Amino acid dipepetide frequency for Streptococcus phage CHPC1042

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.901AlaAla: 5.901 ± 2.058
0.236AlaCys: 0.236 ± 0.144
4.721AlaAsp: 4.721 ± 0.777
5.036AlaGlu: 5.036 ± 0.855
2.675AlaPhe: 2.675 ± 0.869
4.721AlaGly: 4.721 ± 1.203
0.944AlaHis: 0.944 ± 0.29
5.272AlaIle: 5.272 ± 1.306
5.272AlaLys: 5.272 ± 0.754
6.059AlaLeu: 6.059 ± 0.957
2.597AlaMet: 2.597 ± 0.882
4.328AlaAsn: 4.328 ± 0.533
2.124AlaPro: 2.124 ± 0.417
3.541AlaGln: 3.541 ± 0.848
3.069AlaArg: 3.069 ± 0.649
5.429AlaSer: 5.429 ± 1.443
3.777AlaThr: 3.777 ± 0.785
5.036AlaVal: 5.036 ± 1.27
0.787AlaTrp: 0.787 ± 0.277
2.361AlaTyr: 2.361 ± 0.493
0.0AlaXaa: 0.0 ± 0.0
Cys
0.236CysAla: 0.236 ± 0.132
0.157CysCys: 0.157 ± 0.114
0.708CysAsp: 0.708 ± 0.276
0.551CysGlu: 0.551 ± 0.227
0.157CysPhe: 0.157 ± 0.119
0.551CysGly: 0.551 ± 0.249
0.236CysHis: 0.236 ± 0.143
0.236CysIle: 0.236 ± 0.118
0.708CysLys: 0.708 ± 0.265
0.315CysLeu: 0.315 ± 0.17
0.079CysMet: 0.079 ± 0.083
0.315CysAsn: 0.315 ± 0.172
0.079CysPro: 0.079 ± 0.067
0.079CysGln: 0.079 ± 0.083
0.315CysArg: 0.315 ± 0.184
0.944CysSer: 0.944 ± 0.346
0.0CysThr: 0.0 ± 0.0
0.393CysVal: 0.393 ± 0.169
0.236CysTrp: 0.236 ± 0.142
0.393CysTyr: 0.393 ± 0.182
0.0CysXaa: 0.0 ± 0.0
Asp
3.619AspAla: 3.619 ± 0.444
0.944AspCys: 0.944 ± 0.266
4.092AspAsp: 4.092 ± 0.567
4.564AspGlu: 4.564 ± 0.846
3.226AspPhe: 3.226 ± 0.51
5.665AspGly: 5.665 ± 1.028
0.708AspHis: 0.708 ± 0.267
3.619AspIle: 3.619 ± 0.571
5.036AspLys: 5.036 ± 0.829
4.485AspLeu: 4.485 ± 0.556
1.259AspMet: 1.259 ± 0.302
3.934AspAsn: 3.934 ± 0.604
0.708AspPro: 0.708 ± 0.241
1.102AspGln: 1.102 ± 0.268
2.833AspArg: 2.833 ± 0.558
4.17AspSer: 4.17 ± 0.741
3.541AspThr: 3.541 ± 0.728
3.305AspVal: 3.305 ± 0.568
1.18AspTrp: 1.18 ± 0.394
3.226AspTyr: 3.226 ± 0.555
0.0AspXaa: 0.0 ± 0.0
Glu
4.8GluAla: 4.8 ± 0.823
0.393GluCys: 0.393 ± 0.185
3.305GluAsp: 3.305 ± 0.548
4.17GluGlu: 4.17 ± 1.006
2.754GluPhe: 2.754 ± 0.545
2.833GluGly: 2.833 ± 0.512
1.259GluHis: 1.259 ± 0.307
5.744GluIle: 5.744 ± 1.101
5.114GluLys: 5.114 ± 1.01
7.475GluLeu: 7.475 ± 1.23
2.046GluMet: 2.046 ± 0.468
4.249GluAsn: 4.249 ± 0.696
2.046GluPro: 2.046 ± 0.585
3.777GluGln: 3.777 ± 0.639
3.777GluArg: 3.777 ± 0.54
2.597GluSer: 2.597 ± 0.607
3.934GluThr: 3.934 ± 0.668
6.137GluVal: 6.137 ± 0.881
0.944GluTrp: 0.944 ± 0.292
3.462GluTyr: 3.462 ± 0.735
0.0GluXaa: 0.0 ± 0.0
Phe
2.282PheAla: 2.282 ± 0.453
0.315PheCys: 0.315 ± 0.188
2.911PheAsp: 2.911 ± 0.582
4.406PheGlu: 4.406 ± 0.671
1.18PhePhe: 1.18 ± 0.295
3.698PheGly: 3.698 ± 0.713
0.393PheHis: 0.393 ± 0.154
2.439PheIle: 2.439 ± 0.412
4.485PheLys: 4.485 ± 0.604
2.124PheLeu: 2.124 ± 0.477
0.708PheMet: 0.708 ± 0.262
2.833PheAsn: 2.833 ± 0.47
0.629PhePro: 0.629 ± 0.261
1.259PheGln: 1.259 ± 0.276
1.416PheArg: 1.416 ± 0.367
3.541PheSer: 3.541 ± 0.693
2.597PheThr: 2.597 ± 0.512
2.282PheVal: 2.282 ± 0.389
0.708PheTrp: 0.708 ± 0.223
1.416PheTyr: 1.416 ± 0.357
0.0PheXaa: 0.0 ± 0.0
Gly
4.721GlyAla: 4.721 ± 0.932
0.393GlyCys: 0.393 ± 0.217
2.99GlyAsp: 2.99 ± 0.446
3.305GlyGlu: 3.305 ± 0.509
3.226GlyPhe: 3.226 ± 0.502
3.383GlyGly: 3.383 ± 0.506
0.787GlyHis: 0.787 ± 0.325
5.665GlyIle: 5.665 ± 1.687
5.744GlyLys: 5.744 ± 0.898
5.98GlyLeu: 5.98 ± 0.937
1.574GlyMet: 1.574 ± 0.76
3.226GlyAsn: 3.226 ± 0.558
0.866GlyPro: 0.866 ± 0.486
2.911GlyGln: 2.911 ± 0.464
2.754GlyArg: 2.754 ± 0.579
4.092GlySer: 4.092 ± 0.72
4.485GlyThr: 4.485 ± 0.764
4.721GlyVal: 4.721 ± 0.581
0.629GlyTrp: 0.629 ± 0.273
3.226GlyTyr: 3.226 ± 0.497
0.0GlyXaa: 0.0 ± 0.0
His
0.866HisAla: 0.866 ± 0.264
0.079HisCys: 0.079 ± 0.077
1.102HisAsp: 1.102 ± 0.279
0.944HisGlu: 0.944 ± 0.318
0.944HisPhe: 0.944 ± 0.294
0.629HisGly: 0.629 ± 0.283
0.551HisHis: 0.551 ± 0.206
1.18HisIle: 1.18 ± 0.316
1.574HisLys: 1.574 ± 0.4
1.338HisLeu: 1.338 ± 0.337
0.315HisMet: 0.315 ± 0.148
0.708HisAsn: 0.708 ± 0.263
0.315HisPro: 0.315 ± 0.155
0.866HisGln: 0.866 ± 0.304
0.787HisArg: 0.787 ± 0.247
0.787HisSer: 0.787 ± 0.25
1.023HisThr: 1.023 ± 0.28
0.629HisVal: 0.629 ± 0.246
0.157HisTrp: 0.157 ± 0.106
0.236HisTyr: 0.236 ± 0.149
0.0HisXaa: 0.0 ± 0.0
Ile
5.036IleAla: 5.036 ± 0.73
0.472IleCys: 0.472 ± 0.211
4.485IleAsp: 4.485 ± 0.488
5.901IleGlu: 5.901 ± 0.912
1.967IlePhe: 1.967 ± 0.361
5.272IleGly: 5.272 ± 1.12
1.102IleHis: 1.102 ± 0.259
3.383IleIle: 3.383 ± 0.753
5.508IleLys: 5.508 ± 0.55
3.462IleLeu: 3.462 ± 0.495
1.731IleMet: 1.731 ± 0.281
4.013IleAsn: 4.013 ± 0.759
2.518IlePro: 2.518 ± 0.505
3.462IleGln: 3.462 ± 0.471
2.518IleArg: 2.518 ± 0.488
5.429IleSer: 5.429 ± 1.268
3.541IleThr: 3.541 ± 0.668
4.092IleVal: 4.092 ± 0.719
0.393IleTrp: 0.393 ± 0.163
2.282IleTyr: 2.282 ± 0.513
0.0IleXaa: 0.0 ± 0.0
Lys
7.003LysAla: 7.003 ± 0.889
0.393LysCys: 0.393 ± 0.204
4.564LysAsp: 4.564 ± 0.719
8.341LysGlu: 8.341 ± 1.291
3.069LysPhe: 3.069 ± 0.662
5.351LysGly: 5.351 ± 0.731
1.652LysHis: 1.652 ± 0.402
4.878LysIle: 4.878 ± 0.67
7.239LysLys: 7.239 ± 1.538
7.16LysLeu: 7.16 ± 1.19
2.597LysMet: 2.597 ± 0.555
3.698LysAsn: 3.698 ± 0.717
3.226LysPro: 3.226 ± 0.47
3.541LysGln: 3.541 ± 0.742
5.036LysArg: 5.036 ± 0.751
4.17LysSer: 4.17 ± 0.47
5.193LysThr: 5.193 ± 0.795
3.934LysVal: 3.934 ± 0.472
1.259LysTrp: 1.259 ± 0.332
3.934LysTyr: 3.934 ± 0.674
0.0LysXaa: 0.0 ± 0.0
Leu
6.373LeuAla: 6.373 ± 0.985
0.315LeuCys: 0.315 ± 0.179
5.429LeuAsp: 5.429 ± 0.745
6.137LeuGlu: 6.137 ± 0.933
2.911LeuPhe: 2.911 ± 0.482
4.406LeuGly: 4.406 ± 0.884
0.866LeuHis: 0.866 ± 0.24
4.013LeuIle: 4.013 ± 0.469
6.452LeuLys: 6.452 ± 0.874
5.036LeuLeu: 5.036 ± 0.792
2.282LeuMet: 2.282 ± 0.473
5.193LeuAsn: 5.193 ± 0.58
2.361LeuPro: 2.361 ± 0.394
2.518LeuGln: 2.518 ± 0.494
3.462LeuArg: 3.462 ± 0.676
4.878LeuSer: 4.878 ± 0.707
6.373LeuThr: 6.373 ± 0.713
4.721LeuVal: 4.721 ± 0.564
0.472LeuTrp: 0.472 ± 0.198
2.911LeuTyr: 2.911 ± 0.515
0.0LeuXaa: 0.0 ± 0.0
Met
2.597MetAla: 2.597 ± 0.895
0.0MetCys: 0.0 ± 0.0
0.944MetAsp: 0.944 ± 0.28
1.18MetGlu: 1.18 ± 0.376
1.18MetPhe: 1.18 ± 0.232
1.259MetGly: 1.259 ± 0.367
0.236MetHis: 0.236 ± 0.145
1.18MetIle: 1.18 ± 0.323
2.675MetLys: 2.675 ± 0.597
1.731MetLeu: 1.731 ± 0.353
1.023MetMet: 1.023 ± 0.461
1.259MetAsn: 1.259 ± 0.357
0.551MetPro: 0.551 ± 0.2
1.18MetGln: 1.18 ± 0.458
1.259MetArg: 1.259 ± 0.283
2.439MetSer: 2.439 ± 0.527
1.574MetThr: 1.574 ± 0.357
1.81MetVal: 1.81 ± 0.486
0.0MetTrp: 0.0 ± 0.0
0.551MetTyr: 0.551 ± 0.206
0.0MetXaa: 0.0 ± 0.0
Asn
4.092AsnAla: 4.092 ± 0.554
0.315AsnCys: 0.315 ± 0.138
3.777AsnAsp: 3.777 ± 0.61
3.619AsnGlu: 3.619 ± 0.652
2.597AsnPhe: 2.597 ± 0.463
4.485AsnGly: 4.485 ± 0.755
1.102AsnHis: 1.102 ± 0.411
3.462AsnIle: 3.462 ± 0.537
5.036AsnLys: 5.036 ± 0.851
4.406AsnLeu: 4.406 ± 0.808
1.338AsnMet: 1.338 ± 0.373
2.833AsnAsn: 2.833 ± 0.556
2.675AsnPro: 2.675 ± 0.491
1.81AsnGln: 1.81 ± 0.436
2.439AsnArg: 2.439 ± 0.577
3.777AsnSer: 3.777 ± 0.665
2.518AsnThr: 2.518 ± 0.408
2.675AsnVal: 2.675 ± 0.513
1.495AsnTrp: 1.495 ± 0.333
1.731AsnTyr: 1.731 ± 0.458
0.0AsnXaa: 0.0 ± 0.0
Pro
1.338ProAla: 1.338 ± 0.251
0.236ProCys: 0.236 ± 0.153
1.652ProAsp: 1.652 ± 0.418
1.731ProGlu: 1.731 ± 0.417
1.023ProPhe: 1.023 ± 0.248
1.259ProGly: 1.259 ± 0.403
0.315ProHis: 0.315 ± 0.122
1.731ProIle: 1.731 ± 0.34
3.619ProLys: 3.619 ± 0.603
1.888ProLeu: 1.888 ± 0.36
0.157ProMet: 0.157 ± 0.117
1.888ProAsn: 1.888 ± 0.412
0.708ProPro: 0.708 ± 0.171
1.574ProGln: 1.574 ± 0.347
1.338ProArg: 1.338 ± 0.397
2.439ProSer: 2.439 ± 0.461
1.338ProThr: 1.338 ± 0.367
1.731ProVal: 1.731 ± 0.323
0.236ProTrp: 0.236 ± 0.123
1.102ProTyr: 1.102 ± 0.38
0.0ProXaa: 0.0 ± 0.0
Gln
4.406GlnAla: 4.406 ± 0.806
0.236GlnCys: 0.236 ± 0.142
2.361GlnAsp: 2.361 ± 0.434
3.305GlnGlu: 3.305 ± 0.636
2.124GlnPhe: 2.124 ± 0.494
2.361GlnGly: 2.361 ± 0.64
0.315GlnHis: 0.315 ± 0.143
2.361GlnIle: 2.361 ± 0.437
2.833GlnLys: 2.833 ± 0.559
3.856GlnLeu: 3.856 ± 0.44
1.259GlnMet: 1.259 ± 0.37
1.81GlnAsn: 1.81 ± 0.385
0.866GlnPro: 0.866 ± 0.33
2.124GlnGln: 2.124 ± 0.553
1.102GlnArg: 1.102 ± 0.398
1.967GlnSer: 1.967 ± 0.573
3.147GlnThr: 3.147 ± 0.431
2.675GlnVal: 2.675 ± 0.383
0.393GlnTrp: 0.393 ± 0.178
1.652GlnTyr: 1.652 ± 0.392
0.0GlnXaa: 0.0 ± 0.0
Arg
3.226ArgAla: 3.226 ± 0.522
0.551ArgCys: 0.551 ± 0.214
2.282ArgAsp: 2.282 ± 0.461
3.069ArgGlu: 3.069 ± 0.579
1.81ArgPhe: 1.81 ± 0.41
2.99ArgGly: 2.99 ± 0.43
0.551ArgHis: 0.551 ± 0.244
3.069ArgIle: 3.069 ± 0.55
3.777ArgLys: 3.777 ± 0.72
4.564ArgLeu: 4.564 ± 0.584
1.102ArgMet: 1.102 ± 0.298
2.203ArgAsn: 2.203 ± 0.517
0.944ArgPro: 0.944 ± 0.246
1.495ArgGln: 1.495 ± 0.336
1.731ArgArg: 1.731 ± 0.404
2.439ArgSer: 2.439 ± 0.357
1.888ArgThr: 1.888 ± 0.506
2.361ArgVal: 2.361 ± 0.468
0.551ArgTrp: 0.551 ± 0.249
2.597ArgTyr: 2.597 ± 0.496
0.0ArgXaa: 0.0 ± 0.0
Ser
5.901SerAla: 5.901 ± 2.198
0.472SerCys: 0.472 ± 0.225
4.642SerAsp: 4.642 ± 0.788
3.541SerGlu: 3.541 ± 0.576
2.124SerPhe: 2.124 ± 0.441
4.092SerGly: 4.092 ± 0.636
1.023SerHis: 1.023 ± 0.311
5.744SerIle: 5.744 ± 0.873
5.508SerLys: 5.508 ± 0.755
4.8SerLeu: 4.8 ± 0.767
1.495SerMet: 1.495 ± 0.326
3.777SerAsn: 3.777 ± 0.608
1.574SerPro: 1.574 ± 0.322
3.698SerGln: 3.698 ± 0.928
2.518SerArg: 2.518 ± 0.398
4.406SerSer: 4.406 ± 1.063
3.619SerThr: 3.619 ± 0.828
5.272SerVal: 5.272 ± 0.683
0.629SerTrp: 0.629 ± 0.198
1.652SerTyr: 1.652 ± 0.286
0.0SerXaa: 0.0 ± 0.0
Thr
4.092ThrAla: 4.092 ± 1.49
0.315ThrCys: 0.315 ± 0.155
3.462ThrAsp: 3.462 ± 0.651
3.541ThrGlu: 3.541 ± 0.526
3.226ThrPhe: 3.226 ± 0.472
4.249ThrGly: 4.249 ± 0.75
1.338ThrHis: 1.338 ± 0.365
5.114ThrIle: 5.114 ± 0.688
6.059ThrLys: 6.059 ± 0.862
4.564ThrLeu: 4.564 ± 0.515
1.18ThrMet: 1.18 ± 0.753
2.833ThrAsn: 2.833 ± 0.38
1.731ThrPro: 1.731 ± 0.424
2.439ThrGln: 2.439 ± 0.357
2.046ThrArg: 2.046 ± 0.388
3.383ThrSer: 3.383 ± 0.737
3.777ThrThr: 3.777 ± 0.729
4.957ThrVal: 4.957 ± 0.724
0.551ThrTrp: 0.551 ± 0.306
2.203ThrTyr: 2.203 ± 0.657
0.0ThrXaa: 0.0 ± 0.0
Val
3.934ValAla: 3.934 ± 0.976
0.315ValCys: 0.315 ± 0.145
4.406ValAsp: 4.406 ± 0.79
4.328ValGlu: 4.328 ± 0.751
2.833ValPhe: 2.833 ± 0.461
4.013ValGly: 4.013 ± 0.649
0.551ValHis: 0.551 ± 0.287
4.564ValIle: 4.564 ± 0.559
5.823ValLys: 5.823 ± 0.608
4.092ValLeu: 4.092 ± 0.496
0.944ValMet: 0.944 ± 0.225
4.564ValAsn: 4.564 ± 0.765
1.81ValPro: 1.81 ± 0.314
1.967ValGln: 1.967 ± 0.49
2.203ValArg: 2.203 ± 0.415
5.98ValSer: 5.98 ± 0.616
5.272ValThr: 5.272 ± 0.647
4.013ValVal: 4.013 ± 0.57
0.787ValTrp: 0.787 ± 0.232
2.124ValTyr: 2.124 ± 0.448
0.0ValXaa: 0.0 ± 0.0
Trp
0.787TrpAla: 0.787 ± 0.233
0.157TrpCys: 0.157 ± 0.114
0.472TrpAsp: 0.472 ± 0.238
0.944TrpGlu: 0.944 ± 0.309
0.472TrpPhe: 0.472 ± 0.209
0.708TrpGly: 0.708 ± 0.225
0.157TrpHis: 0.157 ± 0.106
0.315TrpIle: 0.315 ± 0.181
0.708TrpLys: 0.708 ± 0.2
0.944TrpLeu: 0.944 ± 0.228
0.157TrpMet: 0.157 ± 0.136
0.787TrpAsn: 0.787 ± 0.275
0.079TrpPro: 0.079 ± 0.081
0.551TrpGln: 0.551 ± 0.217
0.551TrpArg: 0.551 ± 0.22
1.18TrpSer: 1.18 ± 0.634
0.629TrpThr: 0.629 ± 0.249
1.416TrpVal: 1.416 ± 0.362
0.393TrpTrp: 0.393 ± 0.192
0.629TrpTyr: 0.629 ± 0.281
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.675TyrAla: 2.675 ± 0.511
0.393TyrCys: 0.393 ± 0.153
2.911TyrAsp: 2.911 ± 0.651
2.203TyrGlu: 2.203 ± 0.501
2.124TyrPhe: 2.124 ± 0.367
2.754TyrGly: 2.754 ± 0.491
0.944TyrHis: 0.944 ± 0.326
2.597TyrIle: 2.597 ± 0.526
3.069TyrLys: 3.069 ± 0.68
2.833TyrLeu: 2.833 ± 0.472
0.708TyrMet: 0.708 ± 0.237
1.731TyrAsn: 1.731 ± 0.405
1.495TyrPro: 1.495 ± 0.392
1.259TyrGln: 1.259 ± 0.308
2.124TyrArg: 2.124 ± 0.491
2.439TyrSer: 2.439 ± 0.488
2.833TyrThr: 2.833 ± 0.608
2.361TyrVal: 2.361 ± 0.422
0.236TyrTrp: 0.236 ± 0.12
1.888TyrTyr: 1.888 ± 0.503
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 61 proteins (12710 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski