Amino acid dipepetide frequency for Mariniphaga sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.942AlaAla: 4.942 ± 0.066
0.695AlaCys: 0.695 ± 0.022
3.379AlaAsp: 3.379 ± 0.046
4.625AlaGlu: 4.625 ± 0.067
3.344AlaPhe: 3.344 ± 0.049
5.511AlaGly: 5.511 ± 0.064
1.142AlaHis: 1.142 ± 0.025
4.432AlaIle: 4.432 ± 0.056
3.631AlaLys: 3.631 ± 0.059
5.86AlaLeu: 5.86 ± 0.073
1.445AlaMet: 1.445 ± 0.035
2.918AlaAsn: 2.918 ± 0.044
2.097AlaPro: 2.097 ± 0.038
2.185AlaGln: 2.185 ± 0.039
2.828AlaArg: 2.828 ± 0.041
4.014AlaSer: 4.014 ± 0.051
3.369AlaThr: 3.369 ± 0.057
4.461AlaVal: 4.461 ± 0.053
0.879AlaTrp: 0.879 ± 0.026
2.333AlaTyr: 2.333 ± 0.036
0.0AlaXaa: 0.0 ± 0.0
Cys
0.504CysAla: 0.504 ± 0.023
0.121CysCys: 0.121 ± 0.009
0.507CysAsp: 0.507 ± 0.027
0.532CysGlu: 0.532 ± 0.023
0.446CysPhe: 0.446 ± 0.017
0.686CysGly: 0.686 ± 0.024
0.272CysHis: 0.272 ± 0.023
0.555CysIle: 0.555 ± 0.021
0.485CysLys: 0.485 ± 0.018
0.716CysLeu: 0.716 ± 0.023
0.175CysMet: 0.175 ± 0.011
0.459CysAsn: 0.459 ± 0.019
0.423CysPro: 0.423 ± 0.02
0.307CysGln: 0.307 ± 0.016
0.414CysArg: 0.414 ± 0.017
0.616CysSer: 0.616 ± 0.025
0.455CysThr: 0.455 ± 0.018
0.494CysVal: 0.494 ± 0.019
0.104CysTrp: 0.104 ± 0.008
0.381CysTyr: 0.381 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.413AspAla: 3.413 ± 0.054
0.464AspCys: 0.464 ± 0.021
2.626AspAsp: 2.626 ± 0.044
3.753AspGlu: 3.753 ± 0.053
3.409AspPhe: 3.409 ± 0.04
3.943AspGly: 3.943 ± 0.057
0.904AspHis: 0.904 ± 0.024
4.004AspIle: 4.004 ± 0.046
3.368AspLys: 3.368 ± 0.044
4.786AspLeu: 4.786 ± 0.064
1.17AspMet: 1.17 ± 0.024
2.75AspAsn: 2.75 ± 0.047
2.225AspPro: 2.225 ± 0.042
1.427AspGln: 1.427 ± 0.028
2.102AspArg: 2.102 ± 0.036
3.033AspSer: 3.033 ± 0.064
2.41AspThr: 2.41 ± 0.048
3.44AspVal: 3.44 ± 0.04
0.933AspTrp: 0.933 ± 0.022
2.593AspTyr: 2.593 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
4.401GluAla: 4.401 ± 0.065
0.465GluCys: 0.465 ± 0.016
3.194GluAsp: 3.194 ± 0.042
5.482GluGlu: 5.482 ± 0.077
2.899GluPhe: 2.899 ± 0.047
4.398GluGly: 4.398 ± 0.054
1.15GluHis: 1.15 ± 0.027
5.576GluIle: 5.576 ± 0.069
6.695GluLys: 6.695 ± 0.083
6.339GluLeu: 6.339 ± 0.08
2.138GluMet: 2.138 ± 0.03
4.815GluAsn: 4.815 ± 0.058
2.074GluPro: 2.074 ± 0.036
2.384GluGln: 2.384 ± 0.042
2.83GluArg: 2.83 ± 0.046
3.603GluSer: 3.603 ± 0.046
3.828GluThr: 3.828 ± 0.053
4.426GluVal: 4.426 ± 0.058
0.948GluTrp: 0.948 ± 0.024
2.662GluTyr: 2.662 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
3.14PheAla: 3.14 ± 0.04
0.511PheCys: 0.511 ± 0.017
3.166PheAsp: 3.166 ± 0.04
3.378PheGlu: 3.378 ± 0.048
2.98PhePhe: 2.98 ± 0.052
3.564PheGly: 3.564 ± 0.047
0.995PheHis: 0.995 ± 0.024
3.681PheIle: 3.681 ± 0.045
2.756PheLys: 2.756 ± 0.043
4.81PheLeu: 4.81 ± 0.062
1.247PheMet: 1.247 ± 0.028
2.822PheAsn: 2.822 ± 0.051
2.117PhePro: 2.117 ± 0.035
1.61PheGln: 1.61 ± 0.032
2.434PheArg: 2.434 ± 0.04
4.4PheSer: 4.4 ± 0.058
2.896PheThr: 2.896 ± 0.047
3.145PheVal: 3.145 ± 0.051
0.732PheTrp: 0.732 ± 0.02
2.235PheTyr: 2.235 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
4.385GlyAla: 4.385 ± 0.064
0.747GlyCys: 0.747 ± 0.034
3.47GlyAsp: 3.47 ± 0.048
4.644GlyGlu: 4.644 ± 0.054
3.838GlyPhe: 3.838 ± 0.059
4.995GlyGly: 4.995 ± 0.075
1.316GlyHis: 1.316 ± 0.031
5.781GlyIle: 5.781 ± 0.058
5.39GlyLys: 5.39 ± 0.062
6.16GlyLeu: 6.16 ± 0.068
1.973GlyMet: 1.973 ± 0.033
4.063GlyAsn: 4.063 ± 0.058
1.768GlyPro: 1.768 ± 0.033
2.182GlyGln: 2.182 ± 0.04
2.851GlyArg: 2.851 ± 0.05
4.302GlySer: 4.302 ± 0.053
4.248GlyThr: 4.248 ± 0.06
4.583GlyVal: 4.583 ± 0.06
1.158GlyTrp: 1.158 ± 0.03
3.233GlyTyr: 3.233 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
1.091HisAla: 1.091 ± 0.029
0.213HisCys: 0.213 ± 0.013
0.867HisAsp: 0.867 ± 0.02
1.024HisGlu: 1.024 ± 0.026
1.302HisPhe: 1.302 ± 0.03
1.217HisGly: 1.217 ± 0.028
0.498HisHis: 0.498 ± 0.019
1.361HisIle: 1.361 ± 0.032
1.042HisLys: 1.042 ± 0.025
1.923HisLeu: 1.923 ± 0.036
0.338HisMet: 0.338 ± 0.013
0.92HisAsn: 0.92 ± 0.024
1.084HisPro: 1.084 ± 0.028
0.636HisGln: 0.636 ± 0.019
0.83HisArg: 0.83 ± 0.021
1.245HisSer: 1.245 ± 0.027
0.966HisThr: 0.966 ± 0.028
1.054HisVal: 1.054 ± 0.026
0.327HisTrp: 0.327 ± 0.016
0.858HisTyr: 0.858 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
4.575IleAla: 4.575 ± 0.057
0.631IleCys: 0.631 ± 0.024
4.223IleAsp: 4.223 ± 0.054
4.947IleGlu: 4.947 ± 0.057
3.503IlePhe: 3.503 ± 0.055
4.751IleGly: 4.751 ± 0.063
1.488IleHis: 1.488 ± 0.028
5.113IleIle: 5.113 ± 0.061
4.556IleLys: 4.556 ± 0.054
6.616IleLeu: 6.616 ± 0.077
1.324IleMet: 1.324 ± 0.029
3.604IleAsn: 3.604 ± 0.047
3.394IlePro: 3.394 ± 0.046
2.375IleGln: 2.375 ± 0.043
3.328IleArg: 3.328 ± 0.045
5.371IleSer: 5.371 ± 0.059
4.021IleThr: 4.021 ± 0.07
4.239IleVal: 4.239 ± 0.057
0.819IleTrp: 0.819 ± 0.024
2.593IleTyr: 2.593 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.144LysAla: 4.144 ± 0.054
0.405LysCys: 0.405 ± 0.016
3.357LysAsp: 3.357 ± 0.048
5.533LysGlu: 5.533 ± 0.075
2.525LysPhe: 2.525 ± 0.04
4.368LysGly: 4.368 ± 0.049
1.171LysHis: 1.171 ± 0.027
5.391LysIle: 5.391 ± 0.054
5.802LysLys: 5.802 ± 0.069
5.752LysLeu: 5.752 ± 0.066
2.04LysMet: 2.04 ± 0.035
4.529LysAsn: 4.529 ± 0.06
2.445LysPro: 2.445 ± 0.041
2.374LysGln: 2.374 ± 0.045
2.907LysArg: 2.907 ± 0.047
3.816LysSer: 3.816 ± 0.051
3.963LysThr: 3.963 ± 0.051
4.38LysVal: 4.38 ± 0.054
0.925LysTrp: 0.925 ± 0.021
3.002LysTyr: 3.002 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
6.116LeuAla: 6.116 ± 0.074
0.706LeuCys: 0.706 ± 0.021
4.477LeuAsp: 4.477 ± 0.054
5.983LeuGlu: 5.983 ± 0.06
5.24LeuPhe: 5.24 ± 0.072
5.922LeuGly: 5.922 ± 0.067
1.699LeuHis: 1.699 ± 0.037
6.09LeuIle: 6.09 ± 0.068
7.091LeuLys: 7.091 ± 0.072
8.786LeuLeu: 8.786 ± 0.105
2.033LeuMet: 2.033 ± 0.035
5.227LeuAsn: 5.227 ± 0.068
4.087LeuPro: 4.087 ± 0.055
3.048LeuGln: 3.048 ± 0.041
3.616LeuArg: 3.616 ± 0.051
6.326LeuSer: 6.326 ± 0.066
4.925LeuThr: 4.925 ± 0.052
5.557LeuVal: 5.557 ± 0.063
1.074LeuTrp: 1.074 ± 0.028
3.111LeuTyr: 3.111 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
1.844MetAla: 1.844 ± 0.033
0.145MetCys: 0.145 ± 0.009
1.274MetAsp: 1.274 ± 0.03
1.812MetGlu: 1.812 ± 0.034
0.936MetPhe: 0.936 ± 0.023
1.678MetGly: 1.678 ± 0.034
0.423MetHis: 0.423 ± 0.015
1.409MetIle: 1.409 ± 0.031
2.28MetLys: 2.28 ± 0.037
2.052MetLeu: 2.052 ± 0.036
0.566MetMet: 0.566 ± 0.02
1.401MetAsn: 1.401 ± 0.029
1.025MetPro: 1.025 ± 0.024
0.869MetGln: 0.869 ± 0.025
0.944MetArg: 0.944 ± 0.023
1.211MetSer: 1.211 ± 0.029
1.102MetThr: 1.102 ± 0.029
1.614MetVal: 1.614 ± 0.028
0.225MetTrp: 0.225 ± 0.011
0.712MetTyr: 0.712 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.265AsnAla: 3.265 ± 0.053
0.485AsnCys: 0.485 ± 0.023
2.779AsnAsp: 2.779 ± 0.052
3.643AsnGlu: 3.643 ± 0.048
2.659AsnPhe: 2.659 ± 0.041
3.942AsnGly: 3.942 ± 0.058
1.038AsnHis: 1.038 ± 0.025
4.315AsnIle: 4.315 ± 0.058
3.378AsnLys: 3.378 ± 0.053
5.037AsnLeu: 5.037 ± 0.06
1.298AsnMet: 1.298 ± 0.027
3.078AsnAsn: 3.078 ± 0.05
2.861AsnPro: 2.861 ± 0.045
2.025AsnGln: 2.025 ± 0.039
2.59AsnArg: 2.59 ± 0.045
3.268AsnSer: 3.268 ± 0.049
2.9AsnThr: 2.9 ± 0.05
3.28AsnVal: 3.28 ± 0.052
0.873AsnTrp: 0.873 ± 0.027
2.538AsnTyr: 2.538 ± 0.051
0.0AsnXaa: 0.0 ± 0.0
Pro
2.688ProAla: 2.688 ± 0.044
0.253ProCys: 0.253 ± 0.014
2.874ProAsp: 2.874 ± 0.041
4.055ProGlu: 4.055 ± 0.054
2.068ProPhe: 2.068 ± 0.033
3.428ProGly: 3.428 ± 0.047
0.755ProHis: 0.755 ± 0.023
1.965ProIle: 1.965 ± 0.034
1.925ProLys: 1.925 ± 0.038
3.326ProLeu: 3.326 ± 0.048
0.752ProMet: 0.752 ± 0.023
1.857ProAsn: 1.857 ± 0.038
1.249ProPro: 1.249 ± 0.029
1.294ProGln: 1.294 ± 0.03
1.388ProArg: 1.388 ± 0.033
2.242ProSer: 2.242 ± 0.042
1.716ProThr: 1.716 ± 0.037
3.734ProVal: 3.734 ± 0.059
0.568ProTrp: 0.568 ± 0.018
1.499ProTyr: 1.499 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
2.066GlnAla: 2.066 ± 0.037
0.195GlnCys: 0.195 ± 0.011
1.384GlnAsp: 1.384 ± 0.03
2.175GlnGlu: 2.175 ± 0.035
1.573GlnPhe: 1.573 ± 0.033
1.9GlnGly: 1.9 ± 0.036
0.627GlnHis: 0.627 ± 0.023
2.397GlnIle: 2.397 ± 0.037
2.879GlnLys: 2.879 ± 0.043
3.22GlnLeu: 3.22 ± 0.045
0.875GlnMet: 0.875 ± 0.024
2.15GlnAsn: 2.15 ± 0.044
1.356GlnPro: 1.356 ± 0.034
1.445GlnGln: 1.445 ± 0.038
1.413GlnArg: 1.413 ± 0.035
1.967GlnSer: 1.967 ± 0.037
1.861GlnThr: 1.861 ± 0.037
2.202GlnVal: 2.202 ± 0.038
0.456GlnTrp: 0.456 ± 0.018
1.233GlnTyr: 1.233 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
2.435ArgAla: 2.435 ± 0.041
0.318ArgCys: 0.318 ± 0.015
2.014ArgAsp: 2.014 ± 0.035
3.236ArgGlu: 3.236 ± 0.054
2.51ArgPhe: 2.51 ± 0.039
2.51ArgGly: 2.51 ± 0.038
0.793ArgHis: 0.793 ± 0.021
3.414ArgIle: 3.414 ± 0.046
3.308ArgLys: 3.308 ± 0.051
4.032ArgLeu: 4.032 ± 0.058
1.159ArgMet: 1.159 ± 0.027
2.505ArgAsn: 2.505 ± 0.039
1.416ArgPro: 1.416 ± 0.03
1.507ArgGln: 1.507 ± 0.031
1.906ArgArg: 1.906 ± 0.038
2.234ArgSer: 2.234 ± 0.038
2.058ArgThr: 2.058 ± 0.035
2.495ArgVal: 2.495 ± 0.04
0.666ArgTrp: 0.666 ± 0.022
1.884ArgTyr: 1.884 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
3.983SerAla: 3.983 ± 0.057
0.695SerCys: 0.695 ± 0.025
3.407SerAsp: 3.407 ± 0.053
4.193SerGlu: 4.193 ± 0.051
3.786SerPhe: 3.786 ± 0.055
5.511SerGly: 5.511 ± 0.067
1.169SerHis: 1.169 ± 0.026
4.214SerIle: 4.214 ± 0.054
3.608SerLys: 3.608 ± 0.048
5.825SerLeu: 5.825 ± 0.061
1.371SerMet: 1.371 ± 0.03
3.067SerAsn: 3.067 ± 0.056
2.594SerPro: 2.594 ± 0.043
1.982SerGln: 1.982 ± 0.035
2.718SerArg: 2.718 ± 0.042
4.056SerSer: 4.056 ± 0.056
2.948SerThr: 2.948 ± 0.058
4.655SerVal: 4.655 ± 0.066
0.96SerTrp: 0.96 ± 0.024
2.613SerTyr: 2.613 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
3.497ThrAla: 3.497 ± 0.053
0.431ThrCys: 0.431 ± 0.023
3.181ThrAsp: 3.181 ± 0.065
3.511ThrGlu: 3.511 ± 0.044
2.789ThrPhe: 2.789 ± 0.038
4.946ThrGly: 4.946 ± 0.069
1.019ThrHis: 1.019 ± 0.027
3.951ThrIle: 3.951 ± 0.065
2.791ThrLys: 2.791 ± 0.044
4.822ThrLeu: 4.822 ± 0.062
1.031ThrMet: 1.031 ± 0.024
2.488ThrAsn: 2.488 ± 0.046
2.47ThrPro: 2.47 ± 0.04
1.631ThrGln: 1.631 ± 0.029
2.096ThrArg: 2.096 ± 0.034
3.243ThrSer: 3.243 ± 0.052
2.954ThrThr: 2.954 ± 0.051
3.704ThrVal: 3.704 ± 0.061
0.785ThrTrp: 0.785 ± 0.025
1.964ThrTyr: 1.964 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
4.388ValAla: 4.388 ± 0.056
0.648ValCys: 0.648 ± 0.022
3.47ValAsp: 3.47 ± 0.051
4.426ValGlu: 4.426 ± 0.058
3.665ValPhe: 3.665 ± 0.054
3.911ValGly: 3.911 ± 0.052
1.135ValHis: 1.135 ± 0.025
4.484ValIle: 4.484 ± 0.062
4.419ValLys: 4.419 ± 0.055
5.999ValLeu: 5.999 ± 0.063
1.394ValMet: 1.394 ± 0.033
3.341ValAsn: 3.341 ± 0.046
2.623ValPro: 2.623 ± 0.039
2.016ValGln: 2.016 ± 0.035
2.557ValArg: 2.557 ± 0.042
4.606ValSer: 4.606 ± 0.056
3.821ValThr: 3.821 ± 0.089
4.591ValVal: 4.591 ± 0.059
0.855ValTrp: 0.855 ± 0.028
2.516ValTyr: 2.516 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
0.801TrpAla: 0.801 ± 0.024
0.137TrpCys: 0.137 ± 0.009
0.855TrpAsp: 0.855 ± 0.023
1.048TrpGlu: 1.048 ± 0.027
0.697TrpPhe: 0.697 ± 0.021
1.071TrpGly: 1.071 ± 0.027
0.318TrpHis: 0.318 ± 0.017
0.885TrpIle: 0.885 ± 0.023
1.032TrpLys: 1.032 ± 0.025
1.276TrpLeu: 1.276 ± 0.034
0.392TrpMet: 0.392 ± 0.015
0.843TrpAsn: 0.843 ± 0.028
0.441TrpPro: 0.441 ± 0.016
0.604TrpGln: 0.604 ± 0.02
0.621TrpArg: 0.621 ± 0.021
0.806TrpSer: 0.806 ± 0.025
0.688TrpThr: 0.688 ± 0.021
0.823TrpVal: 0.823 ± 0.024
0.236TrpTrp: 0.236 ± 0.012
0.56TrpTyr: 0.56 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.412TyrAla: 2.412 ± 0.044
0.385TyrCys: 0.385 ± 0.014
2.246TyrAsp: 2.246 ± 0.04
2.308TyrGlu: 2.308 ± 0.042
2.449TyrPhe: 2.449 ± 0.038
2.837TyrGly: 2.837 ± 0.058
0.882TyrHis: 0.882 ± 0.023
2.456TyrIle: 2.456 ± 0.041
2.394TyrLys: 2.394 ± 0.038
3.78TyrLeu: 3.78 ± 0.049
0.799TyrMet: 0.799 ± 0.022
2.414TyrAsn: 2.414 ± 0.051
1.886TyrPro: 1.886 ± 0.032
1.474TyrGln: 1.474 ± 0.029
2.028TyrArg: 2.028 ± 0.035
2.995TyrSer: 2.995 ± 0.055
2.177TyrThr: 2.177 ± 0.047
1.989TyrVal: 1.989 ± 0.031
0.609TyrTrp: 0.609 ± 0.02
1.916TyrTyr: 1.916 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4517 proteins (1693228 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski