Amino acid dipepetide frequency for Bacterioplanes sanyensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.969AlaAla: 10.969 ± 0.131	1.097AlaCys: 1.097 ± 0.035	6.186AlaAsp: 6.186 ± 0.078	6.477AlaGlu: 6.477 ± 0.083	3.335AlaPhe: 3.335 ± 0.059	7.255AlaGly: 7.255 ± 0.09	2.072AlaHis: 2.072 ± 0.046	5.331AlaIle: 5.331 ± 0.058	3.417AlaLys: 3.417 ± 0.065	11.962AlaLeu: 11.962 ± 0.11	2.961AlaMet: 2.961 ± 0.054	3.436AlaAsn: 3.436 ± 0.063	3.627AlaPro: 3.627 ± 0.065	5.419AlaGln: 5.419 ± 0.087	4.965AlaArg: 4.965 ± 0.079	6.381AlaSer: 6.381 ± 0.071	4.807AlaThr: 4.807 ± 0.064	6.901AlaVal: 6.901 ± 0.091	1.342AlaTrp: 1.342 ± 0.03	2.479AlaTyr: 2.479 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.925CysAla: 0.925 ± 0.027	0.146CysCys: 0.146 ± 0.011	0.636CysAsp: 0.636 ± 0.023	0.505CysGlu: 0.505 ± 0.023	0.368CysPhe: 0.368 ± 0.015	0.926CysGly: 0.926 ± 0.028	0.338CysHis: 0.338 ± 0.017	0.462CysIle: 0.462 ± 0.018	0.272CysLys: 0.272 ± 0.016	1.078CysLeu: 1.078 ± 0.031	0.209CysMet: 0.209 ± 0.013	0.308CysAsn: 0.308 ± 0.015	0.433CysPro: 0.433 ± 0.019	0.665CysGln: 0.665 ± 0.027	0.574CysArg: 0.574 ± 0.023	0.711CysSer: 0.711 ± 0.023	0.422CysThr: 0.422 ± 0.02	0.611CysVal: 0.611 ± 0.024	0.192CysTrp: 0.192 ± 0.013	0.313CysTyr: 0.313 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.689AspAla: 5.689 ± 0.083	0.613AspCys: 0.613 ± 0.021	4.284AspAsp: 4.284 ± 0.086	3.855AspGlu: 3.855 ± 0.061	2.297AspPhe: 2.297 ± 0.048	4.887AspGly: 4.887 ± 0.076	1.399AspHis: 1.399 ± 0.039	3.756AspIle: 3.756 ± 0.055	2.063AspLys: 2.063 ± 0.048	5.365AspLeu: 5.365 ± 0.061	1.573AspMet: 1.573 ± 0.038	2.336AspAsn: 2.336 ± 0.092	2.237AspPro: 2.237 ± 0.048	2.751AspGln: 2.751 ± 0.053	2.753AspArg: 2.753 ± 0.045	3.735AspSer: 3.735 ± 0.065	2.859AspThr: 2.859 ± 0.054	4.363AspVal: 4.363 ± 0.066	1.094AspTrp: 1.094 ± 0.033	2.083AspTyr: 2.083 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.375GluAla: 5.375 ± 0.085	0.428GluCys: 0.428 ± 0.018	2.617GluAsp: 2.617 ± 0.051	2.974GluGlu: 2.974 ± 0.06	2.169GluPhe: 2.169 ± 0.044	3.213GluGly: 3.213 ± 0.056	1.806GluHis: 1.806 ± 0.036	2.69GluIle: 2.69 ± 0.057	2.223GluLys: 2.223 ± 0.046	7.211GluLeu: 7.211 ± 0.085	1.336GluMet: 1.336 ± 0.034	1.658GluAsn: 1.658 ± 0.034	2.369GluPro: 2.369 ± 0.069	5.35GluGln: 5.35 ± 0.069	4.189GluArg: 4.189 ± 0.068	2.919GluSer: 2.919 ± 0.048	2.463GluThr: 2.463 ± 0.046	4.06GluVal: 4.06 ± 0.071	0.759GluTrp: 0.759 ± 0.023	1.594GluTyr: 1.594 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.685PheAla: 3.685 ± 0.06	0.418PheCys: 0.418 ± 0.017	2.648PheAsp: 2.648 ± 0.046	2.118PheGlu: 2.118 ± 0.031	1.469PhePhe: 1.469 ± 0.04	2.683PheGly: 2.683 ± 0.048	0.813PheHis: 0.813 ± 0.026	1.895PheIle: 1.895 ± 0.041	1.172PheLys: 1.172 ± 0.03	2.917PheLeu: 2.917 ± 0.051	0.915PheMet: 0.915 ± 0.031	1.556PheAsn: 1.556 ± 0.041	1.286PhePro: 1.286 ± 0.031	1.285PheGln: 1.285 ± 0.03	1.82PheArg: 1.82 ± 0.043	2.72PheSer: 2.72 ± 0.055	1.908PheThr: 1.908 ± 0.041	2.458PheVal: 2.458 ± 0.052	0.553PheTrp: 0.553 ± 0.022	1.181PheTyr: 1.181 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	5.756GlyAla: 5.756 ± 0.068	0.872GlyCys: 0.872 ± 0.027	4.4GlyAsp: 4.4 ± 0.099	4.307GlyGlu: 4.307 ± 0.068	3.024GlyPhe: 3.024 ± 0.055	4.996GlyGly: 4.996 ± 0.08	1.788GlyHis: 1.788 ± 0.036	4.171GlyIle: 4.171 ± 0.067	2.951GlyLys: 2.951 ± 0.056	7.288GlyLeu: 7.288 ± 0.071	2.0GlyMet: 2.0 ± 0.047	2.487GlyAsn: 2.487 ± 0.067	1.935GlyPro: 1.935 ± 0.04	3.774GlyGln: 3.774 ± 0.064	3.831GlyArg: 3.831 ± 0.048	4.42GlySer: 4.42 ± 0.073	3.28GlyThr: 3.28 ± 0.067	5.066GlyVal: 5.066 ± 0.072	1.229GlyTrp: 1.229 ± 0.037	2.442GlyTyr: 2.442 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.189HisAla: 2.189 ± 0.052	0.432HisCys: 0.432 ± 0.02	1.349HisAsp: 1.349 ± 0.03	1.197HisGlu: 1.197 ± 0.033	1.051HisPhe: 1.051 ± 0.027	1.929HisGly: 1.929 ± 0.04	0.835HisHis: 0.835 ± 0.028	1.411HisIle: 1.411 ± 0.035	0.759HisLys: 0.759 ± 0.023	2.529HisLeu: 2.529 ± 0.043	0.607HisMet: 0.607 ± 0.021	0.839HisAsn: 0.839 ± 0.024	1.324HisPro: 1.324 ± 0.033	1.584HisGln: 1.584 ± 0.038	1.389HisArg: 1.389 ± 0.036	1.772HisSer: 1.772 ± 0.043	1.303HisThr: 1.303 ± 0.035	1.307HisVal: 1.307 ± 0.032	0.673HisTrp: 0.673 ± 0.025	0.935HisTyr: 0.935 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.681IleAla: 5.681 ± 0.078	0.486IleCys: 0.486 ± 0.018	3.998IleAsp: 3.998 ± 0.058	3.768IleGlu: 3.768 ± 0.058	1.438IlePhe: 1.438 ± 0.034	3.845IleGly: 3.845 ± 0.063	1.17IleHis: 1.17 ± 0.031	2.315IleIle: 2.315 ± 0.048	1.801IleLys: 1.801 ± 0.038	3.956IleLeu: 3.956 ± 0.069	1.007IleMet: 1.007 ± 0.03	2.245IleAsn: 2.245 ± 0.048	2.133IlePro: 2.133 ± 0.039	2.11IleGln: 2.11 ± 0.046	2.964IleArg: 2.964 ± 0.049	3.568IleSer: 3.568 ± 0.054	2.739IleThr: 2.739 ± 0.049	3.31IleVal: 3.31 ± 0.058	0.557IleTrp: 0.557 ± 0.023	1.281IleTyr: 1.281 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.705LysAla: 3.705 ± 0.069	0.177LysCys: 0.177 ± 0.015	1.946LysAsp: 1.946 ± 0.041	1.811LysGlu: 1.811 ± 0.043	0.855LysPhe: 0.855 ± 0.032	2.178LysGly: 2.178 ± 0.045	0.883LysHis: 0.883 ± 0.028	1.557LysIle: 1.557 ± 0.042	1.512LysLys: 1.512 ± 0.045	3.406LysLeu: 3.406 ± 0.053	0.764LysMet: 0.764 ± 0.026	1.131LysAsn: 1.131 ± 0.032	1.821LysPro: 1.821 ± 0.044	2.115LysGln: 2.115 ± 0.048	2.363LysArg: 2.363 ± 0.05	1.844LysSer: 1.844 ± 0.041	1.894LysThr: 1.894 ± 0.036	2.562LysVal: 2.562 ± 0.056	0.321LysTrp: 0.321 ± 0.019	0.766LysTyr: 0.766 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	12.273LeuAla: 12.273 ± 0.114	1.093LeuCys: 1.093 ± 0.031	6.048LeuAsp: 6.048 ± 0.072	5.869LeuGlu: 5.869 ± 0.073	3.609LeuPhe: 3.609 ± 0.066	7.045LeuGly: 7.045 ± 0.081	2.498LeuHis: 2.498 ± 0.048	5.061LeuIle: 5.061 ± 0.082	3.77LeuLys: 3.77 ± 0.055	12.497LeuLeu: 12.497 ± 0.152	2.822LeuMet: 2.822 ± 0.05	3.901LeuAsn: 3.901 ± 0.053	5.423LeuPro: 5.423 ± 0.073	6.995LeuGln: 6.995 ± 0.106	5.903LeuArg: 5.903 ± 0.079	7.869LeuSer: 7.869 ± 0.081	6.145LeuThr: 6.145 ± 0.068	7.132LeuVal: 7.132 ± 0.08	1.452LeuTrp: 1.452 ± 0.037	2.521LeuTyr: 2.521 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.966MetAla: 2.966 ± 0.052	0.194MetCys: 0.194 ± 0.012	1.299MetAsp: 1.299 ± 0.039	1.189MetGlu: 1.189 ± 0.027	0.659MetPhe: 0.659 ± 0.025	1.69MetGly: 1.69 ± 0.046	0.554MetHis: 0.554 ± 0.02	1.154MetIle: 1.154 ± 0.038	1.032MetLys: 1.032 ± 0.028	2.627MetLeu: 2.627 ± 0.047	0.714MetMet: 0.714 ± 0.025	0.96MetAsn: 0.96 ± 0.023	1.336MetPro: 1.336 ± 0.033	1.343MetGln: 1.343 ± 0.036	1.386MetArg: 1.386 ± 0.032	1.832MetSer: 1.832 ± 0.038	1.678MetThr: 1.678 ± 0.037	1.74MetVal: 1.74 ± 0.043	0.203MetTrp: 0.203 ± 0.013	0.415MetTyr: 0.415 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.339AsnAla: 3.339 ± 0.065	0.301AsnCys: 0.301 ± 0.015	2.298AsnAsp: 2.298 ± 0.058	1.879AsnGlu: 1.879 ± 0.041	1.08AsnPhe: 1.08 ± 0.032	2.784AsnGly: 2.784 ± 0.097	0.81AsnHis: 0.81 ± 0.029	1.879AsnIle: 1.879 ± 0.042	1.259AsnLys: 1.259 ± 0.035	3.084AsnLeu: 3.084 ± 0.056	0.817AsnMet: 0.817 ± 0.029	1.44AsnAsn: 1.44 ± 0.042	1.857AsnPro: 1.857 ± 0.041	1.781AsnGln: 1.781 ± 0.041	1.93AsnArg: 1.93 ± 0.042	2.183AsnSer: 2.183 ± 0.061	1.924AsnThr: 1.924 ± 0.042	2.146AsnVal: 2.146 ± 0.046	0.522AsnTrp: 0.522 ± 0.021	1.025AsnTyr: 1.025 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.522ProAla: 4.522 ± 0.069	0.338ProCys: 0.338 ± 0.016	2.798ProAsp: 2.798 ± 0.054	3.225ProGlu: 3.225 ± 0.066	1.529ProPhe: 1.529 ± 0.035	3.059ProGly: 3.059 ± 0.057	1.006ProHis: 1.006 ± 0.034	1.963ProIle: 1.963 ± 0.046	1.425ProLys: 1.425 ± 0.037	4.753ProLeu: 4.753 ± 0.065	1.122ProMet: 1.122 ± 0.034	1.387ProAsn: 1.387 ± 0.038	1.495ProPro: 1.495 ± 0.033	2.372ProGln: 2.372 ± 0.045	1.742ProArg: 1.742 ± 0.039	2.595ProSer: 2.595 ± 0.055	2.123ProThr: 2.123 ± 0.048	3.363ProVal: 3.363 ± 0.06	0.732ProTrp: 0.732 ± 0.025	1.148ProTyr: 1.148 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	6.524GlnAla: 6.524 ± 0.097	0.573GlnCys: 0.573 ± 0.023	2.412GlnAsp: 2.412 ± 0.047	2.317GlnGlu: 2.317 ± 0.048	1.838GlnPhe: 1.838 ± 0.043	3.926GlnGly: 3.926 ± 0.058	2.248GlnHis: 2.248 ± 0.048	2.132GlnIle: 2.132 ± 0.034	1.402GlnLys: 1.402 ± 0.034	7.984GlnLeu: 7.984 ± 0.116	1.156GlnMet: 1.156 ± 0.031	1.329GlnAsn: 1.329 ± 0.036	2.985GlnPro: 2.985 ± 0.064	7.428GlnGln: 7.428 ± 0.164	5.07GlnArg: 5.07 ± 0.092	3.102GlnSer: 3.102 ± 0.047	2.454GlnThr: 2.454 ± 0.046	3.898GlnVal: 3.898 ± 0.066	1.283GlnTrp: 1.283 ± 0.037	1.447GlnTyr: 1.447 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	4.592ArgAla: 4.592 ± 0.064	0.606ArgCys: 0.606 ± 0.024	3.055ArgAsp: 3.055 ± 0.047	3.158ArgGlu: 3.158 ± 0.059	2.509ArgPhe: 2.509 ± 0.047	3.258ArgGly: 3.258 ± 0.053	1.726ArgHis: 1.726 ± 0.04	3.46ArgIle: 3.46 ± 0.053	1.786ArgLys: 1.786 ± 0.043	6.952ArgLeu: 6.952 ± 0.081	1.462ArgMet: 1.462 ± 0.035	1.761ArgAsn: 1.761 ± 0.04	2.249ArgPro: 2.249 ± 0.048	4.126ArgGln: 4.126 ± 0.075	3.748ArgArg: 3.748 ± 0.077	3.506ArgSer: 3.506 ± 0.047	2.475ArgThr: 2.475 ± 0.043	3.607ArgVal: 3.607 ± 0.055	1.245ArgTrp: 1.245 ± 0.037	2.225ArgTyr: 2.225 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.535SerAla: 6.535 ± 0.077	0.619SerCys: 0.619 ± 0.021	4.356SerAsp: 4.356 ± 0.07	3.695SerGlu: 3.695 ± 0.052	2.205SerPhe: 2.205 ± 0.039	5.368SerGly: 5.368 ± 0.075	1.574SerHis: 1.574 ± 0.04	3.141SerIle: 3.141 ± 0.054	2.013SerLys: 2.013 ± 0.043	6.719SerLeu: 6.719 ± 0.083	1.594SerMet: 1.594 ± 0.039	2.288SerAsn: 2.288 ± 0.053	2.51SerPro: 2.51 ± 0.049	3.358SerGln: 3.358 ± 0.052	3.346SerArg: 3.346 ± 0.042	4.468SerSer: 4.468 ± 0.073	3.038SerThr: 3.038 ± 0.055	4.496SerVal: 4.496 ± 0.064	1.062SerTrp: 1.062 ± 0.032	1.807SerTyr: 1.807 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.082ThrAla: 5.082 ± 0.06	0.413ThrCys: 0.413 ± 0.02	3.041ThrAsp: 3.041 ± 0.06	2.886ThrGlu: 2.886 ± 0.05	1.74ThrPhe: 1.74 ± 0.038	3.882ThrGly: 3.882 ± 0.072	1.176ThrHis: 1.176 ± 0.03	2.438ThrIle: 2.438 ± 0.043	1.183ThrLys: 1.183 ± 0.029	6.57ThrLeu: 6.57 ± 0.081	1.02ThrMet: 1.02 ± 0.027	1.485ThrAsn: 1.485 ± 0.039	2.837ThrPro: 2.837 ± 0.056	2.363ThrGln: 2.363 ± 0.04	2.457ThrArg: 2.457 ± 0.045	3.075ThrSer: 3.075 ± 0.052	2.721ThrThr: 2.721 ± 0.067	3.654ThrVal: 3.654 ± 0.065	0.605ThrTrp: 0.605 ± 0.022	1.188ThrTyr: 1.188 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	7.27ValAla: 7.27 ± 0.087	0.761ValCys: 0.761 ± 0.024	4.321ValAsp: 4.321 ± 0.063	4.291ValGlu: 4.291 ± 0.07	2.584ValPhe: 2.584 ± 0.046	4.376ValGly: 4.376 ± 0.063	1.461ValHis: 1.461 ± 0.038	3.659ValIle: 3.659 ± 0.067	2.458ValLys: 2.458 ± 0.053	7.099ValLeu: 7.099 ± 0.081	1.938ValMet: 1.938 ± 0.039	2.489ValAsn: 2.489 ± 0.057	2.741ValPro: 2.741 ± 0.046	2.824ValGln: 2.824 ± 0.046	3.811ValArg: 3.811 ± 0.057	4.767ValSer: 4.767 ± 0.076	3.851ValThr: 3.851 ± 0.06	5.419ValVal: 5.419 ± 0.073	0.891ValTrp: 0.891 ± 0.025	1.725ValTyr: 1.725 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.069TrpAla: 1.069 ± 0.027	0.185TrpCys: 0.185 ± 0.012	0.6TrpAsp: 0.6 ± 0.022	0.513TrpGlu: 0.513 ± 0.019	0.589TrpPhe: 0.589 ± 0.022	0.753TrpGly: 0.753 ± 0.029	0.54TrpHis: 0.54 ± 0.026	0.667TrpIle: 0.667 ± 0.021	0.357TrpLys: 0.357 ± 0.017	2.769TrpLeu: 2.769 ± 0.061	0.399TrpMet: 0.399 ± 0.015	0.409TrpAsn: 0.409 ± 0.018	0.788TrpPro: 0.788 ± 0.031	1.699TrpGln: 1.699 ± 0.045	1.155TrpArg: 1.155 ± 0.037	0.939TrpSer: 0.939 ± 0.031	0.502TrpThr: 0.502 ± 0.02	0.972TrpVal: 0.972 ± 0.026	0.352TrpTrp: 0.352 ± 0.019	0.383TrpTyr: 0.383 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.275TyrAla: 2.275 ± 0.048	0.342TyrCys: 0.342 ± 0.018	1.702TyrAsp: 1.702 ± 0.038	1.37TyrGlu: 1.37 ± 0.036	1.155TyrPhe: 1.155 ± 0.031	1.963TyrGly: 1.963 ± 0.039	0.716TyrHis: 0.716 ± 0.022	1.229TyrIle: 1.229 ± 0.032	0.756TyrLys: 0.756 ± 0.023	3.161TyrLeu: 3.161 ± 0.055	0.553TyrMet: 0.553 ± 0.022	0.895TyrAsn: 0.895 ± 0.029	1.309TyrPro: 1.309 ± 0.028	2.167TyrGln: 2.167 ± 0.046	2.109TyrArg: 2.109 ± 0.045	1.788TyrSer: 1.788 ± 0.043	1.229TyrThr: 1.229 ± 0.034	1.67TyrVal: 1.67 ± 0.039	0.572TyrTrp: 0.572 ± 0.024	0.89TyrTyr: 0.89 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3784 proteins (1254103 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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