Amino acid dipepetide frequency for Collinsella aerofaciens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.901AlaAla: 14.901 ± 0.273	2.095AlaCys: 2.095 ± 0.073	7.19AlaAsp: 7.19 ± 0.136	7.427AlaGlu: 7.427 ± 0.138	3.968AlaPhe: 3.968 ± 0.092	9.287AlaGly: 9.287 ± 0.157	2.264AlaHis: 2.264 ± 0.071	5.852AlaIle: 5.852 ± 0.116	4.799AlaLys: 4.799 ± 0.115	10.77AlaLeu: 10.77 ± 0.146	3.108AlaMet: 3.108 ± 0.072	3.215AlaAsn: 3.215 ± 0.076	4.465AlaPro: 4.465 ± 0.134	3.956AlaGln: 3.956 ± 0.1	6.477AlaArg: 6.477 ± 0.137	6.184AlaSer: 6.184 ± 0.107	5.798AlaThr: 5.798 ± 0.104	8.397AlaVal: 8.397 ± 0.13	1.065AlaTrp: 1.065 ± 0.043	2.869AlaTyr: 2.869 ± 0.072	0.0AlaXaa: 0.0 ± 0.0
Cys	1.799CysAla: 1.799 ± 0.06	0.273CysCys: 0.273 ± 0.022	1.21CysAsp: 1.21 ± 0.052	1.15CysGlu: 1.15 ± 0.049	0.545CysPhe: 0.545 ± 0.031	1.796CysGly: 1.796 ± 0.064	0.365CysHis: 0.365 ± 0.025	0.816CysIle: 0.816 ± 0.036	0.512CysLys: 0.512 ± 0.029	1.243CysLeu: 1.243 ± 0.05	0.43CysMet: 0.43 ± 0.026	0.432CysAsn: 0.432 ± 0.027	0.819CysPro: 0.819 ± 0.048	0.399CysGln: 0.399 ± 0.024	0.9CysArg: 0.9 ± 0.035	0.906CysSer: 0.906 ± 0.042	0.803CysThr: 0.803 ± 0.037	1.248CysVal: 1.248 ± 0.049	0.137CysTrp: 0.137 ± 0.016	0.409CysTyr: 0.409 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	7.934AspAla: 7.934 ± 0.17	0.872AspCys: 0.872 ± 0.038	4.108AspAsp: 4.108 ± 0.104	5.512AspGlu: 5.512 ± 0.087	2.398AspPhe: 2.398 ± 0.059	5.369AspGly: 5.369 ± 0.102	1.176AspHis: 1.176 ± 0.051	3.695AspIle: 3.695 ± 0.083	2.398AspLys: 2.398 ± 0.065	5.52AspLeu: 5.52 ± 0.093	1.696AspMet: 1.696 ± 0.054	1.704AspAsn: 1.704 ± 0.061	3.014AspPro: 3.014 ± 0.071	1.59AspGln: 1.59 ± 0.054	3.557AspArg: 3.557 ± 0.083	3.202AspSer: 3.202 ± 0.082	3.251AspThr: 3.251 ± 0.076	4.905AspVal: 4.905 ± 0.091	0.689AspTrp: 0.689 ± 0.037	2.036AspTyr: 2.036 ± 0.066	0.002AspXaa: 0.002 ± 0.002
Glu	7.18GluAla: 7.18 ± 0.135	0.841GluCys: 0.841 ± 0.039	3.951GluAsp: 3.951 ± 0.08	3.979GluGlu: 3.979 ± 0.121	2.226GluPhe: 2.226 ± 0.066	4.902GluGly: 4.902 ± 0.101	1.845GluHis: 1.845 ± 0.059	3.253GluIle: 3.253 ± 0.079	2.501GluLys: 2.501 ± 0.079	7.198GluLeu: 7.198 ± 0.126	1.763GluMet: 1.763 ± 0.053	2.031GluAsn: 2.031 ± 0.056	2.73GluPro: 2.73 ± 0.079	2.728GluGln: 2.728 ± 0.08	5.139GluArg: 5.139 ± 0.119	3.124GluSer: 3.124 ± 0.073	3.166GluThr: 3.166 ± 0.069	4.563GluVal: 4.563 ± 0.092	0.617GluTrp: 0.617 ± 0.027	1.775GluTyr: 1.775 ± 0.062	0.0GluXaa: 0.0 ± 0.0
Phe	3.983PheAla: 3.983 ± 0.091	0.761PheCys: 0.761 ± 0.036	3.022PheAsp: 3.022 ± 0.058	2.417PheGlu: 2.417 ± 0.063	1.526PhePhe: 1.526 ± 0.061	3.279PheGly: 3.279 ± 0.08	0.623PheHis: 0.623 ± 0.035	1.829PheIle: 1.829 ± 0.057	1.397PheLys: 1.397 ± 0.054	2.839PheLeu: 2.839 ± 0.083	1.025PheMet: 1.025 ± 0.04	1.178PheAsn: 1.178 ± 0.048	1.282PhePro: 1.282 ± 0.046	0.872PheGln: 0.872 ± 0.041	1.528PheArg: 1.528 ± 0.048	2.388PheSer: 2.388 ± 0.068	2.11PheThr: 2.11 ± 0.062	2.986PheVal: 2.986 ± 0.09	0.366PheTrp: 0.366 ± 0.026	1.043PheTyr: 1.043 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	8.176GlyAla: 8.176 ± 0.129	1.621GlyCys: 1.621 ± 0.062	4.786GlyAsp: 4.786 ± 0.082	4.998GlyGlu: 4.998 ± 0.095	3.314GlyPhe: 3.314 ± 0.094	6.217GlyGly: 6.217 ± 0.123	1.655GlyHis: 1.655 ± 0.058	5.173GlyIle: 5.173 ± 0.101	4.001GlyLys: 4.001 ± 0.098	6.979GlyLeu: 6.979 ± 0.13	2.445GlyMet: 2.445 ± 0.063	2.481GlyAsn: 2.481 ± 0.065	2.107GlyPro: 2.107 ± 0.065	2.17GlyGln: 2.17 ± 0.059	4.501GlyArg: 4.501 ± 0.111	4.81GlySer: 4.81 ± 0.109	4.712GlyThr: 4.712 ± 0.099	6.606GlyVal: 6.606 ± 0.1	0.916GlyTrp: 0.916 ± 0.043	2.679GlyTyr: 2.679 ± 0.074	0.0GlyXaa: 0.0 ± 0.0
His	2.224HisAla: 2.224 ± 0.066	0.283HisCys: 0.283 ± 0.024	1.384HisAsp: 1.384 ± 0.051	1.415HisGlu: 1.415 ± 0.048	0.743HisPhe: 0.743 ± 0.035	1.812HisGly: 1.812 ± 0.056	0.482HisHis: 0.482 ± 0.029	1.166HisIle: 1.166 ± 0.047	0.675HisLys: 0.675 ± 0.032	1.655HisLeu: 1.655 ± 0.064	0.574HisMet: 0.574 ± 0.032	0.6HisAsn: 0.6 ± 0.032	1.115HisPro: 1.115 ± 0.049	0.522HisGln: 0.522 ± 0.03	1.079HisArg: 1.079 ± 0.044	0.87HisSer: 0.87 ± 0.039	1.016HisThr: 1.016 ± 0.043	1.76HisVal: 1.76 ± 0.058	0.17HisTrp: 0.17 ± 0.016	0.587HisTyr: 0.587 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.729IleAla: 6.729 ± 0.121	1.052IleCys: 1.052 ± 0.043	4.375IleAsp: 4.375 ± 0.083	4.135IleGlu: 4.135 ± 0.088	1.649IlePhe: 1.649 ± 0.056	4.027IleGly: 4.027 ± 0.1	0.922IleHis: 0.922 ± 0.037	2.802IleIle: 2.802 ± 0.072	2.219IleLys: 2.219 ± 0.071	3.955IleLeu: 3.955 ± 0.088	1.349IleMet: 1.349 ± 0.051	1.775IleAsn: 1.775 ± 0.06	2.475IlePro: 2.475 ± 0.064	1.318IleGln: 1.318 ± 0.048	2.623IleArg: 2.623 ± 0.067	3.119IleSer: 3.119 ± 0.076	2.847IleThr: 2.847 ± 0.07	4.746IleVal: 4.746 ± 0.09	0.476IleTrp: 0.476 ± 0.025	1.325IleTyr: 1.325 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.383LysAla: 4.383 ± 0.111	0.438LysCys: 0.438 ± 0.028	2.19LysAsp: 2.19 ± 0.078	2.144LysGlu: 2.144 ± 0.061	1.13LysPhe: 1.13 ± 0.049	2.864LysGly: 2.864 ± 0.07	0.832LysHis: 0.832 ± 0.039	2.267LysIle: 2.267 ± 0.068	2.339LysLys: 2.339 ± 0.076	3.906LysLeu: 3.906 ± 0.089	1.13LysMet: 1.13 ± 0.04	1.449LysAsn: 1.449 ± 0.051	1.971LysPro: 1.971 ± 0.057	1.436LysGln: 1.436 ± 0.059	2.738LysArg: 2.738 ± 0.078	2.365LysSer: 2.365 ± 0.068	2.717LysThr: 2.717 ± 0.074	2.908LysVal: 2.908 ± 0.07	0.307LysTrp: 0.307 ± 0.025	1.107LysTyr: 1.107 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	10.745LeuAla: 10.745 ± 0.146	1.379LeuCys: 1.379 ± 0.049	6.347LeuAsp: 6.347 ± 0.114	5.585LeuGlu: 5.585 ± 0.122	3.235LeuPhe: 3.235 ± 0.092	7.594LeuGly: 7.594 ± 0.105	1.57LeuHis: 1.57 ± 0.056	4.427LeuIle: 4.427 ± 0.101	3.574LeuLys: 3.574 ± 0.079	7.797LeuLeu: 7.797 ± 0.148	2.587LeuMet: 2.587 ± 0.065	2.828LeuAsn: 2.828 ± 0.067	4.079LeuPro: 4.079 ± 0.075	2.216LeuGln: 2.216 ± 0.054	4.859LeuArg: 4.859 ± 0.094	6.038LeuSer: 6.038 ± 0.113	5.18LeuThr: 5.18 ± 0.107	7.198LeuVal: 7.198 ± 0.109	0.697LeuTrp: 0.697 ± 0.035	2.147LeuTyr: 2.147 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	3.338MetAla: 3.338 ± 0.079	0.391MetCys: 0.391 ± 0.024	1.645MetAsp: 1.645 ± 0.054	1.405MetGlu: 1.405 ± 0.052	0.867MetPhe: 0.867 ± 0.038	2.455MetGly: 2.455 ± 0.063	0.548MetHis: 0.548 ± 0.029	1.31MetIle: 1.31 ± 0.049	1.07MetLys: 1.07 ± 0.04	2.645MetLeu: 2.645 ± 0.076	0.707MetMet: 0.707 ± 0.033	0.939MetAsn: 0.939 ± 0.039	1.508MetPro: 1.508 ± 0.05	0.854MetGln: 0.854 ± 0.037	1.58MetArg: 1.58 ± 0.051	1.832MetSer: 1.832 ± 0.057	1.575MetThr: 1.575 ± 0.052	1.909MetVal: 1.909 ± 0.057	0.214MetTrp: 0.214 ± 0.018	0.612MetTyr: 0.612 ± 0.037	0.0MetXaa: 0.0 ± 0.0
Asn	3.341AsnAla: 3.341 ± 0.077	0.442AsnCys: 0.442 ± 0.028	1.948AsnAsp: 1.948 ± 0.055	1.972AsnGlu: 1.972 ± 0.058	0.936AsnPhe: 0.936 ± 0.041	2.602AsnGly: 2.602 ± 0.076	0.608AsnHis: 0.608 ± 0.034	1.722AsnIle: 1.722 ± 0.058	1.277AsnLys: 1.277 ± 0.05	2.741AsnLeu: 2.741 ± 0.068	0.829AsnMet: 0.829 ± 0.04	1.017AsnAsn: 1.017 ± 0.048	1.743AsnPro: 1.743 ± 0.052	0.828AsnGln: 0.828 ± 0.037	1.688AsnArg: 1.688 ± 0.049	1.568AsnSer: 1.568 ± 0.061	1.694AsnThr: 1.694 ± 0.056	2.591AsnVal: 2.591 ± 0.073	0.306AsnTrp: 0.306 ± 0.024	0.859AsnTyr: 0.859 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	5.019ProAla: 5.019 ± 0.124	0.622ProCys: 0.622 ± 0.039	2.648ProAsp: 2.648 ± 0.071	3.423ProGlu: 3.423 ± 0.088	1.709ProPhe: 1.709 ± 0.055	3.258ProGly: 3.258 ± 0.074	0.872ProHis: 0.872 ± 0.04	2.066ProIle: 2.066 ± 0.056	1.665ProLys: 1.665 ± 0.056	3.637ProLeu: 3.637 ± 0.074	0.94ProMet: 0.94 ± 0.037	1.253ProAsn: 1.253 ± 0.043	0.983ProPro: 0.983 ± 0.041	1.631ProGln: 1.631 ± 0.057	2.108ProArg: 2.108 ± 0.068	2.406ProSer: 2.406 ± 0.069	2.385ProThr: 2.385 ± 0.076	3.86ProVal: 3.86 ± 0.084	0.505ProTrp: 0.505 ± 0.029	1.269ProTyr: 1.269 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.379GlnAla: 3.379 ± 0.084	0.281GlnCys: 0.281 ± 0.023	1.549GlnAsp: 1.549 ± 0.05	1.696GlnGlu: 1.696 ± 0.056	1.004GlnPhe: 1.004 ± 0.038	2.259GlnGly: 2.259 ± 0.058	0.613GlnHis: 0.613 ± 0.037	1.943GlnIle: 1.943 ± 0.056	1.246GlnLys: 1.246 ± 0.054	2.928GlnLeu: 2.928 ± 0.069	0.962GlnMet: 0.962 ± 0.042	1.025GlnAsn: 1.025 ± 0.043	1.235GlnPro: 1.235 ± 0.052	1.338GlnGln: 1.338 ± 0.07	1.876GlnArg: 1.876 ± 0.06	1.479GlnSer: 1.479 ± 0.061	1.743GlnThr: 1.743 ± 0.058	2.34GlnVal: 2.34 ± 0.064	0.327GlnTrp: 0.327 ± 0.026	0.749GlnTyr: 0.749 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	6.328ArgAla: 6.328 ± 0.126	0.862ArgCys: 0.862 ± 0.043	3.559ArgAsp: 3.559 ± 0.085	4.333ArgGlu: 4.333 ± 0.109	2.125ArgPhe: 2.125 ± 0.06	4.102ArgGly: 4.102 ± 0.094	1.232ArgHis: 1.232 ± 0.047	3.279ArgIle: 3.279 ± 0.081	2.157ArgLys: 2.157 ± 0.065	5.093ArgLeu: 5.093 ± 0.091	1.815ArgMet: 1.815 ± 0.053	1.67ArgAsn: 1.67 ± 0.056	2.233ArgPro: 2.233 ± 0.065	1.734ArgGln: 1.734 ± 0.059	4.319ArgArg: 4.319 ± 0.104	3.044ArgSer: 3.044 ± 0.081	2.879ArgThr: 2.879 ± 0.071	4.65ArgVal: 4.65 ± 0.1	0.582ArgTrp: 0.582 ± 0.038	1.84ArgTyr: 1.84 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.926SerAla: 5.926 ± 0.115	0.934SerCys: 0.934 ± 0.045	3.561SerAsp: 3.561 ± 0.079	3.327SerGlu: 3.327 ± 0.08	2.38SerPhe: 2.38 ± 0.07	4.995SerGly: 4.995 ± 0.096	1.129SerHis: 1.129 ± 0.043	3.166SerIle: 3.166 ± 0.079	2.246SerLys: 2.246 ± 0.058	5.232SerLeu: 5.232 ± 0.11	1.598SerMet: 1.598 ± 0.048	1.748SerAsn: 1.748 ± 0.058	2.218SerPro: 2.218 ± 0.065	1.734SerGln: 1.734 ± 0.054	3.206SerArg: 3.206 ± 0.087	3.68SerSer: 3.68 ± 0.098	3.269SerThr: 3.269 ± 0.072	4.508SerVal: 4.508 ± 0.089	0.653SerTrp: 0.653 ± 0.032	1.833SerTyr: 1.833 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	5.767ThrAla: 5.767 ± 0.113	0.954ThrCys: 0.954 ± 0.039	3.304ThrAsp: 3.304 ± 0.076	2.919ThrGlu: 2.919 ± 0.077	2.2ThrPhe: 2.2 ± 0.063	4.817ThrGly: 4.817 ± 0.098	1.132ThrHis: 1.132 ± 0.045	2.985ThrIle: 2.985 ± 0.068	2.075ThrLys: 2.075 ± 0.061	5.036ThrLeu: 5.036 ± 0.102	1.377ThrMet: 1.377 ± 0.047	1.568ThrAsn: 1.568 ± 0.046	3.016ThrPro: 3.016 ± 0.075	1.48ThrGln: 1.48 ± 0.051	2.808ThrArg: 2.808 ± 0.076	3.268ThrSer: 3.268 ± 0.08	3.152ThrThr: 3.152 ± 0.097	5.064ThrVal: 5.064 ± 0.101	0.592ThrTrp: 0.592 ± 0.034	1.604ThrTyr: 1.604 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	9.033ValAla: 9.033 ± 0.151	1.497ValCys: 1.497 ± 0.05	5.33ValAsp: 5.33 ± 0.106	5.289ValGlu: 5.289 ± 0.106	2.978ValPhe: 2.978 ± 0.064	5.597ValGly: 5.597 ± 0.104	1.465ValHis: 1.465 ± 0.047	4.334ValIle: 4.334 ± 0.087	3.022ValLys: 3.022 ± 0.075	7.306ValLeu: 7.306 ± 0.142	2.031ValMet: 2.031 ± 0.063	2.519ValAsn: 2.519 ± 0.059	3.69ValPro: 3.69 ± 0.088	1.946ValGln: 1.946 ± 0.052	4.478ValArg: 4.478 ± 0.101	5.013ValSer: 5.013 ± 0.087	4.674ValThr: 4.674 ± 0.099	6.711ValVal: 6.711 ± 0.139	0.702ValTrp: 0.702 ± 0.033	2.035ValTyr: 2.035 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	0.947TrpAla: 0.947 ± 0.043	0.18TrpCys: 0.18 ± 0.018	0.661TrpAsp: 0.661 ± 0.032	0.597TrpGlu: 0.597 ± 0.031	0.396TrpPhe: 0.396 ± 0.028	0.765TrpGly: 0.765 ± 0.038	0.213TrpHis: 0.213 ± 0.02	0.505TrpIle: 0.505 ± 0.029	0.407TrpLys: 0.407 ± 0.026	0.952TrpLeu: 0.952 ± 0.043	0.321TrpMet: 0.321 ± 0.025	0.365TrpAsn: 0.365 ± 0.024	0.352TrpPro: 0.352 ± 0.025	0.347TrpGln: 0.347 ± 0.023	0.622TrpArg: 0.622 ± 0.03	0.572TrpSer: 0.572 ± 0.032	0.479TrpThr: 0.479 ± 0.029	0.615TrpVal: 0.615 ± 0.036	0.147TrpTrp: 0.147 ± 0.017	0.309TrpTyr: 0.309 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.952TyrAla: 2.952 ± 0.073	0.417TyrCys: 0.417 ± 0.029	1.86TyrAsp: 1.86 ± 0.06	1.788TyrGlu: 1.788 ± 0.054	1.129TyrPhe: 1.129 ± 0.043	2.35TyrGly: 2.35 ± 0.066	0.587TyrHis: 0.587 ± 0.029	1.326TyrIle: 1.326 ± 0.052	1.042TyrLys: 1.042 ± 0.047	2.654TyrLeu: 2.654 ± 0.08	0.711TyrMet: 0.711 ± 0.033	0.916TyrAsn: 0.916 ± 0.042	1.225TyrPro: 1.225 ± 0.045	0.875TyrGln: 0.875 ± 0.043	1.747TyrArg: 1.747 ± 0.058	1.472TyrSer: 1.472 ± 0.052	1.667TyrThr: 1.667 ± 0.052	2.087TyrVal: 2.087 ± 0.058	0.283TyrTrp: 0.283 ± 0.023	0.9TyrTyr: 0.9 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.002	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1812 proteins (611423 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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