Amino acid dipepetide frequency for Salmonella virus BTP1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.808AlaAla: 9.808 ± 1.35
1.226AlaCys: 1.226 ± 0.37
6.13AlaAsp: 6.13 ± 0.755
6.866AlaGlu: 6.866 ± 0.979
2.615AlaPhe: 2.615 ± 0.464
6.702AlaGly: 6.702 ± 1.077
1.226AlaHis: 1.226 ± 0.309
6.212AlaIle: 6.212 ± 0.893
4.087AlaLys: 4.087 ± 0.622
6.702AlaLeu: 6.702 ± 1.006
4.168AlaMet: 4.168 ± 0.631
4.822AlaAsn: 4.822 ± 0.758
2.452AlaPro: 2.452 ± 0.349
3.678AlaGln: 3.678 ± 0.645
4.986AlaArg: 4.986 ± 0.697
6.048AlaSer: 6.048 ± 0.663
5.476AlaThr: 5.476 ± 0.865
5.476AlaVal: 5.476 ± 0.545
1.798AlaTrp: 1.798 ± 0.403
2.289AlaTyr: 2.289 ± 0.507
0.0AlaXaa: 0.0 ± 0.0
Cys
0.899CysAla: 0.899 ± 0.335
0.163CysCys: 0.163 ± 0.108
0.327CysAsp: 0.327 ± 0.184
0.654CysGlu: 0.654 ± 0.255
0.49CysPhe: 0.49 ± 0.19
1.226CysGly: 1.226 ± 0.302
0.49CysHis: 0.49 ± 0.22
0.736CysIle: 0.736 ± 0.296
1.144CysLys: 1.144 ± 0.402
0.409CysLeu: 0.409 ± 0.211
0.327CysMet: 0.327 ± 0.182
0.654CysAsn: 0.654 ± 0.228
0.409CysPro: 0.409 ± 0.174
0.49CysGln: 0.49 ± 0.179
0.981CysArg: 0.981 ± 0.275
0.817CysSer: 0.817 ± 0.277
0.572CysThr: 0.572 ± 0.197
0.899CysVal: 0.899 ± 0.245
0.163CysTrp: 0.163 ± 0.117
0.409CysTyr: 0.409 ± 0.198
0.0CysXaa: 0.0 ± 0.0
Asp
6.212AspAla: 6.212 ± 0.703
0.572AspCys: 0.572 ± 0.272
4.659AspAsp: 4.659 ± 0.738
4.414AspGlu: 4.414 ± 0.743
2.452AspPhe: 2.452 ± 0.504
5.966AspGly: 5.966 ± 0.855
0.899AspHis: 0.899 ± 0.3
4.332AspIle: 4.332 ± 0.528
3.678AspLys: 3.678 ± 0.473
4.332AspLeu: 4.332 ± 0.559
1.553AspMet: 1.553 ± 0.42
2.207AspAsn: 2.207 ± 0.428
1.635AspPro: 1.635 ± 0.474
1.471AspGln: 1.471 ± 0.353
1.962AspArg: 1.962 ± 0.415
2.452AspSer: 2.452 ± 0.426
2.125AspThr: 2.125 ± 0.396
5.067AspVal: 5.067 ± 0.613
1.389AspTrp: 1.389 ± 0.358
3.188AspTyr: 3.188 ± 0.544
0.0AspXaa: 0.0 ± 0.0
Glu
6.048GluAla: 6.048 ± 0.742
1.308GluCys: 1.308 ± 0.409
2.861GluAsp: 2.861 ± 0.444
4.495GluGlu: 4.495 ± 0.809
2.289GluPhe: 2.289 ± 0.483
3.269GluGly: 3.269 ± 0.507
1.144GluHis: 1.144 ± 0.356
3.76GluIle: 3.76 ± 0.576
4.005GluLys: 4.005 ± 0.643
4.986GluLeu: 4.986 ± 0.609
2.37GluMet: 2.37 ± 0.503
2.37GluAsn: 2.37 ± 0.543
2.452GluPro: 2.452 ± 0.48
3.841GluGln: 3.841 ± 0.493
3.841GluArg: 3.841 ± 0.77
4.005GluSer: 4.005 ± 0.605
2.289GluThr: 2.289 ± 0.332
3.596GluVal: 3.596 ± 0.646
1.88GluTrp: 1.88 ± 0.45
2.289GluTyr: 2.289 ± 0.382
0.0GluXaa: 0.0 ± 0.0
Phe
2.779PheAla: 2.779 ± 0.522
0.49PheCys: 0.49 ± 0.254
2.125PheAsp: 2.125 ± 0.403
1.553PheGlu: 1.553 ± 0.324
1.308PhePhe: 1.308 ± 0.441
2.37PheGly: 2.37 ± 0.405
0.409PheHis: 0.409 ± 0.174
1.798PheIle: 1.798 ± 0.35
2.043PheLys: 2.043 ± 0.375
1.553PheLeu: 1.553 ± 0.281
0.817PheMet: 0.817 ± 0.204
1.471PheAsn: 1.471 ± 0.331
1.389PhePro: 1.389 ± 0.334
1.389PheGln: 1.389 ± 0.388
1.716PheArg: 1.716 ± 0.462
2.779PheSer: 2.779 ± 0.474
2.37PheThr: 2.37 ± 0.552
2.043PheVal: 2.043 ± 0.41
0.736PheTrp: 0.736 ± 0.23
1.144PheTyr: 1.144 ± 0.367
0.0PheXaa: 0.0 ± 0.0
Gly
5.394GlyAla: 5.394 ± 0.743
0.736GlyCys: 0.736 ± 0.226
3.515GlyAsp: 3.515 ± 0.504
3.76GlyGlu: 3.76 ± 0.457
2.697GlyPhe: 2.697 ± 0.423
4.495GlyGly: 4.495 ± 0.831
1.308GlyHis: 1.308 ± 0.337
5.721GlyIle: 5.721 ± 0.716
4.495GlyLys: 4.495 ± 0.554
4.822GlyLeu: 4.822 ± 0.717
2.207GlyMet: 2.207 ± 0.574
3.841GlyAsn: 3.841 ± 0.551
1.389GlyPro: 1.389 ± 0.294
4.168GlyGln: 4.168 ± 0.929
4.414GlyArg: 4.414 ± 0.714
4.986GlySer: 4.986 ± 1.13
4.005GlyThr: 4.005 ± 0.733
5.558GlyVal: 5.558 ± 0.683
1.716GlyTrp: 1.716 ± 0.415
2.37GlyTyr: 2.37 ± 0.457
0.0GlyXaa: 0.0 ± 0.0
His
1.308HisAla: 1.308 ± 0.377
0.409HisCys: 0.409 ± 0.161
1.226HisAsp: 1.226 ± 0.326
1.144HisGlu: 1.144 ± 0.36
0.736HisPhe: 0.736 ± 0.234
1.716HisGly: 1.716 ± 0.552
0.572HisHis: 0.572 ± 0.279
0.572HisIle: 0.572 ± 0.226
0.654HisLys: 0.654 ± 0.262
2.125HisLeu: 2.125 ± 0.531
0.572HisMet: 0.572 ± 0.229
0.245HisAsn: 0.245 ± 0.134
0.981HisPro: 0.981 ± 0.29
0.572HisGln: 0.572 ± 0.246
0.899HisArg: 0.899 ± 0.28
0.981HisSer: 0.981 ± 0.243
0.736HisThr: 0.736 ± 0.278
0.981HisVal: 0.981 ± 0.226
0.245HisTrp: 0.245 ± 0.11
0.899HisTyr: 0.899 ± 0.285
0.0HisXaa: 0.0 ± 0.0
Ile
6.62IleAla: 6.62 ± 0.766
0.736IleCys: 0.736 ± 0.253
4.904IleAsp: 4.904 ± 0.618
4.414IleGlu: 4.414 ± 0.554
2.125IlePhe: 2.125 ± 0.52
4.414IleGly: 4.414 ± 0.787
0.981IleHis: 0.981 ± 0.312
4.332IleIle: 4.332 ± 0.83
3.678IleLys: 3.678 ± 0.68
3.515IleLeu: 3.515 ± 0.779
1.226IleMet: 1.226 ± 0.339
3.024IleAsn: 3.024 ± 0.51
3.106IlePro: 3.106 ± 0.507
2.534IleGln: 2.534 ± 0.536
4.332IleArg: 4.332 ± 0.571
4.414IleSer: 4.414 ± 0.699
3.923IleThr: 3.923 ± 0.568
3.596IleVal: 3.596 ± 0.642
0.572IleTrp: 0.572 ± 0.185
1.716IleTyr: 1.716 ± 0.332
0.0IleXaa: 0.0 ± 0.0
Lys
6.293LysAla: 6.293 ± 0.854
0.49LysCys: 0.49 ± 0.186
3.596LysAsp: 3.596 ± 0.476
4.005LysGlu: 4.005 ± 0.727
1.471LysPhe: 1.471 ± 0.468
3.351LysGly: 3.351 ± 0.551
0.736LysHis: 0.736 ± 0.242
3.515LysIle: 3.515 ± 0.435
3.923LysLys: 3.923 ± 0.574
4.986LysLeu: 4.986 ± 0.698
1.308LysMet: 1.308 ± 0.362
2.534LysAsn: 2.534 ± 0.401
3.351LysPro: 3.351 ± 0.642
3.269LysGln: 3.269 ± 0.605
4.659LysArg: 4.659 ± 0.617
3.76LysSer: 3.76 ± 0.591
4.087LysThr: 4.087 ± 0.736
3.269LysVal: 3.269 ± 0.518
0.654LysTrp: 0.654 ± 0.27
2.207LysTyr: 2.207 ± 0.48
0.0LysXaa: 0.0 ± 0.0
Leu
7.683LeuAla: 7.683 ± 0.79
0.899LeuCys: 0.899 ± 0.236
4.25LeuAsp: 4.25 ± 0.602
4.986LeuGlu: 4.986 ± 0.652
1.471LeuPhe: 1.471 ± 0.335
4.332LeuGly: 4.332 ± 0.8
1.144LeuHis: 1.144 ± 0.244
4.414LeuIle: 4.414 ± 0.714
4.74LeuLys: 4.74 ± 0.586
6.375LeuLeu: 6.375 ± 0.714
2.043LeuMet: 2.043 ± 0.401
4.087LeuAsn: 4.087 ± 0.761
2.861LeuPro: 2.861 ± 0.504
3.433LeuGln: 3.433 ± 0.628
4.986LeuArg: 4.986 ± 0.565
6.13LeuSer: 6.13 ± 0.684
4.414LeuThr: 4.414 ± 0.601
3.269LeuVal: 3.269 ± 0.516
1.226LeuTrp: 1.226 ± 0.414
2.37LeuTyr: 2.37 ± 0.383
0.0LeuXaa: 0.0 ± 0.0
Met
3.106MetAla: 3.106 ± 0.532
0.409MetCys: 0.409 ± 0.217
1.144MetAsp: 1.144 ± 0.305
1.389MetGlu: 1.389 ± 0.307
0.572MetPhe: 0.572 ± 0.24
2.289MetGly: 2.289 ± 0.444
0.245MetHis: 0.245 ± 0.155
1.308MetIle: 1.308 ± 0.431
2.207MetLys: 2.207 ± 0.474
2.207MetLeu: 2.207 ± 0.443
0.899MetMet: 0.899 ± 0.291
1.226MetAsn: 1.226 ± 0.351
0.572MetPro: 0.572 ± 0.186
1.88MetGln: 1.88 ± 0.46
1.798MetArg: 1.798 ± 0.364
2.452MetSer: 2.452 ± 0.435
2.043MetThr: 2.043 ± 0.382
1.308MetVal: 1.308 ± 0.348
0.082MetTrp: 0.082 ± 0.095
0.899MetTyr: 0.899 ± 0.287
0.0MetXaa: 0.0 ± 0.0
Asn
5.558AsnAla: 5.558 ± 0.813
0.327AsnCys: 0.327 ± 0.176
2.697AsnAsp: 2.697 ± 0.358
2.779AsnGlu: 2.779 ± 0.51
0.572AsnPhe: 0.572 ± 0.179
3.678AsnGly: 3.678 ± 0.779
1.308AsnHis: 1.308 ± 0.394
2.861AsnIle: 2.861 ± 0.426
2.942AsnLys: 2.942 ± 0.374
3.106AsnLeu: 3.106 ± 0.49
1.389AsnMet: 1.389 ± 0.28
1.716AsnAsn: 1.716 ± 0.307
2.043AsnPro: 2.043 ± 0.334
2.942AsnGln: 2.942 ± 0.585
2.289AsnArg: 2.289 ± 0.43
2.289AsnSer: 2.289 ± 0.405
2.534AsnThr: 2.534 ± 0.483
3.106AsnVal: 3.106 ± 0.7
0.736AsnTrp: 0.736 ± 0.219
1.553AsnTyr: 1.553 ± 0.358
0.0AsnXaa: 0.0 ± 0.0
Pro
3.106ProAla: 3.106 ± 0.363
0.163ProCys: 0.163 ± 0.115
2.861ProAsp: 2.861 ± 0.477
4.414ProGlu: 4.414 ± 0.585
1.226ProPhe: 1.226 ± 0.348
2.452ProGly: 2.452 ± 0.386
0.817ProHis: 0.817 ± 0.301
2.779ProIle: 2.779 ± 0.456
2.615ProLys: 2.615 ± 0.62
2.043ProLeu: 2.043 ± 0.411
0.736ProMet: 0.736 ± 0.266
1.798ProAsn: 1.798 ± 0.413
1.308ProPro: 1.308 ± 0.394
1.88ProGln: 1.88 ± 0.247
1.88ProArg: 1.88 ± 0.451
2.697ProSer: 2.697 ± 0.424
1.798ProThr: 1.798 ± 0.405
3.188ProVal: 3.188 ± 0.551
0.49ProTrp: 0.49 ± 0.217
1.471ProTyr: 1.471 ± 0.372
0.0ProXaa: 0.0 ± 0.0
Gln
3.269GlnAla: 3.269 ± 0.623
0.49GlnCys: 0.49 ± 0.225
2.534GlnAsp: 2.534 ± 0.525
2.125GlnGlu: 2.125 ± 0.522
1.553GlnPhe: 1.553 ± 0.319
3.188GlnGly: 3.188 ± 0.697
0.817GlnHis: 0.817 ± 0.233
3.188GlnIle: 3.188 ± 0.422
2.534GlnLys: 2.534 ± 0.424
4.822GlnLeu: 4.822 ± 0.598
1.226GlnMet: 1.226 ± 0.373
2.37GlnAsn: 2.37 ± 0.745
2.534GlnPro: 2.534 ± 0.407
3.923GlnGln: 3.923 ± 1.028
3.106GlnArg: 3.106 ± 0.575
2.779GlnSer: 2.779 ± 0.541
1.88GlnThr: 1.88 ± 0.412
2.534GlnVal: 2.534 ± 0.513
0.981GlnTrp: 0.981 ± 0.315
1.471GlnTyr: 1.471 ± 0.403
0.0GlnXaa: 0.0 ± 0.0
Arg
4.168ArgAla: 4.168 ± 0.61
0.49ArgCys: 0.49 ± 0.204
3.841ArgAsp: 3.841 ± 0.637
4.25ArgGlu: 4.25 ± 0.743
1.635ArgPhe: 1.635 ± 0.401
3.269ArgGly: 3.269 ± 0.472
1.88ArgHis: 1.88 ± 0.409
4.087ArgIle: 4.087 ± 0.648
3.841ArgLys: 3.841 ± 0.607
5.721ArgLeu: 5.721 ± 0.75
1.962ArgMet: 1.962 ± 0.41
3.188ArgAsn: 3.188 ± 0.587
1.88ArgPro: 1.88 ± 0.381
2.861ArgGln: 2.861 ± 0.501
4.005ArgArg: 4.005 ± 0.801
3.596ArgSer: 3.596 ± 0.471
2.125ArgThr: 2.125 ± 0.506
3.024ArgVal: 3.024 ± 0.474
1.308ArgTrp: 1.308 ± 0.359
1.88ArgTyr: 1.88 ± 0.451
0.0ArgXaa: 0.0 ± 0.0
Ser
5.231SerAla: 5.231 ± 0.89
0.899SerCys: 0.899 ± 0.244
3.76SerAsp: 3.76 ± 0.626
3.433SerGlu: 3.433 ± 0.571
2.452SerPhe: 2.452 ± 0.434
6.784SerGly: 6.784 ± 0.697
0.899SerHis: 0.899 ± 0.3
4.25SerIle: 4.25 ± 0.596
3.024SerLys: 3.024 ± 0.448
5.313SerLeu: 5.313 ± 0.641
2.125SerMet: 2.125 ± 0.291
2.615SerAsn: 2.615 ± 0.52
3.106SerPro: 3.106 ± 0.419
3.024SerGln: 3.024 ± 0.482
3.515SerArg: 3.515 ± 0.499
3.433SerSer: 3.433 ± 0.65
2.942SerThr: 2.942 ± 0.595
4.495SerVal: 4.495 ± 0.717
0.49SerTrp: 0.49 ± 0.211
2.615SerTyr: 2.615 ± 0.588
0.0SerXaa: 0.0 ± 0.0
Thr
5.313ThrAla: 5.313 ± 0.636
0.572ThrCys: 0.572 ± 0.221
2.207ThrAsp: 2.207 ± 0.395
1.798ThrGlu: 1.798 ± 0.428
2.37ThrPhe: 2.37 ± 0.483
4.495ThrGly: 4.495 ± 0.696
0.899ThrHis: 0.899 ± 0.33
3.515ThrIle: 3.515 ± 0.544
4.168ThrLys: 4.168 ± 0.722
3.841ThrLeu: 3.841 ± 0.486
0.49ThrMet: 0.49 ± 0.159
2.942ThrAsn: 2.942 ± 0.508
3.841ThrPro: 3.841 ± 0.55
2.043ThrGln: 2.043 ± 0.32
2.697ThrArg: 2.697 ± 0.478
2.861ThrSer: 2.861 ± 0.531
2.615ThrThr: 2.615 ± 0.465
3.269ThrVal: 3.269 ± 0.581
0.572ThrTrp: 0.572 ± 0.201
1.88ThrTyr: 1.88 ± 0.265
0.0ThrXaa: 0.0 ± 0.0
Val
5.64ValAla: 5.64 ± 0.688
0.736ValCys: 0.736 ± 0.249
3.596ValAsp: 3.596 ± 0.544
4.005ValGlu: 4.005 ± 0.479
1.88ValPhe: 1.88 ± 0.493
4.414ValGly: 4.414 ± 0.699
0.817ValHis: 0.817 ± 0.275
4.25ValIle: 4.25 ± 0.66
4.495ValLys: 4.495 ± 0.642
4.332ValLeu: 4.332 ± 0.611
1.798ValMet: 1.798 ± 0.372
3.596ValAsn: 3.596 ± 0.675
2.125ValPro: 2.125 ± 0.519
1.716ValGln: 1.716 ± 0.369
2.861ValArg: 2.861 ± 0.471
4.904ValSer: 4.904 ± 0.881
3.596ValThr: 3.596 ± 0.666
3.841ValVal: 3.841 ± 0.631
0.736ValTrp: 0.736 ± 0.264
1.635ValTyr: 1.635 ± 0.489
0.0ValXaa: 0.0 ± 0.0
Trp
1.226TrpAla: 1.226 ± 0.327
0.49TrpCys: 0.49 ± 0.19
1.716TrpAsp: 1.716 ± 0.374
0.572TrpGlu: 0.572 ± 0.253
0.899TrpPhe: 0.899 ± 0.288
0.981TrpGly: 0.981 ± 0.256
0.327TrpHis: 0.327 ± 0.18
0.817TrpIle: 0.817 ± 0.233
1.635TrpLys: 1.635 ± 0.471
1.553TrpLeu: 1.553 ± 0.473
0.245TrpMet: 0.245 ± 0.121
0.409TrpAsn: 0.409 ± 0.166
0.736TrpPro: 0.736 ± 0.284
0.736TrpGln: 0.736 ± 0.223
0.899TrpArg: 0.899 ± 0.28
0.899TrpSer: 0.899 ± 0.344
0.654TrpThr: 0.654 ± 0.219
0.981TrpVal: 0.981 ± 0.281
0.49TrpTrp: 0.49 ± 0.219
0.409TrpTyr: 0.409 ± 0.188
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.106TyrAla: 3.106 ± 0.561
0.654TyrCys: 0.654 ± 0.256
2.615TyrAsp: 2.615 ± 0.472
2.043TyrGlu: 2.043 ± 0.396
1.471TyrPhe: 1.471 ± 0.412
2.207TyrGly: 2.207 ± 0.503
0.654TyrHis: 0.654 ± 0.25
1.716TyrIle: 1.716 ± 0.436
1.635TyrLys: 1.635 ± 0.379
2.37TyrLeu: 2.37 ± 0.401
0.49TyrMet: 0.49 ± 0.156
1.308TyrAsn: 1.308 ± 0.386
1.553TyrPro: 1.553 ± 0.435
1.471TyrGln: 1.471 ± 0.333
3.188TyrArg: 3.188 ± 0.456
2.125TyrSer: 2.125 ± 0.507
2.207TyrThr: 2.207 ± 0.438
1.471TyrVal: 1.471 ± 0.364
0.409TyrTrp: 0.409 ± 0.152
1.471TyrTyr: 1.471 ± 0.327
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 61 proteins (12236 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski