Amino acid dipepetide frequency for Alkalibacillus haloalkaliphilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.522AlaAla: 4.522 ± 0.088	0.508AlaCys: 0.508 ± 0.027	3.139AlaAsp: 3.139 ± 0.056	4.398AlaGlu: 4.398 ± 0.085	3.149AlaPhe: 3.149 ± 0.074	4.479AlaGly: 4.479 ± 0.079	1.306AlaHis: 1.306 ± 0.049	5.508AlaIle: 5.508 ± 0.085	3.9AlaLys: 3.9 ± 0.08	6.76AlaLeu: 6.76 ± 0.102	1.875AlaMet: 1.875 ± 0.048	2.791AlaAsn: 2.791 ± 0.062	1.861AlaPro: 1.861 ± 0.051	2.322AlaGln: 2.322 ± 0.061	2.392AlaArg: 2.392 ± 0.051	3.742AlaSer: 3.742 ± 0.069	3.454AlaThr: 3.454 ± 0.075	4.938AlaVal: 4.938 ± 0.091	0.582AlaTrp: 0.582 ± 0.027	2.379AlaTyr: 2.379 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.297CysAla: 0.297 ± 0.022	0.071CysCys: 0.071 ± 0.011	0.376CysAsp: 0.376 ± 0.021	0.42CysGlu: 0.42 ± 0.025	0.219CysPhe: 0.219 ± 0.018	0.575CysGly: 0.575 ± 0.025	0.19CysHis: 0.19 ± 0.016	0.376CysIle: 0.376 ± 0.021	0.295CysLys: 0.295 ± 0.021	0.504CysLeu: 0.504 ± 0.022	0.155CysMet: 0.155 ± 0.013	0.244CysAsn: 0.244 ± 0.016	0.332CysPro: 0.332 ± 0.019	0.23CysGln: 0.23 ± 0.016	0.237CysArg: 0.237 ± 0.017	0.364CysSer: 0.364 ± 0.021	0.318CysThr: 0.318 ± 0.02	0.361CysVal: 0.361 ± 0.021	0.053CysTrp: 0.053 ± 0.008	0.26CysTyr: 0.26 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.378AspAla: 3.378 ± 0.08	0.349AspCys: 0.349 ± 0.019	3.78AspAsp: 3.78 ± 0.081	6.588AspGlu: 6.588 ± 0.123	2.564AspPhe: 2.564 ± 0.055	3.904AspGly: 3.904 ± 0.087	1.601AspHis: 1.601 ± 0.053	4.061AspIle: 4.061 ± 0.076	2.204AspLys: 2.204 ± 0.063	6.06AspLeu: 6.06 ± 0.08	1.425AspMet: 1.425 ± 0.042	1.816AspAsn: 1.816 ± 0.047	2.273AspPro: 2.273 ± 0.059	3.277AspGln: 3.277 ± 0.06	2.637AspArg: 2.637 ± 0.06	2.804AspSer: 2.804 ± 0.063	2.42AspThr: 2.42 ± 0.063	4.561AspVal: 4.561 ± 0.089	0.688AspTrp: 0.688 ± 0.031	2.738AspTyr: 2.738 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	5.831GluAla: 5.831 ± 0.099	0.319GluCys: 0.319 ± 0.021	5.258GluAsp: 5.258 ± 0.094	9.012GluGlu: 9.012 ± 0.153	2.63GluPhe: 2.63 ± 0.064	4.953GluGly: 4.953 ± 0.094	1.989GluHis: 1.989 ± 0.058	5.31GluIle: 5.31 ± 0.087	5.397GluLys: 5.397 ± 0.095	7.553GluLeu: 7.553 ± 0.097	2.404GluMet: 2.404 ± 0.05	3.766GluAsn: 3.766 ± 0.077	2.392GluPro: 2.392 ± 0.058	4.995GluGln: 4.995 ± 0.095	3.95GluArg: 3.95 ± 0.07	4.144GluSer: 4.144 ± 0.081	4.289GluThr: 4.289 ± 0.08	6.474GluVal: 6.474 ± 0.103	0.877GluTrp: 0.877 ± 0.032	2.492GluTyr: 2.492 ± 0.08	0.0GluXaa: 0.0 ± 0.0
Phe	2.796PheAla: 2.796 ± 0.064	0.24PheCys: 0.24 ± 0.016	2.833PheAsp: 2.833 ± 0.055	3.174PheGlu: 3.174 ± 0.062	2.201PhePhe: 2.201 ± 0.071	3.175PheGly: 3.175 ± 0.076	0.954PheHis: 0.954 ± 0.035	3.797PheIle: 3.797 ± 0.102	2.421PheLys: 2.421 ± 0.058	4.119PheLeu: 4.119 ± 0.102	1.171PheMet: 1.171 ± 0.045	2.3PheAsn: 2.3 ± 0.057	1.5PhePro: 1.5 ± 0.04	1.581PheGln: 1.581 ± 0.043	1.445PheArg: 1.445 ± 0.045	2.931PheSer: 2.931 ± 0.06	2.481PheThr: 2.481 ± 0.051	3.252PheVal: 3.252 ± 0.067	0.505PheTrp: 0.505 ± 0.027	1.786PheTyr: 1.786 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	4.565GlyAla: 4.565 ± 0.09	0.514GlyCys: 0.514 ± 0.026	3.749GlyAsp: 3.749 ± 0.076	5.229GlyGlu: 5.229 ± 0.081	3.269GlyPhe: 3.269 ± 0.067	4.52GlyGly: 4.52 ± 0.099	1.582GlyHis: 1.582 ± 0.047	4.962GlyIle: 4.962 ± 0.097	3.912GlyLys: 3.912 ± 0.077	6.323GlyLeu: 6.323 ± 0.092	1.969GlyMet: 1.969 ± 0.049	2.497GlyAsn: 2.497 ± 0.086	1.716GlyPro: 1.716 ± 0.05	2.568GlyGln: 2.568 ± 0.05	2.524GlyArg: 2.524 ± 0.064	3.844GlySer: 3.844 ± 0.075	3.684GlyThr: 3.684 ± 0.07	5.55GlyVal: 5.55 ± 0.087	0.712GlyTrp: 0.712 ± 0.034	2.811GlyTyr: 2.811 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	1.295HisAla: 1.295 ± 0.043	0.168HisCys: 0.168 ± 0.015	1.383HisAsp: 1.383 ± 0.047	1.9HisGlu: 1.9 ± 0.054	1.126HisPhe: 1.126 ± 0.039	1.535HisGly: 1.535 ± 0.045	0.737HisHis: 0.737 ± 0.04	1.607HisIle: 1.607 ± 0.047	1.078HisLys: 1.078 ± 0.04	2.194HisLeu: 2.194 ± 0.055	0.563HisMet: 0.563 ± 0.029	1.032HisAsn: 1.032 ± 0.035	1.054HisPro: 1.054 ± 0.039	0.987HisGln: 0.987 ± 0.041	0.936HisArg: 0.936 ± 0.035	1.274HisSer: 1.274 ± 0.044	1.033HisThr: 1.033 ± 0.037	1.567HisVal: 1.567 ± 0.043	0.228HisTrp: 0.228 ± 0.019	1.006HisTyr: 1.006 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	5.543IleAla: 5.543 ± 0.098	0.442IleCys: 0.442 ± 0.024	4.728IleAsp: 4.728 ± 0.062	6.145IleGlu: 6.145 ± 0.096	3.275IlePhe: 3.275 ± 0.081	5.402IleGly: 5.402 ± 0.093	1.661IleHis: 1.661 ± 0.045	5.734IleIle: 5.734 ± 0.11	3.983IleLys: 3.983 ± 0.074	6.38IleLeu: 6.38 ± 0.103	1.821IleMet: 1.821 ± 0.055	3.632IleAsn: 3.632 ± 0.072	2.978IlePro: 2.978 ± 0.075	2.757IleGln: 2.757 ± 0.053	2.713IleArg: 2.713 ± 0.056	4.608IleSer: 4.608 ± 0.086	4.143IleThr: 4.143 ± 0.066	5.692IleVal: 5.692 ± 0.094	0.608IleTrp: 0.608 ± 0.03	2.458IleTyr: 2.458 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	3.694LysAla: 3.694 ± 0.072	0.275LysCys: 0.275 ± 0.02	3.53LysAsp: 3.53 ± 0.074	5.626LysGlu: 5.626 ± 0.091	1.771LysPhe: 1.771 ± 0.05	3.681LysGly: 3.681 ± 0.077	1.361LysHis: 1.361 ± 0.042	3.427LysIle: 3.427 ± 0.067	4.216LysLys: 4.216 ± 0.097	4.915LysLeu: 4.915 ± 0.078	1.776LysMet: 1.776 ± 0.05	2.341LysAsn: 2.341 ± 0.059	2.054LysPro: 2.054 ± 0.054	3.386LysGln: 3.386 ± 0.077	3.192LysArg: 3.192 ± 0.074	3.187LysSer: 3.187 ± 0.074	2.836LysThr: 2.836 ± 0.061	4.332LysVal: 4.332 ± 0.083	0.712LysTrp: 0.712 ± 0.031	1.827LysTyr: 1.827 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	6.481LeuAla: 6.481 ± 0.108	0.511LeuCys: 0.511 ± 0.03	5.287LeuAsp: 5.287 ± 0.087	7.092LeuGlu: 7.092 ± 0.091	4.576LeuPhe: 4.576 ± 0.096	6.167LeuGly: 6.167 ± 0.106	1.859LeuHis: 1.859 ± 0.05	7.604LeuIle: 7.604 ± 0.133	5.94LeuLys: 5.94 ± 0.092	9.381LeuLeu: 9.381 ± 0.144	2.581LeuMet: 2.581 ± 0.06	5.041LeuAsn: 5.041 ± 0.077	3.589LeuPro: 3.589 ± 0.064	3.43LeuGln: 3.43 ± 0.07	3.294LeuArg: 3.294 ± 0.066	6.406LeuSer: 6.406 ± 0.1	5.804LeuThr: 5.804 ± 0.09	6.504LeuVal: 6.504 ± 0.09	0.693LeuTrp: 0.693 ± 0.029	3.182LeuTyr: 3.182 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.907MetAla: 1.907 ± 0.045	0.117MetCys: 0.117 ± 0.012	1.559MetAsp: 1.559 ± 0.041	1.857MetGlu: 1.857 ± 0.052	1.219MetPhe: 1.219 ± 0.043	1.691MetGly: 1.691 ± 0.053	0.435MetHis: 0.435 ± 0.021	1.969MetIle: 1.969 ± 0.048	2.103MetLys: 2.103 ± 0.051	2.593MetLeu: 2.593 ± 0.057	0.837MetMet: 0.837 ± 0.032	1.567MetAsn: 1.567 ± 0.041	0.92MetPro: 0.92 ± 0.036	0.915MetGln: 0.915 ± 0.035	1.13MetArg: 1.13 ± 0.038	1.895MetSer: 1.895 ± 0.045	1.799MetThr: 1.799 ± 0.051	1.914MetVal: 1.914 ± 0.05	0.2MetTrp: 0.2 ± 0.014	0.776MetTyr: 0.776 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.392AsnAla: 2.392 ± 0.053	0.293AsnCys: 0.293 ± 0.02	2.725AsnAsp: 2.725 ± 0.065	4.363AsnGlu: 4.363 ± 0.084	1.767AsnPhe: 1.767 ± 0.05	3.061AsnGly: 3.061 ± 0.073	1.191AsnHis: 1.191 ± 0.037	3.339AsnIle: 3.339 ± 0.064	2.585AsnLys: 2.585 ± 0.068	3.944AsnLeu: 3.944 ± 0.069	1.166AsnMet: 1.166 ± 0.036	2.254AsnAsn: 2.254 ± 0.062	1.994AsnPro: 1.994 ± 0.055	2.473AsnGln: 2.473 ± 0.06	2.173AsnArg: 2.173 ± 0.058	2.311AsnSer: 2.311 ± 0.047	2.141AsnThr: 2.141 ± 0.055	3.325AsnVal: 3.325 ± 0.057	0.574AsnTrp: 0.574 ± 0.022	1.788AsnTyr: 1.788 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	1.802ProAla: 1.802 ± 0.043	0.181ProCys: 0.181 ± 0.015	2.038ProAsp: 2.038 ± 0.055	2.999ProGlu: 2.999 ± 0.067	1.892ProPhe: 1.892 ± 0.051	2.186ProGly: 2.186 ± 0.064	0.778ProHis: 0.778 ± 0.031	2.767ProIle: 2.767 ± 0.059	2.071ProLys: 2.071 ± 0.053	3.231ProLeu: 3.231 ± 0.066	0.821ProMet: 0.821 ± 0.028	1.932ProAsn: 1.932 ± 0.048	0.936ProPro: 0.936 ± 0.034	1.063ProGln: 1.063 ± 0.036	1.032ProArg: 1.032 ± 0.031	2.145ProSer: 2.145 ± 0.047	2.053ProThr: 2.053 ± 0.049	2.8ProVal: 2.8 ± 0.062	0.37ProTrp: 0.37 ± 0.03	1.476ProTyr: 1.476 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.969GlnAla: 2.969 ± 0.053	0.199GlnCys: 0.199 ± 0.017	2.296GlnAsp: 2.296 ± 0.06	3.274GlnGlu: 3.274 ± 0.065	1.982GlnPhe: 1.982 ± 0.05	2.481GlnGly: 2.481 ± 0.051	0.994GlnHis: 0.994 ± 0.036	2.767GlnIle: 2.767 ± 0.054	2.416GlnLys: 2.416 ± 0.059	4.829GlnLeu: 4.829 ± 0.087	1.273GlnMet: 1.273 ± 0.045	1.869GlnAsn: 1.869 ± 0.051	1.356GlnPro: 1.356 ± 0.041	2.308GlnGln: 2.308 ± 0.065	1.54GlnArg: 1.54 ± 0.039	2.729GlnSer: 2.729 ± 0.061	2.274GlnThr: 2.274 ± 0.059	3.115GlnVal: 3.115 ± 0.066	0.4GlnTrp: 0.4 ± 0.018	1.677GlnTyr: 1.677 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	2.255ArgAla: 2.255 ± 0.056	0.214ArgCys: 0.214 ± 0.016	2.269ArgAsp: 2.269 ± 0.053	3.395ArgGlu: 3.395 ± 0.074	1.81ArgPhe: 1.81 ± 0.049	2.371ArgGly: 2.371 ± 0.052	0.924ArgHis: 0.924 ± 0.033	2.765ArgIle: 2.765 ± 0.061	2.677ArgLys: 2.677 ± 0.065	3.964ArgLeu: 3.964 ± 0.078	1.231ArgMet: 1.231 ± 0.036	1.861ArgAsn: 1.861 ± 0.046	1.242ArgPro: 1.242 ± 0.04	1.741ArgGln: 1.741 ± 0.047	1.881ArgArg: 1.881 ± 0.052	2.217ArgSer: 2.217 ± 0.049	1.983ArgThr: 1.983 ± 0.049	2.957ArgVal: 2.957 ± 0.063	0.346ArgTrp: 0.346 ± 0.023	1.543ArgTyr: 1.543 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.307SerAla: 3.307 ± 0.067	0.312SerCys: 0.312 ± 0.02	3.332SerAsp: 3.332 ± 0.07	4.533SerGlu: 4.533 ± 0.086	3.086SerPhe: 3.086 ± 0.059	4.18SerGly: 4.18 ± 0.066	1.355SerHis: 1.355 ± 0.042	4.736SerIle: 4.736 ± 0.08	3.36SerLys: 3.36 ± 0.068	5.785SerLeu: 5.785 ± 0.092	1.707SerMet: 1.707 ± 0.045	2.751SerAsn: 2.751 ± 0.06	2.006SerPro: 2.006 ± 0.05	2.332SerGln: 2.332 ± 0.052	2.234SerArg: 2.234 ± 0.047	3.772SerSer: 3.772 ± 0.078	3.065SerThr: 3.065 ± 0.059	4.361SerVal: 4.361 ± 0.069	0.557SerTrp: 0.557 ± 0.024	2.228SerTyr: 2.228 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	3.398ThrAla: 3.398 ± 0.057	0.332ThrCys: 0.332 ± 0.021	3.053ThrAsp: 3.053 ± 0.067	3.775ThrGlu: 3.775 ± 0.077	2.613ThrPhe: 2.613 ± 0.063	3.947ThrGly: 3.947 ± 0.07	1.129ThrHis: 1.129 ± 0.034	4.597ThrIle: 4.597 ± 0.083	2.805ThrLys: 2.805 ± 0.062	5.264ThrLeu: 5.264 ± 0.073	1.307ThrMet: 1.307 ± 0.042	2.522ThrAsn: 2.522 ± 0.055	2.177ThrPro: 2.177 ± 0.052	1.701ThrGln: 1.701 ± 0.049	1.773ThrArg: 1.773 ± 0.04	3.194ThrSer: 3.194 ± 0.071	3.032ThrThr: 3.032 ± 0.085	4.473ThrVal: 4.473 ± 0.084	0.498ThrTrp: 0.498 ± 0.025	2.048ThrTyr: 2.048 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	4.959ValAla: 4.959 ± 0.087	0.514ValCys: 0.514 ± 0.021	4.734ValAsp: 4.734 ± 0.09	6.188ValGlu: 6.188 ± 0.106	3.057ValPhe: 3.057 ± 0.071	5.204ValGly: 5.204 ± 0.08	1.527ValHis: 1.527 ± 0.043	5.963ValIle: 5.963 ± 0.095	4.281ValLys: 4.281 ± 0.077	6.96ValLeu: 6.96 ± 0.115	2.034ValMet: 2.034 ± 0.049	3.507ValAsn: 3.507 ± 0.071	2.646ValPro: 2.646 ± 0.045	2.658ValGln: 2.658 ± 0.061	2.693ValArg: 2.693 ± 0.059	4.758ValSer: 4.758 ± 0.079	4.478ValThr: 4.478 ± 0.071	5.883ValVal: 5.883 ± 0.092	0.624ValTrp: 0.624 ± 0.028	2.542ValTyr: 2.542 ± 0.063	0.0ValXaa: 0.0 ± 0.0
Trp	0.522TrpAla: 0.522 ± 0.024	0.065TrpCys: 0.065 ± 0.009	0.563TrpAsp: 0.563 ± 0.027	0.677TrpGlu: 0.677 ± 0.03	0.568TrpPhe: 0.568 ± 0.032	0.552TrpGly: 0.552 ± 0.026	0.225TrpHis: 0.225 ± 0.016	0.788TrpIle: 0.788 ± 0.031	0.595TrpLys: 0.595 ± 0.027	1.126TrpLeu: 1.126 ± 0.037	0.351TrpMet: 0.351 ± 0.023	0.397TrpAsn: 0.397 ± 0.023	0.263TrpPro: 0.263 ± 0.015	0.391TrpGln: 0.391 ± 0.02	0.365TrpArg: 0.365 ± 0.021	0.579TrpSer: 0.579 ± 0.028	0.497TrpThr: 0.497 ± 0.028	0.725TrpVal: 0.725 ± 0.03	0.12TrpTrp: 0.12 ± 0.011	0.381TrpTyr: 0.381 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.094TyrAla: 2.094 ± 0.054	0.254TyrCys: 0.254 ± 0.018	2.497TyrAsp: 2.497 ± 0.103	3.391TyrGlu: 3.391 ± 0.065	1.887TyrPhe: 1.887 ± 0.054	2.436TyrGly: 2.436 ± 0.056	0.907TyrHis: 0.907 ± 0.031	2.625TyrIle: 2.625 ± 0.052	1.898TyrLys: 1.898 ± 0.056	3.536TyrLeu: 3.536 ± 0.074	0.938TyrMet: 0.938 ± 0.032	1.737TyrAsn: 1.737 ± 0.044	1.281TyrPro: 1.281 ± 0.04	1.632TyrGln: 1.632 ± 0.049	1.506TyrArg: 1.506 ± 0.041	2.094TyrSer: 2.094 ± 0.055	1.856TyrThr: 1.856 ± 0.048	2.424TyrVal: 2.424 ± 0.044	0.403TyrTrp: 0.403 ± 0.023	1.592TyrTyr: 1.592 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2984 proteins (843071 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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