Amino acid dipepetide frequency for Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.975AlaAla: 4.975 ± 0.739
2.864AlaCys: 2.864 ± 0.666
2.186AlaAsp: 2.186 ± 0.203
2.714AlaGlu: 2.714 ± 0.349
4.674AlaPhe: 4.674 ± 0.941
3.392AlaGly: 3.392 ± 0.432
0.905AlaHis: 0.905 ± 0.251
5.352AlaIle: 5.352 ± 0.491
4.9AlaLys: 4.9 ± 0.864
5.126AlaLeu: 5.126 ± 1.221
1.809AlaMet: 1.809 ± 0.28
3.844AlaAsn: 3.844 ± 0.397
1.734AlaPro: 1.734 ± 0.368
1.055AlaGln: 1.055 ± 0.368
2.714AlaArg: 2.714 ± 0.189
4.071AlaSer: 4.071 ± 0.491
3.392AlaThr: 3.392 ± 0.447
5.277AlaVal: 5.277 ± 0.538
0.678AlaTrp: 0.678 ± 0.103
3.618AlaTyr: 3.618 ± 1.286
0.0AlaXaa: 0.0 ± 0.0
Cys
1.885CysAla: 1.885 ± 0.457
1.055CysCys: 1.055 ± 0.56
2.035CysAsp: 2.035 ± 0.428
1.055CysGlu: 1.055 ± 0.23
1.658CysPhe: 1.658 ± 0.334
3.166CysGly: 3.166 ± 0.58
0.226CysHis: 0.226 ± 0.104
2.035CysIle: 2.035 ± 0.488
1.658CysLys: 1.658 ± 0.278
1.734CysLeu: 1.734 ± 0.25
0.905CysMet: 0.905 ± 0.271
1.885CysAsn: 1.885 ± 0.459
1.131CysPro: 1.131 ± 0.151
0.226CysGln: 0.226 ± 0.132
1.055CysArg: 1.055 ± 0.161
2.035CysSer: 2.035 ± 0.371
2.035CysThr: 2.035 ± 0.512
2.488CysVal: 2.488 ± 0.431
0.528CysTrp: 0.528 ± 0.188
2.563CysTyr: 2.563 ± 0.506
0.0CysXaa: 0.0 ± 0.0
Asp
3.92AspAla: 3.92 ± 0.528
1.809AspCys: 1.809 ± 0.304
2.563AspAsp: 2.563 ± 0.336
2.864AspGlu: 2.864 ± 0.369
3.543AspPhe: 3.543 ± 0.69
3.241AspGly: 3.241 ± 0.528
0.678AspHis: 0.678 ± 0.113
3.844AspIle: 3.844 ± 0.477
2.412AspLys: 2.412 ± 0.253
4.975AspLeu: 4.975 ± 0.325
1.131AspMet: 1.131 ± 0.293
3.392AspAsn: 3.392 ± 0.261
1.96AspPro: 1.96 ± 0.374
1.206AspGln: 1.206 ± 0.358
1.658AspArg: 1.658 ± 0.269
2.412AspSer: 2.412 ± 0.379
2.035AspThr: 2.035 ± 0.557
5.126AspVal: 5.126 ± 1.113
1.055AspTrp: 1.055 ± 0.376
3.241AspTyr: 3.241 ± 0.483
0.0AspXaa: 0.0 ± 0.0
Glu
3.241GluAla: 3.241 ± 0.416
1.281GluCys: 1.281 ± 0.165
2.412GluAsp: 2.412 ± 0.367
3.694GluGlu: 3.694 ± 0.711
3.015GluPhe: 3.015 ± 0.599
3.769GluGly: 3.769 ± 0.396
1.357GluHis: 1.357 ± 0.478
2.638GluIle: 2.638 ± 0.308
2.789GluLys: 2.789 ± 0.464
3.392GluLeu: 3.392 ± 0.293
0.829GluMet: 0.829 ± 0.301
3.317GluAsn: 3.317 ± 0.566
1.432GluPro: 1.432 ± 0.179
1.809GluGln: 1.809 ± 0.307
2.638GluArg: 2.638 ± 0.582
3.241GluSer: 3.241 ± 0.743
1.809GluThr: 1.809 ± 0.292
4.372GluVal: 4.372 ± 0.459
0.377GluTrp: 0.377 ± 0.225
1.734GluTyr: 1.734 ± 0.37
0.0GluXaa: 0.0 ± 0.0
Phe
1.885PheAla: 1.885 ± 0.28
1.809PheCys: 1.809 ± 0.395
3.166PheAsp: 3.166 ± 0.365
3.543PheGlu: 3.543 ± 0.556
3.166PhePhe: 3.166 ± 0.529
4.297PheGly: 4.297 ± 0.382
0.151PheHis: 0.151 ± 0.13
3.769PheIle: 3.769 ± 0.697
4.674PheLys: 4.674 ± 0.891
3.015PheLeu: 3.015 ± 0.45
1.734PheMet: 1.734 ± 0.466
4.824PheAsn: 4.824 ± 0.759
0.603PhePro: 0.603 ± 0.609
0.528PheGln: 0.528 ± 0.16
0.98PheArg: 0.98 ± 0.231
3.769PheSer: 3.769 ± 0.618
3.317PheThr: 3.317 ± 0.634
7.689PheVal: 7.689 ± 1.011
0.98PheTrp: 0.98 ± 0.258
2.94PheTyr: 2.94 ± 0.367
0.0PheXaa: 0.0 ± 0.0
Gly
4.9GlyAla: 4.9 ± 0.715
1.809GlyCys: 1.809 ± 0.323
5.88GlyAsp: 5.88 ± 0.421
2.789GlyGlu: 2.789 ± 0.479
4.674GlyPhe: 4.674 ± 0.518
3.543GlyGly: 3.543 ± 0.437
0.603GlyHis: 0.603 ± 0.087
2.789GlyIle: 2.789 ± 0.325
4.824GlyLys: 4.824 ± 0.852
5.051GlyLeu: 5.051 ± 0.498
1.206GlyMet: 1.206 ± 0.297
3.618GlyAsn: 3.618 ± 0.268
1.508GlyPro: 1.508 ± 0.337
1.055GlyGln: 1.055 ± 0.418
1.658GlyArg: 1.658 ± 0.798
4.9GlySer: 4.9 ± 0.869
3.844GlyThr: 3.844 ± 0.708
6.257GlyVal: 6.257 ± 0.567
0.226GlyTrp: 0.226 ± 0.187
3.091GlyTyr: 3.091 ± 0.335
0.0GlyXaa: 0.0 ± 0.0
His
1.206HisAla: 1.206 ± 0.365
0.377HisCys: 0.377 ± 0.169
0.829HisAsp: 0.829 ± 0.178
0.452HisGlu: 0.452 ± 0.217
0.98HisPhe: 0.98 ± 0.177
0.754HisGly: 0.754 ± 0.099
0.302HisHis: 0.302 ± 0.119
0.905HisIle: 0.905 ± 0.34
1.583HisLys: 1.583 ± 0.331
1.658HisLeu: 1.658 ± 0.152
0.452HisMet: 0.452 ± 0.192
1.432HisAsn: 1.432 ± 0.194
0.452HisPro: 0.452 ± 0.164
0.377HisGln: 0.377 ± 0.157
0.302HisArg: 0.302 ± 0.085
0.905HisSer: 0.905 ± 0.524
0.829HisThr: 0.829 ± 0.248
1.734HisVal: 1.734 ± 0.346
0.075HisTrp: 0.075 ± 0.147
0.905HisTyr: 0.905 ± 0.187
0.0HisXaa: 0.0 ± 0.0
Ile
4.674IleAla: 4.674 ± 0.803
1.357IleCys: 1.357 ± 0.459
2.789IleAsp: 2.789 ± 0.716
3.317IleGlu: 3.317 ± 0.405
2.337IlePhe: 2.337 ± 0.334
3.543IleGly: 3.543 ± 0.488
0.603IleHis: 0.603 ± 0.207
3.468IleIle: 3.468 ± 1.222
3.92IleLys: 3.92 ± 0.826
5.578IleLeu: 5.578 ± 1.062
1.206IleMet: 1.206 ± 0.352
2.94IleAsn: 2.94 ± 0.215
2.488IlePro: 2.488 ± 0.399
1.583IleGln: 1.583 ± 0.203
1.508IleArg: 1.508 ± 0.299
2.789IleSer: 2.789 ± 0.585
3.618IleThr: 3.618 ± 0.941
9.423IleVal: 9.423 ± 2.071
0.603IleTrp: 0.603 ± 0.193
2.186IleTyr: 2.186 ± 0.741
0.0IleXaa: 0.0 ± 0.0
Lys
4.221LysAla: 4.221 ± 0.826
2.261LysCys: 2.261 ± 0.658
3.468LysAsp: 3.468 ± 0.587
2.488LysGlu: 2.488 ± 0.47
2.94LysPhe: 2.94 ± 0.41
3.392LysGly: 3.392 ± 0.694
2.035LysHis: 2.035 ± 0.65
3.618LysIle: 3.618 ± 1.002
3.166LysLys: 3.166 ± 0.78
6.558LysLeu: 6.558 ± 0.64
1.734LysMet: 1.734 ± 0.362
3.694LysAsn: 3.694 ± 0.437
3.392LysPro: 3.392 ± 1.111
2.412LysGln: 2.412 ± 0.612
1.734LysArg: 1.734 ± 0.357
4.674LysSer: 4.674 ± 0.807
3.543LysThr: 3.543 ± 0.663
4.598LysVal: 4.598 ± 0.595
0.377LysTrp: 0.377 ± 0.225
2.714LysTyr: 2.714 ± 0.296
0.0LysXaa: 0.0 ± 0.0
Leu
5.201LeuAla: 5.201 ± 1.057
2.714LeuCys: 2.714 ± 0.668
3.694LeuAsp: 3.694 ± 0.377
5.503LeuGlu: 5.503 ± 0.505
4.221LeuPhe: 4.221 ± 0.349
5.051LeuGly: 5.051 ± 0.638
1.357LeuHis: 1.357 ± 0.387
4.071LeuIle: 4.071 ± 1.026
5.503LeuLys: 5.503 ± 0.702
7.463LeuLeu: 7.463 ± 2.683
1.658LeuMet: 1.658 ± 0.405
4.824LeuAsn: 4.824 ± 1.0
3.543LeuPro: 3.543 ± 0.641
3.468LeuGln: 3.468 ± 0.41
1.809LeuArg: 1.809 ± 0.495
6.784LeuSer: 6.784 ± 0.68
5.051LeuThr: 5.051 ± 1.168
5.729LeuVal: 5.729 ± 0.748
1.432LeuTrp: 1.432 ± 0.324
3.317LeuTyr: 3.317 ± 0.564
0.0LeuXaa: 0.0 ± 0.0
Met
1.734MetAla: 1.734 ± 0.557
1.131MetCys: 1.131 ± 0.41
0.98MetAsp: 0.98 ± 0.334
0.151MetGlu: 0.151 ± 0.13
0.829MetPhe: 0.829 ± 0.469
1.357MetGly: 1.357 ± 0.333
0.754MetHis: 0.754 ± 0.265
1.432MetIle: 1.432 ± 0.271
0.905MetLys: 0.905 ± 0.359
2.94MetLeu: 2.94 ± 0.416
0.452MetMet: 0.452 ± 0.19
0.528MetAsn: 0.528 ± 0.263
1.206MetPro: 1.206 ± 0.273
0.905MetGln: 0.905 ± 0.187
1.206MetArg: 1.206 ± 0.243
1.583MetSer: 1.583 ± 0.563
1.885MetThr: 1.885 ± 0.374
1.508MetVal: 1.508 ± 0.623
0.075MetTrp: 0.075 ± 0.196
1.432MetTyr: 1.432 ± 0.158
0.0MetXaa: 0.0 ± 0.0
Asn
3.844AsnAla: 3.844 ± 0.19
2.261AsnCys: 2.261 ± 0.413
2.186AsnAsp: 2.186 ± 0.191
2.789AsnGlu: 2.789 ± 0.487
3.543AsnPhe: 3.543 ± 0.531
6.332AsnGly: 6.332 ± 0.471
0.905AsnHis: 0.905 ± 0.266
3.091AsnIle: 3.091 ± 1.503
3.015AsnLys: 3.015 ± 0.527
4.372AsnLeu: 4.372 ± 0.573
1.583AsnMet: 1.583 ± 0.241
4.824AsnAsn: 4.824 ± 0.587
1.583AsnPro: 1.583 ± 0.26
1.583AsnGln: 1.583 ± 0.54
1.885AsnArg: 1.885 ± 0.44
4.221AsnSer: 4.221 ± 0.774
3.618AsnThr: 3.618 ± 0.349
6.407AsnVal: 6.407 ± 1.38
0.452AsnTrp: 0.452 ± 0.464
2.261AsnTyr: 2.261 ± 0.385
0.0AsnXaa: 0.0 ± 0.0
Pro
1.658ProAla: 1.658 ± 0.495
0.528ProCys: 0.528 ± 0.183
1.809ProAsp: 1.809 ± 0.309
1.658ProGlu: 1.658 ± 0.216
1.432ProPhe: 1.432 ± 0.176
2.638ProGly: 2.638 ± 0.425
0.377ProHis: 0.377 ± 0.134
2.488ProIle: 2.488 ± 0.412
2.186ProLys: 2.186 ± 0.543
2.94ProLeu: 2.94 ± 0.422
0.377ProMet: 0.377 ± 0.294
1.131ProAsn: 1.131 ± 0.517
1.206ProPro: 1.206 ± 0.23
1.206ProGln: 1.206 ± 0.37
0.905ProArg: 0.905 ± 0.579
3.694ProSer: 3.694 ± 0.59
2.111ProThr: 2.111 ± 0.174
2.714ProVal: 2.714 ± 0.323
0.905ProTrp: 0.905 ± 0.127
0.829ProTyr: 0.829 ± 0.256
0.0ProXaa: 0.0 ± 0.0
Gln
2.638GlnAla: 2.638 ± 0.518
0.377GlnCys: 0.377 ± 0.225
1.055GlnAsp: 1.055 ± 0.286
2.035GlnGlu: 2.035 ± 0.567
0.98GlnPhe: 0.98 ± 0.334
1.885GlnGly: 1.885 ± 0.399
0.452GlnHis: 0.452 ± 0.279
1.809GlnIle: 1.809 ± 0.363
1.432GlnLys: 1.432 ± 0.529
2.864GlnLeu: 2.864 ± 0.26
0.452GlnMet: 0.452 ± 0.217
0.829GlnAsn: 0.829 ± 0.109
1.432GlnPro: 1.432 ± 0.588
1.432GlnGln: 1.432 ± 0.8
1.281GlnArg: 1.281 ± 0.508
2.488GlnSer: 2.488 ± 0.378
1.885GlnThr: 1.885 ± 0.534
1.96GlnVal: 1.96 ± 0.437
0.528GlnTrp: 0.528 ± 0.353
1.432GlnTyr: 1.432 ± 0.177
0.0GlnXaa: 0.0 ± 0.0
Arg
2.789ArgAla: 2.789 ± 0.433
1.508ArgCys: 1.508 ± 0.416
1.809ArgAsp: 1.809 ± 0.546
0.226ArgGlu: 0.226 ± 0.082
2.337ArgPhe: 2.337 ± 0.3
2.035ArgGly: 2.035 ± 0.478
0.302ArgHis: 0.302 ± 0.116
1.131ArgIle: 1.131 ± 0.249
1.734ArgLys: 1.734 ± 0.494
2.563ArgLeu: 2.563 ± 0.988
0.603ArgMet: 0.603 ± 0.183
2.488ArgAsn: 2.488 ± 0.286
0.754ArgPro: 0.754 ± 0.18
1.508ArgGln: 1.508 ± 0.568
0.829ArgArg: 0.829 ± 0.29
3.015ArgSer: 3.015 ± 1.99
2.789ArgThr: 2.789 ± 1.051
1.809ArgVal: 1.809 ± 0.171
0.377ArgTrp: 0.377 ± 0.134
1.357ArgTyr: 1.357 ± 0.297
0.0ArgXaa: 0.0 ± 0.0
Ser
5.051SerAla: 5.051 ± 0.215
1.357SerCys: 1.357 ± 0.343
4.221SerAsp: 4.221 ± 0.906
3.241SerGlu: 3.241 ± 0.473
3.995SerPhe: 3.995 ± 0.554
3.995SerGly: 3.995 ± 0.449
1.432SerHis: 1.432 ± 0.317
4.9SerIle: 4.9 ± 1.184
4.598SerLys: 4.598 ± 0.832
4.9SerLeu: 4.9 ± 0.518
2.111SerMet: 2.111 ± 0.443
2.94SerAsn: 2.94 ± 0.376
1.583SerPro: 1.583 ± 0.277
2.035SerGln: 2.035 ± 0.381
2.111SerArg: 2.111 ± 1.782
4.674SerSer: 4.674 ± 0.746
4.146SerThr: 4.146 ± 0.283
6.784SerVal: 6.784 ± 1.049
0.905SerTrp: 0.905 ± 0.545
4.071SerTyr: 4.071 ± 0.468
0.0SerXaa: 0.0 ± 0.0
Thr
3.618ThrAla: 3.618 ± 0.606
2.412ThrCys: 2.412 ± 0.345
2.488ThrAsp: 2.488 ± 0.547
2.714ThrGlu: 2.714 ± 0.279
3.091ThrPhe: 3.091 ± 0.506
3.769ThrGly: 3.769 ± 0.737
0.754ThrHis: 0.754 ± 0.522
3.769ThrIle: 3.769 ± 0.4
2.412ThrLys: 2.412 ± 0.547
5.654ThrLeu: 5.654 ± 1.776
1.055ThrMet: 1.055 ± 0.325
3.543ThrAsn: 3.543 ± 0.37
2.714ThrPro: 2.714 ± 0.336
2.488ThrGln: 2.488 ± 0.262
2.488ThrArg: 2.488 ± 0.536
3.92ThrSer: 3.92 ± 0.345
4.9ThrThr: 4.9 ± 1.424
5.88ThrVal: 5.88 ± 1.435
0.98ThrTrp: 0.98 ± 0.173
2.035ThrTyr: 2.035 ± 0.334
0.0ThrXaa: 0.0 ± 0.0
Val
4.146ValAla: 4.146 ± 0.768
2.563ValCys: 2.563 ± 0.464
5.051ValAsp: 5.051 ± 0.535
5.352ValGlu: 5.352 ± 0.915
4.975ValPhe: 4.975 ± 0.653
4.221ValGly: 4.221 ± 0.427
2.261ValHis: 2.261 ± 0.366
6.03ValIle: 6.03 ± 0.638
7.387ValLys: 7.387 ± 1.779
7.99ValLeu: 7.99 ± 0.816
1.809ValMet: 1.809 ± 0.596
7.01ValAsn: 7.01 ± 0.514
2.035ValPro: 2.035 ± 0.534
3.166ValGln: 3.166 ± 0.983
3.091ValArg: 3.091 ± 0.411
7.086ValSer: 7.086 ± 0.616
6.106ValThr: 6.106 ± 0.749
7.764ValVal: 7.764 ± 0.32
0.528ValTrp: 0.528 ± 0.132
3.618ValTyr: 3.618 ± 0.369
0.0ValXaa: 0.0 ± 0.0
Trp
0.452TrpAla: 0.452 ± 0.172
0.151TrpCys: 0.151 ± 0.101
0.754TrpAsp: 0.754 ± 0.184
0.528TrpGlu: 0.528 ± 0.188
1.583TrpPhe: 1.583 ± 0.473
0.302TrpGly: 0.302 ± 0.335
0.226TrpHis: 0.226 ± 0.187
0.678TrpIle: 0.678 ± 0.229
0.528TrpLys: 0.528 ± 0.172
1.206TrpLeu: 1.206 ± 0.226
0.226TrpMet: 0.226 ± 0.082
1.281TrpAsn: 1.281 ± 0.254
0.678TrpPro: 0.678 ± 0.554
0.151TrpGln: 0.151 ± 0.058
0.377TrpArg: 0.377 ± 0.169
0.528TrpSer: 0.528 ± 0.37
1.055TrpThr: 1.055 ± 0.274
0.377TrpVal: 0.377 ± 0.134
0.151TrpTrp: 0.151 ± 0.265
0.528TrpTyr: 0.528 ± 0.124
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.241TyrAla: 3.241 ± 0.728
1.734TyrCys: 1.734 ± 0.15
3.694TyrAsp: 3.694 ± 0.807
2.035TyrGlu: 2.035 ± 0.343
2.864TyrPhe: 2.864 ± 0.646
3.543TyrGly: 3.543 ± 0.269
0.829TyrHis: 0.829 ± 0.25
2.111TyrIle: 2.111 ± 0.227
3.392TyrLys: 3.392 ± 0.747
2.412TyrLeu: 2.412 ± 0.283
1.583TyrMet: 1.583 ± 0.48
2.412TyrAsn: 2.412 ± 0.596
1.432TyrPro: 1.432 ± 0.301
1.055TyrGln: 1.055 ± 0.166
1.734TyrArg: 1.734 ± 0.51
2.261TyrSer: 2.261 ± 0.371
2.714TyrThr: 2.714 ± 0.724
4.297TyrVal: 4.297 ± 0.999
0.528TyrTrp: 0.528 ± 0.273
2.94TyrTyr: 2.94 ± 0.314
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (13267 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski