Amino acid dipepetide frequency for Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.38AlaAla: 4.38 ± 0.127	0.433AlaCys: 0.433 ± 0.029	2.593AlaAsp: 2.593 ± 0.088	2.61AlaGlu: 2.61 ± 0.09	3.121AlaPhe: 3.121 ± 0.096	4.6AlaGly: 4.6 ± 0.114	0.775AlaHis: 0.775 ± 0.037	5.812AlaIle: 5.812 ± 0.124	2.438AlaLys: 2.438 ± 0.081	5.793AlaLeu: 5.793 ± 0.123	2.234AlaMet: 2.234 ± 0.077	1.982AlaAsn: 1.982 ± 0.063	1.628AlaPro: 1.628 ± 0.06	0.904AlaGln: 0.904 ± 0.051	2.909AlaArg: 2.909 ± 0.083	4.25AlaSer: 4.25 ± 0.1	2.381AlaThr: 2.381 ± 0.073	4.127AlaVal: 4.127 ± 0.096	0.507AlaTrp: 0.507 ± 0.029	2.648AlaTyr: 2.648 ± 0.081	0.0AlaXaa: 0.0 ± 0.0
Cys	0.261CysAla: 0.261 ± 0.024	0.045CysCys: 0.045 ± 0.012	0.463CysAsp: 0.463 ± 0.034	0.299CysGlu: 0.299 ± 0.026	0.208CysPhe: 0.208 ± 0.021	0.603CysGly: 0.603 ± 0.039	0.153CysHis: 0.153 ± 0.019	0.601CysIle: 0.601 ± 0.043	0.295CysLys: 0.295 ± 0.027	0.431CysLeu: 0.431 ± 0.026	0.18CysMet: 0.18 ± 0.02	0.41CysAsn: 0.41 ± 0.031	0.393CysPro: 0.393 ± 0.031	0.089CysGln: 0.089 ± 0.013	0.371CysArg: 0.371 ± 0.023	0.48CysSer: 0.48 ± 0.031	0.312CysThr: 0.312 ± 0.03	0.331CysVal: 0.331 ± 0.029	0.028CysTrp: 0.028 ± 0.008	0.229CysTyr: 0.229 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.185AspAla: 3.185 ± 0.092	0.236AspCys: 0.236 ± 0.022	4.146AspAsp: 4.146 ± 0.122	4.278AspGlu: 4.278 ± 0.107	3.232AspPhe: 3.232 ± 0.084	2.986AspGly: 2.986 ± 0.087	0.942AspHis: 0.942 ± 0.046	6.826AspIle: 6.826 ± 0.118	3.531AspLys: 3.531 ± 0.095	5.799AspLeu: 5.799 ± 0.113	1.587AspMet: 1.587 ± 0.061	3.147AspAsn: 3.147 ± 0.076	2.167AspPro: 2.167 ± 0.072	0.781AspGln: 0.781 ± 0.04	2.043AspArg: 2.043 ± 0.062	3.399AspSer: 3.399 ± 0.079	2.052AspThr: 2.052 ± 0.068	4.061AspVal: 4.061 ± 0.086	0.407AspTrp: 0.407 ± 0.027	3.851AspTyr: 3.851 ± 0.092	0.0AspXaa: 0.0 ± 0.0
Glu	2.826GluAla: 2.826 ± 0.095	0.316GluCys: 0.316 ± 0.024	2.888GluAsp: 2.888 ± 0.074	3.098GluGlu: 3.098 ± 0.109	2.483GluPhe: 2.483 ± 0.083	1.956GluGly: 1.956 ± 0.067	0.942GluHis: 0.942 ± 0.049	6.833GluIle: 6.833 ± 0.138	5.237GluLys: 5.237 ± 0.142	4.853GluLeu: 4.853 ± 0.116	1.869GluMet: 1.869 ± 0.072	4.889GluAsn: 4.889 ± 0.114	1.852GluPro: 1.852 ± 0.079	0.811GluGln: 0.811 ± 0.047	3.155GluArg: 3.155 ± 0.093	3.883GluSer: 3.883 ± 0.106	2.765GluThr: 2.765 ± 0.082	2.587GluVal: 2.587 ± 0.084	0.45GluTrp: 0.45 ± 0.03	2.93GluTyr: 2.93 ± 0.079	0.0GluXaa: 0.0 ± 0.0
Phe	2.54PheAla: 2.54 ± 0.089	0.293PheCys: 0.293 ± 0.026	2.621PheAsp: 2.621 ± 0.07	2.094PheGlu: 2.094 ± 0.064	2.642PhePhe: 2.642 ± 0.097	3.03PheGly: 3.03 ± 0.093	0.815PheHis: 0.815 ± 0.044	5.914PheIle: 5.914 ± 0.161	3.03PheLys: 3.03 ± 0.089	4.356PheLeu: 4.356 ± 0.135	1.521PheMet: 1.521 ± 0.065	3.455PheAsn: 3.455 ± 0.083	1.623PhePro: 1.623 ± 0.059	0.891PheGln: 0.891 ± 0.044	1.594PheArg: 1.594 ± 0.063	4.178PheSer: 4.178 ± 0.102	2.154PheThr: 2.154 ± 0.071	2.546PheVal: 2.546 ± 0.079	0.371PheTrp: 0.371 ± 0.029	2.901PheTyr: 2.901 ± 0.098	0.0PheXaa: 0.0 ± 0.0
Gly	3.618GlyAla: 3.618 ± 0.097	0.371GlyCys: 0.371 ± 0.028	3.497GlyAsp: 3.497 ± 0.1	2.958GlyGlu: 2.958 ± 0.09	3.565GlyPhe: 3.565 ± 0.099	3.947GlyGly: 3.947 ± 0.105	1.21GlyHis: 1.21 ± 0.055	8.481GlyIle: 8.481 ± 0.16	3.97GlyLys: 3.97 ± 0.103	5.687GlyLeu: 5.687 ± 0.122	1.852GlyMet: 1.852 ± 0.068	3.716GlyAsn: 3.716 ± 0.101	1.806GlyPro: 1.806 ± 0.063	0.974GlyGln: 0.974 ± 0.051	3.196GlyArg: 3.196 ± 0.084	5.148GlySer: 5.148 ± 0.102	3.559GlyThr: 3.559 ± 0.097	3.467GlyVal: 3.467 ± 0.103	0.516GlyTrp: 0.516 ± 0.037	3.669GlyTyr: 3.669 ± 0.084	0.0GlyXaa: 0.0 ± 0.0
His	0.832HisAla: 0.832 ± 0.044	0.108HisCys: 0.108 ± 0.016	0.993HisAsp: 0.993 ± 0.047	0.906HisGlu: 0.906 ± 0.047	0.753HisPhe: 0.753 ± 0.041	1.772HisGly: 1.772 ± 0.068	0.257HisHis: 0.257 ± 0.023	1.18HisIle: 1.18 ± 0.049	0.69HisLys: 0.69 ± 0.041	1.269HisLeu: 1.269 ± 0.059	0.439HisMet: 0.439 ± 0.029	0.764HisAsn: 0.764 ± 0.04	0.671HisPro: 0.671 ± 0.04	0.204HisGln: 0.204 ± 0.017	0.603HisArg: 0.603 ± 0.035	0.902HisSer: 0.902 ± 0.044	0.581HisThr: 0.581 ± 0.04	1.05HisVal: 1.05 ± 0.05	0.159HisTrp: 0.159 ± 0.019	0.747HisTyr: 0.747 ± 0.039	0.0HisXaa: 0.0 ± 0.0
Ile	6.347IleAla: 6.347 ± 0.128	0.579IleCys: 0.579 ± 0.035	7.136IleAsp: 7.136 ± 0.151	6.661IleGlu: 6.661 ± 0.131	5.04IlePhe: 5.04 ± 0.15	6.538IleGly: 6.538 ± 0.15	1.19IleHis: 1.19 ± 0.053	13.18IleIle: 13.18 ± 0.268	9.854IleLys: 9.854 ± 0.167	8.532IleLeu: 8.532 ± 0.154	3.064IleMet: 3.064 ± 0.074	8.106IleAsn: 8.106 ± 0.17	4.142IlePro: 4.142 ± 0.086	1.178IleGln: 1.178 ± 0.054	3.82IleArg: 3.82 ± 0.098	8.77IleSer: 8.77 ± 0.17	4.923IleThr: 4.923 ± 0.112	5.789IleVal: 5.789 ± 0.12	0.569IleTrp: 0.569 ± 0.034	5.362IleTyr: 5.362 ± 0.111	0.0IleXaa: 0.0 ± 0.0
Lys	2.964LysAla: 2.964 ± 0.093	0.579LysCys: 0.579 ± 0.038	3.979LysAsp: 3.979 ± 0.081	3.629LysGlu: 3.629 ± 0.128	2.629LysPhe: 2.629 ± 0.077	2.846LysGly: 2.846 ± 0.084	0.842LysHis: 0.842 ± 0.046	7.879LysIle: 7.879 ± 0.144	5.961LysLys: 5.961 ± 0.135	5.012LysLeu: 5.012 ± 0.117	2.304LysMet: 2.304 ± 0.074	7.187LysAsn: 7.187 ± 0.148	2.067LysPro: 2.067 ± 0.078	0.787LysGln: 0.787 ± 0.046	4.119LysArg: 4.119 ± 0.088	5.029LysSer: 5.029 ± 0.123	3.582LysThr: 3.582 ± 0.096	2.867LysVal: 2.867 ± 0.098	0.452LysTrp: 0.452 ± 0.03	4.286LysTyr: 4.286 ± 0.095	0.0LysXaa: 0.0 ± 0.0
Leu	4.832LeuAla: 4.832 ± 0.121	0.537LeuCys: 0.537 ± 0.033	4.359LeuAsp: 4.359 ± 0.1	4.556LeuGlu: 4.556 ± 0.116	4.146LeuPhe: 4.146 ± 0.117	6.262LeuGly: 6.262 ± 0.123	1.059LeuHis: 1.059 ± 0.052	9.254LeuIle: 9.254 ± 0.164	7.529LeuLys: 7.529 ± 0.124	7.07LeuLeu: 7.07 ± 0.152	2.589LeuMet: 2.589 ± 0.068	6.383LeuAsn: 6.383 ± 0.138	2.778LeuPro: 2.778 ± 0.089	1.097LeuGln: 1.097 ± 0.048	3.677LeuArg: 3.677 ± 0.091	7.446LeuSer: 7.446 ± 0.129	3.529LeuThr: 3.529 ± 0.084	4.061LeuVal: 4.061 ± 0.123	0.609LeuTrp: 0.609 ± 0.037	4.456LeuTyr: 4.456 ± 0.098	0.0LeuXaa: 0.0 ± 0.0
Met	2.273MetAla: 2.273 ± 0.08	0.159MetCys: 0.159 ± 0.016	2.247MetAsp: 2.247 ± 0.068	2.387MetGlu: 2.387 ± 0.079	1.165MetPhe: 1.165 ± 0.053	1.53MetGly: 1.53 ± 0.063	0.613MetHis: 0.613 ± 0.039	2.99MetIle: 2.99 ± 0.08	2.107MetLys: 2.107 ± 0.076	2.761MetLeu: 2.761 ± 0.084	0.766MetMet: 0.766 ± 0.043	2.099MetAsn: 2.099 ± 0.065	1.545MetPro: 1.545 ± 0.063	0.509MetGln: 0.509 ± 0.038	1.193MetArg: 1.193 ± 0.057	1.857MetSer: 1.857 ± 0.061	1.207MetThr: 1.207 ± 0.047	1.861MetVal: 1.861 ± 0.062	0.159MetTrp: 0.159 ± 0.019	1.184MetTyr: 1.184 ± 0.049	0.0MetXaa: 0.0 ± 0.0
Asn	3.59AsnAla: 3.59 ± 0.093	0.325AsnCys: 0.325 ± 0.028	5.031AsnAsp: 5.031 ± 0.124	4.348AsnGlu: 4.348 ± 0.102	2.695AsnPhe: 2.695 ± 0.073	4.719AsnGly: 4.719 ± 0.115	0.906AsnHis: 0.906 ± 0.052	8.216AsnIle: 8.216 ± 0.154	4.369AsnLys: 4.369 ± 0.131	4.968AsnLeu: 4.968 ± 0.121	1.757AsnMet: 1.757 ± 0.063	4.791AsnAsn: 4.791 ± 0.149	2.37AsnPro: 2.37 ± 0.069	0.881AsnGln: 0.881 ± 0.042	2.51AsnArg: 2.51 ± 0.079	3.966AsnSer: 3.966 ± 0.113	2.551AsnThr: 2.551 ± 0.087	4.225AsnVal: 4.225 ± 0.113	0.323AsnTrp: 0.323 ± 0.025	3.629AsnTyr: 3.629 ± 0.106	0.0AsnXaa: 0.0 ± 0.0
Pro	2.241ProAla: 2.241 ± 0.077	0.212ProCys: 0.212 ± 0.02	2.561ProAsp: 2.561 ± 0.079	3.363ProGlu: 3.363 ± 0.092	1.844ProPhe: 1.844 ± 0.065	3.346ProGly: 3.346 ± 0.098	0.486ProHis: 0.486 ± 0.026	1.867ProIle: 1.867 ± 0.063	1.364ProLys: 1.364 ± 0.065	3.223ProLeu: 3.223 ± 0.087	0.915ProMet: 0.915 ± 0.046	1.12ProAsn: 1.12 ± 0.048	1.044ProPro: 1.044 ± 0.057	0.628ProGln: 0.628 ± 0.046	1.343ProArg: 1.343 ± 0.05	2.041ProSer: 2.041 ± 0.068	1.19ProThr: 1.19 ± 0.055	3.724ProVal: 3.724 ± 0.103	0.359ProTrp: 0.359 ± 0.028	2.003ProTyr: 2.003 ± 0.067	0.0ProXaa: 0.0 ± 0.0
Gln	1.014GlnAla: 1.014 ± 0.053	0.102GlnCys: 0.102 ± 0.012	0.736GlnAsp: 0.736 ± 0.036	0.942GlnGlu: 0.942 ± 0.05	0.668GlnPhe: 0.668 ± 0.042	0.959GlnGly: 0.959 ± 0.045	0.233GlnHis: 0.233 ± 0.02	1.369GlnIle: 1.369 ± 0.054	1.006GlnLys: 1.006 ± 0.048	1.21GlnLeu: 1.21 ± 0.053	0.471GlnMet: 0.471 ± 0.033	0.866GlnAsn: 0.866 ± 0.044	0.477GlnPro: 0.477 ± 0.034	0.297GlnGln: 0.297 ± 0.024	0.9GlnArg: 0.9 ± 0.044	0.938GlnSer: 0.938 ± 0.038	0.613GlnThr: 0.613 ± 0.038	0.881GlnVal: 0.881 ± 0.041	0.187GlnTrp: 0.187 ± 0.019	0.772GlnTyr: 0.772 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	2.597ArgAla: 2.597 ± 0.078	0.386ArgCys: 0.386 ± 0.033	2.689ArgAsp: 2.689 ± 0.078	2.863ArgGlu: 2.863 ± 0.095	2.113ArgPhe: 2.113 ± 0.073	2.152ArgGly: 2.152 ± 0.07	0.83ArgHis: 0.83 ± 0.039	4.978ArgIle: 4.978 ± 0.105	2.89ArgLys: 2.89 ± 0.089	4.057ArgLeu: 4.057 ± 0.09	1.356ArgMet: 1.356 ± 0.053	2.555ArgAsn: 2.555 ± 0.08	1.708ArgPro: 1.708 ± 0.061	0.749ArgGln: 0.749 ± 0.039	2.141ArgArg: 2.141 ± 0.069	3.435ArgSer: 3.435 ± 0.091	1.691ArgThr: 1.691 ± 0.066	2.122ArgVal: 2.122 ± 0.068	0.276ArgTrp: 0.276 ± 0.026	2.635ArgTyr: 2.635 ± 0.083	0.0ArgXaa: 0.0 ± 0.0
Ser	3.682SerAla: 3.682 ± 0.1	0.494SerCys: 0.494 ± 0.036	4.015SerAsp: 4.015 ± 0.105	3.796SerGlu: 3.796 ± 0.103	3.947SerPhe: 3.947 ± 0.106	6.61SerGly: 6.61 ± 0.122	0.936SerHis: 0.936 ± 0.044	8.244SerIle: 8.244 ± 0.149	4.303SerLys: 4.303 ± 0.094	6.729SerLeu: 6.729 ± 0.128	3.007SerMet: 3.007 ± 0.074	3.87SerAsn: 3.87 ± 0.102	2.16SerPro: 2.16 ± 0.07	1.199SerGln: 1.199 ± 0.047	4.015SerArg: 4.015 ± 0.092	5.555SerSer: 5.555 ± 0.134	2.86SerThr: 2.86 ± 0.099	4.102SerVal: 4.102 ± 0.083	0.688SerTrp: 0.688 ± 0.039	4.187SerTyr: 4.187 ± 0.092	0.0SerXaa: 0.0 ± 0.0
Thr	2.964ThrAla: 2.964 ± 0.083	0.278ThrCys: 0.278 ± 0.023	2.224ThrAsp: 2.224 ± 0.063	2.167ThrGlu: 2.167 ± 0.072	2.209ThrPhe: 2.209 ± 0.077	4.883ThrGly: 4.883 ± 0.124	0.596ThrHis: 0.596 ± 0.037	3.907ThrIle: 3.907 ± 0.101	2.012ThrLys: 2.012 ± 0.065	3.949ThrLeu: 3.949 ± 0.1	1.426ThrMet: 1.426 ± 0.054	1.835ThrAsn: 1.835 ± 0.072	1.819ThrPro: 1.819 ± 0.064	0.675ThrGln: 0.675 ± 0.036	1.952ThrArg: 1.952 ± 0.068	3.151ThrSer: 3.151 ± 0.103	1.914ThrThr: 1.914 ± 0.081	3.378ThrVal: 3.378 ± 0.094	0.405ThrTrp: 0.405 ± 0.03	1.993ThrTyr: 1.993 ± 0.077	0.0ThrXaa: 0.0 ± 0.0
Val	2.969ValAla: 2.969 ± 0.096	0.397ValCys: 0.397 ± 0.032	2.863ValAsp: 2.863 ± 0.08	2.635ValGlu: 2.635 ± 0.076	3.219ValPhe: 3.219 ± 0.08	2.695ValGly: 2.695 ± 0.078	0.925ValHis: 0.925 ± 0.046	6.217ValIle: 6.217 ± 0.144	4.03ValLys: 4.03 ± 0.08	5.216ValLeu: 5.216 ± 0.123	1.562ValMet: 1.562 ± 0.064	3.811ValAsn: 3.811 ± 0.101	2.54ValPro: 2.54 ± 0.07	0.978ValGln: 0.978 ± 0.046	2.137ValArg: 2.137 ± 0.073	5.388ValSer: 5.388 ± 0.109	3.119ValThr: 3.119 ± 0.097	3.045ValVal: 3.045 ± 0.085	0.39ValTrp: 0.39 ± 0.034	3.181ValTyr: 3.181 ± 0.08	0.0ValXaa: 0.0 ± 0.0
Trp	0.429TrpAla: 0.429 ± 0.028	0.055TrpCys: 0.055 ± 0.01	0.344TrpAsp: 0.344 ± 0.027	0.384TrpGlu: 0.384 ± 0.031	0.414TrpPhe: 0.414 ± 0.027	0.386TrpGly: 0.386 ± 0.028	0.208TrpHis: 0.208 ± 0.023	0.647TrpIle: 0.647 ± 0.037	0.522TrpLys: 0.522 ± 0.033	0.673TrpLeu: 0.673 ± 0.038	0.221TrpMet: 0.221 ± 0.024	0.473TrpAsn: 0.473 ± 0.034	0.261TrpPro: 0.261 ± 0.024	0.172TrpGln: 0.172 ± 0.02	0.378TrpArg: 0.378 ± 0.027	0.524TrpSer: 0.524 ± 0.033	0.327TrpThr: 0.327 ± 0.028	0.401TrpVal: 0.401 ± 0.027	0.117TrpTrp: 0.117 ± 0.016	0.405TrpTyr: 0.405 ± 0.032	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.582TyrAla: 2.582 ± 0.07	0.274TyrCys: 0.274 ± 0.026	3.274TyrAsp: 3.274 ± 0.082	2.65TyrGlu: 2.65 ± 0.086	2.476TyrPhe: 2.476 ± 0.082	3.387TyrGly: 3.387 ± 0.08	0.961TyrHis: 0.961 ± 0.045	6.385TyrIle: 6.385 ± 0.14	3.864TyrLys: 3.864 ± 0.107	4.641TyrLeu: 4.641 ± 0.109	1.487TyrMet: 1.487 ± 0.056	4.711TyrAsn: 4.711 ± 0.145	1.827TyrPro: 1.827 ± 0.062	0.838TyrGln: 0.838 ± 0.036	2.169TyrArg: 2.169 ± 0.065	4.057TyrSer: 4.057 ± 0.099	2.425TyrThr: 2.425 ± 0.082	2.691TyrVal: 2.691 ± 0.076	0.369TyrTrp: 0.369 ± 0.029	3.37TyrTyr: 3.37 ± 0.111	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1535 proteins (471263 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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