Amino acid dipepetide frequency for Muribaculaceae bacterium Z82

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.901AlaAla: 16.901 ± 0.271
2.209AlaCys: 2.209 ± 0.096
7.642AlaAsp: 7.642 ± 0.187
7.651AlaGlu: 7.651 ± 0.142
4.599AlaPhe: 4.599 ± 0.096
10.52AlaGly: 10.52 ± 0.145
1.872AlaHis: 1.872 ± 0.051
5.159AlaIle: 5.159 ± 0.119
4.294AlaLys: 4.294 ± 0.088
12.039AlaLeu: 12.039 ± 0.28
3.315AlaMet: 3.315 ± 0.087
3.11AlaAsn: 3.11 ± 0.114
4.825AlaPro: 4.825 ± 0.111
4.282AlaGln: 4.282 ± 0.092
6.744AlaArg: 6.744 ± 0.203
7.771AlaSer: 7.771 ± 0.116
5.745AlaThr: 5.745 ± 0.137
9.815AlaVal: 9.815 ± 0.177
1.357AlaTrp: 1.357 ± 0.042
2.995AlaTyr: 2.995 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
1.879CysAla: 1.879 ± 0.079
0.283CysCys: 0.283 ± 0.021
0.978CysAsp: 0.978 ± 0.047
0.923CysGlu: 0.923 ± 0.046
0.584CysPhe: 0.584 ± 0.032
1.592CysGly: 1.592 ± 0.071
0.333CysHis: 0.333 ± 0.028
0.77CysIle: 0.77 ± 0.04
0.509CysLys: 0.509 ± 0.031
1.36CysLeu: 1.36 ± 0.061
0.385CysMet: 0.385 ± 0.025
0.389CysAsn: 0.389 ± 0.029
0.793CysPro: 0.793 ± 0.049
0.369CysGln: 0.369 ± 0.025
0.813CysArg: 0.813 ± 0.044
0.976CysSer: 0.976 ± 0.042
0.824CysThr: 0.824 ± 0.037
1.279CysVal: 1.279 ± 0.055
0.183CysTrp: 0.183 ± 0.018
0.414CysTyr: 0.414 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
8.013AspAla: 8.013 ± 0.174
0.728AspCys: 0.728 ± 0.042
3.954AspAsp: 3.954 ± 0.137
5.224AspGlu: 5.224 ± 0.114
2.306AspPhe: 2.306 ± 0.061
6.372AspGly: 6.372 ± 0.262
0.797AspHis: 0.797 ± 0.035
2.653AspIle: 2.653 ± 0.067
1.887AspLys: 1.887 ± 0.052
4.854AspLeu: 4.854 ± 0.079
1.532AspMet: 1.532 ± 0.048
1.574AspAsn: 1.574 ± 0.092
3.182AspPro: 3.182 ± 0.108
1.628AspGln: 1.628 ± 0.052
3.249AspArg: 3.249 ± 0.077
3.133AspSer: 3.133 ± 0.078
2.678AspThr: 2.678 ± 0.117
4.77AspVal: 4.77 ± 0.089
0.76AspTrp: 0.76 ± 0.028
2.105AspTyr: 2.105 ± 0.086
0.0AspXaa: 0.0 ± 0.0
Glu
8.178GluAla: 8.178 ± 0.143
0.734GluCys: 0.734 ± 0.037
3.45GluAsp: 3.45 ± 0.072
4.505GluGlu: 4.505 ± 0.1
1.863GluPhe: 1.863 ± 0.053
5.825GluGly: 5.825 ± 0.088
1.197GluHis: 1.197 ± 0.046
2.392GluIle: 2.392 ± 0.069
2.477GluLys: 2.477 ± 0.08
5.996GluLeu: 5.996 ± 0.129
1.537GluMet: 1.537 ± 0.051
1.867GluAsn: 1.867 ± 0.074
2.82GluPro: 2.82 ± 0.067
2.427GluGln: 2.427 ± 0.048
4.887GluArg: 4.887 ± 0.128
3.487GluSer: 3.487 ± 0.069
3.133GluThr: 3.133 ± 0.081
4.447GluVal: 4.447 ± 0.091
0.68GluTrp: 0.68 ± 0.03
1.686GluTyr: 1.686 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
4.645PheAla: 4.645 ± 0.109
0.675PheCys: 0.675 ± 0.036
2.88PheAsp: 2.88 ± 0.062
2.176PheGlu: 2.176 ± 0.053
1.431PhePhe: 1.431 ± 0.059
3.755PheGly: 3.755 ± 0.091
0.519PheHis: 0.519 ± 0.031
1.457PheIle: 1.457 ± 0.054
1.079PheLys: 1.079 ± 0.038
3.317PheLeu: 3.317 ± 0.108
0.962PheMet: 0.962 ± 0.037
0.997PheAsn: 0.997 ± 0.044
1.385PhePro: 1.385 ± 0.052
0.952PheGln: 0.952 ± 0.032
1.705PheArg: 1.705 ± 0.047
2.431PheSer: 2.431 ± 0.068
1.975PheThr: 1.975 ± 0.06
3.194PheVal: 3.194 ± 0.074
0.44PheTrp: 0.44 ± 0.026
1.115PheTyr: 1.115 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
9.765GlyAla: 9.765 ± 0.142
1.746GlyCys: 1.746 ± 0.064
4.745GlyAsp: 4.745 ± 0.107
5.242GlyGlu: 5.242 ± 0.086
3.584GlyPhe: 3.584 ± 0.074
6.991GlyGly: 6.991 ± 0.126
1.4GlyHis: 1.4 ± 0.039
4.54GlyIle: 4.54 ± 0.084
3.534GlyLys: 3.534 ± 0.072
7.671GlyLeu: 7.671 ± 0.139
2.456GlyMet: 2.456 ± 0.064
2.759GlyAsn: 2.759 ± 0.154
2.602GlyPro: 2.602 ± 0.079
2.702GlyGln: 2.702 ± 0.063
5.179GlyArg: 5.179 ± 0.108
5.717GlySer: 5.717 ± 0.103
5.032GlyThr: 5.032 ± 0.213
6.693GlyVal: 6.693 ± 0.101
1.3GlyTrp: 1.3 ± 0.058
2.912GlyTyr: 2.912 ± 0.106
0.0GlyXaa: 0.0 ± 0.0
His
1.654HisAla: 1.654 ± 0.049
0.295HisCys: 0.295 ± 0.022
1.04HisAsp: 1.04 ± 0.039
0.937HisGlu: 0.937 ± 0.035
0.543HisPhe: 0.543 ± 0.025
1.644HisGly: 1.644 ± 0.048
0.32HisHis: 0.32 ± 0.022
0.814HisIle: 0.814 ± 0.038
0.5HisLys: 0.5 ± 0.024
1.432HisLeu: 1.432 ± 0.05
0.38HisMet: 0.38 ± 0.023
0.444HisAsn: 0.444 ± 0.022
1.037HisPro: 1.037 ± 0.041
0.438HisGln: 0.438 ± 0.022
0.981HisArg: 0.981 ± 0.046
0.951HisSer: 0.951 ± 0.037
0.773HisThr: 0.773 ± 0.032
1.281HisVal: 1.281 ± 0.04
0.181HisTrp: 0.181 ± 0.017
0.523HisTyr: 0.523 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.754IleAla: 5.754 ± 0.136
0.705IleCys: 0.705 ± 0.04
3.206IleAsp: 3.206 ± 0.068
2.975IleGlu: 2.975 ± 0.073
1.291IlePhe: 1.291 ± 0.054
3.708IleGly: 3.708 ± 0.092
0.689IleHis: 0.689 ± 0.035
1.888IleIle: 1.888 ± 0.066
1.337IleLys: 1.337 ± 0.045
3.253IleLeu: 3.253 ± 0.09
1.206IleMet: 1.206 ± 0.04
1.257IleAsn: 1.257 ± 0.046
2.276IlePro: 2.276 ± 0.055
1.177IleGln: 1.177 ± 0.039
2.227IleArg: 2.227 ± 0.062
2.493IleSer: 2.493 ± 0.052
2.418IleThr: 2.418 ± 0.062
4.073IleVal: 4.073 ± 0.088
0.369IleTrp: 0.369 ± 0.022
1.204IleTyr: 1.204 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
4.281LysAla: 4.281 ± 0.088
0.396LysCys: 0.396 ± 0.028
2.033LysAsp: 2.033 ± 0.055
2.009LysGlu: 2.009 ± 0.061
0.78LysPhe: 0.78 ± 0.034
2.924LysGly: 2.924 ± 0.078
0.625LysHis: 0.625 ± 0.034
1.317LysIle: 1.317 ± 0.043
1.72LysLys: 1.72 ± 0.067
3.223LysLeu: 3.223 ± 0.073
0.852LysMet: 0.852 ± 0.034
1.074LysAsn: 1.074 ± 0.052
1.811LysPro: 1.811 ± 0.055
1.193LysGln: 1.193 ± 0.046
2.524LysArg: 2.524 ± 0.076
2.003LysSer: 2.003 ± 0.062
2.12LysThr: 2.12 ± 0.066
2.689LysVal: 2.689 ± 0.074
0.366LysTrp: 0.366 ± 0.021
0.891LysTyr: 0.891 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
11.962LeuAla: 11.962 ± 0.241
1.565LeuCys: 1.565 ± 0.073
5.466LeuAsp: 5.466 ± 0.088
5.1LeuGlu: 5.1 ± 0.097
3.753LeuPhe: 3.753 ± 0.107
7.9LeuGly: 7.9 ± 0.15
1.377LeuHis: 1.377 ± 0.04
3.565LeuIle: 3.565 ± 0.105
2.768LeuLys: 2.768 ± 0.059
8.648LeuLeu: 8.648 ± 0.252
2.488LeuMet: 2.488 ± 0.077
2.175LeuAsn: 2.175 ± 0.07
4.467LeuPro: 4.467 ± 0.07
2.61LeuGln: 2.61 ± 0.063
5.43LeuArg: 5.43 ± 0.127
6.473LeuSer: 6.473 ± 0.128
4.641LeuThr: 4.641 ± 0.093
8.001LeuVal: 8.001 ± 0.165
1.018LeuTrp: 1.018 ± 0.038
2.471LeuTyr: 2.471 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
3.454MetAla: 3.454 ± 0.086
0.281MetCys: 0.281 ± 0.022
1.482MetAsp: 1.482 ± 0.047
1.634MetGlu: 1.634 ± 0.048
0.802MetPhe: 0.802 ± 0.042
2.418MetGly: 2.418 ± 0.06
0.396MetHis: 0.396 ± 0.023
0.949MetIle: 0.949 ± 0.042
0.93MetLys: 0.93 ± 0.038
2.511MetLeu: 2.511 ± 0.081
0.664MetMet: 0.664 ± 0.037
0.822MetAsn: 0.822 ± 0.034
1.36MetPro: 1.36 ± 0.043
0.802MetGln: 0.802 ± 0.034
1.725MetArg: 1.725 ± 0.062
1.509MetSer: 1.509 ± 0.047
1.563MetThr: 1.563 ± 0.046
1.945MetVal: 1.945 ± 0.052
0.204MetTrp: 0.204 ± 0.017
0.579MetTyr: 0.579 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.3AsnAla: 3.3 ± 0.124
0.36AsnCys: 0.36 ± 0.025
1.594AsnAsp: 1.594 ± 0.104
1.659AsnGlu: 1.659 ± 0.051
0.853AsnPhe: 0.853 ± 0.05
2.519AsnGly: 2.519 ± 0.141
0.531AsnHis: 0.531 ± 0.03
1.342AsnIle: 1.342 ± 0.046
0.888AsnLys: 0.888 ± 0.042
2.588AsnLeu: 2.588 ± 0.084
0.682AsnMet: 0.682 ± 0.028
0.876AsnAsn: 0.876 ± 0.074
2.076AsnPro: 2.076 ± 0.071
0.851AsnGln: 0.851 ± 0.044
1.742AsnArg: 1.742 ± 0.058
1.54AsnSer: 1.54 ± 0.089
1.478AsnThr: 1.478 ± 0.1
2.251AsnVal: 2.251 ± 0.079
0.344AsnTrp: 0.344 ± 0.024
0.874AsnTyr: 0.874 ± 0.085
0.0AsnXaa: 0.0 ± 0.0
Pro
5.58ProAla: 5.58 ± 0.096
0.642ProCys: 0.642 ± 0.034
3.123ProAsp: 3.123 ± 0.088
3.562ProGlu: 3.562 ± 0.073
1.897ProPhe: 1.897 ± 0.054
3.601ProGly: 3.601 ± 0.072
0.767ProHis: 0.767 ± 0.038
1.707ProIle: 1.707 ± 0.05
1.588ProLys: 1.588 ± 0.044
4.096ProLeu: 4.096 ± 0.09
0.985ProMet: 0.985 ± 0.043
1.264ProAsn: 1.264 ± 0.056
1.352ProPro: 1.352 ± 0.05
1.583ProGln: 1.583 ± 0.059
2.184ProArg: 2.184 ± 0.063
3.002ProSer: 3.002 ± 0.074
2.31ProThr: 2.31 ± 0.057
3.864ProVal: 3.864 ± 0.076
0.597ProTrp: 0.597 ± 0.027
1.408ProTyr: 1.408 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
4.196GlnAla: 4.196 ± 0.083
0.356GlnCys: 0.356 ± 0.025
1.542GlnAsp: 1.542 ± 0.056
1.95GlnGlu: 1.95 ± 0.057
0.957GlnPhe: 0.957 ± 0.035
2.497GlnGly: 2.497 ± 0.055
0.515GlnHis: 0.515 ± 0.026
1.459GlnIle: 1.459 ± 0.043
1.198GlnLys: 1.198 ± 0.044
3.075GlnLeu: 3.075 ± 0.075
0.855GlnMet: 0.855 ± 0.038
0.881GlnAsn: 0.881 ± 0.049
1.624GlnPro: 1.624 ± 0.047
1.381GlnGln: 1.381 ± 0.051
2.179GlnArg: 2.179 ± 0.07
1.637GlnSer: 1.637 ± 0.046
1.665GlnThr: 1.665 ± 0.058
2.577GlnVal: 2.577 ± 0.059
0.462GlnTrp: 0.462 ± 0.04
0.664GlnTyr: 0.664 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
6.395ArgAla: 6.395 ± 0.139
0.924ArgCys: 0.924 ± 0.042
3.461ArgAsp: 3.461 ± 0.077
4.265ArgGlu: 4.265 ± 0.118
2.576ArgPhe: 2.576 ± 0.071
4.075ArgGly: 4.075 ± 0.108
0.998ArgHis: 0.998 ± 0.042
3.246ArgIle: 3.246 ± 0.096
2.506ArgLys: 2.506 ± 0.083
5.255ArgLeu: 5.255 ± 0.11
1.808ArgMet: 1.808 ± 0.065
1.828ArgAsn: 1.828 ± 0.053
2.581ArgPro: 2.581 ± 0.072
2.116ArgGln: 2.116 ± 0.059
4.406ArgArg: 4.406 ± 0.148
3.49ArgSer: 3.49 ± 0.094
3.211ArgThr: 3.211 ± 0.083
4.021ArgVal: 4.021 ± 0.073
0.717ArgTrp: 0.717 ± 0.032
1.875ArgTyr: 1.875 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
6.988SerAla: 6.988 ± 0.117
0.97SerCys: 0.97 ± 0.044
3.675SerAsp: 3.675 ± 0.125
3.22SerGlu: 3.22 ± 0.081
2.639SerPhe: 2.639 ± 0.061
5.559SerGly: 5.559 ± 0.097
1.023SerHis: 1.023 ± 0.037
2.665SerIle: 2.665 ± 0.062
2.043SerLys: 2.043 ± 0.05
5.772SerLeu: 5.772 ± 0.132
1.701SerMet: 1.701 ± 0.046
1.751SerAsn: 1.751 ± 0.083
2.702SerPro: 2.702 ± 0.063
2.138SerGln: 2.138 ± 0.059
3.475SerArg: 3.475 ± 0.077
3.976SerSer: 3.976 ± 0.101
3.089SerThr: 3.089 ± 0.095
4.946SerVal: 4.946 ± 0.07
0.861SerTrp: 0.861 ± 0.032
1.872SerTyr: 1.872 ± 0.076
0.0SerXaa: 0.0 ± 0.0
Thr
5.712ThrAla: 5.712 ± 0.133
0.74ThrCys: 0.74 ± 0.038
3.348ThrAsp: 3.348 ± 0.187
2.828ThrGlu: 2.828 ± 0.086
2.008ThrPhe: 2.008 ± 0.05
4.731ThrGly: 4.731 ± 0.13
0.885ThrHis: 0.885 ± 0.035
2.401ThrIle: 2.401 ± 0.059
1.64ThrLys: 1.64 ± 0.072
4.795ThrLeu: 4.795 ± 0.089
1.271ThrMet: 1.271 ± 0.041
1.546ThrAsn: 1.546 ± 0.12
2.765ThrPro: 2.765 ± 0.075
1.492ThrGln: 1.492 ± 0.072
2.565ThrArg: 2.565 ± 0.069
2.929ThrSer: 2.929 ± 0.114
2.797ThrThr: 2.797 ± 0.186
4.975ThrVal: 4.975 ± 0.138
0.676ThrTrp: 0.676 ± 0.039
1.705ThrTyr: 1.705 ± 0.125
0.0ThrXaa: 0.0 ± 0.0
Val
9.906ValAla: 9.906 ± 0.157
1.413ValCys: 1.413 ± 0.063
4.994ValAsp: 4.994 ± 0.103
5.113ValGlu: 5.113 ± 0.09
3.07ValPhe: 3.07 ± 0.079
6.33ValGly: 6.33 ± 0.103
1.2ValHis: 1.2 ± 0.04
3.519ValIle: 3.519 ± 0.077
2.592ValLys: 2.592 ± 0.065
7.855ValLeu: 7.855 ± 0.16
1.964ValMet: 1.964 ± 0.062
2.372ValAsn: 2.372 ± 0.093
3.813ValPro: 3.813 ± 0.077
2.217ValGln: 2.217 ± 0.053
5.082ValArg: 5.082 ± 0.102
5.329ValSer: 5.329 ± 0.087
4.222ValThr: 4.222 ± 0.139
7.531ValVal: 7.531 ± 0.142
0.835ValTrp: 0.835 ± 0.042
2.23ValTyr: 2.23 ± 0.082
0.0ValXaa: 0.0 ± 0.0
Trp
1.197TrpAla: 1.197 ± 0.038
0.191TrpCys: 0.191 ± 0.015
0.673TrpAsp: 0.673 ± 0.034
0.773TrpGlu: 0.773 ± 0.036
0.4TrpPhe: 0.4 ± 0.023
0.974TrpGly: 0.974 ± 0.038
0.237TrpHis: 0.237 ± 0.017
0.485TrpIle: 0.485 ± 0.025
0.44TrpLys: 0.44 ± 0.024
1.221TrpLeu: 1.221 ± 0.037
0.366TrpMet: 0.366 ± 0.021
0.422TrpAsn: 0.422 ± 0.034
0.414TrpPro: 0.414 ± 0.024
0.439TrpGln: 0.439 ± 0.024
0.736TrpArg: 0.736 ± 0.031
0.676TrpSer: 0.676 ± 0.032
0.577TrpThr: 0.577 ± 0.038
0.914TrpVal: 0.914 ± 0.042
0.179TrpTrp: 0.179 ± 0.016
0.557TrpTyr: 0.557 ± 0.058
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.085TyrAla: 3.085 ± 0.062
0.423TyrCys: 0.423 ± 0.026
2.116TyrAsp: 2.116 ± 0.141
1.838TyrGlu: 1.838 ± 0.053
1.154TyrPhe: 1.154 ± 0.052
2.638TyrGly: 2.638 ± 0.079
0.488TyrHis: 0.488 ± 0.028
1.177TyrIle: 1.177 ± 0.036
0.899TyrLys: 0.899 ± 0.052
2.914TyrLeu: 2.914 ± 0.08
0.619TyrMet: 0.619 ± 0.026
0.944TyrAsn: 0.944 ± 0.076
1.227TyrPro: 1.227 ± 0.036
0.873TyrGln: 0.873 ± 0.049
1.918TyrArg: 1.918 ± 0.062
1.546TyrSer: 1.546 ± 0.051
1.559TyrThr: 1.559 ± 0.127
2.321TyrVal: 2.321 ± 0.096
0.343TyrTrp: 0.343 ± 0.023
1.16TyrTyr: 1.16 ± 0.08
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2214 proteins (760548 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski