Amino acid dipepetide frequency for Cohaesibacter gelatinilyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.601AlaAla: 10.601 ± 0.116	1.031AlaCys: 1.031 ± 0.026	5.845AlaAsp: 5.845 ± 0.121	6.112AlaGlu: 6.112 ± 0.077	4.28AlaPhe: 4.28 ± 0.053	8.031AlaGly: 8.031 ± 0.135	2.041AlaHis: 2.041 ± 0.038	6.538AlaIle: 6.538 ± 0.076	5.175AlaLys: 5.175 ± 0.063	11.167AlaLeu: 11.167 ± 0.105	3.201AlaMet: 3.201 ± 0.054	3.419AlaAsn: 3.419 ± 0.058	3.807AlaPro: 3.807 ± 0.066	3.771AlaGln: 3.771 ± 0.055	5.383AlaArg: 5.383 ± 0.076	6.468AlaSer: 6.468 ± 0.071	4.846AlaThr: 4.846 ± 0.064	6.426AlaVal: 6.426 ± 0.084	1.089AlaTrp: 1.089 ± 0.029	2.444AlaTyr: 2.444 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.923CysAla: 0.923 ± 0.027	0.146CysCys: 0.146 ± 0.01	0.611CysAsp: 0.611 ± 0.023	0.568CysGlu: 0.568 ± 0.02	0.401CysPhe: 0.401 ± 0.02	0.915CysGly: 0.915 ± 0.027	0.311CysHis: 0.311 ± 0.018	0.512CysIle: 0.512 ± 0.021	0.368CysLys: 0.368 ± 0.017	1.11CysLeu: 1.11 ± 0.028	0.217CysMet: 0.217 ± 0.012	0.321CysAsn: 0.321 ± 0.014	0.493CysPro: 0.493 ± 0.021	0.338CysGln: 0.338 ± 0.016	0.504CysArg: 0.504 ± 0.021	0.617CysSer: 0.617 ± 0.02	0.447CysThr: 0.447 ± 0.016	0.587CysVal: 0.587 ± 0.022	0.119CysTrp: 0.119 ± 0.009	0.254CysTyr: 0.254 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.615AspAla: 5.615 ± 0.09	0.644AspCys: 0.644 ± 0.024	3.436AspAsp: 3.436 ± 0.106	3.972AspGlu: 3.972 ± 0.058	2.517AspPhe: 2.517 ± 0.042	5.024AspGly: 5.024 ± 0.137	1.556AspHis: 1.556 ± 0.035	3.873AspIle: 3.873 ± 0.058	2.669AspLys: 2.669 ± 0.047	6.61AspLeu: 6.61 ± 0.077	1.762AspMet: 1.762 ± 0.039	1.811AspAsn: 1.811 ± 0.043	2.88AspPro: 2.88 ± 0.05	2.523AspGln: 2.523 ± 0.042	3.404AspArg: 3.404 ± 0.054	2.49AspSer: 2.49 ± 0.059	2.446AspThr: 2.446 ± 0.191	3.972AspVal: 3.972 ± 0.064	0.966AspTrp: 0.966 ± 0.024	1.806AspTyr: 1.806 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	6.922GluAla: 6.922 ± 0.092	0.452GluCys: 0.452 ± 0.02	3.415GluAsp: 3.415 ± 0.05	4.338GluGlu: 4.338 ± 0.068	1.998GluPhe: 1.998 ± 0.038	4.325GluGly: 4.325 ± 0.071	1.225GluHis: 1.225 ± 0.031	4.095GluIle: 4.095 ± 0.059	3.353GluLys: 3.353 ± 0.057	5.94GluLeu: 5.94 ± 0.074	1.765GluMet: 1.765 ± 0.037	2.323GluAsn: 2.323 ± 0.055	2.373GluPro: 2.373 ± 0.042	2.894GluGln: 2.894 ± 0.051	3.901GluArg: 3.901 ± 0.065	2.606GluSer: 2.606 ± 0.048	3.436GluThr: 3.436 ± 0.048	3.829GluVal: 3.829 ± 0.062	0.658GluTrp: 0.658 ± 0.022	0.998GluTyr: 0.998 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.207PheAla: 4.207 ± 0.055	0.505PheCys: 0.505 ± 0.019	2.843PheAsp: 2.843 ± 0.04	2.551PheGlu: 2.551 ± 0.04	1.718PhePhe: 1.718 ± 0.039	3.655PheGly: 3.655 ± 0.054	0.813PheHis: 0.813 ± 0.026	2.131PheIle: 2.131 ± 0.046	1.553PheLys: 1.553 ± 0.038	3.857PheLeu: 3.857 ± 0.056	1.008PheMet: 1.008 ± 0.028	1.307PheAsn: 1.307 ± 0.033	1.54PhePro: 1.54 ± 0.038	1.147PheGln: 1.147 ± 0.029	1.888PheArg: 1.888 ± 0.037	2.841PheSer: 2.841 ± 0.051	2.015PheThr: 2.015 ± 0.034	2.871PheVal: 2.871 ± 0.049	0.577PheTrp: 0.577 ± 0.019	1.062PheTyr: 1.062 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.259GlyAla: 7.259 ± 0.138	0.83GlyCys: 0.83 ± 0.023	4.366GlyAsp: 4.366 ± 0.213	4.573GlyGlu: 4.573 ± 0.059	3.628GlyPhe: 3.628 ± 0.055	6.274GlyGly: 6.274 ± 0.262	1.786GlyHis: 1.786 ± 0.036	4.763GlyIle: 4.763 ± 0.06	4.21GlyLys: 4.21 ± 0.059	8.504GlyLeu: 8.504 ± 0.089	2.301GlyMet: 2.301 ± 0.044	2.542GlyAsn: 2.542 ± 0.092	2.78GlyPro: 2.78 ± 0.053	3.159GlyGln: 3.159 ± 0.052	4.229GlyArg: 4.229 ± 0.063	4.926GlySer: 4.926 ± 0.131	4.069GlyThr: 4.069 ± 0.078	5.36GlyVal: 5.36 ± 0.066	1.182GlyTrp: 1.182 ± 0.028	2.362GlyTyr: 2.362 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.909HisAla: 1.909 ± 0.037	0.276HisCys: 0.276 ± 0.015	1.299HisAsp: 1.299 ± 0.035	1.207HisGlu: 1.207 ± 0.027	1.033HisPhe: 1.033 ± 0.027	1.784HisGly: 1.784 ± 0.037	0.655HisHis: 0.655 ± 0.028	1.319HisIle: 1.319 ± 0.029	0.859HisLys: 0.859 ± 0.024	2.221HisLeu: 2.221 ± 0.039	0.607HisMet: 0.607 ± 0.018	0.641HisAsn: 0.641 ± 0.021	1.221HisPro: 1.221 ± 0.029	0.76HisGln: 0.76 ± 0.022	1.154HisArg: 1.154 ± 0.03	1.253HisSer: 1.253 ± 0.032	0.832HisThr: 0.832 ± 0.026	1.429HisVal: 1.429 ± 0.034	0.372HisTrp: 0.372 ± 0.013	0.657HisTyr: 0.657 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.026IleAla: 7.026 ± 0.078	0.729IleCys: 0.729 ± 0.024	3.919IleAsp: 3.919 ± 0.047	4.19IleGlu: 4.19 ± 0.074	2.351IlePhe: 2.351 ± 0.047	5.28IleGly: 5.28 ± 0.09	1.119IleHis: 1.119 ± 0.029	3.261IleIle: 3.261 ± 0.056	2.562IleLys: 2.562 ± 0.046	6.233IleLeu: 6.233 ± 0.081	1.365IleMet: 1.365 ± 0.034	1.98IleAsn: 1.98 ± 0.04	2.657IlePro: 2.657 ± 0.047	1.78IleGln: 1.78 ± 0.038	3.166IleArg: 3.166 ± 0.047	4.235IleSer: 4.235 ± 0.055	3.242IleThr: 3.242 ± 0.046	4.075IleVal: 4.075 ± 0.055	0.821IleTrp: 0.821 ± 0.023	1.432IleTyr: 1.432 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	5.495LysAla: 5.495 ± 0.08	0.282LysCys: 0.282 ± 0.015	3.004LysAsp: 3.004 ± 0.052	2.824LysGlu: 2.824 ± 0.047	1.321LysPhe: 1.321 ± 0.036	3.608LysGly: 3.608 ± 0.058	0.945LysHis: 0.945 ± 0.028	2.818LysIle: 2.818 ± 0.046	2.492LysLys: 2.492 ± 0.055	4.522LysLeu: 4.522 ± 0.068	1.265LysMet: 1.265 ± 0.032	1.535LysAsn: 1.535 ± 0.031	2.391LysPro: 2.391 ± 0.051	1.859LysGln: 1.859 ± 0.042	2.873LysArg: 2.873 ± 0.049	3.071LysSer: 3.071 ± 0.051	2.58LysThr: 2.58 ± 0.051	3.059LysVal: 3.059 ± 0.046	0.523LysTrp: 0.523 ± 0.02	0.895LysTyr: 0.895 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	11.223LeuAla: 11.223 ± 0.106	1.012LeuCys: 1.012 ± 0.027	6.167LeuAsp: 6.167 ± 0.074	5.962LeuGlu: 5.962 ± 0.08	4.152LeuPhe: 4.152 ± 0.066	7.838LeuGly: 7.838 ± 0.082	1.977LeuHis: 1.977 ± 0.04	6.272LeuIle: 6.272 ± 0.087	4.824LeuLys: 4.824 ± 0.06	9.612LeuLeu: 9.612 ± 0.115	2.726LeuMet: 2.726 ± 0.051	3.373LeuAsn: 3.373 ± 0.05	4.938LeuPro: 4.938 ± 0.068	3.279LeuGln: 3.279 ± 0.049	5.254LeuArg: 5.254 ± 0.061	7.798LeuSer: 7.798 ± 0.08	5.674LeuThr: 5.674 ± 0.073	6.915LeuVal: 6.915 ± 0.073	1.103LeuTrp: 1.103 ± 0.031	2.304LeuTyr: 2.304 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.114MetAla: 3.114 ± 0.046	0.197MetCys: 0.197 ± 0.011	1.533MetAsp: 1.533 ± 0.032	1.505MetGlu: 1.505 ± 0.037	0.842MetPhe: 0.842 ± 0.027	2.114MetGly: 2.114 ± 0.042	0.496MetHis: 0.496 ± 0.017	1.776MetIle: 1.776 ± 0.041	1.39MetLys: 1.39 ± 0.036	2.645MetLeu: 2.645 ± 0.046	0.846MetMet: 0.846 ± 0.024	0.946MetAsn: 0.946 ± 0.025	1.466MetPro: 1.466 ± 0.035	1.05MetGln: 1.05 ± 0.025	1.638MetArg: 1.638 ± 0.036	2.044MetSer: 2.044 ± 0.045	1.832MetThr: 1.832 ± 0.036	1.934MetVal: 1.934 ± 0.039	0.193MetTrp: 0.193 ± 0.012	0.311MetTyr: 0.311 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.318AsnAla: 3.318 ± 0.056	0.384AsnCys: 0.384 ± 0.017	1.991AsnAsp: 1.991 ± 0.078	1.897AsnGlu: 1.897 ± 0.032	1.256AsnPhe: 1.256 ± 0.028	2.945AsnGly: 2.945 ± 0.063	0.78AsnHis: 0.78 ± 0.023	2.039AsnIle: 2.039 ± 0.041	1.46AsnLys: 1.46 ± 0.031	3.477AsnLeu: 3.477 ± 0.07	0.905AsnMet: 0.905 ± 0.024	1.15AsnAsn: 1.15 ± 0.03	2.01AsnPro: 2.01 ± 0.045	1.288AsnGln: 1.288 ± 0.029	1.955AsnArg: 1.955 ± 0.039	2.006AsnSer: 2.006 ± 0.042	1.414AsnThr: 1.414 ± 0.033	2.139AsnVal: 2.139 ± 0.052	0.558AsnTrp: 0.558 ± 0.021	0.852AsnTyr: 0.852 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	4.098ProAla: 4.098 ± 0.066	0.346ProCys: 0.346 ± 0.014	3.369ProAsp: 3.369 ± 0.053	3.059ProGlu: 3.059 ± 0.051	1.922ProPhe: 1.922 ± 0.036	3.177ProGly: 3.177 ± 0.052	1.005ProHis: 1.005 ± 0.027	2.625ProIle: 2.625 ± 0.046	2.168ProLys: 2.168 ± 0.046	4.098ProLeu: 4.098 ± 0.059	1.121ProMet: 1.121 ± 0.032	1.631ProAsn: 1.631 ± 0.034	1.594ProPro: 1.594 ± 0.04	1.645ProGln: 1.645 ± 0.034	1.933ProArg: 1.933 ± 0.048	2.935ProSer: 2.935 ± 0.059	2.304ProThr: 2.304 ± 0.043	3.478ProVal: 3.478 ± 0.053	0.527ProTrp: 0.527 ± 0.02	1.143ProTyr: 1.143 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.99GlnAla: 3.99 ± 0.057	0.284GlnCys: 0.284 ± 0.015	2.135GlnAsp: 2.135 ± 0.042	2.075GlnGlu: 2.075 ± 0.04	1.272GlnPhe: 1.272 ± 0.026	2.651GlnGly: 2.651 ± 0.045	0.749GlnHis: 0.749 ± 0.022	2.586GlnIle: 2.586 ± 0.042	1.862GlnLys: 1.862 ± 0.039	3.404GlnLeu: 3.404 ± 0.05	1.184GlnMet: 1.184 ± 0.031	1.299GlnAsn: 1.299 ± 0.031	1.57GlnPro: 1.57 ± 0.035	1.586GlnGln: 1.586 ± 0.04	2.09GlnArg: 2.09 ± 0.041	2.776GlnSer: 2.776 ± 0.046	2.207GlnThr: 2.207 ± 0.041	2.335GlnVal: 2.335 ± 0.045	0.442GlnTrp: 0.442 ± 0.017	0.712GlnTyr: 0.712 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	4.967ArgAla: 4.967 ± 0.067	0.444ArgCys: 0.444 ± 0.02	3.151ArgAsp: 3.151 ± 0.05	3.271ArgGlu: 3.271 ± 0.059	2.421ArgPhe: 2.421 ± 0.043	3.342ArgGly: 3.342 ± 0.059	1.335ArgHis: 1.335 ± 0.036	3.321ArgIle: 3.321 ± 0.05	2.839ArgLys: 2.839 ± 0.054	6.055ArgLeu: 6.055 ± 0.078	1.576ArgMet: 1.576 ± 0.032	1.945ArgAsn: 1.945 ± 0.043	2.373ArgPro: 2.373 ± 0.048	2.41ArgGln: 2.41 ± 0.044	3.312ArgArg: 3.312 ± 0.061	3.459ArgSer: 3.459 ± 0.055	2.541ArgThr: 2.541 ± 0.051	3.496ArgVal: 3.496 ± 0.051	0.713ArgTrp: 0.713 ± 0.023	1.511ArgTyr: 1.511 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.887SerAla: 5.887 ± 0.076	0.617SerCys: 0.617 ± 0.024	4.085SerAsp: 4.085 ± 0.07	3.85SerGlu: 3.85 ± 0.054	2.766SerPhe: 2.766 ± 0.048	5.628SerGly: 5.628 ± 0.108	1.446SerHis: 1.446 ± 0.035	3.871SerIle: 3.871 ± 0.054	2.941SerLys: 2.941 ± 0.05	6.776SerLeu: 6.776 ± 0.077	1.772SerMet: 1.772 ± 0.032	2.372SerAsn: 2.372 ± 0.045	2.631SerPro: 2.631 ± 0.051	2.298SerGln: 2.298 ± 0.043	3.323SerArg: 3.323 ± 0.054	4.243SerSer: 4.243 ± 0.072	2.851SerThr: 2.851 ± 0.046	4.245SerVal: 4.245 ± 0.053	0.83SerTrp: 0.83 ± 0.025	1.676SerTyr: 1.676 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	4.905ThrAla: 4.905 ± 0.062	0.477ThrCys: 0.477 ± 0.02	2.796ThrAsp: 2.796 ± 0.055	2.709ThrGlu: 2.709 ± 0.042	2.042ThrPhe: 2.042 ± 0.04	4.613ThrGly: 4.613 ± 0.121	1.082ThrHis: 1.082 ± 0.028	3.436ThrIle: 3.436 ± 0.052	2.199ThrLys: 2.199 ± 0.042	5.461ThrLeu: 5.461 ± 0.126	1.323ThrMet: 1.323 ± 0.032	1.839ThrAsn: 1.839 ± 0.036	2.694ThrPro: 2.694 ± 0.044	1.651ThrGln: 1.651 ± 0.033	2.608ThrArg: 2.608 ± 0.042	3.294ThrSer: 3.294 ± 0.047	2.596ThrThr: 2.596 ± 0.049	3.347ThrVal: 3.347 ± 0.057	0.576ThrTrp: 0.576 ± 0.02	1.262ThrTyr: 1.262 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	6.898ValAla: 6.898 ± 0.084	0.654ValCys: 0.654 ± 0.025	3.767ValAsp: 3.767 ± 0.063	4.184ValGlu: 4.184 ± 0.055	2.566ValPhe: 2.566 ± 0.051	4.954ValGly: 4.954 ± 0.061	1.253ValHis: 1.253 ± 0.029	4.246ValIle: 4.246 ± 0.057	2.917ValLys: 2.917 ± 0.055	6.545ValLeu: 6.545 ± 0.073	1.986ValMet: 1.986 ± 0.04	2.154ValAsn: 2.154 ± 0.054	3.045ValPro: 3.045 ± 0.049	2.155ValGln: 2.155 ± 0.04	3.63ValArg: 3.63 ± 0.056	4.634ValSer: 4.634 ± 0.064	3.951ValThr: 3.951 ± 0.056	4.765ValVal: 4.765 ± 0.065	0.811ValTrp: 0.811 ± 0.021	1.445ValTyr: 1.445 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.04TrpAla: 1.04 ± 0.027	0.141TrpCys: 0.141 ± 0.009	0.699TrpAsp: 0.699 ± 0.021	0.585TrpGlu: 0.585 ± 0.02	0.574TrpPhe: 0.574 ± 0.022	0.884TrpGly: 0.884 ± 0.026	0.312TrpHis: 0.312 ± 0.013	0.757TrpIle: 0.757 ± 0.025	0.542TrpLys: 0.542 ± 0.021	1.573TrpLeu: 1.573 ± 0.036	0.396TrpMet: 0.396 ± 0.016	0.489TrpAsn: 0.489 ± 0.017	0.621TrpPro: 0.621 ± 0.02	0.615TrpGln: 0.615 ± 0.02	0.729TrpArg: 0.729 ± 0.021	0.852TrpSer: 0.852 ± 0.028	0.618TrpThr: 0.618 ± 0.02	0.749TrpVal: 0.749 ± 0.022	0.185TrpTrp: 0.185 ± 0.01	0.289TrpTyr: 0.289 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.278TyrAla: 2.278 ± 0.04	0.311TyrCys: 0.311 ± 0.016	1.548TyrAsp: 1.548 ± 0.035	1.413TyrGlu: 1.413 ± 0.027	1.028TyrPhe: 1.028 ± 0.025	2.062TyrGly: 2.062 ± 0.036	0.604TyrHis: 0.604 ± 0.019	1.184TyrIle: 1.184 ± 0.026	0.978TyrLys: 0.978 ± 0.025	2.592TyrLeu: 2.592 ± 0.045	0.546TyrMet: 0.546 ± 0.022	0.748TyrAsn: 0.748 ± 0.024	1.094TyrPro: 1.094 ± 0.022	0.998TyrGln: 0.998 ± 0.027	1.508TyrArg: 1.508 ± 0.036	1.559TyrSer: 1.559 ± 0.047	1.009TyrThr: 1.009 ± 0.029	1.549TyrVal: 1.549 ± 0.03	0.405TyrTrp: 0.405 ± 0.018	0.669TyrTyr: 0.669 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4776 proteins (1509822 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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