Amino acid dipepetide frequency for Hepatocystis sp. ex Piliocolobus tephrosceles

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	0.822AlaAla: 0.822 ± 0.024	0.447AlaCys: 0.447 ± 0.011	1.164AlaAsp: 1.164 ± 0.025	1.325AlaGlu: 1.325 ± 0.033	1.042AlaPhe: 1.042 ± 0.021	0.831AlaGly: 0.831 ± 0.024	0.554AlaHis: 0.554 ± 0.015	1.955AlaIle: 1.955 ± 0.03	2.161AlaLys: 2.161 ± 0.036	2.085AlaLeu: 2.085 ± 0.034	0.419AlaMet: 0.419 ± 0.012	2.168AlaAsn: 2.168 ± 0.042	0.532AlaPro: 0.532 ± 0.017	0.729AlaGln: 0.729 ± 0.018	0.58AlaArg: 0.58 ± 0.015	1.71AlaSer: 1.71 ± 0.03	1.654AlaThr: 1.654 ± 0.035	1.081AlaVal: 1.081 ± 0.025	0.134AlaTrp: 0.134 ± 0.006	1.232AlaTyr: 1.232 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.486CysAla: 0.486 ± 0.013	0.35CysCys: 0.35 ± 0.011	1.047CysAsp: 1.047 ± 0.02	0.944CysGlu: 0.944 ± 0.019	0.971CysPhe: 0.971 ± 0.02	0.65CysGly: 0.65 ± 0.017	0.312CysHis: 0.312 ± 0.008	1.754CysIle: 1.754 ± 0.024	1.46CysLys: 1.46 ± 0.022	1.632CysLeu: 1.632 ± 0.022	0.333CysMet: 0.333 ± 0.01	1.885CysAsn: 1.885 ± 0.034	0.397CysPro: 0.397 ± 0.013	0.335CysGln: 0.335 ± 0.009	0.375CysArg: 0.375 ± 0.01	1.561CysSer: 1.561 ± 0.031	0.984CysThr: 0.984 ± 0.02	0.889CysVal: 0.889 ± 0.02	0.076CysTrp: 0.076 ± 0.005	0.92CysTyr: 0.92 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	1.309AspAla: 1.309 ± 0.03	0.754AspCys: 0.754 ± 0.017	4.008AspAsp: 4.008 ± 0.061	4.344AspGlu: 4.344 ± 0.058	2.048AspPhe: 2.048 ± 0.024	2.338AspGly: 2.338 ± 0.05	0.95AspHis: 0.95 ± 0.021	6.04AspIle: 6.04 ± 0.055	6.36AspLys: 6.36 ± 0.081	3.667AspLeu: 3.667 ± 0.039	1.234AspMet: 1.234 ± 0.022	7.1AspAsn: 7.1 ± 0.07	0.829AspPro: 0.829 ± 0.019	1.197AspGln: 1.197 ± 0.025	1.317AspArg: 1.317 ± 0.031	4.21AspSer: 4.21 ± 0.05	3.205AspThr: 3.205 ± 0.041	2.817AspVal: 2.817 ± 0.034	0.202AspTrp: 0.202 ± 0.008	2.616AspTyr: 2.616 ± 0.03	0.001AspXaa: 0.001 ± 0.0
Glu	1.519GluAla: 1.519 ± 0.036	0.986GluCys: 0.986 ± 0.021	3.363GluAsp: 3.363 ± 0.049	6.215GluGlu: 6.215 ± 0.145	1.826GluPhe: 1.826 ± 0.025	1.774GluGly: 1.774 ± 0.036	1.608GluHis: 1.608 ± 0.029	4.866GluIle: 4.866 ± 0.046	9.683GluLys: 9.683 ± 0.105	4.765GluLeu: 4.765 ± 0.062	1.171GluMet: 1.171 ± 0.024	7.926GluAsn: 7.926 ± 0.083	0.988GluPro: 0.988 ± 0.037	3.155GluGln: 3.155 ± 0.053	1.816GluArg: 1.816 ± 0.036	3.515GluSer: 3.515 ± 0.05	2.96GluThr: 2.96 ± 0.035	2.305GluVal: 2.305 ± 0.042	0.321GluTrp: 0.321 ± 0.012	3.03GluTyr: 3.03 ± 0.034	0.001GluXaa: 0.001 ± 0.0
Phe	0.914PheAla: 0.914 ± 0.019	0.92PheCys: 0.92 ± 0.016	2.355PheAsp: 2.355 ± 0.031	2.313PheGlu: 2.313 ± 0.026	3.751PhePhe: 3.751 ± 0.059	1.224PheGly: 1.224 ± 0.027	0.828PheHis: 0.828 ± 0.018	4.377PheIle: 4.377 ± 0.052	3.634PheLys: 3.634 ± 0.039	4.873PheLeu: 4.873 ± 0.057	0.855PheMet: 0.855 ± 0.017	4.47PheAsn: 4.47 ± 0.043	0.864PhePro: 0.864 ± 0.016	1.032PheGln: 1.032 ± 0.018	0.87PheArg: 0.87 ± 0.017	2.996PheSer: 2.996 ± 0.032	1.871PheThr: 1.871 ± 0.024	2.023PheVal: 2.023 ± 0.031	0.231PheTrp: 0.231 ± 0.008	2.925PheTyr: 2.925 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	0.909GlyAla: 0.909 ± 0.024	0.588GlyCys: 0.588 ± 0.02	2.264GlyAsp: 2.264 ± 0.046	2.082GlyGlu: 2.082 ± 0.038	1.166GlyPhe: 1.166 ± 0.022	2.217GlyGly: 2.217 ± 0.073	0.699GlyHis: 0.699 ± 0.02	2.817GlyIle: 2.817 ± 0.046	2.999GlyLys: 2.999 ± 0.041	2.229GlyLeu: 2.229 ± 0.04	0.674GlyMet: 0.674 ± 0.022	4.085GlyAsn: 4.085 ± 0.071	0.503GlyPro: 0.503 ± 0.018	0.796GlyGln: 0.796 ± 0.024	0.958GlyArg: 0.958 ± 0.027	3.416GlySer: 3.416 ± 0.068	2.26GlyThr: 2.26 ± 0.046	1.881GlyVal: 1.881 ± 0.047	0.164GlyTrp: 0.164 ± 0.007	1.546GlyTyr: 1.546 ± 0.024	0.001GlyXaa: 0.001 ± 0.001
His	0.491HisAla: 0.491 ± 0.013	0.286HisCys: 0.286 ± 0.011	1.134HisAsp: 1.134 ± 0.023	1.129HisGlu: 1.129 ± 0.022	1.042HisPhe: 1.042 ± 0.02	0.658HisGly: 0.658 ± 0.018	0.416HisHis: 0.416 ± 0.018	2.3HisIle: 2.3 ± 0.028	1.977HisLys: 1.977 ± 0.028	1.651HisLeu: 1.651 ± 0.026	0.575HisMet: 0.575 ± 0.014	2.661HisAsn: 2.661 ± 0.042	0.498HisPro: 0.498 ± 0.016	0.401HisGln: 0.401 ± 0.014	0.47HisArg: 0.47 ± 0.015	1.481HisSer: 1.481 ± 0.027	1.281HisThr: 1.281 ± 0.029	1.068HisVal: 1.068 ± 0.018	0.089HisTrp: 0.089 ± 0.005	0.916HisTyr: 0.916 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	1.889IleAla: 1.889 ± 0.031	1.906IleCys: 1.906 ± 0.027	4.822IleAsp: 4.822 ± 0.041	5.101IleGlu: 5.101 ± 0.054	4.421IlePhe: 4.421 ± 0.048	2.525IleGly: 2.525 ± 0.034	2.103IleHis: 2.103 ± 0.025	7.855IleIle: 7.855 ± 0.064	10.534IleLys: 10.534 ± 0.071	7.7IleLeu: 7.7 ± 0.073	1.399IleMet: 1.399 ± 0.023	12.545IleAsn: 12.545 ± 0.101	2.201IlePro: 2.201 ± 0.03	2.737IleGln: 2.737 ± 0.032	2.103IleArg: 2.103 ± 0.026	6.086IleSer: 6.086 ± 0.05	4.329IleThr: 4.329 ± 0.039	3.251IleVal: 3.251 ± 0.041	0.431IleTrp: 0.431 ± 0.013	5.599IleTyr: 5.599 ± 0.061	0.001IleXaa: 0.001 ± 0.001
Lys	1.954LysAla: 1.954 ± 0.037	1.813LysCys: 1.813 ± 0.03	5.107LysAsp: 5.107 ± 0.06	8.387LysGlu: 8.387 ± 0.083	3.035LysPhe: 3.035 ± 0.033	2.94LysGly: 2.94 ± 0.04	2.627LysHis: 2.627 ± 0.035	9.707LysIle: 9.707 ± 0.071	21.05LysLys: 21.05 ± 0.167	7.769LysLeu: 7.769 ± 0.067	2.211LysMet: 2.211 ± 0.03	16.942LysAsn: 16.942 ± 0.124	1.624LysPro: 1.624 ± 0.03	4.233LysGln: 4.233 ± 0.053	3.568LysArg: 3.568 ± 0.044	6.479LysSer: 6.479 ± 0.061	5.901LysThr: 5.901 ± 0.059	3.55LysVal: 3.55 ± 0.041	0.544LysTrp: 0.544 ± 0.013	6.013LysTyr: 6.013 ± 0.052	0.001LysXaa: 0.001 ± 0.001
Leu	1.788LeuAla: 1.788 ± 0.033	1.74LeuCys: 1.74 ± 0.024	3.411LeuAsp: 3.411 ± 0.038	3.993LeuGlu: 3.993 ± 0.05	4.745LeuPhe: 4.745 ± 0.061	2.079LeuGly: 2.079 ± 0.035	1.741LeuHis: 1.741 ± 0.025	6.483LeuIle: 6.483 ± 0.058	9.326LeuLys: 9.326 ± 0.073	7.786LeuLeu: 7.786 ± 0.074	1.28LeuMet: 1.28 ± 0.021	9.116LeuAsn: 9.116 ± 0.067	1.916LeuPro: 1.916 ± 0.027	2.443LeuGln: 2.443 ± 0.033	1.926LeuArg: 1.926 ± 0.029	5.687LeuSer: 5.687 ± 0.05	3.71LeuThr: 3.71 ± 0.046	2.7LeuVal: 2.7 ± 0.037	0.414LeuTrp: 0.414 ± 0.014	4.638LeuTyr: 4.638 ± 0.048	0.001LeuXaa: 0.001 ± 0.0
Met	0.465MetAla: 0.465 ± 0.015	0.362MetCys: 0.362 ± 0.011	1.228MetAsp: 1.228 ± 0.025	1.184MetGlu: 1.184 ± 0.025	0.95MetPhe: 0.95 ± 0.017	0.769MetGly: 0.769 ± 0.022	0.496MetHis: 0.496 ± 0.013	1.24MetIle: 1.24 ± 0.018	1.84MetLys: 1.84 ± 0.023	1.721MetLeu: 1.721 ± 0.023	0.339MetMet: 0.339 ± 0.011	2.598MetAsn: 2.598 ± 0.047	0.427MetPro: 0.427 ± 0.014	0.651MetGln: 0.651 ± 0.014	0.453MetArg: 0.453 ± 0.013	1.382MetSer: 1.382 ± 0.023	0.795MetThr: 0.795 ± 0.016	0.716MetVal: 0.716 ± 0.017	0.102MetTrp: 0.102 ± 0.006	1.22MetTyr: 1.22 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.58AsnAla: 2.58 ± 0.035	1.822AsnCys: 1.822 ± 0.034	8.105AsnAsp: 8.105 ± 0.086	9.269AsnGlu: 9.269 ± 0.088	4.611AsnPhe: 4.611 ± 0.047	4.728AsnGly: 4.728 ± 0.079	1.867AsnHis: 1.867 ± 0.033	14.163AsnIle: 14.163 ± 0.11	15.494AsnLys: 15.494 ± 0.114	7.792AsnLeu: 7.792 ± 0.059	3.022AsnMet: 3.022 ± 0.057	27.71AsnAsn: 27.71 ± 0.451	1.66AsnPro: 1.66 ± 0.035	2.631AsnGln: 2.631 ± 0.042	2.855AsnArg: 2.855 ± 0.043	10.832AsnSer: 10.832 ± 0.144	7.587AsnThr: 7.587 ± 0.099	6.348AsnVal: 6.348 ± 0.062	0.375AsnTrp: 0.375 ± 0.01	6.402AsnTyr: 6.402 ± 0.06	0.004AsnXaa: 0.004 ± 0.001
Pro	0.444ProAla: 0.444 ± 0.017	0.341ProCys: 0.341 ± 0.012	0.833ProAsp: 0.833 ± 0.021	0.956ProGlu: 0.956 ± 0.035	1.146ProPhe: 1.146 ± 0.021	0.514ProGly: 0.514 ± 0.017	0.433ProHis: 0.433 ± 0.013	1.776ProIle: 1.776 ± 0.027	1.532ProLys: 1.532 ± 0.028	1.836ProLeu: 1.836 ± 0.03	0.345ProMet: 0.345 ± 0.011	2.169ProAsn: 2.169 ± 0.042	0.653ProPro: 0.653 ± 0.02	0.563ProGln: 0.563 ± 0.017	0.413ProArg: 0.413 ± 0.012	1.438ProSer: 1.438 ± 0.024	1.267ProThr: 1.267 ± 0.03	0.933ProVal: 0.933 ± 0.024	0.12ProTrp: 0.12 ± 0.007	1.176ProTyr: 1.176 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	0.655GlnAla: 0.655 ± 0.017	0.402GlnCys: 0.402 ± 0.012	1.129GlnAsp: 1.129 ± 0.024	1.711GlnGlu: 1.711 ± 0.039	1.072GlnPhe: 1.072 ± 0.019	0.671GlnGly: 0.671 ± 0.018	0.704GlnHis: 0.704 ± 0.021	2.525GlnIle: 2.525 ± 0.031	3.608GlnLys: 3.608 ± 0.048	2.422GlnLeu: 2.422 ± 0.029	0.63GlnMet: 0.63 ± 0.016	3.993GlnAsn: 3.993 ± 0.06	0.604GlnPro: 0.604 ± 0.022	1.468GlnGln: 1.468 ± 0.061	0.725GlnArg: 0.725 ± 0.019	1.765GlnSer: 1.765 ± 0.028	1.796GlnThr: 1.796 ± 0.035	1.072GlnVal: 1.072 ± 0.023	0.141GlnTrp: 0.141 ± 0.006	1.31GlnTyr: 1.31 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	0.635ArgAla: 0.635 ± 0.017	0.423ArgCys: 0.423 ± 0.011	1.396ArgAsp: 1.396 ± 0.034	1.569ArgGlu: 1.569 ± 0.032	0.939ArgPhe: 0.939 ± 0.019	0.986ArgGly: 0.986 ± 0.024	0.556ArgHis: 0.556 ± 0.014	2.023ArgIle: 2.023 ± 0.026	2.924ArgLys: 2.924 ± 0.038	1.833ArgLeu: 1.833 ± 0.032	0.49ArgMet: 0.49 ± 0.013	2.881ArgAsn: 2.881 ± 0.04	0.43ArgPro: 0.43 ± 0.013	0.695ArgGln: 0.695 ± 0.017	1.017ArgArg: 1.017 ± 0.024	1.953ArgSer: 1.953 ± 0.041	1.329ArgThr: 1.329 ± 0.025	1.057ArgVal: 1.057 ± 0.02	0.151ArgTrp: 0.151 ± 0.006	1.202ArgTyr: 1.202 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	1.678SerAla: 1.678 ± 0.025	1.368SerCys: 1.368 ± 0.024	5.185SerAsp: 5.185 ± 0.061	3.826SerGlu: 3.826 ± 0.048	3.321SerPhe: 3.321 ± 0.035	3.737SerGly: 3.737 ± 0.08	1.353SerHis: 1.353 ± 0.021	5.982SerIle: 5.982 ± 0.046	6.025SerLys: 6.025 ± 0.056	5.153SerLeu: 5.153 ± 0.044	1.219SerMet: 1.219 ± 0.023	11.144SerAsn: 11.144 ± 0.143	1.248SerPro: 1.248 ± 0.024	1.495SerGln: 1.495 ± 0.022	1.692SerArg: 1.692 ± 0.032	8.928SerSer: 8.928 ± 0.142	4.191SerThr: 4.191 ± 0.054	3.142SerVal: 3.142 ± 0.034	0.275SerTrp: 0.275 ± 0.011	3.694SerTyr: 3.694 ± 0.04	0.001SerXaa: 0.001 ± 0.001
Thr	1.478ThrAla: 1.478 ± 0.037	1.102ThrCys: 1.102 ± 0.021	3.565ThrAsp: 3.565 ± 0.049	3.117ThrGlu: 3.117 ± 0.042	2.305ThrPhe: 2.305 ± 0.03	2.094ThrGly: 2.094 ± 0.046	1.259ThrHis: 1.259 ± 0.022	4.194ThrIle: 4.194 ± 0.042	5.024ThrLys: 5.024 ± 0.055	3.653ThrLeu: 3.653 ± 0.037	0.848ThrMet: 0.848 ± 0.017	8.07ThrAsn: 8.07 ± 0.09	1.354ThrPro: 1.354 ± 0.029	1.434ThrGln: 1.434 ± 0.026	1.099ThrArg: 1.099 ± 0.022	4.212ThrSer: 4.212 ± 0.052	4.685ThrThr: 4.685 ± 0.104	2.346ThrVal: 2.346 ± 0.032	0.222ThrTrp: 0.222 ± 0.009	2.993ThrTyr: 2.993 ± 0.03	0.001ThrXaa: 0.001 ± 0.001
Val	1.213ValAla: 1.213 ± 0.025	0.863ValCys: 0.863 ± 0.016	2.682ValAsp: 2.682 ± 0.035	2.777ValGlu: 2.777 ± 0.051	1.809ValPhe: 1.809 ± 0.025	1.754ValGly: 1.754 ± 0.039	1.049ValHis: 1.049 ± 0.018	3.349ValIle: 3.349 ± 0.039	4.065ValLys: 4.065 ± 0.042	3.598ValLeu: 3.598 ± 0.039	0.674ValMet: 0.674 ± 0.015	4.704ValAsn: 4.704 ± 0.058	1.077ValPro: 1.077 ± 0.026	1.24ValGln: 1.24 ± 0.024	1.044ValArg: 1.044 ± 0.02	3.188ValSer: 3.188 ± 0.04	2.366ValThr: 2.366 ± 0.033	2.056ValVal: 2.056 ± 0.036	0.212ValTrp: 0.212 ± 0.008	2.184ValTyr: 2.184 ± 0.028	0.002ValXaa: 0.002 ± 0.001
Trp	0.129TrpAla: 0.129 ± 0.006	0.099TrpCys: 0.099 ± 0.006	0.278TrpAsp: 0.278 ± 0.009	0.249TrpGlu: 0.249 ± 0.009	0.231TrpPhe: 0.231 ± 0.009	0.202TrpGly: 0.202 ± 0.009	0.079TrpHis: 0.079 ± 0.005	0.378TrpIle: 0.378 ± 0.012	0.479TrpLys: 0.479 ± 0.012	0.431TrpLeu: 0.431 ± 0.012	0.095TrpMet: 0.095 ± 0.006	0.435TrpAsn: 0.435 ± 0.012	0.097TrpPro: 0.097 ± 0.006	0.102TrpGln: 0.102 ± 0.006	0.157TrpArg: 0.157 ± 0.007	0.327TrpSer: 0.327 ± 0.011	0.179TrpThr: 0.179 ± 0.008	0.25TrpVal: 0.25 ± 0.009	0.04TrpTrp: 0.04 ± 0.004	0.21TrpTyr: 0.21 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.265TyrAla: 1.265 ± 0.02	0.787TyrCys: 0.787 ± 0.019	3.47TyrAsp: 3.47 ± 0.036	3.302TyrGlu: 3.302 ± 0.036	2.895TyrPhe: 2.895 ± 0.043	1.563TyrGly: 1.563 ± 0.031	0.888TyrHis: 0.888 ± 0.017	5.756TyrIle: 5.756 ± 0.057	5.278TyrLys: 5.278 ± 0.057	4.325TyrLeu: 4.325 ± 0.043	1.123TyrMet: 1.123 ± 0.023	7.253TyrAsn: 7.253 ± 0.075	0.988TyrPro: 0.988 ± 0.018	1.065TyrGln: 1.065 ± 0.02	1.052TyrArg: 1.052 ± 0.018	3.489TyrSer: 3.489 ± 0.035	2.705TyrThr: 2.705 ± 0.03	2.418TyrVal: 2.418 ± 0.03	0.203TyrTrp: 0.203 ± 0.008	3.019TyrTyr: 3.019 ± 0.046	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.002XaaAsn: 0.002 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.154XaaXaa: 0.154 ± 0.043

Statistics based on 5281 proteins (3455889 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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