Amino acid dipepetide frequency for Erysiphe pulchra

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.221AlaAla: 5.221 ± 0.052	0.907AlaCys: 0.907 ± 0.018	2.859AlaAsp: 2.859 ± 0.031	3.913AlaGlu: 3.913 ± 0.043	2.504AlaPhe: 2.504 ± 0.033	3.64AlaGly: 3.64 ± 0.042	1.399AlaHis: 1.399 ± 0.02	4.399AlaIle: 4.399 ± 0.04	3.957AlaLys: 3.957 ± 0.036	6.28AlaLeu: 6.28 ± 0.053	1.331AlaMet: 1.331 ± 0.02	2.765AlaAsn: 2.765 ± 0.031	3.068AlaPro: 3.068 ± 0.039	2.625AlaGln: 2.625 ± 0.03	3.872AlaArg: 3.872 ± 0.041	5.643AlaSer: 5.643 ± 0.042	3.897AlaThr: 3.897 ± 0.043	3.614AlaVal: 3.614 ± 0.039	0.807AlaTrp: 0.807 ± 0.015	1.759AlaTyr: 1.759 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	0.763CysAla: 0.763 ± 0.015	0.226CysCys: 0.226 ± 0.009	0.706CysAsp: 0.706 ± 0.017	0.771CysGlu: 0.771 ± 0.016	0.555CysPhe: 0.555 ± 0.013	0.984CysGly: 0.984 ± 0.021	0.366CysHis: 0.366 ± 0.012	0.864CysIle: 0.864 ± 0.018	0.776CysLys: 0.776 ± 0.02	1.353CysLeu: 1.353 ± 0.022	0.27CysMet: 0.27 ± 0.009	0.624CysAsn: 0.624 ± 0.014	0.606CysPro: 0.606 ± 0.017	0.547CysGln: 0.547 ± 0.014	0.775CysArg: 0.775 ± 0.016	1.136CysSer: 1.136 ± 0.02	0.702CysThr: 0.702 ± 0.016	0.719CysVal: 0.719 ± 0.016	0.189CysTrp: 0.189 ± 0.007	0.39CysTyr: 0.39 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.122AspAla: 3.122 ± 0.031	0.707AspCys: 0.707 ± 0.017	3.693AspAsp: 3.693 ± 0.042	4.464AspGlu: 4.464 ± 0.046	2.459AspPhe: 2.459 ± 0.029	3.108AspGly: 3.108 ± 0.032	1.197AspHis: 1.197 ± 0.022	3.815AspIle: 3.815 ± 0.038	2.917AspLys: 2.917 ± 0.029	5.35AspLeu: 5.35 ± 0.041	1.062AspMet: 1.062 ± 0.019	2.467AspAsn: 2.467 ± 0.034	2.609AspPro: 2.609 ± 0.03	2.034AspGln: 2.034 ± 0.026	2.701AspArg: 2.701 ± 0.035	4.586AspSer: 4.586 ± 0.045	2.763AspThr: 2.763 ± 0.026	3.107AspVal: 3.107 ± 0.028	0.72AspTrp: 0.72 ± 0.016	1.619AspTyr: 1.619 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	4.424GluAla: 4.424 ± 0.04	0.749GluCys: 0.749 ± 0.016	3.927GluAsp: 3.927 ± 0.041	5.472GluGlu: 5.472 ± 0.062	2.316GluPhe: 2.316 ± 0.028	2.937GluGly: 2.937 ± 0.031	1.2GluHis: 1.2 ± 0.018	4.867GluIle: 4.867 ± 0.046	5.226GluLys: 5.226 ± 0.058	5.622GluLeu: 5.622 ± 0.048	1.409GluMet: 1.409 ± 0.023	4.059GluAsn: 4.059 ± 0.042	2.197GluPro: 2.197 ± 0.027	2.347GluGln: 2.347 ± 0.03	3.76GluArg: 3.76 ± 0.041	5.222GluSer: 5.222 ± 0.047	3.546GluThr: 3.546 ± 0.034	3.547GluVal: 3.547 ± 0.041	0.834GluTrp: 0.834 ± 0.017	1.789GluTyr: 1.789 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	2.474PheAla: 2.474 ± 0.026	0.611PheCys: 0.611 ± 0.013	2.387PheAsp: 2.387 ± 0.028	2.498PheGlu: 2.498 ± 0.031	1.637PhePhe: 1.637 ± 0.026	2.514PheGly: 2.514 ± 0.036	0.919PheHis: 0.919 ± 0.016	2.293PheIle: 2.293 ± 0.031	2.135PheLys: 2.135 ± 0.028	3.673PheLeu: 3.673 ± 0.038	0.731PheMet: 0.731 ± 0.017	1.872PheAsn: 1.872 ± 0.024	1.902PhePro: 1.902 ± 0.024	1.571PheGln: 1.571 ± 0.023	2.028PheArg: 2.028 ± 0.027	3.603PheSer: 3.603 ± 0.035	2.195PheThr: 2.195 ± 0.029	2.117PheVal: 2.117 ± 0.026	0.505PheTrp: 0.505 ± 0.013	1.178PheTyr: 1.178 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	3.317GlyAla: 3.317 ± 0.043	0.707GlyCys: 0.707 ± 0.014	2.72GlyAsp: 2.72 ± 0.028	3.014GlyGlu: 3.014 ± 0.028	2.407GlyPhe: 2.407 ± 0.029	3.736GlyGly: 3.736 ± 0.062	1.397GlyHis: 1.397 ± 0.023	3.874GlyIle: 3.874 ± 0.036	3.68GlyLys: 3.68 ± 0.038	5.019GlyLeu: 5.019 ± 0.045	1.157GlyMet: 1.157 ± 0.022	2.76GlyAsn: 2.76 ± 0.03	2.403GlyPro: 2.403 ± 0.031	2.037GlyGln: 2.037 ± 0.027	3.176GlyArg: 3.176 ± 0.039	4.692GlySer: 4.692 ± 0.039	3.14GlyThr: 3.14 ± 0.032	3.194GlyVal: 3.194 ± 0.038	0.815GlyTrp: 0.815 ± 0.016	1.809GlyTyr: 1.809 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	1.281HisAla: 1.281 ± 0.022	0.316HisCys: 0.316 ± 0.012	1.242HisAsp: 1.242 ± 0.022	1.41HisGlu: 1.41 ± 0.022	0.908HisPhe: 0.908 ± 0.015	1.32HisGly: 1.32 ± 0.021	0.686HisHis: 0.686 ± 0.014	1.456HisIle: 1.456 ± 0.023	1.188HisLys: 1.188 ± 0.021	2.202HisLeu: 2.202 ± 0.026	0.42HisMet: 0.42 ± 0.011	1.103HisAsn: 1.103 ± 0.018	1.318HisPro: 1.318 ± 0.025	1.081HisGln: 1.081 ± 0.021	1.362HisArg: 1.362 ± 0.022	1.925HisSer: 1.925 ± 0.028	1.211HisThr: 1.211 ± 0.019	1.2HisVal: 1.2 ± 0.019	0.265HisTrp: 0.265 ± 0.009	0.674HisTyr: 0.674 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.278IleAla: 4.278 ± 0.038	0.993IleCys: 0.993 ± 0.018	3.891IleAsp: 3.891 ± 0.034	4.286IleGlu: 4.286 ± 0.039	2.709IlePhe: 2.709 ± 0.031	3.388IleGly: 3.388 ± 0.042	1.464IleHis: 1.464 ± 0.019	3.96IleIle: 3.96 ± 0.044	3.981IleLys: 3.981 ± 0.037	6.186IleLeu: 6.186 ± 0.056	1.135IleMet: 1.135 ± 0.02	3.156IleAsn: 3.156 ± 0.031	3.658IlePro: 3.658 ± 0.037	2.636IleGln: 2.636 ± 0.028	3.557IleArg: 3.557 ± 0.031	6.351IleSer: 6.351 ± 0.045	3.659IleThr: 3.659 ± 0.035	3.475IleVal: 3.475 ± 0.035	0.832IleTrp: 0.832 ± 0.016	1.826IleTyr: 1.826 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.249LysAla: 4.249 ± 0.044	0.827LysCys: 0.827 ± 0.017	3.417LysAsp: 3.417 ± 0.031	4.49LysGlu: 4.49 ± 0.05	2.324LysPhe: 2.324 ± 0.027	2.988LysGly: 2.988 ± 0.034	1.204LysHis: 1.204 ± 0.018	4.543LysIle: 4.543 ± 0.044	5.293LysLys: 5.293 ± 0.053	5.68LysLeu: 5.68 ± 0.045	1.24LysMet: 1.24 ± 0.017	3.823LysAsn: 3.823 ± 0.037	2.826LysPro: 2.826 ± 0.033	2.219LysGln: 2.219 ± 0.027	3.982LysArg: 3.982 ± 0.038	5.805LysSer: 5.805 ± 0.048	3.701LysThr: 3.701 ± 0.034	3.285LysVal: 3.285 ± 0.037	0.714LysTrp: 0.714 ± 0.016	1.936LysTyr: 1.936 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	6.4LeuAla: 6.4 ± 0.05	1.289LeuCys: 1.289 ± 0.022	5.185LeuAsp: 5.185 ± 0.043	6.183LeuGlu: 6.183 ± 0.058	3.397LeuPhe: 3.397 ± 0.034	4.957LeuGly: 4.957 ± 0.05	2.095LeuHis: 2.095 ± 0.025	5.343LeuIle: 5.343 ± 0.049	5.88LeuLys: 5.88 ± 0.045	8.298LeuLeu: 8.298 ± 0.085	1.697LeuMet: 1.697 ± 0.023	4.488LeuAsn: 4.488 ± 0.033	5.149LeuPro: 5.149 ± 0.046	4.073LeuGln: 4.073 ± 0.037	5.613LeuArg: 5.613 ± 0.04	8.381LeuSer: 8.381 ± 0.059	5.003LeuThr: 5.003 ± 0.048	4.737LeuVal: 4.737 ± 0.04	1.029LeuTrp: 1.029 ± 0.019	2.506LeuTyr: 2.506 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	1.652MetAla: 1.652 ± 0.025	0.219MetCys: 0.219 ± 0.008	1.074MetAsp: 1.074 ± 0.021	1.23MetGlu: 1.23 ± 0.018	0.599MetPhe: 0.599 ± 0.014	1.153MetGly: 1.153 ± 0.022	0.362MetHis: 0.362 ± 0.012	1.213MetIle: 1.213 ± 0.021	1.277MetLys: 1.277 ± 0.018	1.613MetLeu: 1.613 ± 0.024	0.473MetMet: 0.473 ± 0.014	0.988MetAsn: 0.988 ± 0.017	0.942MetPro: 0.942 ± 0.016	0.731MetGln: 0.731 ± 0.019	1.128MetArg: 1.128 ± 0.017	1.773MetSer: 1.773 ± 0.023	1.232MetThr: 1.232 ± 0.019	1.026MetVal: 1.026 ± 0.019	0.196MetTrp: 0.196 ± 0.009	0.469MetTyr: 0.469 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.812AsnAla: 2.812 ± 0.028	0.724AsnCys: 0.724 ± 0.017	2.773AsnAsp: 2.773 ± 0.028	3.271AsnGlu: 3.271 ± 0.035	2.295AsnPhe: 2.295 ± 0.029	3.03AsnGly: 3.03 ± 0.038	1.248AsnHis: 1.248 ± 0.019	3.434AsnIle: 3.434 ± 0.034	2.892AsnLys: 2.892 ± 0.032	5.071AsnLeu: 5.071 ± 0.039	0.979AsnMet: 0.979 ± 0.022	2.794AsnAsn: 2.794 ± 0.038	2.643AsnPro: 2.643 ± 0.03	2.173AsnGln: 2.173 ± 0.027	2.522AsnArg: 2.522 ± 0.029	5.195AsnSer: 5.195 ± 0.053	2.959AsnThr: 2.959 ± 0.032	2.638AsnVal: 2.638 ± 0.032	0.636AsnTrp: 0.636 ± 0.014	1.563AsnTyr: 1.563 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	2.983ProAla: 2.983 ± 0.033	0.547ProCys: 0.547 ± 0.015	2.504ProAsp: 2.504 ± 0.03	3.253ProGlu: 3.253 ± 0.034	1.854ProPhe: 1.854 ± 0.023	2.575ProGly: 2.575 ± 0.03	1.166ProHis: 1.166 ± 0.022	3.313ProIle: 3.313 ± 0.034	3.156ProLys: 3.156 ± 0.033	4.426ProLeu: 4.426 ± 0.039	0.843ProMet: 0.843 ± 0.016	2.602ProAsn: 2.602 ± 0.03	3.569ProPro: 3.569 ± 0.062	2.126ProGln: 2.126 ± 0.031	2.666ProArg: 2.666 ± 0.037	5.282ProSer: 5.282 ± 0.053	3.384ProThr: 3.384 ± 0.043	2.742ProVal: 2.742 ± 0.032	0.548ProTrp: 0.548 ± 0.013	1.443ProTyr: 1.443 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	2.779GlnAla: 2.779 ± 0.033	0.46GlnCys: 0.46 ± 0.012	2.081GlnAsp: 2.081 ± 0.026	2.66GlnGlu: 2.66 ± 0.029	1.399GlnPhe: 1.399 ± 0.023	1.962GlnGly: 1.962 ± 0.03	0.894GlnHis: 0.894 ± 0.019	2.855GlnIle: 2.855 ± 0.03	2.926GlnLys: 2.926 ± 0.034	3.485GlnLeu: 3.485 ± 0.038	0.826GlnMet: 0.826 ± 0.016	2.634GlnAsn: 2.634 ± 0.031	1.844GlnPro: 1.844 ± 0.028	2.144GlnGln: 2.144 ± 0.055	2.47GlnArg: 2.47 ± 0.025	3.524GlnSer: 3.524 ± 0.043	2.279GlnThr: 2.279 ± 0.028	2.179GlnVal: 2.179 ± 0.026	0.434GlnTrp: 0.434 ± 0.012	1.179GlnTyr: 1.179 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	3.693ArgAla: 3.693 ± 0.036	0.8ArgCys: 0.8 ± 0.017	3.02ArgAsp: 3.02 ± 0.033	3.795ArgGlu: 3.795 ± 0.04	2.094ArgPhe: 2.094 ± 0.028	3.02ArgGly: 3.02 ± 0.037	1.299ArgHis: 1.299 ± 0.022	3.573ArgIle: 3.573 ± 0.036	4.194ArgLys: 4.194 ± 0.038	5.259ArgLeu: 5.259 ± 0.042	1.1ArgMet: 1.1 ± 0.019	3.008ArgAsn: 3.008 ± 0.034	2.747ArgPro: 2.747 ± 0.032	2.516ArgGln: 2.516 ± 0.029	4.202ArgArg: 4.202 ± 0.046	4.788ArgSer: 4.788 ± 0.053	2.928ArgThr: 2.928 ± 0.036	2.938ArgVal: 2.938 ± 0.03	0.732ArgTrp: 0.732 ± 0.017	1.633ArgTyr: 1.633 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	4.906SerAla: 4.906 ± 0.039	1.131SerCys: 1.131 ± 0.019	4.721SerAsp: 4.721 ± 0.046	5.268SerGlu: 5.268 ± 0.044	3.409SerPhe: 3.409 ± 0.038	5.005SerGly: 5.005 ± 0.044	2.175SerHis: 2.175 ± 0.022	5.951SerIle: 5.951 ± 0.049	5.8SerLys: 5.8 ± 0.054	8.331SerLeu: 8.331 ± 0.064	1.719SerMet: 1.719 ± 0.024	5.086SerAsn: 5.086 ± 0.048	5.167SerPro: 5.167 ± 0.062	4.053SerGln: 4.053 ± 0.04	5.214SerArg: 5.214 ± 0.053	10.367SerSer: 10.367 ± 0.101	5.861SerThr: 5.861 ± 0.056	4.339SerVal: 4.339 ± 0.038	1.021SerTrp: 1.021 ± 0.014	2.395SerTyr: 2.395 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	3.766ThrAla: 3.766 ± 0.034	0.769ThrCys: 0.769 ± 0.018	2.715ThrAsp: 2.715 ± 0.03	3.335ThrGlu: 3.335 ± 0.034	2.161ThrPhe: 2.161 ± 0.026	3.318ThrGly: 3.318 ± 0.038	1.322ThrHis: 1.322 ± 0.019	3.709ThrIle: 3.709 ± 0.037	3.522ThrLys: 3.522 ± 0.036	5.155ThrLeu: 5.155 ± 0.041	1.059ThrMet: 1.059 ± 0.019	2.868ThrAsn: 2.868 ± 0.034	3.512ThrPro: 3.512 ± 0.037	2.308ThrGln: 2.308 ± 0.03	3.028ThrArg: 3.028 ± 0.029	5.887ThrSer: 5.887 ± 0.049	3.886ThrThr: 3.886 ± 0.046	3.166ThrVal: 3.166 ± 0.032	0.68ThrTrp: 0.68 ± 0.015	1.599ThrTyr: 1.599 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	3.79ValAla: 3.79 ± 0.035	0.727ValCys: 0.727 ± 0.015	3.172ValAsp: 3.172 ± 0.03	3.683ValGlu: 3.683 ± 0.039	2.123ValPhe: 2.123 ± 0.028	3.011ValGly: 3.011 ± 0.029	1.099ValHis: 1.099 ± 0.017	3.441ValIle: 3.441 ± 0.034	3.409ValLys: 3.409 ± 0.039	4.697ValLeu: 4.697 ± 0.043	1.072ValMet: 1.072 ± 0.018	2.513ValAsn: 2.513 ± 0.028	2.827ValPro: 2.827 ± 0.03	2.048ValGln: 2.048 ± 0.026	2.858ValArg: 2.858 ± 0.032	4.449ValSer: 4.449 ± 0.037	3.117ValThr: 3.117 ± 0.032	3.229ValVal: 3.229 ± 0.032	0.652ValTrp: 0.652 ± 0.016	1.479ValTyr: 1.479 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	0.834TrpAla: 0.834 ± 0.019	0.183TrpCys: 0.183 ± 0.007	0.741TrpAsp: 0.741 ± 0.017	0.702TrpGlu: 0.702 ± 0.015	0.411TrpPhe: 0.411 ± 0.012	0.635TrpGly: 0.635 ± 0.014	0.324TrpHis: 0.324 ± 0.01	0.825TrpIle: 0.825 ± 0.017	0.816TrpLys: 0.816 ± 0.015	1.109TrpLeu: 1.109 ± 0.019	0.286TrpMet: 0.286 ± 0.008	0.661TrpAsn: 0.661 ± 0.014	0.539TrpPro: 0.539 ± 0.013	0.464TrpGln: 0.464 ± 0.012	0.796TrpArg: 0.796 ± 0.017	0.895TrpSer: 0.895 ± 0.016	0.744TrpThr: 0.744 ± 0.016	0.68TrpVal: 0.68 ± 0.017	0.223TrpTrp: 0.223 ± 0.009	0.332TrpTyr: 0.332 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.715TyrAla: 1.715 ± 0.025	0.428TyrCys: 0.428 ± 0.012	1.674TyrAsp: 1.674 ± 0.023	1.75TyrGlu: 1.75 ± 0.025	1.286TyrPhe: 1.286 ± 0.023	1.774TyrGly: 1.774 ± 0.025	0.753TyrHis: 0.753 ± 0.015	1.691TyrIle: 1.691 ± 0.022	1.52TyrLys: 1.52 ± 0.021	2.895TyrLeu: 2.895 ± 0.034	0.543TyrMet: 0.543 ± 0.012	1.38TyrAsn: 1.38 ± 0.022	1.455TyrPro: 1.455 ± 0.023	1.278TyrGln: 1.278 ± 0.02	1.63TyrArg: 1.63 ± 0.024	2.416TyrSer: 2.416 ± 0.028	1.559TyrThr: 1.559 ± 0.023	1.465TyrVal: 1.465 ± 0.022	0.366TyrTrp: 0.366 ± 0.009	0.95TyrTyr: 0.95 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6853 proteins (3364779 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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