Amino acid dipepetide frequency for Oleiphilus sp. HI0079

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.117AlaAla: 8.117 ± 0.117	1.06AlaCys: 1.06 ± 0.033	4.872AlaAsp: 4.872 ± 0.07	6.105AlaGlu: 6.105 ± 0.089	3.879AlaPhe: 3.879 ± 0.06	6.254AlaGly: 6.254 ± 0.089	1.863AlaHis: 1.863 ± 0.04	5.641AlaIle: 5.641 ± 0.085	4.787AlaLys: 4.787 ± 0.08	10.863AlaLeu: 10.863 ± 0.125	2.547AlaMet: 2.547 ± 0.05	3.336AlaAsn: 3.336 ± 0.062	3.134AlaPro: 3.134 ± 0.058	3.794AlaGln: 3.794 ± 0.067	4.522AlaArg: 4.522 ± 0.062	6.393AlaSer: 6.393 ± 0.072	4.248AlaThr: 4.248 ± 0.074	5.871AlaVal: 5.871 ± 0.08	1.032AlaTrp: 1.032 ± 0.029	2.597AlaTyr: 2.597 ± 0.054	0.003AlaXaa: 0.003 ± 0.002
Cys	0.93CysAla: 0.93 ± 0.032	0.148CysCys: 0.148 ± 0.013	0.649CysAsp: 0.649 ± 0.024	0.615CysGlu: 0.615 ± 0.024	0.493CysPhe: 0.493 ± 0.025	0.87CysGly: 0.87 ± 0.034	0.317CysHis: 0.317 ± 0.022	0.596CysIle: 0.596 ± 0.025	0.466CysLys: 0.466 ± 0.022	0.983CysLeu: 0.983 ± 0.03	0.232CysMet: 0.232 ± 0.015	0.302CysAsn: 0.302 ± 0.018	0.446CysPro: 0.446 ± 0.023	0.326CysGln: 0.326 ± 0.019	0.495CysArg: 0.495 ± 0.023	0.745CysSer: 0.745 ± 0.024	0.493CysThr: 0.493 ± 0.024	0.674CysVal: 0.674 ± 0.029	0.116CysTrp: 0.116 ± 0.01	0.265CysTyr: 0.265 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.468AspAla: 5.468 ± 0.076	0.571AspCys: 0.571 ± 0.023	3.226AspAsp: 3.226 ± 0.065	4.307AspGlu: 4.307 ± 0.076	2.523AspPhe: 2.523 ± 0.057	4.104AspGly: 4.104 ± 0.083	1.22AspHis: 1.22 ± 0.033	3.747AspIle: 3.747 ± 0.066	2.808AspLys: 2.808 ± 0.052	5.96AspLeu: 5.96 ± 0.086	1.479AspMet: 1.479 ± 0.038	1.987AspAsn: 1.987 ± 0.048	2.364AspPro: 2.364 ± 0.051	2.517AspGln: 2.517 ± 0.047	2.835AspArg: 2.835 ± 0.056	3.552AspSer: 3.552 ± 0.064	2.755AspThr: 2.755 ± 0.055	4.135AspVal: 4.135 ± 0.069	0.729AspTrp: 0.729 ± 0.029	1.971AspTyr: 1.971 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.121GluAla: 6.121 ± 0.082	0.561GluCys: 0.561 ± 0.022	3.574GluAsp: 3.574 ± 0.065	4.444GluGlu: 4.444 ± 0.08	2.576GluPhe: 2.576 ± 0.057	4.222GluGly: 4.222 ± 0.07	1.732GluHis: 1.732 ± 0.051	3.98GluIle: 3.98 ± 0.062	3.589GluLys: 3.589 ± 0.078	7.703GluLeu: 7.703 ± 0.097	1.612GluMet: 1.612 ± 0.042	2.696GluAsn: 2.696 ± 0.052	2.32GluPro: 2.32 ± 0.07	3.987GluGln: 3.987 ± 0.067	4.23GluArg: 4.23 ± 0.07	4.422GluSer: 4.422 ± 0.068	3.316GluThr: 3.316 ± 0.058	4.467GluVal: 4.467 ± 0.074	0.743GluTrp: 0.743 ± 0.028	1.786GluTyr: 1.786 ± 0.047	0.001GluXaa: 0.001 ± 0.001
Phe	3.638PheAla: 3.638 ± 0.062	0.501PheCys: 0.501 ± 0.022	2.923PheAsp: 2.923 ± 0.053	2.973PheGlu: 2.973 ± 0.051	1.764PhePhe: 1.764 ± 0.051	3.315PheGly: 3.315 ± 0.063	0.782PheHis: 0.782 ± 0.026	2.429PheIle: 2.429 ± 0.05	2.092PheLys: 2.092 ± 0.044	3.714PheLeu: 3.714 ± 0.071	0.963PheMet: 0.963 ± 0.031	1.686PheAsn: 1.686 ± 0.042	1.505PhePro: 1.505 ± 0.041	1.293PheGln: 1.293 ± 0.032	1.768PheArg: 1.768 ± 0.043	3.301PheSer: 3.301 ± 0.055	1.969PheThr: 1.969 ± 0.051	3.093PheVal: 3.093 ± 0.062	0.502PheTrp: 0.502 ± 0.026	1.311PheTyr: 1.311 ± 0.039	0.001PheXaa: 0.001 ± 0.001
Gly	6.121GlyAla: 6.121 ± 0.088	0.834GlyCys: 0.834 ± 0.028	3.833GlyAsp: 3.833 ± 0.08	4.48GlyGlu: 4.48 ± 0.065	3.406GlyPhe: 3.406 ± 0.061	4.957GlyGly: 4.957 ± 0.098	1.5GlyHis: 1.5 ± 0.044	4.406GlyIle: 4.406 ± 0.063	3.722GlyLys: 3.722 ± 0.067	7.597GlyLeu: 7.597 ± 0.104	1.987GlyMet: 1.987 ± 0.045	2.339GlyAsn: 2.339 ± 0.055	1.846GlyPro: 1.846 ± 0.044	2.677GlyGln: 2.677 ± 0.063	3.392GlyArg: 3.392 ± 0.06	4.522GlySer: 4.522 ± 0.083	3.36GlyThr: 3.36 ± 0.058	5.404GlyVal: 5.404 ± 0.075	0.821GlyTrp: 0.821 ± 0.028	2.346GlyTyr: 2.346 ± 0.053	0.003GlyXaa: 0.003 ± 0.002
His	1.852HisAla: 1.852 ± 0.042	0.312HisCys: 0.312 ± 0.016	1.127HisAsp: 1.127 ± 0.034	1.307HisGlu: 1.307 ± 0.045	1.057HisPhe: 1.057 ± 0.031	1.61HisGly: 1.61 ± 0.046	0.655HisHis: 0.655 ± 0.028	1.288HisIle: 1.288 ± 0.038	0.962HisLys: 0.962 ± 0.034	2.135HisLeu: 2.135 ± 0.048	0.533HisMet: 0.533 ± 0.024	0.746HisAsn: 0.746 ± 0.031	1.11HisPro: 1.11 ± 0.033	0.859HisGln: 0.859 ± 0.03	1.095HisArg: 1.095 ± 0.034	1.407HisSer: 1.407 ± 0.038	1.022HisThr: 1.022 ± 0.031	1.453HisVal: 1.453 ± 0.039	0.277HisTrp: 0.277 ± 0.016	0.803HisTyr: 0.803 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.219IleAla: 6.219 ± 0.094	0.644IleCys: 0.644 ± 0.025	4.306IleAsp: 4.306 ± 0.072	4.952IleGlu: 4.952 ± 0.069	2.01IlePhe: 2.01 ± 0.047	4.434IleGly: 4.434 ± 0.069	1.18IleHis: 1.18 ± 0.034	3.115IleIle: 3.115 ± 0.066	3.068IleLys: 3.068 ± 0.06	5.041IleLeu: 5.041 ± 0.068	1.191IleMet: 1.191 ± 0.035	2.576IleAsn: 2.576 ± 0.049	2.589IlePro: 2.589 ± 0.05	2.179IleGln: 2.179 ± 0.047	2.894IleArg: 2.894 ± 0.057	4.404IleSer: 4.404 ± 0.068	3.08IleThr: 3.08 ± 0.062	4.09IleVal: 4.09 ± 0.07	0.51IleTrp: 0.51 ± 0.022	1.574IleTyr: 1.574 ± 0.046	0.003IleXaa: 0.003 ± 0.002
Lys	4.961LysAla: 4.961 ± 0.079	0.312LysCys: 0.312 ± 0.02	2.701LysAsp: 2.701 ± 0.047	3.319LysGlu: 3.319 ± 0.067	1.385LysPhe: 1.385 ± 0.035	3.32LysGly: 3.32 ± 0.069	1.277LysHis: 1.277 ± 0.038	2.711LysIle: 2.711 ± 0.059	2.798LysLys: 2.798 ± 0.08	5.17LysLeu: 5.17 ± 0.075	1.177LysMet: 1.177 ± 0.036	1.96LysAsn: 1.96 ± 0.043	2.37LysPro: 2.37 ± 0.052	2.6LysGln: 2.6 ± 0.052	3.013LysArg: 3.013 ± 0.057	3.232LysSer: 3.232 ± 0.063	2.845LysThr: 2.845 ± 0.05	3.507LysVal: 3.507 ± 0.059	0.513LysTrp: 0.513 ± 0.02	1.237LysTyr: 1.237 ± 0.033	0.001LysXaa: 0.001 ± 0.001
Leu	9.858LeuAla: 9.858 ± 0.117	1.118LeuCys: 1.118 ± 0.034	6.218LeuAsp: 6.218 ± 0.09	7.022LeuGlu: 7.022 ± 0.095	4.077LeuPhe: 4.077 ± 0.078	7.416LeuGly: 7.416 ± 0.106	1.953LeuHis: 1.953 ± 0.045	6.162LeuIle: 6.162 ± 0.085	5.628LeuLys: 5.628 ± 0.079	10.107LeuLeu: 10.107 ± 0.153	2.473LeuMet: 2.473 ± 0.049	4.375LeuAsn: 4.375 ± 0.068	4.441LeuPro: 4.441 ± 0.073	3.511LeuGln: 3.511 ± 0.063	5.116LeuArg: 5.116 ± 0.066	8.598LeuSer: 8.598 ± 0.106	5.071LeuThr: 5.071 ± 0.072	7.327LeuVal: 7.327 ± 0.114	0.998LeuTrp: 0.998 ± 0.03	2.568LeuTyr: 2.568 ± 0.058	0.003LeuXaa: 0.003 ± 0.002
Met	2.312MetAla: 2.312 ± 0.05	0.201MetCys: 0.201 ± 0.013	1.261MetAsp: 1.261 ± 0.035	1.232MetGlu: 1.232 ± 0.039	0.895MetPhe: 0.895 ± 0.029	1.701MetGly: 1.701 ± 0.045	0.585MetHis: 0.585 ± 0.023	1.36MetIle: 1.36 ± 0.041	1.286MetLys: 1.286 ± 0.04	2.634MetLeu: 2.634 ± 0.05	0.681MetMet: 0.681 ± 0.027	0.972MetAsn: 0.972 ± 0.031	1.23MetPro: 1.23 ± 0.033	1.11MetGln: 1.11 ± 0.032	1.401MetArg: 1.401 ± 0.035	2.043MetSer: 2.043 ± 0.046	1.466MetThr: 1.466 ± 0.034	1.55MetVal: 1.55 ± 0.043	0.184MetTrp: 0.184 ± 0.014	0.579MetTyr: 0.579 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.599AsnAla: 3.599 ± 0.065	0.382AsnCys: 0.382 ± 0.019	2.29AsnAsp: 2.29 ± 0.053	2.493AsnGlu: 2.493 ± 0.049	1.433AsnPhe: 1.433 ± 0.042	2.71AsnGly: 2.71 ± 0.052	0.708AsnHis: 0.708 ± 0.03	2.567AsnIle: 2.567 ± 0.054	1.913AsnLys: 1.913 ± 0.043	3.631AsnLeu: 3.631 ± 0.059	0.96AsnMet: 0.96 ± 0.03	1.534AsnAsn: 1.534 ± 0.047	1.959AsnPro: 1.959 ± 0.051	1.646AsnGln: 1.646 ± 0.04	1.946AsnArg: 1.946 ± 0.044	2.492AsnSer: 2.492 ± 0.056	2.153AsnThr: 2.153 ± 0.049	2.516AsnVal: 2.516 ± 0.055	0.497AsnTrp: 0.497 ± 0.02	1.158AsnTyr: 1.158 ± 0.036	0.001AsnXaa: 0.001 ± 0.001
Pro	3.15ProAla: 3.15 ± 0.065	0.329ProCys: 0.329 ± 0.018	2.581ProAsp: 2.581 ± 0.055	3.536ProGlu: 3.536 ± 0.065	1.749ProPhe: 1.749 ± 0.042	2.45ProGly: 2.45 ± 0.046	0.792ProHis: 0.792 ± 0.029	2.356ProIle: 2.356 ± 0.055	2.088ProLys: 2.088 ± 0.044	3.797ProLeu: 3.797 ± 0.066	0.974ProMet: 0.974 ± 0.031	1.704ProAsn: 1.704 ± 0.044	1.29ProPro: 1.29 ± 0.036	1.358ProGln: 1.358 ± 0.039	1.539ProArg: 1.539 ± 0.037	2.874ProSer: 2.874 ± 0.052	1.89ProThr: 1.89 ± 0.039	3.017ProVal: 3.017 ± 0.056	0.495ProTrp: 0.495 ± 0.022	1.185ProTyr: 1.185 ± 0.032	0.004ProXaa: 0.004 ± 0.002
Gln	4.158GlnAla: 4.158 ± 0.079	0.355GlnCys: 0.355 ± 0.019	2.024GlnAsp: 2.024 ± 0.051	2.502GlnGlu: 2.502 ± 0.06	1.556GlnPhe: 1.556 ± 0.04	2.687GlnGly: 2.687 ± 0.053	1.049GlnHis: 1.049 ± 0.033	2.429GlnIle: 2.429 ± 0.048	1.919GlnLys: 1.919 ± 0.046	4.283GlnLeu: 4.283 ± 0.076	0.93GlnMet: 0.93 ± 0.031	1.609GlnAsn: 1.609 ± 0.039	1.417GlnPro: 1.417 ± 0.041	2.081GlnGln: 2.081 ± 0.056	2.441GlnArg: 2.441 ± 0.056	2.922GlnSer: 2.922 ± 0.067	2.134GlnThr: 2.134 ± 0.043	2.822GlnVal: 2.822 ± 0.056	0.479GlnTrp: 0.479 ± 0.022	1.127GlnTyr: 1.127 ± 0.035	0.002GlnXaa: 0.002 ± 0.001
Arg	4.144ArgAla: 4.144 ± 0.058	0.499ArgCys: 0.499 ± 0.027	2.8ArgAsp: 2.8 ± 0.055	3.435ArgGlu: 3.435 ± 0.062	2.666ArgPhe: 2.666 ± 0.053	2.823ArgGly: 2.823 ± 0.05	1.171ArgHis: 1.171 ± 0.036	3.284ArgIle: 3.284 ± 0.06	2.534ArgLys: 2.534 ± 0.052	5.622ArgLeu: 5.622 ± 0.085	1.364ArgMet: 1.364 ± 0.033	1.965ArgAsn: 1.965 ± 0.046	1.787ArgPro: 1.787 ± 0.047	1.977ArgGln: 1.977 ± 0.046	2.549ArgArg: 2.549 ± 0.058	3.349ArgSer: 3.349 ± 0.054	2.281ArgThr: 2.281 ± 0.046	3.729ArgVal: 3.729 ± 0.065	0.66ArgTrp: 0.66 ± 0.025	1.993ArgTyr: 1.993 ± 0.05	0.002ArgXaa: 0.002 ± 0.002
Ser	6.403SerAla: 6.403 ± 0.08	0.606SerCys: 0.606 ± 0.029	4.397SerAsp: 4.397 ± 0.065	4.892SerGlu: 4.892 ± 0.071	3.019SerPhe: 3.019 ± 0.062	5.51SerGly: 5.51 ± 0.083	1.36SerHis: 1.36 ± 0.035	4.489SerIle: 4.489 ± 0.064	3.525SerLys: 3.525 ± 0.057	7.364SerLeu: 7.364 ± 0.09	1.814SerMet: 1.814 ± 0.041	2.749SerAsn: 2.749 ± 0.052	2.5SerPro: 2.5 ± 0.045	2.619SerGln: 2.619 ± 0.06	3.217SerArg: 3.217 ± 0.059	5.371SerSer: 5.371 ± 0.086	3.451SerThr: 3.451 ± 0.055	4.986SerVal: 4.986 ± 0.081	0.794SerTrp: 0.794 ± 0.025	2.014SerTyr: 2.014 ± 0.044	0.004SerXaa: 0.004 ± 0.002
Thr	4.201ThrAla: 4.201 ± 0.066	0.451ThrCys: 0.451 ± 0.023	2.642ThrAsp: 2.642 ± 0.056	3.216ThrGlu: 3.216 ± 0.06	1.961ThrPhe: 1.961 ± 0.044	3.809ThrGly: 3.809 ± 0.067	1.093ThrHis: 1.093 ± 0.035	3.015ThrIle: 3.015 ± 0.053	2.245ThrLys: 2.245 ± 0.047	5.705ThrLeu: 5.705 ± 0.07	1.136ThrMet: 1.136 ± 0.035	1.911ThrAsn: 1.911 ± 0.041	2.506ThrPro: 2.506 ± 0.056	2.058ThrGln: 2.058 ± 0.048	2.371ThrArg: 2.371 ± 0.046	3.322ThrSer: 3.322 ± 0.066	2.553ThrThr: 2.553 ± 0.053	3.497ThrVal: 3.497 ± 0.073	0.516ThrTrp: 0.516 ± 0.025	1.496ThrTyr: 1.496 ± 0.05	0.002ThrXaa: 0.002 ± 0.001
Val	6.446ValAla: 6.446 ± 0.093	0.814ValCys: 0.814 ± 0.028	4.476ValAsp: 4.476 ± 0.074	4.72ValGlu: 4.72 ± 0.072	3.127ValPhe: 3.127 ± 0.06	4.598ValGly: 4.598 ± 0.074	1.442ValHis: 1.442 ± 0.041	4.393ValIle: 4.393 ± 0.078	3.209ValLys: 3.209 ± 0.058	7.114ValLeu: 7.114 ± 0.078	1.782ValMet: 1.782 ± 0.042	2.784ValAsn: 2.784 ± 0.055	2.646ValPro: 2.646 ± 0.06	2.332ValGln: 2.332 ± 0.046	3.44ValArg: 3.44 ± 0.052	5.244ValSer: 5.244 ± 0.071	3.652ValThr: 3.652 ± 0.069	5.46ValVal: 5.46 ± 0.08	0.731ValTrp: 0.731 ± 0.029	1.861ValTyr: 1.861 ± 0.045	0.002ValXaa: 0.002 ± 0.001
Trp	0.8TrpAla: 0.8 ± 0.032	0.138TrpCys: 0.138 ± 0.011	0.582TrpAsp: 0.582 ± 0.024	0.635TrpGlu: 0.635 ± 0.026	0.593TrpPhe: 0.593 ± 0.025	0.719TrpGly: 0.719 ± 0.028	0.259TrpHis: 0.259 ± 0.017	0.585TrpIle: 0.585 ± 0.023	0.473TrpLys: 0.473 ± 0.024	1.452TrpLeu: 1.452 ± 0.042	0.307TrpMet: 0.307 ± 0.015	0.377TrpAsn: 0.377 ± 0.021	0.433TrpPro: 0.433 ± 0.019	0.594TrpGln: 0.594 ± 0.023	0.665TrpArg: 0.665 ± 0.027	0.825TrpSer: 0.825 ± 0.032	0.509TrpThr: 0.509 ± 0.02	0.786TrpVal: 0.786 ± 0.028	0.165TrpTrp: 0.165 ± 0.014	0.306TrpTyr: 0.306 ± 0.017	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.417TyrAla: 2.417 ± 0.052	0.323TyrCys: 0.323 ± 0.017	1.773TyrAsp: 1.773 ± 0.046	1.892TyrGlu: 1.892 ± 0.053	1.358TyrPhe: 1.358 ± 0.037	2.039TyrGly: 2.039 ± 0.044	0.669TyrHis: 0.669 ± 0.03	1.502TyrIle: 1.502 ± 0.039	1.299TyrLys: 1.299 ± 0.037	3.162TyrLeu: 3.162 ± 0.064	0.542TyrMet: 0.542 ± 0.025	0.978TyrAsn: 0.978 ± 0.033	1.258TyrPro: 1.258 ± 0.037	1.409TyrGln: 1.409 ± 0.035	1.705TyrArg: 1.705 ± 0.045	2.064TyrSer: 2.064 ± 0.047	1.459TyrThr: 1.459 ± 0.039	1.885TyrVal: 1.885 ± 0.043	0.444TyrTrp: 0.444 ± 0.024	0.91TyrTyr: 0.91 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.003XaaAsp: 0.003 ± 0.002	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.003XaaGly: 0.003 ± 0.002	0.002XaaHis: 0.002 ± 0.001	0.003XaaIle: 0.003 ± 0.002	0.002XaaLys: 0.002 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.002XaaAsn: 0.002 ± 0.001	0.003XaaPro: 0.003 ± 0.002	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.003XaaSer: 0.003 ± 0.002	0.001XaaThr: 0.001 ± 0.001	0.003XaaVal: 0.003 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3311 proteins (1015081 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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