± 0.054
5.252AlaAsp: 5.252 ± 0.132
5.484AlaGlu: 5.484 ± 0.178
2.621AlaPhe: 2.621 ± 0.106
6.625AlaGly: 6.625 ± 0.173
1.613AlaHis: 1.613 ± 0.078
6.298AlaIle: 6.298 ± 0.165
6.185AlaLys: 6.185 ± 0.163
7.876AlaLeu: 7.876 ± 0.195
2.152AlaMet: 2.152 ± 0.079
3.885AlaAsn: 3.885 ± 0.126
3.061AlaPro: 3.061 ± 0.135
3.48AlaGln: 3.48 ± 0.124
5.361AlaArg: 5.361 ± 0.16
5.805AlaSer: 5.805 ± 0.174
4.677AlaThr: 4.677 ± 0.143
6.664AlaVal: 6.664 ± 0.159
0.93AlaTrp: 0.93 ± 0.058
2.698AlaTyr: 2.698 ± 0.106
0.0AlaXaa: 0.0 ± 0.0
Cys
0.602CysAla: 0.602 ± 0.044
0.07CysCys: 0.07 ± 0.016
0.493CysAsp: 0.493 ± 0.048
0.321CysGlu: 0.321 ± 0.038
0.275CysPhe: 0.275 ± 0.033
0.546CysGly: 0.546 ± 0.042
0.169CysHis: 0.169 ± 0.027
0.391CysIle: 0.391 ± 0.037
0.331CysLys: 0.331 ± 0.035
0.655CysLeu: 0.655 ± 0.045
0.151CysMet: 0.151 ± 0.025
0.278CysAsn: 0.278 ± 0.03
0.345CysPro: 0.345 ± 0.041
0.37CysGln: 0.37 ± 0.036
0.359CysArg: 0.359 ± 0.041
0.483CysSer: 0.483 ± 0.037
0.363CysThr: 0.363 ± 0.04
0.377CysVal: 0.377 ± 0.035
0.123CysTrp: 0.123 ± 0.031
0.264CysTyr: 0.264 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
4.515AspAla: 4.515 ± 0.133
0.37AspCys: 0.37 ± 0.037
4.089AspAsp: 4.089 ± 0.136
4.403AspGlu: 4.403 ± 0.146
2.515AspPhe: 2.515 ± 0.099
4.41AspGly: 4.41 ± 0.139
0.916AspHis: 0.916 ± 0.06
4.593AspIle: 4.593 ± 0.133
4.353AspLys: 4.353 ± 0.146
4.685AspLeu: 4.685 ± 0.151
1.451AspMet: 1.451 ± 0.077
2.751AspAsn: 2.751 ± 0.101
2.004AspPro: 2.004 ± 0.091
2.046AspGln: 2.046 ± 0.083
2.839AspArg: 2.839 ± 0.105
3.677AspSer: 3.677 ± 0.127
3.35AspThr: 3.35 ± 0.128
3.663AspVal: 3.663 ± 0.107
0.743AspTrp: 0.743 ± 0.055
2.215AspTyr: 2.215 ± 0.096
0.0AspXaa: 0.0 ± 0.0
Glu
5.157GluAla: 5.157 ± 0.176
0.394GluCys: 0.394 ± 0.031
2.849GluAsp: 2.849 ± 0.112
3.406GluGlu: 3.406 ± 0.14
2.092GluPhe: 2.092 ± 0.081
2.709GluGly: 2.709 ± 0.09
1.148GluHis: 1.148 ± 0.073
4.537GluIle: 4.537 ± 0.137
4.29GluLys: 4.29 ± 0.128
6.481GluLeu: 6.481 ± 0.153
1.423GluMet: 1.423 ± 0.085
2.444GluAsn: 2.444 ± 0.089
1.839GluPro: 1.839 ± 0.086
2.881GluGln: 2.881 ± 0.1
3.617GluArg: 3.617 ± 0.135
3.209GluSer: 3.209 ± 0.113
3.138GluThr: 3.138 ± 0.112
4.135GluVal: 4.135 ± 0.15
0.511GluTrp: 0.511 ± 0.04
2.089GluTyr: 2.089 ± 0.082
0.0GluXaa: 0.0 ± 0.0
Phe
3.575PheAla: 3.575 ± 0.113
0.335PheCys: 0.335 ± 0.034
2.402PheAsp: 2.402 ± 0.096
1.994PheGlu: 1.994 ± 0.085
1.37PhePhe: 1.37 ± 0.073
2.818PheGly: 2.818 ± 0.118
0.627PheHis: 0.627 ± 0.045
2.286PheIle: 2.286 ± 0.107
1.518PheLys: 1.518 ± 0.079
2.98PheLeu: 2.98 ± 0.112
0.923PheMet: 0.923 ± 0.062
1.687PheAsn: 1.687 ± 0.081
1.134PhePro: 1.134 ± 0.071
0.916PheGln: 0.916 ± 0.062
1.789PheArg: 1.789 ± 0.068
2.561PheSer: 2.561 ± 0.096
2.314PheThr: 2.314 ± 0.089
2.515PheVal: 2.515 ± 0.113
0.497PheTrp: 0.497 ± 0.043
1.257PheTyr: 1.257 ± 0.074
0.0PheXaa: 0.0 ± 0.0
Gly
5.357GlyAla: 5.357 ± 0.141
0.423GlyCys: 0.423 ± 0.036
3.994GlyAsp: 3.994 ± 0.128
4.135GlyGlu: 4.135 ± 0.129
2.687GlyPhe: 2.687 ± 0.103
4.938GlyGly: 4.938 ± 0.154
1.254GlyHis: 1.254 ± 0.069
4.375GlyIle: 4.375 ± 0.13
4.551GlyLys: 4.551 ± 0.132
6.129GlyLeu: 6.129 ± 0.158
1.578GlyMet: 1.578 ± 0.089
2.522GlyAsn: 2.522 ± 0.11
1.486GlyPro: 1.486 ± 0.081
2.55GlyGln: 2.55 ± 0.099
3.614GlyArg: 3.614 ± 0.118
4.445GlySer: 4.445 ± 0.124
3.572GlyThr: 3.572 ± 0.106
5.326GlyVal: 5.326 ± 0.131
0.969GlyTrp: 0.969 ± 0.065
2.42GlyTyr: 2.42 ± 0.092
0.0GlyXaa: 0.0 ± 0.0
His
1.356HisAla: 1.356 ± 0.074
0.158HisCys: 0.158 ± 0.022
1.254HisAsp: 1.254 ± 0.08
1.138HisGlu: 1.138 ± 0.057
0.655HisPhe: 0.655 ± 0.052
1.36HisGly: 1.36 ± 0.078
0.451HisHis: 0.451 ± 0.049
1.356HisIle: 1.356 ± 0.071
0.891HisLys: 0.891 ± 0.049
1.596HisLeu: 1.596 ± 0.076
0.352HisMet: 0.352 ± 0.037
0.789HisAsn: 0.789 ± 0.064
0.965HisPro: 0.965 ± 0.061
0.849HisGln: 0.849 ± 0.061
0.986HisArg: 0.986 ± 0.058
1.152HisSer: 1.152 ± 0.075
0.955HisThr: 0.955 ± 0.06
1.109HisVal: 1.109 ± 0.063
0.19HisTrp: 0.19 ± 0.026
0.711HisTyr: 0.711 ± 0.052
0.0HisXaa: 0.0 ± 0.0
Ile
7.044IleAla: 7.044 ± 0.187
0.49IleCys: 0.49 ± 0.043
4.917IleAsp: 4.917 ± 0.137
4.206IleGlu: 4.206 ± 0.13
2.286IlePhe: 2.286 ± 0.11
4.758IleGly: 4.758 ± 0.149
1.067IleHis: 1.067 ± 0.057
5.833IleIle: 5.833 ± 0.208
4.213IleLys: 4.213 ± 0.116
5.695IleLeu: 5.695 ± 0.15
1.434IleMet: 1.434 ± 0.074
3.283IleAsn: 3.283 ± 0.114
2.473IlePro: 2.473 ± 0.089
2.022IleGln: 2.022 ± 0.086
3.336IleArg: 3.336 ± 0.136
4.646IleSer: 4.646 ± 0.148
3.994IleThr: 3.994 ± 0.135
5.35IleVal: 5.35 ± 0.14
0.595IleTrp: 0.595 ± 0.044
2.152IleTyr: 2.152 ± 0.089
0.0IleXaa: 0.0 ± 0.0
Lys
4.751LysAla: 4.751 ± 0.136
0.306LysCys: 0.306 ± 0.029
3.427LysAsp: 3.427 ± 0.144
3.163LysGlu: 3.163 ± 0.124
1.951LysPhe: 1.951 ± 0.087
3.244LysGly: 3.244 ± 0.108
1.222LysHis: 1.222 ± 0.069
4.501LysIle: 4.501 ± 0.128
4.871LysLys: 4.871 ± 0.172
6.294LysLeu: 6.294 ± 0.173
1.596LysMet: 1.596 ± 0.079
3.004LysAsn: 3.004 ± 0.105
2.709LysPro: 2.709 ± 0.108
2.93LysGln: 2.93 ± 0.1
3.572LysArg: 3.572 ± 0.112
4.012LysSer: 4.012 ± 0.156
3.755LysThr: 3.755 ± 0.157
3.54LysVal: 3.54 ± 0.121
0.511LysTrp: 0.511 ± 0.044
2.244LysTyr: 2.244 ± 0.085
0.0LysXaa: 0.0 ± 0.0
Leu
9.982LeuAla: 9.982 ± 0.209
0.595LeuCys: 0.595 ± 0.043
5.283LeuAsp: 5.283 ± 0.132
5.083LeuGlu: 5.083 ± 0.14
3.145LeuPhe: 3.145 ± 0.113
5.692LeuGly: 5.692 ± 0.159
1.698LeuHis: 1.698 ± 0.078
5.822LeuIle: 5.822 ± 0.157
4.794LeuLys: 4.794 ± 0.126
8.591LeuLeu: 8.591 ± 0.251
2.177LeuMet: 2.177 ± 0.097
3.417LeuAsn: 3.417 ± 0.116
4.318LeuPro: 4.318 ± 0.125
3.543LeuGln: 3.543 ± 0.106
5.628LeuArg: 5.628 ± 0.16
6.474LeuSer: 6.474 ± 0.152
5.206LeuThr: 5.206 ± 0.144
6.875LeuVal: 6.875 ± 0.179
0.898LeuTrp: 0.898 ± 0.068
2.723LeuTyr: 2.723 ± 0.1
0.0LeuXaa: 0.0 ± 0.0
Met
2.106MetAla: 2.106 ± 0.091
0.123MetCys: 0.123 ± 0.019
0.955MetAsp: 0.955 ± 0.067
0.951MetGlu: 0.951 ± 0.063
0.726MetPhe: 0.726 ± 0.058
1.268MetGly: 1.268 ± 0.075
0.377MetHis: 0.377 ± 0.033
1.634MetIle: 1.634 ± 0.082
1.56MetLys: 1.56 ± 0.083
2.099MetLeu: 2.099 ± 0.079
0.592MetMet: 0.592 ± 0.053
1.06MetAsn: 1.06 ± 0.051
1.152MetPro: 1.152 ± 0.066
0.926MetGln: 0.926 ± 0.06
1.529MetArg: 1.529 ± 0.073
1.832MetSer: 1.832 ± 0.082
1.571MetThr: 1.571 ± 0.067
1.539MetVal: 1.539 ± 0.073
0.169MetTrp: 0.169 ± 0.023
0.68MetTyr: 0.68 ± 0.05
0.0MetXaa: 0.0 ± 0.0
Asn
3.452AsnAla: 3.452 ± 0.134
0.31AsnCys: 0.31 ± 0.031
2.758AsnAsp: 2.758 ± 0.113
2.497AsnGlu: 2.497 ± 0.085
1.585AsnPhe: 1.585 ± 0.068
3.011AsnGly: 3.011 ± 0.113
0.655AsnHis: 0.655 ± 0.051
3.212AsnIle: 3.212 ± 0.123
2.765AsnLys: 2.765 ± 0.11
3.586AsnLeu: 3.586 ± 0.116
0.912AsnMet: 0.912 ± 0.063
2.395AsnAsn: 2.395 ± 0.104
2.275AsnPro: 2.275 ± 0.091
1.881AsnGln: 1.881 ± 0.083
2.367AsnArg: 2.367 ± 0.095
3.029AsnSer: 3.029 ± 0.126
2.381AsnThr: 2.381 ± 0.102
2.642AsnVal: 2.642 ± 0.095
0.454AsnTrp: 0.454 ± 0.039
1.49AsnTyr: 1.49 ± 0.075
0.0AsnXaa: 0.0 ± 0.0
Pro
3.748ProAla: 3.748 ± 0.148
0.19ProCys: 0.19 ± 0.035
2.536ProAsp: 2.536 ± 0.096
3.061ProGlu: 3.061 ± 0.11
1.353ProPhe: 1.353 ± 0.068
2.613ProGly: 2.613 ± 0.098
0.764ProHis: 0.764 ± 0.054
2.289ProIle: 2.289 ± 0.089
2.335ProLys: 2.335 ± 0.101
3.304ProLeu: 3.304 ± 0.106
0.719ProMet: 0.719 ± 0.05
1.814ProAsn: 1.814 ± 0.087
1.416ProPro: 1.416 ± 0.085
1.712ProGln: 1.712 ± 0.086
1.927ProArg: 1.927 ± 0.075
2.564ProSer: 2.564 ± 0.108
2.402ProThr: 2.402 ± 0.103
2.786ProVal: 2.786 ± 0.101
0.377ProTrp: 0.377 ± 0.033
1.134ProTyr: 1.134 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
4.082GlnAla: 4.082 ± 0.137
0.243GlnCys: 0.243 ± 0.031
1.634GlnAsp: 1.634 ± 0.08
1.828GlnGlu: 1.828 ± 0.085
1.384GlnPhe: 1.384 ± 0.083
1.807GlnGly: 1.807 ± 0.076
0.863GlnHis: 0.863 ± 0.063
2.772GlnIle: 2.772 ± 0.101
2.656GlnLys: 2.656 ± 0.103
4.452GlnLeu: 4.452 ± 0.144
0.94GlnMet: 0.94 ± 0.056
1.712GlnAsn: 1.712 ± 0.08
2.3GlnPro: 2.3 ± 0.118
2.402GlnGln: 2.402 ± 0.123
2.599GlnArg: 2.599 ± 0.093
2.494GlnSer: 2.494 ± 0.09
2.606GlnThr: 2.606 ± 0.102
2.402GlnVal: 2.402 ± 0.085
0.44GlnTrp: 0.44 ± 0.046
1.391GlnTyr: 1.391 ± 0.08
0.0GlnXaa: 0.0 ± 0.0
Arg
4.646ArgAla: 4.646 ± 0.133
0.366ArgCys: 0.366 ± 0.04
3.427ArgAsp: 3.427 ± 0.114
3.48ArgGlu: 3.48 ± 0.124
2.029ArgPhe: 2.029 ± 0.086
3.367ArgGly: 3.367 ± 0.121
1.268ArgHis: 1.268 ± 0.067
3.582ArgIle: 3.582 ± 0.107
3.156ArgLys: 3.156 ± 0.124
5.614ArgLeu: 5.614 ± 0.151
1.345ArgMet: 1.345 ± 0.068
2.339ArgAsn: 2.339 ± 0.084
2.064ArgPro: 2.064 ± 0.081
3.469ArgGln: 3.469 ± 0.118
4.558ArgArg: 4.558 ± 0.156
3.402ArgSer: 3.402 ± 0.118
2.737ArgThr: 2.737 ± 0.09
3.607ArgVal: 3.607 ± 0.127
0.564ArgTrp: 0.564 ± 0.041
2.363ArgTyr: 2.363 ± 0.1
0.0ArgXaa: 0.0 ± 0.0
Ser
5.322SerAla: 5.322 ± 0.153
0.461SerCys: 0.461 ± 0.049
4.11SerAsp: 4.11 ± 0.126
3.917SerGlu: 3.917 ± 0.127
2.483SerPhe: 2.483 ± 0.092
5.174SerGly: 5.174 ± 0.16
1.127SerHis: 1.127 ± 0.066
4.248SerIle: 4.248 ± 0.125
3.737SerLys: 3.737 ± 0.129
5.998SerLeu: 5.998 ± 0.146
1.476SerMet: 1.476 ± 0.08
2.768SerAsn: 2.768 ± 0.11
2.483SerPro: 2.483 ± 0.094
2.821SerGln: 2.821 ± 0.096
3.815SerArg: 3.815 ± 0.123
4.896SerSer: 4.896 ± 0.176
3.684SerThr: 3.684 ± 0.142
4.663SerVal: 4.663 ± 0.139
0.775SerTrp: 0.775 ± 0.051
2.05SerTyr: 2.05 ± 0.096
0.0SerXaa: 0.0 ± 0.0
Thr
5.297ThrAla: 5.297 ± 0.16
0.363ThrCys: 0.363 ± 0.038
3.135ThrAsp: 3.135 ± 0.129
2.832ThrGlu: 2.832 ± 0.097
1.955ThrPhe: 1.955 ± 0.079
4.22ThrGly: 4.22 ± 0.11
1.081ThrHis: 1.081 ± 0.065
4.336ThrIle: 4.336 ± 0.133
3.121ThrLys: 3.121 ± 0.117
5.304ThrLeu: 5.304 ± 0.145
1.18ThrMet: 1.18 ± 0.063
2.392ThrAsn: 2.392 ± 0.115
2.839ThrPro: 2.839 ± 0.104
1.743ThrGln: 1.743 ± 0.098
2.638ThrArg: 2.638 ± 0.092
3.586ThrSer: 3.586 ± 0.133
3.596ThrThr: 3.596 ± 0.125
4.315ThrVal: 4.315 ± 0.14
0.458ThrTrp: 0.458 ± 0.04
1.86ThrTyr: 1.86 ± 0.077
0.0ThrXaa: 0.0 ± 0.0
Val
6.759ValAla: 6.759 ± 0.172
0.683ValCys: 0.683 ± 0.053
4.279ValAsp: 4.279 ± 0.111
4.202ValGlu: 4.202 ± 0.136
2.592ValPhe: 2.592 ± 0.09
4.766ValGly: 4.766 ± 0.138
1.028ValHis: 1.028 ± 0.062
5.04ValIle: 5.04 ± 0.136
4.1ValLys: 4.1 ± 0.123
6.224ValLeu: 6.224 ± 0.18
1.543ValMet: 1.543 ± 0.08
3.085ValAsn: 3.085 ± 0.119
2.501ValPro: 2.501 ± 0.101
2.258ValGln: 2.258 ± 0.087
3.741ValArg: 3.741 ± 0.132
4.921ValSer: 4.921 ± 0.133
3.716ValThr: 3.716 ± 0.124
5.794ValVal: 5.794 ± 0.186
0.74ValTrp: 0.74 ± 0.053
2.194ValTyr: 2.194 ± 0.08
0.0ValXaa: 0.0 ± 0.0
Trp
0.75TrpAla: 0.75 ± 0.055
0.12TrpCys: 0.12 ± 0.019
0.458TrpAsp: 0.458 ± 0.042
0.391TrpGlu: 0.391 ± 0.036
0.426TrpPhe: 0.426 ± 0.041
0.599TrpGly: 0.599 ± 0.057
0.268TrpHis: 0.268 ± 0.031
0.557TrpIle: 0.557 ± 0.039
0.398TrpLys: 0.398 ± 0.038
1.5TrpLeu: 1.5 ± 0.084
0.303TrpMet: 0.303 ± 0.03
0.416TrpAsn: 0.416 ± 0.041
0.384TrpPro: 0.384 ± 0.037
0.74TrpGln: 0.74 ± 0.049
0.937TrpArg: 0.937 ± 0.067
0.62TrpSer: 0.62 ± 0.048
0.472TrpThr: 0.472 ± 0.041
0.616TrpVal: 0.616 ± 0.048
0.194TrpTrp: 0.194 ± 0.028
0.359TrpTyr: 0.359 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.775TyrAla: 2.775 ± 0.103
0.352TyrCys: 0.352 ± 0.04
2.335TyrAsp: 2.335 ± 0.089
1.86TyrGlu: 1.86 ± 0.079
1.367TyrPhe: 1.367 ± 0.072
2.399TyrGly: 2.399 ± 0.089
0.676TyrHis: 0.676 ± 0.048
2.131TyrIle: 2.131 ± 0.089
1.782TyrLys: 1.782 ± 0.08
2.881TyrLeu: 2.881 ± 0.11
0.599TyrMet: 0.599 ± 0.044
1.617TyrAsn: 1.617 ± 0.084
1.296TyrPro: 1.296 ± 0.081
1.469TyrGln: 1.469 ± 0.076
2.173TyrArg: 2.173 ± 0.095
2.205TyrSer: 2.205 ± 0.099
1.761TyrThr: 1.761 ± 0.079
2.247TyrVal: 2.247 ± 0.091
0.37TyrTrp: 0.37 ± 0.036
1.275TyrTyr: 1.275 ± 0.072
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 930 proteins (283914 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski