Amino acid dipepetide frequency for Thermosynechococcus elongatus (strain BP-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.769AlaAla: 11.769 ± 0.163
0.998AlaCys: 0.998 ± 0.038
4.254AlaAsp: 4.254 ± 0.095
5.88AlaGlu: 5.88 ± 0.104
3.028AlaPhe: 3.028 ± 0.068
6.498AlaGly: 6.498 ± 0.12
1.878AlaHis: 1.878 ± 0.055
6.849AlaIle: 6.849 ± 0.097
3.493AlaLys: 3.493 ± 0.08
11.704AlaLeu: 11.704 ± 0.168
2.146AlaMet: 2.146 ± 0.053
3.041AlaAsn: 3.041 ± 0.087
4.31AlaPro: 4.31 ± 0.077
5.494AlaGln: 5.494 ± 0.095
5.135AlaArg: 5.135 ± 0.1
4.43AlaSer: 4.43 ± 0.072
5.634AlaThr: 5.634 ± 0.091
7.034AlaVal: 7.034 ± 0.107
1.316AlaTrp: 1.316 ± 0.045
2.804AlaTyr: 2.804 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
0.781CysAla: 0.781 ± 0.032
0.208CysCys: 0.208 ± 0.018
0.624CysAsp: 0.624 ± 0.029
0.524CysGlu: 0.524 ± 0.026
0.434CysPhe: 0.434 ± 0.024
1.133CysGly: 1.133 ± 0.047
0.379CysHis: 0.379 ± 0.021
0.462CysIle: 0.462 ± 0.025
0.238CysLys: 0.238 ± 0.018
1.275CysLeu: 1.275 ± 0.038
0.167CysMet: 0.167 ± 0.018
0.309CysAsn: 0.309 ± 0.018
0.776CysPro: 0.776 ± 0.035
0.768CysGln: 0.768 ± 0.048
0.874CysArg: 0.874 ± 0.035
0.58CysSer: 0.58 ± 0.043
0.515CysThr: 0.515 ± 0.024
0.717CysVal: 0.717 ± 0.032
0.197CysTrp: 0.197 ± 0.018
0.363CysTyr: 0.363 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.694AspAla: 3.694 ± 0.074
0.528AspCys: 0.528 ± 0.026
1.664AspAsp: 1.664 ± 0.054
2.27AspGlu: 2.27 ± 0.07
1.842AspPhe: 1.842 ± 0.054
2.686AspGly: 2.686 ± 0.066
0.981AspHis: 0.981 ± 0.039
2.403AspIle: 2.403 ± 0.059
1.054AspLys: 1.054 ± 0.05
5.865AspLeu: 5.865 ± 0.097
0.622AspMet: 0.622 ± 0.032
1.105AspAsn: 1.105 ± 0.038
3.1AspPro: 3.1 ± 0.071
2.115AspGln: 2.115 ± 0.053
4.999AspArg: 4.999 ± 0.073
1.977AspSer: 1.977 ± 0.05
2.112AspThr: 2.112 ± 0.056
3.018AspVal: 3.018 ± 0.063
0.936AspTrp: 0.936 ± 0.036
1.593AspTyr: 1.593 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
6.124GluAla: 6.124 ± 0.106
0.488GluCys: 0.488 ± 0.024
2.252GluAsp: 2.252 ± 0.054
3.707GluGlu: 3.707 ± 0.09
2.0GluPhe: 2.0 ± 0.058
3.567GluGly: 3.567 ± 0.086
1.199GluHis: 1.199 ± 0.037
3.697GluIle: 3.697 ± 0.066
2.225GluLys: 2.225 ± 0.061
7.094GluLeu: 7.094 ± 0.103
1.315GluMet: 1.315 ± 0.038
1.602GluAsn: 1.602 ± 0.046
2.884GluPro: 2.884 ± 0.071
3.557GluGln: 3.557 ± 0.084
4.221GluArg: 4.221 ± 0.07
2.529GluSer: 2.529 ± 0.066
3.382GluThr: 3.382 ± 0.07
4.382GluVal: 4.382 ± 0.09
0.909GluTrp: 0.909 ± 0.036
1.447GluTyr: 1.447 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
3.157PheAla: 3.157 ± 0.072
0.569PheCys: 0.569 ± 0.027
1.947PheAsp: 1.947 ± 0.059
1.769PheGlu: 1.769 ± 0.053
1.56PhePhe: 1.56 ± 0.046
2.83PheGly: 2.83 ± 0.063
0.73PheHis: 0.73 ± 0.03
1.816PheIle: 1.816 ± 0.06
0.885PheLys: 0.885 ± 0.032
4.153PheLeu: 4.153 ± 0.07
0.644PheMet: 0.644 ± 0.027
1.285PheAsn: 1.285 ± 0.041
1.815PhePro: 1.815 ± 0.046
1.665PheGln: 1.665 ± 0.053
2.057PheArg: 2.057 ± 0.046
2.155PheSer: 2.155 ± 0.049
1.868PheThr: 1.868 ± 0.048
2.356PheVal: 2.356 ± 0.066
0.696PheTrp: 0.696 ± 0.033
1.281PheTyr: 1.281 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
5.86GlyAla: 5.86 ± 0.115
0.972GlyCys: 0.972 ± 0.035
3.702GlyAsp: 3.702 ± 0.076
4.149GlyGlu: 4.149 ± 0.081
2.838GlyPhe: 2.838 ± 0.065
5.205GlyGly: 5.205 ± 0.116
1.681GlyHis: 1.681 ± 0.049
4.873GlyIle: 4.873 ± 0.134
2.761GlyLys: 2.761 ± 0.068
8.027GlyLeu: 8.027 ± 0.126
1.806GlyMet: 1.806 ± 0.048
2.318GlyAsn: 2.318 ± 0.117
1.932GlyPro: 1.932 ± 0.058
3.979GlyGln: 3.979 ± 0.083
4.269GlyArg: 4.269 ± 0.086
3.85GlySer: 3.85 ± 0.084
4.047GlyThr: 4.047 ± 0.087
5.443GlyVal: 5.443 ± 0.084
1.411GlyTrp: 1.411 ± 0.052
2.399GlyTyr: 2.399 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
1.517HisAla: 1.517 ± 0.05
0.423HisCys: 0.423 ± 0.022
0.788HisAsp: 0.788 ± 0.035
0.929HisGlu: 0.929 ± 0.033
0.801HisPhe: 0.801 ± 0.034
1.44HisGly: 1.44 ± 0.048
0.872HisHis: 0.872 ± 0.038
1.096HisIle: 1.096 ± 0.036
0.491HisLys: 0.491 ± 0.024
3.201HisLeu: 3.201 ± 0.072
0.249HisMet: 0.249 ± 0.019
0.524HisAsn: 0.524 ± 0.027
1.872HisPro: 1.872 ± 0.058
1.375HisGln: 1.375 ± 0.048
1.649HisArg: 1.649 ± 0.055
1.194HisSer: 1.194 ± 0.04
1.125HisThr: 1.125 ± 0.036
1.081HisVal: 1.081 ± 0.041
0.57HisTrp: 0.57 ± 0.028
0.828HisTyr: 0.828 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
7.082IleAla: 7.082 ± 0.111
0.679IleCys: 0.679 ± 0.031
2.986IleAsp: 2.986 ± 0.067
3.563IleGlu: 3.563 ± 0.074
1.952IlePhe: 1.952 ± 0.055
4.04IleGly: 4.04 ± 0.079
1.342IleHis: 1.342 ± 0.045
2.522IleIle: 2.522 ± 0.062
1.53IleLys: 1.53 ± 0.051
6.092IleLeu: 6.092 ± 0.101
0.67IleMet: 0.67 ± 0.032
1.643IleAsn: 1.643 ± 0.056
3.322IlePro: 3.322 ± 0.07
2.661IleGln: 2.661 ± 0.069
3.371IleArg: 3.371 ± 0.079
2.882IleSer: 2.882 ± 0.061
3.105IleThr: 3.105 ± 0.063
3.761IleVal: 3.761 ± 0.069
0.688IleTrp: 0.688 ± 0.031
1.577IleTyr: 1.577 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
3.343LysAla: 3.343 ± 0.085
0.279LysCys: 0.279 ± 0.022
1.38LysAsp: 1.38 ± 0.049
2.051LysGlu: 2.051 ± 0.058
0.801LysPhe: 0.801 ± 0.036
2.269LysGly: 2.269 ± 0.053
0.552LysHis: 0.552 ± 0.025
2.006LysIle: 2.006 ± 0.06
1.268LysLys: 1.268 ± 0.052
3.252LysLeu: 3.252 ± 0.069
0.617LysMet: 0.617 ± 0.031
1.028LysAsn: 1.028 ± 0.039
1.65LysPro: 1.65 ± 0.056
1.546LysGln: 1.546 ± 0.052
1.911LysArg: 1.911 ± 0.052
1.575LysSer: 1.575 ± 0.047
1.982LysThr: 1.982 ± 0.052
2.311LysVal: 2.311 ± 0.062
0.347LysTrp: 0.347 ± 0.021
0.81LysTyr: 0.81 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
12.589LeuAla: 12.589 ± 0.162
1.25LeuCys: 1.25 ± 0.044
5.22LeuAsp: 5.22 ± 0.084
7.712LeuGlu: 7.712 ± 0.132
3.741LeuPhe: 3.741 ± 0.083
9.244LeuGly: 9.244 ± 0.121
2.387LeuHis: 2.387 ± 0.071
5.976LeuIle: 5.976 ± 0.104
4.11LeuLys: 4.11 ± 0.065
13.332LeuLeu: 13.332 ± 0.224
2.421LeuMet: 2.421 ± 0.061
3.818LeuAsn: 3.818 ± 0.078
7.293LeuPro: 7.293 ± 0.114
6.514LeuGln: 6.514 ± 0.117
7.969LeuArg: 7.969 ± 0.108
7.11LeuSer: 7.11 ± 0.115
6.698LeuThr: 6.698 ± 0.092
8.003LeuVal: 8.003 ± 0.101
1.971LeuTrp: 1.971 ± 0.065
2.844LeuTyr: 2.844 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
2.499MetAla: 2.499 ± 0.056
0.088MetCys: 0.088 ± 0.01
0.787MetAsp: 0.787 ± 0.031
0.961MetGlu: 0.961 ± 0.037
0.495MetPhe: 0.495 ± 0.025
1.697MetGly: 1.697 ± 0.052
0.284MetHis: 0.284 ± 0.021
1.135MetIle: 1.135 ± 0.038
0.645MetLys: 0.645 ± 0.03
1.85MetLeu: 1.85 ± 0.05
0.522MetMet: 0.522 ± 0.024
0.604MetAsn: 0.604 ± 0.031
1.061MetPro: 1.061 ± 0.042
0.848MetGln: 0.848 ± 0.036
1.007MetArg: 1.007 ± 0.036
1.194MetSer: 1.194 ± 0.041
1.498MetThr: 1.498 ± 0.042
1.572MetVal: 1.572 ± 0.048
0.135MetTrp: 0.135 ± 0.013
0.308MetTyr: 0.308 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.609AsnAla: 2.609 ± 0.066
0.401AsnCys: 0.401 ± 0.026
1.067AsnAsp: 1.067 ± 0.038
1.319AsnGlu: 1.319 ± 0.055
1.227AsnPhe: 1.227 ± 0.046
2.15AsnGly: 2.15 ± 0.059
0.709AsnHis: 0.709 ± 0.029
1.536AsnIle: 1.536 ± 0.054
0.718AsnLys: 0.718 ± 0.047
3.807AsnLeu: 3.807 ± 0.09
0.447AsnMet: 0.447 ± 0.024
0.82AsnAsn: 0.82 ± 0.036
2.387AsnPro: 2.387 ± 0.055
1.549AsnGln: 1.549 ± 0.048
2.093AsnArg: 2.093 ± 0.052
1.437AsnSer: 1.437 ± 0.051
1.54AsnThr: 1.54 ± 0.087
1.803AsnVal: 1.803 ± 0.048
0.553AsnTrp: 0.553 ± 0.03
0.937AsnTyr: 0.937 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
4.896ProAla: 4.896 ± 0.086
0.487ProCys: 0.487 ± 0.026
2.701ProAsp: 2.701 ± 0.063
4.356ProGlu: 4.356 ± 0.085
1.93ProPhe: 1.93 ± 0.055
3.064ProGly: 3.064 ± 0.065
1.293ProHis: 1.293 ± 0.046
2.875ProIle: 2.875 ± 0.059
1.789ProLys: 1.789 ± 0.051
7.346ProLeu: 7.346 ± 0.118
1.275ProMet: 1.275 ± 0.049
1.754ProAsn: 1.754 ± 0.061
4.144ProPro: 4.144 ± 0.123
3.71ProGln: 3.71 ± 0.075
3.0ProArg: 3.0 ± 0.072
3.121ProSer: 3.121 ± 0.07
3.518ProThr: 3.518 ± 0.085
3.872ProVal: 3.872 ± 0.074
1.058ProTrp: 1.058 ± 0.039
1.575ProTyr: 1.575 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
5.739GlnAla: 5.739 ± 0.104
0.483GlnCys: 0.483 ± 0.032
1.755GlnAsp: 1.755 ± 0.051
3.587GlnGlu: 3.587 ± 0.08
1.86GlnPhe: 1.86 ± 0.048
4.376GlnGly: 4.376 ± 0.091
1.116GlnHis: 1.116 ± 0.037
2.944GlnIle: 2.944 ± 0.057
1.803GlnLys: 1.803 ± 0.053
6.818GlnLeu: 6.818 ± 0.111
1.074GlnMet: 1.074 ± 0.04
1.177GlnAsn: 1.177 ± 0.06
3.345GlnPro: 3.345 ± 0.077
4.812GlnGln: 4.812 ± 0.134
4.92GlnArg: 4.92 ± 0.093
2.379GlnSer: 2.379 ± 0.061
3.079GlnThr: 3.079 ± 0.067
4.306GlnVal: 4.306 ± 0.088
1.234GlnTrp: 1.234 ± 0.044
1.127GlnTyr: 1.127 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
5.092ArgAla: 5.092 ± 0.09
0.809ArgCys: 0.809 ± 0.034
3.283ArgAsp: 3.283 ± 0.058
3.777ArgGlu: 3.777 ± 0.078
2.592ArgPhe: 2.592 ± 0.064
4.002ArgGly: 4.002 ± 0.083
1.71ArgHis: 1.71 ± 0.048
3.415ArgIle: 3.415 ± 0.068
1.785ArgLys: 1.785 ± 0.059
8.346ArgLeu: 8.346 ± 0.109
1.151ArgMet: 1.151 ± 0.046
1.816ArgAsn: 1.816 ± 0.056
3.607ArgPro: 3.607 ± 0.08
5.202ArgGln: 5.202 ± 0.096
4.693ArgArg: 4.693 ± 0.089
3.645ArgSer: 3.645 ± 0.067
2.929ArgThr: 2.929 ± 0.063
4.271ArgVal: 4.271 ± 0.071
1.499ArgTrp: 1.499 ± 0.052
2.418ArgTyr: 2.418 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
4.377SerAla: 4.377 ± 0.071
0.535SerCys: 0.535 ± 0.026
2.764SerAsp: 2.764 ± 0.063
2.807SerGlu: 2.807 ± 0.068
1.864SerPhe: 1.864 ± 0.044
4.062SerGly: 4.062 ± 0.085
1.314SerHis: 1.314 ± 0.041
2.45SerIle: 2.45 ± 0.065
1.346SerLys: 1.346 ± 0.045
6.728SerLeu: 6.728 ± 0.095
1.072SerMet: 1.072 ± 0.04
1.372SerAsn: 1.372 ± 0.045
3.605SerPro: 3.605 ± 0.073
2.909SerGln: 2.909 ± 0.061
3.402SerArg: 3.402 ± 0.076
2.988SerSer: 2.988 ± 0.069
2.655SerThr: 2.655 ± 0.061
3.371SerVal: 3.371 ± 0.064
0.774SerTrp: 0.774 ± 0.033
1.375SerTyr: 1.375 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
5.816ThrAla: 5.816 ± 0.091
0.685ThrCys: 0.685 ± 0.073
2.204ThrAsp: 2.204 ± 0.052
2.779ThrGlu: 2.779 ± 0.066
1.974ThrPhe: 1.974 ± 0.046
4.066ThrGly: 4.066 ± 0.081
1.107ThrHis: 1.107 ± 0.036
2.983ThrIle: 2.983 ± 0.059
1.344ThrLys: 1.344 ± 0.043
7.535ThrLeu: 7.535 ± 0.101
0.854ThrMet: 0.854 ± 0.033
1.453ThrAsn: 1.453 ± 0.036
4.349ThrPro: 4.349 ± 0.082
2.321ThrGln: 2.321 ± 0.051
2.622ThrArg: 2.622 ± 0.056
2.616ThrSer: 2.616 ± 0.065
3.443ThrThr: 3.443 ± 0.067
4.415ThrVal: 4.415 ± 0.074
0.736ThrTrp: 0.736 ± 0.036
1.73ThrTyr: 1.73 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
7.412ValAla: 7.412 ± 0.123
0.801ValCys: 0.801 ± 0.032
3.384ValAsp: 3.384 ± 0.064
4.068ValGlu: 4.068 ± 0.071
2.451ValPhe: 2.451 ± 0.06
5.385ValGly: 5.385 ± 0.094
1.294ValHis: 1.294 ± 0.047
4.375ValIle: 4.375 ± 0.081
2.392ValLys: 2.392 ± 0.054
7.665ValLeu: 7.665 ± 0.106
1.507ValMet: 1.507 ± 0.041
2.247ValAsn: 2.247 ± 0.054
3.759ValPro: 3.759 ± 0.069
3.24ValGln: 3.24 ± 0.065
4.046ValArg: 4.046 ± 0.085
3.792ValSer: 3.792 ± 0.061
4.001ValThr: 4.001 ± 0.076
5.59ValVal: 5.59 ± 0.103
0.888ValTrp: 0.888 ± 0.039
1.797ValTyr: 1.797 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
1.125TrpAla: 1.125 ± 0.044
0.196TrpCys: 0.196 ± 0.017
0.547TrpAsp: 0.547 ± 0.028
0.8TrpGlu: 0.8 ± 0.031
0.648TrpPhe: 0.648 ± 0.035
1.408TrpGly: 1.408 ± 0.051
0.466TrpHis: 0.466 ± 0.026
0.794TrpIle: 0.794 ± 0.03
0.387TrpLys: 0.387 ± 0.027
2.54TrpLeu: 2.54 ± 0.085
0.241TrpMet: 0.241 ± 0.019
0.388TrpAsn: 0.388 ± 0.023
0.717TrpPro: 0.717 ± 0.035
2.063TrpGln: 2.063 ± 0.064
1.247TrpArg: 1.247 ± 0.039
0.901TrpSer: 0.901 ± 0.036
0.543TrpThr: 0.543 ± 0.03
1.066TrpVal: 1.066 ± 0.041
0.374TrpTrp: 0.374 ± 0.026
0.453TrpTyr: 0.453 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.213TyrAla: 2.213 ± 0.046
0.447TyrCys: 0.447 ± 0.025
1.255TyrAsp: 1.255 ± 0.034
1.573TyrGlu: 1.573 ± 0.046
1.199TyrPhe: 1.199 ± 0.042
2.403TyrGly: 2.403 ± 0.061
0.731TyrHis: 0.731 ± 0.033
1.263TyrIle: 1.263 ± 0.04
0.713TyrLys: 0.713 ± 0.036
3.571TyrLeu: 3.571 ± 0.067
0.387TyrMet: 0.387 ± 0.023
0.802TyrAsn: 0.802 ± 0.031
1.837TyrPro: 1.837 ± 0.05
1.608TyrGln: 1.608 ± 0.044
2.556TyrArg: 2.556 ± 0.059
1.414TyrSer: 1.414 ± 0.037
1.359TyrThr: 1.359 ± 0.047
1.723TyrVal: 1.723 ± 0.054
0.613TyrTrp: 0.613 ± 0.029
0.898TyrTyr: 0.898 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2452 proteins (770355 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski