Amino acid dipepetide frequency for Catenovulum sp. CCB-QB4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.112AlaAla: 7.112 ± 0.096
0.926AlaCys: 0.926 ± 0.028
5.212AlaAsp: 5.212 ± 0.066
5.386AlaGlu: 5.386 ± 0.076
3.298AlaPhe: 3.298 ± 0.05
5.53AlaGly: 5.53 ± 0.077
1.59AlaHis: 1.59 ± 0.036
5.918AlaIle: 5.918 ± 0.064
5.378AlaLys: 5.378 ± 0.072
8.535AlaLeu: 8.535 ± 0.109
2.033AlaMet: 2.033 ± 0.043
4.875AlaAsn: 4.875 ± 0.084
2.71AlaPro: 2.71 ± 0.068
4.225AlaGln: 4.225 ± 0.069
3.073AlaArg: 3.073 ± 0.055
5.612AlaSer: 5.612 ± 0.103
4.786AlaThr: 4.786 ± 0.121
5.289AlaVal: 5.289 ± 0.078
1.001AlaTrp: 1.001 ± 0.031
2.666AlaTyr: 2.666 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.702CysAla: 0.702 ± 0.024
0.165CysCys: 0.165 ± 0.01
0.508CysAsp: 0.508 ± 0.018
0.466CysGlu: 0.466 ± 0.019
0.478CysPhe: 0.478 ± 0.02
0.722CysGly: 0.722 ± 0.024
0.351CysHis: 0.351 ± 0.019
0.545CysIle: 0.545 ± 0.019
0.417CysLys: 0.417 ± 0.015
0.988CysLeu: 0.988 ± 0.034
0.183CysMet: 0.183 ± 0.011
0.357CysAsn: 0.357 ± 0.017
0.36CysPro: 0.36 ± 0.016
0.595CysGln: 0.595 ± 0.018
0.403CysArg: 0.403 ± 0.017
0.688CysSer: 0.688 ± 0.023
0.394CysThr: 0.394 ± 0.017
0.577CysVal: 0.577 ± 0.022
0.123CysTrp: 0.123 ± 0.01
0.322CysTyr: 0.322 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.538AspAla: 4.538 ± 0.077
0.561AspCys: 0.561 ± 0.019
3.663AspAsp: 3.663 ± 0.12
3.658AspGlu: 3.658 ± 0.054
2.835AspPhe: 2.835 ± 0.053
4.408AspGly: 4.408 ± 0.154
1.041AspHis: 1.041 ± 0.03
4.461AspIle: 4.461 ± 0.063
3.879AspLys: 3.879 ± 0.056
5.598AspLeu: 5.598 ± 0.068
1.334AspMet: 1.334 ± 0.033
3.511AspAsn: 3.511 ± 0.074
2.301AspPro: 2.301 ± 0.055
2.1AspGln: 2.1 ± 0.049
1.904AspArg: 1.904 ± 0.04
3.861AspSer: 3.861 ± 0.124
3.174AspThr: 3.174 ± 0.104
3.992AspVal: 3.992 ± 0.086
1.012AspTrp: 1.012 ± 0.029
2.328AspTyr: 2.328 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
4.303GluAla: 4.303 ± 0.069
0.392GluCys: 0.392 ± 0.016
2.675GluAsp: 2.675 ± 0.054
2.845GluGlu: 2.845 ± 0.062
2.633GluPhe: 2.633 ± 0.045
2.99GluGly: 2.99 ± 0.067
1.436GluHis: 1.436 ± 0.032
3.602GluIle: 3.602 ± 0.051
3.384GluLys: 3.384 ± 0.064
6.84GluLeu: 6.84 ± 0.088
1.294GluMet: 1.294 ± 0.032
2.812GluAsn: 2.812 ± 0.046
1.999GluPro: 1.999 ± 0.045
4.449GluGln: 4.449 ± 0.074
2.619GluArg: 2.619 ± 0.057
3.382GluSer: 3.382 ± 0.05
2.888GluThr: 2.888 ± 0.046
3.7GluVal: 3.7 ± 0.059
0.751GluTrp: 0.751 ± 0.028
1.9GluTyr: 1.9 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.778PheAla: 3.778 ± 0.051
0.47PheCys: 0.47 ± 0.018
3.138PheAsp: 3.138 ± 0.05
2.522PheGlu: 2.522 ± 0.048
1.579PhePhe: 1.579 ± 0.033
2.849PheGly: 2.849 ± 0.051
0.786PheHis: 0.786 ± 0.022
2.725PheIle: 2.725 ± 0.041
2.363PheLys: 2.363 ± 0.045
2.987PheLeu: 2.987 ± 0.055
0.884PheMet: 0.884 ± 0.024
2.542PheAsn: 2.542 ± 0.048
1.311PhePro: 1.311 ± 0.045
1.29PheGln: 1.29 ± 0.028
1.361PheArg: 1.361 ± 0.029
3.553PheSer: 3.553 ± 0.063
2.674PheThr: 2.674 ± 0.099
2.865PheVal: 2.865 ± 0.045
0.562PheTrp: 0.562 ± 0.023
1.495PheTyr: 1.495 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
4.744GlyAla: 4.744 ± 0.108
0.755GlyCys: 0.755 ± 0.027
4.031GlyAsp: 4.031 ± 0.116
3.942GlyGlu: 3.942 ± 0.051
3.138GlyPhe: 3.138 ± 0.045
4.35GlyGly: 4.35 ± 0.09
1.428GlyHis: 1.428 ± 0.03
4.204GlyIle: 4.204 ± 0.072
3.906GlyLys: 3.906 ± 0.06
6.453GlyLeu: 6.453 ± 0.068
1.462GlyMet: 1.462 ± 0.035
3.098GlyAsn: 3.098 ± 0.079
1.376GlyPro: 1.376 ± 0.032
3.288GlyGln: 3.288 ± 0.051
2.652GlyArg: 2.652 ± 0.05
4.121GlySer: 4.121 ± 0.105
3.465GlyThr: 3.465 ± 0.107
4.715GlyVal: 4.715 ± 0.067
0.951GlyTrp: 0.951 ± 0.028
2.616GlyTyr: 2.616 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
1.658HisAla: 1.658 ± 0.036
0.276HisCys: 0.276 ± 0.014
1.161HisAsp: 1.161 ± 0.026
1.143HisGlu: 1.143 ± 0.026
1.079HisPhe: 1.079 ± 0.028
1.47HisGly: 1.47 ± 0.034
0.634HisHis: 0.634 ± 0.021
1.415HisIle: 1.415 ± 0.032
1.232HisLys: 1.232 ± 0.029
2.191HisLeu: 2.191 ± 0.045
0.473HisMet: 0.473 ± 0.017
1.084HisAsn: 1.084 ± 0.03
1.057HisPro: 1.057 ± 0.025
1.199HisGln: 1.199 ± 0.031
0.845HisArg: 0.845 ± 0.023
1.394HisSer: 1.394 ± 0.033
1.105HisThr: 1.105 ± 0.028
1.26HisVal: 1.26 ± 0.031
0.379HisTrp: 0.379 ± 0.015
0.959HisTyr: 0.959 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.103IleAla: 6.103 ± 0.065
0.683IleCys: 0.683 ± 0.021
4.66IleAsp: 4.66 ± 0.072
4.592IleGlu: 4.592 ± 0.074
2.119IlePhe: 2.119 ± 0.044
4.161IleGly: 4.161 ± 0.059
1.26IleHis: 1.26 ± 0.029
3.345IleIle: 3.345 ± 0.058
3.883IleLys: 3.883 ± 0.067
4.816IleLeu: 4.816 ± 0.071
1.101IleMet: 1.101 ± 0.026
3.836IleAsn: 3.836 ± 0.052
2.375IlePro: 2.375 ± 0.041
2.519IleGln: 2.519 ± 0.046
2.517IleArg: 2.517 ± 0.041
4.685IleSer: 4.685 ± 0.081
3.814IleThr: 3.814 ± 0.078
3.819IleVal: 3.819 ± 0.057
0.7IleTrp: 0.7 ± 0.025
1.952IleTyr: 1.952 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
4.827LysAla: 4.827 ± 0.072
0.349LysCys: 0.349 ± 0.016
2.86LysAsp: 2.86 ± 0.041
2.637LysGlu: 2.637 ± 0.051
1.913LysPhe: 1.913 ± 0.042
3.207LysGly: 3.207 ± 0.053
1.397LysHis: 1.397 ± 0.033
3.25LysIle: 3.25 ± 0.051
2.918LysLys: 2.918 ± 0.058
5.788LysLeu: 5.788 ± 0.08
1.204LysMet: 1.204 ± 0.033
2.61LysAsn: 2.61 ± 0.048
2.811LysPro: 2.811 ± 0.047
4.014LysGln: 4.014 ± 0.067
2.741LysArg: 2.741 ± 0.056
3.251LysSer: 3.251 ± 0.059
3.233LysThr: 3.233 ± 0.052
3.943LysVal: 3.943 ± 0.073
0.654LysTrp: 0.654 ± 0.02
1.703LysTyr: 1.703 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
10.064LeuAla: 10.064 ± 0.116
0.874LeuCys: 0.874 ± 0.026
6.07LeuAsp: 6.07 ± 0.068
5.179LeuGlu: 5.179 ± 0.077
3.887LeuPhe: 3.887 ± 0.063
6.101LeuGly: 6.101 ± 0.082
1.902LeuHis: 1.902 ± 0.045
5.873LeuIle: 5.873 ± 0.091
5.237LeuLys: 5.237 ± 0.073
9.305LeuLeu: 9.305 ± 0.126
2.221LeuMet: 2.221 ± 0.047
5.332LeuAsn: 5.332 ± 0.067
4.317LeuPro: 4.317 ± 0.06
4.381LeuGln: 4.381 ± 0.077
3.698LeuArg: 3.698 ± 0.061
7.632LeuSer: 7.632 ± 0.106
6.379LeuThr: 6.379 ± 0.081
6.564LeuVal: 6.564 ± 0.088
0.972LeuTrp: 0.972 ± 0.026
2.763LeuTyr: 2.763 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
2.174MetAla: 2.174 ± 0.048
0.157MetCys: 0.157 ± 0.011
1.102MetAsp: 1.102 ± 0.029
0.98MetGlu: 0.98 ± 0.026
0.789MetPhe: 0.789 ± 0.026
1.322MetGly: 1.322 ± 0.035
0.428MetHis: 0.428 ± 0.019
1.114MetIle: 1.114 ± 0.031
1.139MetLys: 1.139 ± 0.032
2.331MetLeu: 2.331 ± 0.046
0.556MetMet: 0.556 ± 0.021
0.871MetAsn: 0.871 ± 0.025
1.102MetPro: 1.102 ± 0.027
1.217MetGln: 1.217 ± 0.031
1.015MetArg: 1.015 ± 0.031
1.531MetSer: 1.531 ± 0.039
1.313MetThr: 1.313 ± 0.035
1.338MetVal: 1.338 ± 0.034
0.208MetTrp: 0.208 ± 0.013
0.49MetTyr: 0.49 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
4.05AsnAla: 4.05 ± 0.072
0.463AsnCys: 0.463 ± 0.02
3.208AsnAsp: 3.208 ± 0.13
2.756AsnGlu: 2.756 ± 0.052
1.896AsnPhe: 1.896 ± 0.046
3.739AsnGly: 3.739 ± 0.083
1.12AsnHis: 1.12 ± 0.025
3.322AsnIle: 3.322 ± 0.053
2.951AsnLys: 2.951 ± 0.047
4.856AsnLeu: 4.856 ± 0.066
1.058AsnMet: 1.058 ± 0.03
2.955AsnAsn: 2.955 ± 0.061
2.274AsnPro: 2.274 ± 0.044
3.134AsnGln: 3.134 ± 0.061
1.997AsnArg: 1.997 ± 0.041
3.297AsnSer: 3.297 ± 0.056
2.956AsnThr: 2.956 ± 0.059
3.088AsnVal: 3.088 ± 0.059
0.819AsnTrp: 0.819 ± 0.029
1.826AsnTyr: 1.826 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
2.882ProAla: 2.882 ± 0.053
0.295ProCys: 0.295 ± 0.014
2.403ProAsp: 2.403 ± 0.049
2.901ProGlu: 2.901 ± 0.05
1.639ProPhe: 1.639 ± 0.036
1.958ProGly: 1.958 ± 0.04
0.87ProHis: 0.87 ± 0.025
2.567ProIle: 2.567 ± 0.042
2.022ProLys: 2.022 ± 0.04
3.566ProLeu: 3.566 ± 0.056
0.802ProMet: 0.802 ± 0.026
2.242ProAsn: 2.242 ± 0.05
1.02ProPro: 1.02 ± 0.03
1.834ProGln: 1.834 ± 0.04
1.184ProArg: 1.184 ± 0.024
2.599ProSer: 2.599 ± 0.049
2.287ProThr: 2.287 ± 0.066
2.841ProVal: 2.841 ± 0.043
0.497ProTrp: 0.497 ± 0.019
1.311ProTyr: 1.311 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
5.623GlnAla: 5.623 ± 0.09
0.379GlnCys: 0.379 ± 0.017
2.725GlnAsp: 2.725 ± 0.05
2.405GlnGlu: 2.405 ± 0.048
2.137GlnPhe: 2.137 ± 0.042
3.502GlnGly: 3.502 ± 0.055
1.433GlnHis: 1.433 ± 0.035
3.13GlnIle: 3.13 ± 0.058
2.389GlnLys: 2.389 ± 0.052
5.736GlnLeu: 5.736 ± 0.095
0.997GlnMet: 0.997 ± 0.025
2.262GlnAsn: 2.262 ± 0.046
2.053GlnPro: 2.053 ± 0.046
4.401GlnGln: 4.401 ± 0.109
2.218GlnArg: 2.218 ± 0.042
3.372GlnSer: 3.372 ± 0.062
3.124GlnThr: 3.124 ± 0.052
3.937GlnVal: 3.937 ± 0.064
0.672GlnTrp: 0.672 ± 0.024
1.702GlnTyr: 1.702 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
2.851ArgAla: 2.851 ± 0.049
0.363ArgCys: 0.363 ± 0.015
2.251ArgAsp: 2.251 ± 0.058
2.248ArgGlu: 2.248 ± 0.044
2.061ArgPhe: 2.061 ± 0.037
2.21ArgGly: 2.21 ± 0.051
0.996ArgHis: 0.996 ± 0.025
2.662ArgIle: 2.662 ± 0.046
2.134ArgLys: 2.134 ± 0.042
4.405ArgLeu: 4.405 ± 0.064
0.968ArgMet: 0.968 ± 0.03
1.856ArgAsn: 1.856 ± 0.034
1.404ArgPro: 1.404 ± 0.033
2.286ArgGln: 2.286 ± 0.045
1.809ArgArg: 1.809 ± 0.043
2.263ArgSer: 2.263 ± 0.043
1.881ArgThr: 1.881 ± 0.041
2.781ArgVal: 2.781 ± 0.048
0.602ArgTrp: 0.602 ± 0.018
1.664ArgTyr: 1.664 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
5.658SerAla: 5.658 ± 0.124
0.626SerCys: 0.626 ± 0.024
4.039SerAsp: 4.039 ± 0.099
3.707SerGlu: 3.707 ± 0.05
3.031SerPhe: 3.031 ± 0.068
4.9SerGly: 4.9 ± 0.12
1.672SerHis: 1.672 ± 0.031
4.243SerIle: 4.243 ± 0.06
3.312SerLys: 3.312 ± 0.052
6.996SerLeu: 6.996 ± 0.077
1.317SerMet: 1.317 ± 0.035
3.197SerAsn: 3.197 ± 0.076
2.289SerPro: 2.289 ± 0.038
4.053SerGln: 4.053 ± 0.063
2.677SerArg: 2.677 ± 0.05
4.663SerSer: 4.663 ± 0.108
3.532SerThr: 3.532 ± 0.073
4.607SerVal: 4.607 ± 0.117
0.882SerTrp: 0.882 ± 0.029
2.349SerTyr: 2.349 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
4.791ThrAla: 4.791 ± 0.122
0.47ThrCys: 0.47 ± 0.019
3.457ThrAsp: 3.457 ± 0.099
3.158ThrGlu: 3.158 ± 0.051
2.306ThrPhe: 2.306 ± 0.063
4.223ThrGly: 4.223 ± 0.106
1.221ThrHis: 1.221 ± 0.03
3.684ThrIle: 3.684 ± 0.125
2.662ThrLys: 2.662 ± 0.046
6.09ThrLeu: 6.09 ± 0.101
0.98ThrMet: 0.98 ± 0.026
2.606ThrAsn: 2.606 ± 0.055
2.753ThrPro: 2.753 ± 0.062
2.951ThrGln: 2.951 ± 0.053
2.058ThrArg: 2.058 ± 0.039
3.885ThrSer: 3.885 ± 0.094
3.372ThrThr: 3.372 ± 0.092
3.881ThrVal: 3.881 ± 0.148
0.752ThrTrp: 0.752 ± 0.024
1.848ThrTyr: 1.848 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
5.95ValAla: 5.95 ± 0.08
0.644ValCys: 0.644 ± 0.023
4.367ValAsp: 4.367 ± 0.063
4.421ValGlu: 4.421 ± 0.063
2.703ValPhe: 2.703 ± 0.045
4.088ValGly: 4.088 ± 0.071
1.154ValHis: 1.154 ± 0.027
4.415ValIle: 4.415 ± 0.064
3.917ValLys: 3.917 ± 0.062
6.004ValLeu: 6.004 ± 0.076
1.437ValMet: 1.437 ± 0.034
3.747ValAsn: 3.747 ± 0.079
2.29ValPro: 2.29 ± 0.043
2.331ValGln: 2.331 ± 0.035
2.461ValArg: 2.461 ± 0.043
4.884ValSer: 4.884 ± 0.105
4.321ValThr: 4.321 ± 0.123
4.796ValVal: 4.796 ± 0.075
0.76ValTrp: 0.76 ± 0.024
2.079ValTyr: 2.079 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.847TrpAla: 0.847 ± 0.026
0.12TrpCys: 0.12 ± 0.01
0.666TrpAsp: 0.666 ± 0.03
0.396TrpGlu: 0.396 ± 0.017
0.579TrpPhe: 0.579 ± 0.021
0.811TrpGly: 0.811 ± 0.025
0.459TrpHis: 0.459 ± 0.019
0.617TrpIle: 0.617 ± 0.021
0.459TrpLys: 0.459 ± 0.021
1.859TrpLeu: 1.859 ± 0.036
0.263TrpMet: 0.263 ± 0.014
0.519TrpAsn: 0.519 ± 0.022
0.507TrpPro: 0.507 ± 0.016
1.437TrpGln: 1.437 ± 0.038
0.728TrpArg: 0.728 ± 0.023
0.73TrpSer: 0.73 ± 0.025
0.578TrpThr: 0.578 ± 0.021
0.782TrpVal: 0.782 ± 0.026
0.194TrpTrp: 0.194 ± 0.013
0.478TrpTyr: 0.478 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.501TyrAla: 2.501 ± 0.043
0.376TyrCys: 0.376 ± 0.017
1.964TyrAsp: 1.964 ± 0.049
1.552TyrGlu: 1.552 ± 0.033
1.633TyrPhe: 1.633 ± 0.036
2.154TyrGly: 2.154 ± 0.045
0.838TyrHis: 0.838 ± 0.023
1.848TyrIle: 1.848 ± 0.039
1.728TyrLys: 1.728 ± 0.036
3.405TyrLeu: 3.405 ± 0.055
0.607TyrMet: 0.607 ± 0.021
1.451TyrAsn: 1.451 ± 0.041
1.411TyrPro: 1.411 ± 0.033
2.496TyrGln: 2.496 ± 0.05
1.733TyrArg: 1.733 ± 0.042
2.346TyrSer: 2.346 ± 0.061
1.871TyrThr: 1.871 ± 0.067
1.997TyrVal: 1.997 ± 0.035
0.537TyrTrp: 0.537 ± 0.022
1.299TyrTyr: 1.299 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4272 proteins (1643176 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski