Amino acid dipepetide frequency for Peptoniphilus coxii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.561AlaAla: 5.561 ± 0.136
0.669AlaCys: 0.669 ± 0.038
4.083AlaAsp: 4.083 ± 0.098
4.954AlaGlu: 4.954 ± 0.097
3.252AlaPhe: 3.252 ± 0.087
5.016AlaGly: 5.016 ± 0.108
1.245AlaHis: 1.245 ± 0.051
5.899AlaIle: 5.899 ± 0.121
5.662AlaLys: 5.662 ± 0.116
7.882AlaLeu: 7.882 ± 0.154
2.725AlaMet: 2.725 ± 0.082
2.711AlaAsn: 2.711 ± 0.086
2.397AlaPro: 2.397 ± 0.077
1.972AlaGln: 1.972 ± 0.063
3.16AlaArg: 3.16 ± 0.083
3.904AlaSer: 3.904 ± 0.092
3.686AlaThr: 3.686 ± 0.084
5.211AlaVal: 5.211 ± 0.115
0.478AlaTrp: 0.478 ± 0.031
2.62AlaTyr: 2.62 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.579CysAla: 0.579 ± 0.032
0.113CysCys: 0.113 ± 0.019
0.552CysAsp: 0.552 ± 0.027
0.436CysGlu: 0.436 ± 0.026
0.359CysPhe: 0.359 ± 0.027
0.947CysGly: 0.947 ± 0.054
0.246CysHis: 0.246 ± 0.021
0.63CysIle: 0.63 ± 0.035
0.453CysLys: 0.453 ± 0.025
0.722CysLeu: 0.722 ± 0.034
0.255CysMet: 0.255 ± 0.021
0.312CysAsn: 0.312 ± 0.024
0.443CysPro: 0.443 ± 0.038
0.188CysGln: 0.188 ± 0.021
0.388CysArg: 0.388 ± 0.028
0.508CysSer: 0.508 ± 0.033
0.379CysThr: 0.379 ± 0.027
0.524CysVal: 0.524 ± 0.032
0.064CysTrp: 0.064 ± 0.011
0.363CysTyr: 0.363 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
4.285AspAla: 4.285 ± 0.106
0.446AspCys: 0.446 ± 0.03
4.033AspAsp: 4.033 ± 0.098
5.453AspGlu: 5.453 ± 0.107
2.955AspPhe: 2.955 ± 0.081
4.862AspGly: 4.862 ± 0.14
1.362AspHis: 1.362 ± 0.051
4.812AspIle: 4.812 ± 0.094
4.301AspLys: 4.301 ± 0.159
5.853AspLeu: 5.853 ± 0.119
1.794AspMet: 1.794 ± 0.055
2.208AspAsn: 2.208 ± 0.066
2.376AspPro: 2.376 ± 0.076
1.558AspGln: 1.558 ± 0.066
3.111AspArg: 3.111 ± 0.081
2.902AspSer: 2.902 ± 0.077
2.888AspThr: 2.888 ± 0.081
4.561AspVal: 4.561 ± 0.102
0.428AspTrp: 0.428 ± 0.03
2.92AspTyr: 2.92 ± 0.07
0.0AspXaa: 0.0 ± 0.0
Glu
5.977GluAla: 5.977 ± 0.128
0.46GluCys: 0.46 ± 0.031
5.007GluAsp: 5.007 ± 0.102
7.565GluGlu: 7.565 ± 0.169
2.495GluPhe: 2.495 ± 0.067
5.359GluGly: 5.359 ± 0.112
1.328GluHis: 1.328 ± 0.048
5.411GluIle: 5.411 ± 0.118
7.626GluLys: 7.626 ± 0.163
6.296GluLeu: 6.296 ± 0.13
2.022GluMet: 2.022 ± 0.073
4.148GluAsn: 4.148 ± 0.1
1.983GluPro: 1.983 ± 0.072
2.02GluGln: 2.02 ± 0.062
3.968GluArg: 3.968 ± 0.121
4.031GluSer: 4.031 ± 0.092
3.624GluThr: 3.624 ± 0.1
4.793GluVal: 4.793 ± 0.115
0.425GluTrp: 0.425 ± 0.029
2.257GluTyr: 2.257 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
2.912PheAla: 2.912 ± 0.075
0.4PheCys: 0.4 ± 0.028
2.781PheAsp: 2.781 ± 0.082
2.588PheGlu: 2.588 ± 0.064
2.252PhePhe: 2.252 ± 0.084
3.079PheGly: 3.079 ± 0.09
0.885PheHis: 0.885 ± 0.043
3.366PheIle: 3.366 ± 0.086
2.854PheLys: 2.854 ± 0.077
4.217PheLeu: 4.217 ± 0.105
1.181PheMet: 1.181 ± 0.053
1.735PheAsn: 1.735 ± 0.051
1.436PhePro: 1.436 ± 0.055
1.31PheGln: 1.31 ± 0.056
1.848PheArg: 1.848 ± 0.059
3.024PheSer: 3.024 ± 0.076
2.376PheThr: 2.376 ± 0.073
2.877PheVal: 2.877 ± 0.071
0.289PheTrp: 0.289 ± 0.02
1.809PheTyr: 1.809 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
4.972GlyAla: 4.972 ± 0.131
0.712GlyCys: 0.712 ± 0.044
4.685GlyAsp: 4.685 ± 0.099
5.595GlyGlu: 5.595 ± 0.119
3.259GlyPhe: 3.259 ± 0.09
5.308GlyGly: 5.308 ± 0.118
1.461GlyHis: 1.461 ± 0.061
6.0GlyIle: 6.0 ± 0.119
6.052GlyLys: 6.052 ± 0.149
6.191GlyLeu: 6.191 ± 0.117
2.178GlyMet: 2.178 ± 0.068
3.137GlyAsn: 3.137 ± 0.091
1.503GlyPro: 1.503 ± 0.054
1.765GlyGln: 1.765 ± 0.059
3.196GlyArg: 3.196 ± 0.095
3.954GlySer: 3.954 ± 0.084
3.681GlyThr: 3.681 ± 0.107
5.064GlyVal: 5.064 ± 0.107
0.513GlyTrp: 0.513 ± 0.038
3.153GlyTyr: 3.153 ± 0.084
0.0GlyXaa: 0.0 ± 0.0
His
1.188HisAla: 1.188 ± 0.053
0.243HisCys: 0.243 ± 0.022
1.112HisAsp: 1.112 ± 0.059
1.053HisGlu: 1.053 ± 0.046
0.988HisPhe: 0.988 ± 0.044
1.402HisGly: 1.402 ± 0.054
0.524HisHis: 0.524 ± 0.036
1.51HisIle: 1.51 ± 0.055
0.988HisLys: 0.988 ± 0.045
1.871HisLeu: 1.871 ± 0.064
0.567HisMet: 0.567 ± 0.032
0.632HisAsn: 0.632 ± 0.033
0.898HisPro: 0.898 ± 0.041
0.423HisGln: 0.423 ± 0.027
1.032HisArg: 1.032 ± 0.046
1.057HisSer: 1.057 ± 0.042
0.906HisThr: 0.906 ± 0.043
1.321HisVal: 1.321 ± 0.057
0.195HisTrp: 0.195 ± 0.018
0.945HisTyr: 0.945 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.018IleAla: 6.018 ± 0.129
0.754IleCys: 0.754 ± 0.037
4.956IleAsp: 4.956 ± 0.096
5.388IleGlu: 5.388 ± 0.112
3.198IlePhe: 3.198 ± 0.091
5.561IleGly: 5.561 ± 0.113
1.441IleHis: 1.441 ± 0.05
4.835IleIle: 4.835 ± 0.117
4.639IleLys: 4.639 ± 0.115
7.638IleLeu: 7.638 ± 0.17
1.728IleMet: 1.728 ± 0.053
2.819IleAsn: 2.819 ± 0.088
3.035IlePro: 3.035 ± 0.089
2.204IleGln: 2.204 ± 0.062
3.637IleArg: 3.637 ± 0.092
4.52IleSer: 4.52 ± 0.113
3.923IleThr: 3.923 ± 0.103
5.299IleVal: 5.299 ± 0.102
0.421IleTrp: 0.421 ± 0.033
2.608IleTyr: 2.608 ± 0.072
0.0IleXaa: 0.0 ± 0.0
Lys
5.586LysAla: 5.586 ± 0.144
0.416LysCys: 0.416 ± 0.033
5.591LysAsp: 5.591 ± 0.183
7.468LysGlu: 7.468 ± 0.136
2.01LysPhe: 2.01 ± 0.066
5.389LysGly: 5.389 ± 0.097
1.163LysHis: 1.163 ± 0.045
5.419LysIle: 5.419 ± 0.105
6.804LysLys: 6.804 ± 0.144
5.713LysLeu: 5.713 ± 0.114
2.096LysMet: 2.096 ± 0.062
4.237LysAsn: 4.237 ± 0.098
2.48LysPro: 2.48 ± 0.115
2.024LysGln: 2.024 ± 0.075
3.784LysArg: 3.784 ± 0.091
4.194LysSer: 4.194 ± 0.097
4.2LysThr: 4.2 ± 0.122
4.78LysVal: 4.78 ± 0.144
0.531LysTrp: 0.531 ± 0.035
2.279LysTyr: 2.279 ± 0.079
0.0LysXaa: 0.0 ± 0.0
Leu
7.342LeuAla: 7.342 ± 0.147
0.811LeuCys: 0.811 ± 0.035
5.627LeuAsp: 5.627 ± 0.102
6.501LeuGlu: 6.501 ± 0.136
4.306LeuPhe: 4.306 ± 0.116
6.094LeuGly: 6.094 ± 0.12
1.732LeuHis: 1.732 ± 0.056
6.285LeuIle: 6.285 ± 0.113
7.326LeuLys: 7.326 ± 0.13
8.822LeuLeu: 8.822 ± 0.194
2.626LeuMet: 2.626 ± 0.079
4.085LeuAsn: 4.085 ± 0.09
3.552LeuPro: 3.552 ± 0.083
2.456LeuGln: 2.456 ± 0.072
4.207LeuArg: 4.207 ± 0.104
6.692LeuSer: 6.692 ± 0.137
4.734LeuThr: 4.734 ± 0.09
5.476LeuVal: 5.476 ± 0.111
0.701LeuTrp: 0.701 ± 0.044
3.313LeuTyr: 3.313 ± 0.079
0.0LeuXaa: 0.0 ± 0.0
Met
2.626MetAla: 2.626 ± 0.077
0.22MetCys: 0.22 ± 0.019
1.969MetAsp: 1.969 ± 0.055
2.557MetGlu: 2.557 ± 0.074
0.862MetPhe: 0.862 ± 0.041
2.07MetGly: 2.07 ± 0.07
0.384MetHis: 0.384 ± 0.025
2.073MetIle: 2.073 ± 0.069
2.505MetLys: 2.505 ± 0.066
2.231MetLeu: 2.231 ± 0.067
0.88MetMet: 0.88 ± 0.046
1.487MetAsn: 1.487 ± 0.049
0.999MetPro: 0.999 ± 0.04
0.639MetGln: 0.639 ± 0.036
1.296MetArg: 1.296 ± 0.045
1.599MetSer: 1.599 ± 0.056
1.686MetThr: 1.686 ± 0.059
1.818MetVal: 1.818 ± 0.054
0.145MetTrp: 0.145 ± 0.017
0.676MetTyr: 0.676 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
2.652AsnAla: 2.652 ± 0.088
0.402AsnCys: 0.402 ± 0.026
2.337AsnAsp: 2.337 ± 0.078
2.787AsnGlu: 2.787 ± 0.069
1.873AsnPhe: 1.873 ± 0.067
3.178AsnGly: 3.178 ± 0.105
0.899AsnHis: 0.899 ± 0.039
3.429AsnIle: 3.429 ± 0.085
3.166AsnLys: 3.166 ± 0.105
4.256AsnLeu: 4.256 ± 0.084
1.269AsnMet: 1.269 ± 0.041
1.79AsnAsn: 1.79 ± 0.072
2.158AsnPro: 2.158 ± 0.083
1.275AsnGln: 1.275 ± 0.052
2.339AsnArg: 2.339 ± 0.066
2.038AsnSer: 2.038 ± 0.075
2.149AsnThr: 2.149 ± 0.082
2.82AsnVal: 2.82 ± 0.083
0.349AsnTrp: 0.349 ± 0.026
1.622AsnTyr: 1.622 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
2.279ProAla: 2.279 ± 0.083
0.269ProCys: 0.269 ± 0.024
2.011ProAsp: 2.011 ± 0.071
2.944ProGlu: 2.944 ± 0.085
1.659ProPhe: 1.659 ± 0.055
2.367ProGly: 2.367 ± 0.102
0.705ProHis: 0.705 ± 0.033
2.488ProIle: 2.488 ± 0.063
2.649ProLys: 2.649 ± 0.092
3.231ProLeu: 3.231 ± 0.08
0.988ProMet: 0.988 ± 0.041
1.431ProAsn: 1.431 ± 0.072
0.894ProPro: 0.894 ± 0.063
0.906ProGln: 0.906 ± 0.049
1.222ProArg: 1.222 ± 0.048
2.151ProSer: 2.151 ± 0.068
1.871ProThr: 1.871 ± 0.079
2.78ProVal: 2.78 ± 0.075
0.278ProTrp: 0.278 ± 0.024
1.377ProTyr: 1.377 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
1.873GlnAla: 1.873 ± 0.067
0.212GlnCys: 0.212 ± 0.02
1.466GlnAsp: 1.466 ± 0.048
1.937GlnGlu: 1.937 ± 0.073
1.057GlnPhe: 1.057 ± 0.041
1.809GlnGly: 1.809 ± 0.057
0.395GlnHis: 0.395 ± 0.029
1.917GlnIle: 1.917 ± 0.063
2.413GlnLys: 2.413 ± 0.072
2.224GlnLeu: 2.224 ± 0.067
0.868GlnMet: 0.868 ± 0.037
1.338GlnAsn: 1.338 ± 0.046
0.806GlnPro: 0.806 ± 0.052
0.77GlnGln: 0.77 ± 0.041
1.346GlnArg: 1.346 ± 0.054
1.638GlnSer: 1.638 ± 0.061
1.347GlnThr: 1.347 ± 0.054
1.701GlnVal: 1.701 ± 0.055
0.333GlnTrp: 0.333 ± 0.026
0.922GlnTyr: 0.922 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
3.252ArgAla: 3.252 ± 0.081
0.365ArgCys: 0.365 ± 0.029
2.845ArgAsp: 2.845 ± 0.084
4.279ArgGlu: 4.279 ± 0.102
2.135ArgPhe: 2.135 ± 0.061
3.139ArgGly: 3.139 ± 0.078
0.995ArgHis: 0.995 ± 0.049
3.552ArgIle: 3.552 ± 0.09
3.53ArgLys: 3.53 ± 0.079
4.216ArgLeu: 4.216 ± 0.112
1.462ArgMet: 1.462 ± 0.054
1.91ArgAsn: 1.91 ± 0.062
1.487ArgPro: 1.487 ± 0.059
1.353ArgGln: 1.353 ± 0.053
2.716ArgArg: 2.716 ± 0.087
2.56ArgSer: 2.56 ± 0.073
2.048ArgThr: 2.048 ± 0.072
3.07ArgVal: 3.07 ± 0.077
0.319ArgTrp: 0.319 ± 0.027
1.978ArgTyr: 1.978 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
3.943SerAla: 3.943 ± 0.095
0.474SerCys: 0.474 ± 0.029
3.252SerAsp: 3.252 ± 0.074
3.621SerGlu: 3.621 ± 0.089
3.006SerPhe: 3.006 ± 0.076
4.617SerGly: 4.617 ± 0.102
1.121SerHis: 1.121 ± 0.042
4.658SerIle: 4.658 ± 0.111
3.996SerLys: 3.996 ± 0.089
5.791SerLeu: 5.791 ± 0.121
1.74SerMet: 1.74 ± 0.058
2.227SerAsn: 2.227 ± 0.059
1.887SerPro: 1.887 ± 0.054
1.427SerGln: 1.427 ± 0.055
2.599SerArg: 2.599 ± 0.062
3.13SerSer: 3.13 ± 0.088
2.833SerThr: 2.833 ± 0.087
4.2SerVal: 4.2 ± 0.079
0.428SerTrp: 0.428 ± 0.033
2.408SerTyr: 2.408 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
3.73ThrAla: 3.73 ± 0.1
0.436ThrCys: 0.436 ± 0.032
2.822ThrAsp: 2.822 ± 0.083
3.3ThrGlu: 3.3 ± 0.095
2.388ThrPhe: 2.388 ± 0.083
4.024ThrGly: 4.024 ± 0.087
0.891ThrHis: 0.891 ± 0.034
4.212ThrIle: 4.212 ± 0.091
3.406ThrLys: 3.406 ± 0.115
4.984ThrLeu: 4.984 ± 0.097
1.485ThrMet: 1.485 ± 0.053
1.864ThrAsn: 1.864 ± 0.069
2.24ThrPro: 2.24 ± 0.097
1.186ThrGln: 1.186 ± 0.048
2.08ThrArg: 2.08 ± 0.062
2.889ThrSer: 2.889 ± 0.066
2.826ThrThr: 2.826 ± 0.09
4.182ThrVal: 4.182 ± 0.112
0.405ThrTrp: 0.405 ± 0.033
1.696ThrTyr: 1.696 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
5.338ValAla: 5.338 ± 0.104
0.621ValCys: 0.621 ± 0.034
4.731ValAsp: 4.731 ± 0.095
5.432ValGlu: 5.432 ± 0.116
3.059ValPhe: 3.059 ± 0.078
4.642ValGly: 4.642 ± 0.109
1.238ValHis: 1.238 ± 0.045
4.966ValIle: 4.966 ± 0.107
4.756ValLys: 4.756 ± 0.117
6.457ValLeu: 6.457 ± 0.123
1.737ValMet: 1.737 ± 0.058
2.856ValAsn: 2.856 ± 0.088
2.456ValPro: 2.456 ± 0.07
1.689ValGln: 1.689 ± 0.056
2.875ValArg: 2.875 ± 0.085
4.088ValSer: 4.088 ± 0.092
3.622ValThr: 3.622 ± 0.13
5.149ValVal: 5.149 ± 0.117
0.365ValTrp: 0.365 ± 0.026
2.415ValTyr: 2.415 ± 0.077
0.0ValXaa: 0.0 ± 0.0
Trp
0.544TrpAla: 0.544 ± 0.038
0.06TrpCys: 0.06 ± 0.011
0.45TrpAsp: 0.45 ± 0.038
0.485TrpGlu: 0.485 ± 0.033
0.264TrpPhe: 0.264 ± 0.025
0.492TrpGly: 0.492 ± 0.034
0.14TrpHis: 0.14 ± 0.016
0.595TrpIle: 0.595 ± 0.033
0.572TrpLys: 0.572 ± 0.04
0.544TrpLeu: 0.544 ± 0.034
0.227TrpMet: 0.227 ± 0.021
0.382TrpAsn: 0.382 ± 0.03
0.195TrpPro: 0.195 ± 0.021
0.253TrpGln: 0.253 ± 0.023
0.361TrpArg: 0.361 ± 0.025
0.395TrpSer: 0.395 ± 0.03
0.338TrpThr: 0.338 ± 0.031
0.428TrpVal: 0.428 ± 0.031
0.05TrpTrp: 0.05 ± 0.01
0.228TrpTyr: 0.228 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.431TyrAla: 2.431 ± 0.072
0.377TyrCys: 0.377 ± 0.029
2.796TyrAsp: 2.796 ± 0.079
2.452TyrGlu: 2.452 ± 0.066
1.843TyrPhe: 1.843 ± 0.058
3.02TyrGly: 3.02 ± 0.077
0.703TyrHis: 0.703 ± 0.034
2.562TyrIle: 2.562 ± 0.064
2.468TyrLys: 2.468 ± 0.082
3.546TyrLeu: 3.546 ± 0.084
0.892TyrMet: 0.892 ± 0.039
1.48TyrAsn: 1.48 ± 0.061
1.277TyrPro: 1.277 ± 0.049
0.954TyrGln: 0.954 ± 0.046
2.05TyrArg: 2.05 ± 0.067
2.086TyrSer: 2.086 ± 0.067
1.93TyrThr: 1.93 ± 0.06
2.438TyrVal: 2.438 ± 0.063
0.285TyrTrp: 0.285 ± 0.023
1.533TyrTyr: 1.533 ± 0.056
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1860 proteins (564815 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski