Amino acid dipepetide frequency for Streptococcus satellite phage Javan257

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.352AlaAla: 2.352 ± 0.906
0.784AlaCys: 0.784 ± 0.367
6.272AlaAsp: 6.272 ± 2.112
5.88AlaGlu: 5.88 ± 1.646
3.136AlaPhe: 3.136 ± 1.061
3.136AlaGly: 3.136 ± 1.167
0.392AlaHis: 0.392 ± 0.302
6.664AlaIle: 6.664 ± 1.348
7.84AlaLys: 7.84 ± 1.158
2.352AlaLeu: 2.352 ± 0.92
0.784AlaMet: 0.784 ± 0.634
3.528AlaAsn: 3.528 ± 1.292
1.176AlaPro: 1.176 ± 0.531
3.136AlaGln: 3.136 ± 1.034
4.704AlaArg: 4.704 ± 1.364
4.704AlaSer: 4.704 ± 1.028
4.704AlaThr: 4.704 ± 0.981
5.096AlaVal: 5.096 ± 1.256
0.784AlaTrp: 0.784 ± 0.367
3.92AlaTyr: 3.92 ± 1.262
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.392CysGly: 0.392 ± 0.313
0.392CysHis: 0.392 ± 0.313
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.784CysLeu: 0.784 ± 0.492
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.392CysPro: 0.392 ± 0.313
0.0CysGln: 0.0 ± 0.0
0.392CysArg: 0.392 ± 0.302
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.392CysVal: 0.392 ± 0.313
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.176AspAla: 1.176 ± 0.81
0.0AspCys: 0.0 ± 0.0
2.352AspAsp: 2.352 ± 0.78
5.096AspGlu: 5.096 ± 1.221
3.528AspPhe: 3.528 ± 0.983
1.96AspGly: 1.96 ± 0.832
1.176AspHis: 1.176 ± 0.536
4.704AspIle: 4.704 ± 1.18
5.096AspLys: 5.096 ± 0.952
5.88AspLeu: 5.88 ± 1.472
1.568AspMet: 1.568 ± 0.805
3.92AspAsn: 3.92 ± 0.858
1.96AspPro: 1.96 ± 0.749
0.784AspGln: 0.784 ± 0.425
2.744AspArg: 2.744 ± 0.848
1.96AspSer: 1.96 ± 0.743
3.92AspThr: 3.92 ± 1.174
4.312AspVal: 4.312 ± 0.713
0.784AspTrp: 0.784 ± 0.626
3.136AspTyr: 3.136 ± 0.94
0.0AspXaa: 0.0 ± 0.0
Glu
7.84GluAla: 7.84 ± 1.972
0.0GluCys: 0.0 ± 0.0
3.92GluAsp: 3.92 ± 1.295
2.744GluGlu: 2.744 ± 1.146
1.176GluPhe: 1.176 ± 0.65
4.704GluGly: 4.704 ± 0.742
0.0GluHis: 0.0 ± 0.0
5.096GluIle: 5.096 ± 1.081
9.016GluLys: 9.016 ± 1.593
12.152GluLeu: 12.152 ± 2.086
1.568GluMet: 1.568 ± 0.639
3.92GluAsn: 3.92 ± 0.926
0.392GluPro: 0.392 ± 0.313
5.096GluGln: 5.096 ± 1.447
7.84GluArg: 7.84 ± 1.685
2.352GluSer: 2.352 ± 0.944
6.272GluThr: 6.272 ± 0.892
4.312GluVal: 4.312 ± 1.601
0.784GluTrp: 0.784 ± 0.506
3.92GluTyr: 3.92 ± 0.967
0.0GluXaa: 0.0 ± 0.0
Phe
1.96PheAla: 1.96 ± 0.726
0.0PheCys: 0.0 ± 0.0
3.528PheAsp: 3.528 ± 1.111
3.528PheGlu: 3.528 ± 0.622
0.392PhePhe: 0.392 ± 0.302
2.352PheGly: 2.352 ± 1.042
1.176PheHis: 1.176 ± 0.411
3.528PheIle: 3.528 ± 1.271
1.568PheLys: 1.568 ± 0.9
6.664PheLeu: 6.664 ± 1.219
0.0PheMet: 0.0 ± 0.0
1.568PheAsn: 1.568 ± 0.609
0.392PhePro: 0.392 ± 0.405
1.176PheGln: 1.176 ± 0.742
2.352PheArg: 2.352 ± 0.729
1.568PheSer: 1.568 ± 0.75
1.96PheThr: 1.96 ± 0.906
1.176PheVal: 1.176 ± 0.714
0.0PheTrp: 0.0 ± 0.0
1.96PheTyr: 1.96 ± 0.677
0.0PheXaa: 0.0 ± 0.0
Gly
2.352GlyAla: 2.352 ± 0.8
0.784GlyCys: 0.784 ± 0.367
0.784GlyAsp: 0.784 ± 0.367
3.92GlyGlu: 3.92 ± 0.871
2.744GlyPhe: 2.744 ± 0.765
2.744GlyGly: 2.744 ± 0.94
2.744GlyHis: 2.744 ± 1.446
2.744GlyIle: 2.744 ± 0.854
4.704GlyLys: 4.704 ± 1.078
4.704GlyLeu: 4.704 ± 1.214
1.176GlyMet: 1.176 ± 0.663
1.176GlyAsn: 1.176 ± 0.905
0.0GlyPro: 0.0 ± 0.0
2.352GlyGln: 2.352 ± 0.958
2.744GlyArg: 2.744 ± 0.923
2.744GlySer: 2.744 ± 1.185
3.136GlyThr: 3.136 ± 0.949
4.312GlyVal: 4.312 ± 1.013
0.784GlyTrp: 0.784 ± 0.536
4.312GlyTyr: 4.312 ± 1.222
0.0GlyXaa: 0.0 ± 0.0
His
1.96HisAla: 1.96 ± 1.249
0.392HisCys: 0.392 ± 0.313
0.0HisAsp: 0.0 ± 0.0
0.784HisGlu: 0.784 ± 0.471
0.392HisPhe: 0.392 ± 0.302
1.568HisGly: 1.568 ± 0.723
0.392HisHis: 0.392 ± 0.418
1.176HisIle: 1.176 ± 0.638
0.784HisLys: 0.784 ± 0.626
2.352HisLeu: 2.352 ± 0.84
0.784HisMet: 0.784 ± 0.544
0.392HisAsn: 0.392 ± 0.39
1.176HisPro: 1.176 ± 0.744
0.784HisGln: 0.784 ± 0.586
0.784HisArg: 0.784 ± 0.616
1.176HisSer: 1.176 ± 0.411
1.96HisThr: 1.96 ± 0.627
0.784HisVal: 0.784 ± 0.673
0.392HisTrp: 0.392 ± 0.431
2.352HisTyr: 2.352 ± 0.798
0.0HisXaa: 0.0 ± 0.0
Ile
4.312IleAla: 4.312 ± 1.254
0.0IleCys: 0.0 ± 0.0
4.312IleAsp: 4.312 ± 1.098
6.664IleGlu: 6.664 ± 1.426
3.528IlePhe: 3.528 ± 0.893
1.568IleGly: 1.568 ± 0.566
1.176IleHis: 1.176 ± 0.661
4.704IleIle: 4.704 ± 1.515
7.84IleLys: 7.84 ± 1.647
5.88IleLeu: 5.88 ± 1.165
0.784IleMet: 0.784 ± 0.502
1.96IleAsn: 1.96 ± 0.714
1.96IlePro: 1.96 ± 0.747
3.136IleGln: 3.136 ± 0.881
3.136IleArg: 3.136 ± 0.966
5.096IleSer: 5.096 ± 1.821
3.528IleThr: 3.528 ± 1.426
4.312IleVal: 4.312 ± 1.134
1.176IleTrp: 1.176 ± 0.696
3.136IleTyr: 3.136 ± 0.895
0.0IleXaa: 0.0 ± 0.0
Lys
7.84LysAla: 7.84 ± 1.347
0.0LysCys: 0.0 ± 0.0
4.704LysAsp: 4.704 ± 1.243
9.8LysGlu: 9.8 ± 2.208
2.352LysPhe: 2.352 ± 0.716
5.88LysGly: 5.88 ± 1.591
1.96LysHis: 1.96 ± 0.977
7.056LysIle: 7.056 ± 1.557
10.192LysLys: 10.192 ± 1.223
8.232LysLeu: 8.232 ± 2.053
0.784LysMet: 0.784 ± 0.452
7.056LysAsn: 7.056 ± 1.177
3.136LysPro: 3.136 ± 0.785
4.312LysGln: 4.312 ± 1.329
4.312LysArg: 4.312 ± 1.042
2.744LysSer: 2.744 ± 0.949
4.704LysThr: 4.704 ± 1.023
5.488LysVal: 5.488 ± 1.245
0.392LysTrp: 0.392 ± 0.302
1.568LysTyr: 1.568 ± 0.716
0.0LysXaa: 0.0 ± 0.0
Leu
6.272LeuAla: 6.272 ± 0.907
0.0LeuCys: 0.0 ± 0.0
6.272LeuAsp: 6.272 ± 1.097
9.8LeuGlu: 9.8 ± 2.092
1.96LeuPhe: 1.96 ± 0.864
5.488LeuGly: 5.488 ± 1.316
1.568LeuHis: 1.568 ± 0.797
2.352LeuIle: 2.352 ± 0.876
9.016LeuLys: 9.016 ± 1.532
6.272LeuLeu: 6.272 ± 1.785
1.568LeuMet: 1.568 ± 0.79
2.744LeuAsn: 2.744 ± 1.276
1.568LeuPro: 1.568 ± 0.513
6.664LeuGln: 6.664 ± 1.374
3.92LeuArg: 3.92 ± 1.003
6.272LeuSer: 6.272 ± 1.579
8.624LeuThr: 8.624 ± 1.355
4.312LeuVal: 4.312 ± 0.922
1.96LeuTrp: 1.96 ± 0.952
4.704LeuTyr: 4.704 ± 1.196
0.0LeuXaa: 0.0 ± 0.0
Met
1.568MetAla: 1.568 ± 0.717
0.0MetCys: 0.0 ± 0.0
1.176MetAsp: 1.176 ± 0.536
2.352MetGlu: 2.352 ± 0.785
0.784MetPhe: 0.784 ± 0.617
0.784MetGly: 0.784 ± 0.464
0.784MetHis: 0.784 ± 0.57
0.392MetIle: 0.392 ± 0.317
1.176MetLys: 1.176 ± 0.717
0.784MetLeu: 0.784 ± 0.506
0.392MetMet: 0.392 ± 0.418
2.744MetAsn: 2.744 ± 1.079
0.392MetPro: 0.392 ± 0.459
0.784MetGln: 0.784 ± 0.425
0.0MetArg: 0.0 ± 0.0
0.392MetSer: 0.392 ± 0.431
1.568MetThr: 1.568 ± 0.643
0.392MetVal: 0.392 ± 0.397
0.0MetTrp: 0.0 ± 0.0
0.784MetTyr: 0.784 ± 0.557
0.0MetXaa: 0.0 ± 0.0
Asn
2.744AsnAla: 2.744 ± 0.855
0.392AsnCys: 0.392 ± 0.405
2.352AsnAsp: 2.352 ± 0.849
2.352AsnGlu: 2.352 ± 0.717
2.352AsnPhe: 2.352 ± 0.799
3.92AsnGly: 3.92 ± 1.044
1.176AsnHis: 1.176 ± 0.673
3.136AsnIle: 3.136 ± 0.954
7.056AsnLys: 7.056 ± 2.323
2.352AsnLeu: 2.352 ± 0.819
1.176AsnMet: 1.176 ± 0.623
1.176AsnAsn: 1.176 ± 0.661
2.352AsnPro: 2.352 ± 0.685
2.352AsnGln: 2.352 ± 0.61
0.784AsnArg: 0.784 ± 0.468
2.744AsnSer: 2.744 ± 0.819
3.528AsnThr: 3.528 ± 1.278
2.352AsnVal: 2.352 ± 0.836
0.392AsnTrp: 0.392 ± 0.418
2.744AsnTyr: 2.744 ± 0.948
0.0AsnXaa: 0.0 ± 0.0
Pro
1.568ProAla: 1.568 ± 0.595
0.0ProCys: 0.0 ± 0.0
2.352ProAsp: 2.352 ± 0.672
2.352ProGlu: 2.352 ± 1.125
0.392ProPhe: 0.392 ± 0.418
1.176ProGly: 1.176 ± 0.504
0.784ProHis: 0.784 ± 0.415
0.784ProIle: 0.784 ± 0.626
0.784ProLys: 0.784 ± 0.492
3.136ProLeu: 3.136 ± 1.181
0.784ProMet: 0.784 ± 0.454
1.176ProAsn: 1.176 ± 0.391
1.568ProPro: 1.568 ± 0.875
0.784ProGln: 0.784 ± 0.45
0.784ProArg: 0.784 ± 0.502
1.176ProSer: 1.176 ± 0.668
1.568ProThr: 1.568 ± 0.9
1.96ProVal: 1.96 ± 0.683
0.784ProTrp: 0.784 ± 0.492
1.568ProTyr: 1.568 ± 0.843
0.0ProXaa: 0.0 ± 0.0
Gln
3.136GlnAla: 3.136 ± 1.305
0.392GlnCys: 0.392 ± 0.313
1.568GlnAsp: 1.568 ± 0.668
3.92GlnGlu: 3.92 ± 0.883
1.96GlnPhe: 1.96 ± 0.884
3.136GlnGly: 3.136 ± 0.965
1.568GlnHis: 1.568 ± 0.536
4.704GlnIle: 4.704 ± 1.418
3.92GlnLys: 3.92 ± 1.633
5.096GlnLeu: 5.096 ± 1.301
0.784GlnMet: 0.784 ± 0.657
1.568GlnAsn: 1.568 ± 0.904
1.568GlnPro: 1.568 ± 0.692
4.704GlnGln: 4.704 ± 1.496
1.96GlnArg: 1.96 ± 1.02
4.312GlnSer: 4.312 ± 1.248
2.744GlnThr: 2.744 ± 1.001
1.176GlnVal: 1.176 ± 0.391
0.392GlnTrp: 0.392 ± 0.317
2.744GlnTyr: 2.744 ± 1.095
0.0GlnXaa: 0.0 ± 0.0
Arg
2.744ArgAla: 2.744 ± 1.103
0.0ArgCys: 0.0 ± 0.0
2.744ArgAsp: 2.744 ± 1.13
3.528ArgGlu: 3.528 ± 0.672
2.352ArgPhe: 2.352 ± 0.968
1.176ArgGly: 1.176 ± 0.56
1.568ArgHis: 1.568 ± 0.558
4.704ArgIle: 4.704 ± 1.115
3.136ArgLys: 3.136 ± 0.789
6.664ArgLeu: 6.664 ± 1.346
0.784ArgMet: 0.784 ± 0.53
1.176ArgAsn: 1.176 ± 0.606
0.0ArgPro: 0.0 ± 0.0
2.744ArgGln: 2.744 ± 0.846
2.744ArgArg: 2.744 ± 1.136
2.744ArgSer: 2.744 ± 0.988
2.352ArgThr: 2.352 ± 0.702
1.176ArgVal: 1.176 ± 0.757
1.176ArgTrp: 1.176 ± 0.573
3.92ArgTyr: 3.92 ± 1.213
0.0ArgXaa: 0.0 ± 0.0
Ser
4.704SerAla: 4.704 ± 0.982
0.0SerCys: 0.0 ± 0.0
4.312SerAsp: 4.312 ± 1.121
2.744SerGlu: 2.744 ± 1.041
1.176SerPhe: 1.176 ± 0.74
1.568SerGly: 1.568 ± 0.768
0.392SerHis: 0.392 ± 0.397
6.272SerIle: 6.272 ± 1.26
4.312SerLys: 4.312 ± 1.217
2.352SerLeu: 2.352 ± 0.693
1.568SerMet: 1.568 ± 0.819
3.136SerAsn: 3.136 ± 0.923
1.568SerPro: 1.568 ± 0.707
3.528SerGln: 3.528 ± 0.951
1.568SerArg: 1.568 ± 0.762
2.744SerSer: 2.744 ± 0.758
3.136SerThr: 3.136 ± 0.737
3.92SerVal: 3.92 ± 1.185
0.392SerTrp: 0.392 ± 0.431
2.352SerTyr: 2.352 ± 0.745
0.0SerXaa: 0.0 ± 0.0
Thr
7.056ThrAla: 7.056 ± 1.167
0.0ThrCys: 0.0 ± 0.0
2.352ThrAsp: 2.352 ± 0.98
8.624ThrGlu: 8.624 ± 2.348
1.176ThrPhe: 1.176 ± 0.596
3.528ThrGly: 3.528 ± 0.862
1.176ThrHis: 1.176 ± 0.514
4.704ThrIle: 4.704 ± 1.267
6.272ThrLys: 6.272 ± 1.065
5.88ThrLeu: 5.88 ± 1.71
1.96ThrMet: 1.96 ± 0.855
2.744ThrAsn: 2.744 ± 0.698
2.744ThrPro: 2.744 ± 0.861
3.528ThrGln: 3.528 ± 1.494
1.568ThrArg: 1.568 ± 0.677
3.136ThrSer: 3.136 ± 0.89
4.312ThrThr: 4.312 ± 0.879
3.136ThrVal: 3.136 ± 1.075
0.392ThrTrp: 0.392 ± 0.317
2.744ThrTyr: 2.744 ± 0.852
0.0ThrXaa: 0.0 ± 0.0
Val
6.272ValAla: 6.272 ± 1.391
0.0ValCys: 0.0 ± 0.0
3.528ValAsp: 3.528 ± 1.04
3.92ValGlu: 3.92 ± 1.335
2.352ValPhe: 2.352 ± 1.102
2.352ValGly: 2.352 ± 0.839
1.176ValHis: 1.176 ± 0.661
3.528ValIle: 3.528 ± 0.79
3.528ValLys: 3.528 ± 0.732
3.136ValLeu: 3.136 ± 0.653
0.0ValMet: 0.0 ± 0.0
3.136ValAsn: 3.136 ± 0.777
1.96ValPro: 1.96 ± 0.668
0.784ValGln: 0.784 ± 0.47
2.352ValArg: 2.352 ± 0.622
2.744ValSer: 2.744 ± 0.668
5.88ValThr: 5.88 ± 1.584
3.92ValVal: 3.92 ± 1.22
0.0ValTrp: 0.0 ± 0.0
3.528ValTyr: 3.528 ± 1.311
0.0ValXaa: 0.0 ± 0.0
Trp
1.176TrpAla: 1.176 ± 0.686
0.0TrpCys: 0.0 ± 0.0
1.176TrpAsp: 1.176 ± 0.486
1.176TrpGlu: 1.176 ± 0.61
0.392TrpPhe: 0.392 ± 0.431
0.392TrpGly: 0.392 ± 0.313
0.0TrpHis: 0.0 ± 0.0
0.392TrpIle: 0.392 ± 0.445
1.176TrpLys: 1.176 ± 0.504
1.568TrpLeu: 1.568 ± 0.587
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
1.176TrpGln: 1.176 ± 0.594
0.0TrpArg: 0.0 ± 0.0
0.784TrpSer: 0.784 ± 0.367
0.392TrpThr: 0.392 ± 0.431
0.0TrpVal: 0.0 ± 0.0
0.392TrpTrp: 0.392 ± 0.302
0.784TrpTyr: 0.784 ± 0.626
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.312TyrAla: 4.312 ± 1.305
0.0TyrCys: 0.0 ± 0.0
2.352TyrAsp: 2.352 ± 0.784
3.92TyrGlu: 3.92 ± 1.153
4.704TyrPhe: 4.704 ± 1.571
3.528TyrGly: 3.528 ± 1.238
0.784TyrHis: 0.784 ± 0.484
1.568TyrIle: 1.568 ± 0.84
5.096TyrLys: 5.096 ± 1.794
5.096TyrLeu: 5.096 ± 0.917
0.392TyrMet: 0.392 ± 0.317
4.312TyrAsn: 4.312 ± 0.992
1.176TyrPro: 1.176 ± 0.939
3.528TyrGln: 3.528 ± 1.215
2.744TyrArg: 2.744 ± 0.801
2.352TyrSer: 2.352 ± 0.865
2.744TyrThr: 2.744 ± 1.131
1.568TyrVal: 1.568 ± 0.466
0.0TyrTrp: 0.0 ± 0.0
3.528TyrTyr: 3.528 ± 0.887
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14 proteins (2552 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski