Amino acid dipepetide frequency for Subdoligranulum variabile DSM 15176

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.716AlaAla: 13.716 ± 0.202	1.683AlaCys: 1.683 ± 0.042	6.076AlaAsp: 6.076 ± 0.091	6.607AlaGlu: 6.607 ± 0.1	3.614AlaPhe: 3.614 ± 0.064	8.323AlaGly: 8.323 ± 0.122	1.71AlaHis: 1.71 ± 0.04	4.833AlaIle: 4.833 ± 0.067	4.254AlaLys: 4.254 ± 0.077	10.841AlaLeu: 10.841 ± 0.111	2.78AlaMet: 2.78 ± 0.055	2.609AlaAsn: 2.609 ± 0.057	3.829AlaPro: 3.829 ± 0.083	3.972AlaGln: 3.972 ± 0.062	5.357AlaArg: 5.357 ± 0.09	4.468AlaSer: 4.468 ± 0.077	4.506AlaThr: 4.506 ± 0.088	8.328AlaVal: 8.328 ± 0.121	1.148AlaTrp: 1.148 ± 0.035	2.965AlaTyr: 2.965 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.754CysAla: 1.754 ± 0.045	0.378CysCys: 0.378 ± 0.02	0.936CysAsp: 0.936 ± 0.032	0.931CysGlu: 0.931 ± 0.031	0.674CysPhe: 0.674 ± 0.031	1.82CysGly: 1.82 ± 0.041	0.406CysHis: 0.406 ± 0.022	0.933CysIle: 0.933 ± 0.031	0.815CysLys: 0.815 ± 0.03	1.594CysLeu: 1.594 ± 0.042	0.429CysMet: 0.429 ± 0.019	0.538CysAsn: 0.538 ± 0.022	0.831CysPro: 0.831 ± 0.03	0.535CysGln: 0.535 ± 0.023	1.177CysArg: 1.177 ± 0.041	0.918CysSer: 0.918 ± 0.033	0.983CysThr: 0.983 ± 0.036	1.188CysVal: 1.188 ± 0.04	0.225CysTrp: 0.225 ± 0.016	0.601CysTyr: 0.601 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	5.734AspAla: 5.734 ± 0.082	0.974AspCys: 0.974 ± 0.035	2.82AspAsp: 2.82 ± 0.062	3.714AspGlu: 3.714 ± 0.069	2.554AspPhe: 2.554 ± 0.056	4.951AspGly: 4.951 ± 0.081	1.059AspHis: 1.059 ± 0.034	2.968AspIle: 2.968 ± 0.054	2.517AspLys: 2.517 ± 0.058	5.417AspLeu: 5.417 ± 0.092	1.298AspMet: 1.298 ± 0.033	1.723AspAsn: 1.723 ± 0.05	2.756AspPro: 2.756 ± 0.055	1.459AspGln: 1.459 ± 0.043	2.969AspArg: 2.969 ± 0.062	2.696AspSer: 2.696 ± 0.051	3.43AspThr: 3.43 ± 0.064	3.491AspVal: 3.491 ± 0.053	0.792AspTrp: 0.792 ± 0.026	2.287AspTyr: 2.287 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	6.069GluAla: 6.069 ± 0.081	0.736GluCys: 0.736 ± 0.029	3.335GluAsp: 3.335 ± 0.067	4.878GluGlu: 4.878 ± 0.089	1.802GluPhe: 1.802 ± 0.044	4.081GluGly: 4.081 ± 0.065	1.24GluHis: 1.24 ± 0.034	3.649GluIle: 3.649 ± 0.069	3.994GluLys: 3.994 ± 0.074	6.168GluLeu: 6.168 ± 0.085	1.867GluMet: 1.867 ± 0.046	2.778GluAsn: 2.778 ± 0.053	2.307GluPro: 2.307 ± 0.053	2.916GluGln: 2.916 ± 0.064	3.333GluArg: 3.333 ± 0.069	2.911GluSer: 2.911 ± 0.059	3.523GluThr: 3.523 ± 0.06	3.784GluVal: 3.784 ± 0.062	0.597GluTrp: 0.597 ± 0.025	2.173GluTyr: 2.173 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.984PheAla: 3.984 ± 0.082	0.958PheCys: 0.958 ± 0.032	2.419PheAsp: 2.419 ± 0.053	1.947PheGlu: 1.947 ± 0.042	1.756PhePhe: 1.756 ± 0.058	3.243PheGly: 3.243 ± 0.074	0.762PheHis: 0.762 ± 0.024	1.81PheIle: 1.81 ± 0.048	1.284PheLys: 1.284 ± 0.041	3.989PheLeu: 3.989 ± 0.074	0.856PheMet: 0.856 ± 0.028	1.207PheAsn: 1.207 ± 0.034	1.463PhePro: 1.463 ± 0.039	1.111PheGln: 1.111 ± 0.036	1.849PheArg: 1.849 ± 0.041	2.552PheSer: 2.552 ± 0.051	2.489PheThr: 2.489 ± 0.047	2.843PheVal: 2.843 ± 0.06	0.574PheTrp: 0.574 ± 0.027	1.449PheTyr: 1.449 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	6.831GlyAla: 6.831 ± 0.108	1.526GlyCys: 1.526 ± 0.044	3.728GlyAsp: 3.728 ± 0.059	4.354GlyGlu: 4.354 ± 0.06	2.923GlyPhe: 2.923 ± 0.059	5.92GlyGly: 5.92 ± 0.088	1.494GlyHis: 1.494 ± 0.043	4.952GlyIle: 4.952 ± 0.083	4.24GlyLys: 4.24 ± 0.071	7.052GlyLeu: 7.052 ± 0.095	2.408GlyMet: 2.408 ± 0.052	2.517GlyAsn: 2.517 ± 0.059	2.154GlyPro: 2.154 ± 0.051	2.801GlyGln: 2.801 ± 0.053	4.181GlyArg: 4.181 ± 0.07	4.286GlySer: 4.286 ± 0.073	4.903GlyThr: 4.903 ± 0.083	5.842GlyVal: 5.842 ± 0.089	1.083GlyTrp: 1.083 ± 0.034	3.155GlyTyr: 3.155 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.577HisAla: 1.577 ± 0.041	0.46HisCys: 0.46 ± 0.023	1.05HisAsp: 1.05 ± 0.034	0.981HisGlu: 0.981 ± 0.032	0.883HisPhe: 0.883 ± 0.03	1.543HisGly: 1.543 ± 0.042	0.519HisHis: 0.519 ± 0.024	1.121HisIle: 1.121 ± 0.033	0.846HisLys: 0.846 ± 0.033	1.893HisLeu: 1.893 ± 0.042	0.446HisMet: 0.446 ± 0.021	0.704HisAsn: 0.704 ± 0.029	1.184HisPro: 1.184 ± 0.035	0.625HisGln: 0.625 ± 0.026	1.202HisArg: 1.202 ± 0.033	1.062HisSer: 1.062 ± 0.03	1.253HisThr: 1.253 ± 0.037	1.016HisVal: 1.016 ± 0.034	0.27HisTrp: 0.27 ± 0.018	0.855HisTyr: 0.855 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.185IleAla: 5.185 ± 0.072	1.023IleCys: 1.023 ± 0.032	3.092IleAsp: 3.092 ± 0.066	3.005IleGlu: 3.005 ± 0.061	2.115IlePhe: 2.115 ± 0.047	3.861IleGly: 3.861 ± 0.075	1.026IleHis: 1.026 ± 0.036	2.65IleIle: 2.65 ± 0.065	1.955IleLys: 1.955 ± 0.051	5.584IleLeu: 5.584 ± 0.096	1.199IleMet: 1.199 ± 0.033	1.792IleAsn: 1.792 ± 0.045	2.613IlePro: 2.613 ± 0.05	1.837IleGln: 1.837 ± 0.048	3.108IleArg: 3.108 ± 0.067	3.213IleSer: 3.213 ± 0.067	3.322IleThr: 3.322 ± 0.056	3.883IleVal: 3.883 ± 0.073	0.566IleTrp: 0.566 ± 0.022	1.873IleTyr: 1.873 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.395LysAla: 4.395 ± 0.082	0.496LysCys: 0.496 ± 0.022	2.423LysAsp: 2.423 ± 0.056	3.408LysGlu: 3.408 ± 0.071	1.301LysPhe: 1.301 ± 0.032	3.041LysGly: 3.041 ± 0.063	0.771LysHis: 0.771 ± 0.032	2.668LysIle: 2.668 ± 0.06	3.143LysLys: 3.143 ± 0.078	4.114LysLeu: 4.114 ± 0.079	1.399LysMet: 1.399 ± 0.046	2.02LysAsn: 2.02 ± 0.052	1.99LysPro: 1.99 ± 0.044	1.846LysGln: 1.846 ± 0.054	2.642LysArg: 2.642 ± 0.061	2.241LysSer: 2.241 ± 0.046	2.915LysThr: 2.915 ± 0.057	2.997LysVal: 2.997 ± 0.068	0.404LysTrp: 0.404 ± 0.022	1.647LysTyr: 1.647 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	10.531LeuAla: 10.531 ± 0.12	2.391LeuCys: 2.391 ± 0.054	5.683LeuAsp: 5.683 ± 0.078	5.48LeuGlu: 5.48 ± 0.08	4.115LeuPhe: 4.115 ± 0.077	6.931LeuGly: 6.931 ± 0.1	2.199LeuHis: 2.199 ± 0.041	4.632LeuIle: 4.632 ± 0.075	3.838LeuLys: 3.838 ± 0.068	11.193LeuLeu: 11.193 ± 0.17	2.491LeuMet: 2.491 ± 0.05	3.177LeuAsn: 3.177 ± 0.058	5.498LeuPro: 5.498 ± 0.08	4.173LeuGln: 4.173 ± 0.072	5.982LeuArg: 5.982 ± 0.093	5.71LeuSer: 5.71 ± 0.08	6.14LeuThr: 6.14 ± 0.09	6.663LeuVal: 6.663 ± 0.1	1.228LeuTrp: 1.228 ± 0.039	3.555LeuTyr: 3.555 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	2.822MetAla: 2.822 ± 0.055	0.296MetCys: 0.296 ± 0.017	1.565MetAsp: 1.565 ± 0.04	1.763MetGlu: 1.763 ± 0.051	0.816MetPhe: 0.816 ± 0.031	1.917MetGly: 1.917 ± 0.05	0.463MetHis: 0.463 ± 0.022	1.395MetIle: 1.395 ± 0.043	1.54MetLys: 1.54 ± 0.041	2.704MetLeu: 2.704 ± 0.057	0.797MetMet: 0.797 ± 0.031	1.09MetAsn: 1.09 ± 0.036	1.407MetPro: 1.407 ± 0.038	1.237MetGln: 1.237 ± 0.039	1.306MetArg: 1.306 ± 0.038	1.374MetSer: 1.374 ± 0.034	1.641MetThr: 1.641 ± 0.042	1.789MetVal: 1.789 ± 0.044	0.216MetTrp: 0.216 ± 0.015	0.702MetTyr: 0.702 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.242AsnAla: 3.242 ± 0.062	0.554AsnCys: 0.554 ± 0.024	1.668AsnAsp: 1.668 ± 0.043	1.754AsnGlu: 1.754 ± 0.042	1.281AsnPhe: 1.281 ± 0.036	3.076AsnGly: 3.076 ± 0.054	0.64AsnHis: 0.64 ± 0.026	1.998AsnIle: 1.998 ± 0.042	1.422AsnLys: 1.422 ± 0.046	3.322AsnLeu: 3.322 ± 0.06	0.872AsnMet: 0.872 ± 0.035	1.164AsnAsn: 1.164 ± 0.042	1.872AsnPro: 1.872 ± 0.04	1.176AsnGln: 1.176 ± 0.034	1.911AsnArg: 1.911 ± 0.042	1.599AsnSer: 1.599 ± 0.043	2.01AsnThr: 2.01 ± 0.049	2.19AsnVal: 2.19 ± 0.052	0.385AsnTrp: 0.385 ± 0.022	1.366AsnTyr: 1.366 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	4.982ProAla: 4.982 ± 0.099	0.707ProCys: 0.707 ± 0.026	3.056ProAsp: 3.056 ± 0.058	3.782ProGlu: 3.782 ± 0.067	1.735ProPhe: 1.735 ± 0.045	3.465ProGly: 3.465 ± 0.069	0.851ProHis: 0.851 ± 0.026	1.901ProIle: 1.901 ± 0.053	1.695ProLys: 1.695 ± 0.045	3.979ProLeu: 3.979 ± 0.061	1.074ProMet: 1.074 ± 0.036	1.296ProAsn: 1.296 ± 0.04	1.485ProPro: 1.485 ± 0.045	1.85ProGln: 1.85 ± 0.044	2.055ProArg: 2.055 ± 0.047	2.042ProSer: 2.042 ± 0.046	2.227ProThr: 2.227 ± 0.057	3.81ProVal: 3.81 ± 0.065	0.519ProTrp: 0.519 ± 0.022	1.631ProTyr: 1.631 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.808GlnAla: 3.808 ± 0.069	0.478GlnCys: 0.478 ± 0.022	1.921GlnAsp: 1.921 ± 0.049	2.49GlnGlu: 2.49 ± 0.059	1.303GlnPhe: 1.303 ± 0.04	2.669GlnGly: 2.669 ± 0.053	0.691GlnHis: 0.691 ± 0.026	2.093GlnIle: 2.093 ± 0.044	2.296GlnLys: 2.296 ± 0.053	3.586GlnLeu: 3.586 ± 0.056	1.242GlnMet: 1.242 ± 0.039	1.638GlnAsn: 1.638 ± 0.042	1.657GlnPro: 1.657 ± 0.047	1.946GlnGln: 1.946 ± 0.05	2.29GlnArg: 2.29 ± 0.053	1.982GlnSer: 1.982 ± 0.046	2.183GlnThr: 2.183 ± 0.043	2.263GlnVal: 2.263 ± 0.059	0.494GlnTrp: 0.494 ± 0.027	1.494GlnTyr: 1.494 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	4.977ArgAla: 4.977 ± 0.077	1.014ArgCys: 1.014 ± 0.035	2.828ArgAsp: 2.828 ± 0.054	3.7ArgGlu: 3.7 ± 0.067	2.259ArgPhe: 2.259 ± 0.042	3.411ArgGly: 3.411 ± 0.068	1.212ArgHis: 1.212 ± 0.033	3.166ArgIle: 3.166 ± 0.06	2.967ArgLys: 2.967 ± 0.069	5.574ArgLeu: 5.574 ± 0.084	1.688ArgMet: 1.688 ± 0.042	1.81ArgAsn: 1.81 ± 0.042	2.399ArgPro: 2.399 ± 0.052	2.6ArgGln: 2.6 ± 0.057	4.2ArgArg: 4.2 ± 0.082	2.589ArgSer: 2.589 ± 0.049	3.226ArgThr: 3.226 ± 0.056	3.36ArgVal: 3.36 ± 0.06	0.741ArgTrp: 0.741 ± 0.031	2.379ArgTyr: 2.379 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	4.946SerAla: 4.946 ± 0.076	0.836SerCys: 0.836 ± 0.029	2.907SerAsp: 2.907 ± 0.051	2.985SerGlu: 2.985 ± 0.056	2.231SerPhe: 2.231 ± 0.053	4.593SerGly: 4.593 ± 0.068	1.044SerHis: 1.044 ± 0.032	2.813SerIle: 2.813 ± 0.053	2.028SerLys: 2.028 ± 0.049	5.153SerLeu: 5.153 ± 0.081	1.48SerMet: 1.48 ± 0.036	1.552SerAsn: 1.552 ± 0.042	2.128SerPro: 2.128 ± 0.046	1.777SerGln: 1.777 ± 0.047	2.838SerArg: 2.838 ± 0.057	2.845SerSer: 2.845 ± 0.066	2.908SerThr: 2.908 ± 0.052	3.851SerVal: 3.851 ± 0.065	0.689SerTrp: 0.689 ± 0.031	1.916SerTyr: 1.916 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	6.435ThrAla: 6.435 ± 0.095	0.798ThrCys: 0.798 ± 0.029	3.358ThrAsp: 3.358 ± 0.067	3.452ThrGlu: 3.452 ± 0.068	2.12ThrPhe: 2.12 ± 0.05	5.105ThrGly: 5.105 ± 0.076	1.016ThrHis: 1.016 ± 0.03	3.288ThrIle: 3.288 ± 0.061	1.996ThrLys: 1.996 ± 0.047	6.202ThrLeu: 6.202 ± 0.09	1.541ThrMet: 1.541 ± 0.041	1.665ThrAsn: 1.665 ± 0.041	3.384ThrPro: 3.384 ± 0.061	1.849ThrGln: 1.849 ± 0.041	2.781ThrArg: 2.781 ± 0.054	2.608ThrSer: 2.608 ± 0.059	3.16ThrThr: 3.16 ± 0.066	5.335ThrVal: 5.335 ± 0.084	0.605ThrTrp: 0.605 ± 0.024	1.786ThrTyr: 1.786 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	6.27ValAla: 6.27 ± 0.097	1.462ValCys: 1.462 ± 0.042	3.82ValAsp: 3.82 ± 0.065	4.108ValGlu: 4.108 ± 0.068	2.984ValPhe: 2.984 ± 0.055	4.592ValGly: 4.592 ± 0.074	1.258ValHis: 1.258 ± 0.035	3.688ValIle: 3.688 ± 0.065	2.976ValLys: 2.976 ± 0.056	8.085ValLeu: 8.085 ± 0.104	1.814ValMet: 1.814 ± 0.048	2.254ValAsn: 2.254 ± 0.049	3.272ValPro: 3.272 ± 0.064	2.734ValGln: 2.734 ± 0.056	3.929ValArg: 3.929 ± 0.062	4.045ValSer: 4.045 ± 0.063	4.616ValThr: 4.616 ± 0.083	5.275ValVal: 5.275 ± 0.091	0.897ValTrp: 0.897 ± 0.03	2.583ValTyr: 2.583 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.987TrpAla: 0.987 ± 0.037	0.234TrpCys: 0.234 ± 0.015	0.604TrpAsp: 0.604 ± 0.025	0.662TrpGlu: 0.662 ± 0.029	0.532TrpPhe: 0.532 ± 0.028	0.884TrpGly: 0.884 ± 0.035	0.305TrpHis: 0.305 ± 0.018	0.515TrpIle: 0.515 ± 0.024	0.538TrpLys: 0.538 ± 0.024	1.454TrpLeu: 1.454 ± 0.045	0.369TrpMet: 0.369 ± 0.021	0.506TrpAsn: 0.506 ± 0.023	0.474TrpPro: 0.474 ± 0.026	0.758TrpGln: 0.758 ± 0.029	0.723TrpArg: 0.723 ± 0.027	0.515TrpSer: 0.515 ± 0.024	0.564TrpThr: 0.564 ± 0.027	0.717TrpVal: 0.717 ± 0.029	0.151TrpTrp: 0.151 ± 0.012	0.494TrpTyr: 0.494 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.374TyrAla: 3.374 ± 0.062	0.663TyrCys: 0.663 ± 0.028	2.322TyrAsp: 2.322 ± 0.056	2.14TyrGlu: 2.14 ± 0.051	1.548TyrPhe: 1.548 ± 0.043	2.924TyrGly: 2.924 ± 0.057	0.823TyrHis: 0.823 ± 0.029	1.827TyrIle: 1.827 ± 0.053	1.516TyrLys: 1.516 ± 0.04	3.707TyrLeu: 3.707 ± 0.066	0.789TyrMet: 0.789 ± 0.028	1.462TyrAsn: 1.462 ± 0.038	1.44TyrPro: 1.44 ± 0.037	1.321TyrGln: 1.321 ± 0.037	2.267TyrArg: 2.267 ± 0.053	1.865TyrSer: 1.865 ± 0.044	2.487TyrThr: 2.487 ± 0.053	2.037TyrVal: 2.037 ± 0.054	0.401TyrTrp: 0.401 ± 0.018	1.535TyrTyr: 1.535 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3378 proteins (991092 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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