Amino acid dipepetide frequency for Lutispora thermophila DSM 19022

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.161AlaAla: 5.161 ± 0.108	0.751AlaCys: 0.751 ± 0.031	3.343AlaAsp: 3.343 ± 0.059	4.35AlaGlu: 4.35 ± 0.073	2.698AlaPhe: 2.698 ± 0.058	4.385AlaGly: 4.385 ± 0.077	0.928AlaHis: 0.928 ± 0.029	6.14AlaIle: 6.14 ± 0.099	4.928AlaLys: 4.928 ± 0.079	6.44AlaLeu: 6.44 ± 0.091	2.063AlaMet: 2.063 ± 0.051	2.682AlaAsn: 2.682 ± 0.051	1.552AlaPro: 1.552 ± 0.046	1.78AlaGln: 1.78 ± 0.047	2.377AlaArg: 2.377 ± 0.053	3.607AlaSer: 3.607 ± 0.064	2.805AlaThr: 2.805 ± 0.064	4.829AlaVal: 4.829 ± 0.075	0.447AlaTrp: 0.447 ± 0.024	2.464AlaTyr: 2.464 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.6CysAla: 0.6 ± 0.03	0.21CysCys: 0.21 ± 0.017	0.671CysAsp: 0.671 ± 0.031	0.755CysGlu: 0.755 ± 0.027	0.494CysPhe: 0.494 ± 0.023	1.052CysGly: 1.052 ± 0.037	0.241CysHis: 0.241 ± 0.014	1.117CysIle: 1.117 ± 0.038	0.806CysLys: 0.806 ± 0.032	0.867CysLeu: 0.867 ± 0.031	0.309CysMet: 0.309 ± 0.019	0.589CysAsn: 0.589 ± 0.021	0.515CysPro: 0.515 ± 0.027	0.283CysGln: 0.283 ± 0.016	0.465CysArg: 0.465 ± 0.023	0.809CysSer: 0.809 ± 0.029	0.495CysThr: 0.495 ± 0.023	0.586CysVal: 0.586 ± 0.023	0.099CysTrp: 0.099 ± 0.011	0.436CysTyr: 0.436 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.117AspAla: 3.117 ± 0.06	0.589AspCys: 0.589 ± 0.025	3.05AspAsp: 3.05 ± 0.056	4.848AspGlu: 4.848 ± 0.087	2.674AspPhe: 2.674 ± 0.048	3.736AspGly: 3.736 ± 0.063	0.706AspHis: 0.706 ± 0.026	6.405AspIle: 6.405 ± 0.087	5.071AspLys: 5.071 ± 0.08	4.658AspLeu: 4.658 ± 0.064	1.963AspMet: 1.963 ± 0.044	3.095AspAsn: 3.095 ± 0.059	1.561AspPro: 1.561 ± 0.04	0.995AspGln: 0.995 ± 0.033	2.292AspArg: 2.292 ± 0.051	3.037AspSer: 3.037 ± 0.051	2.468AspThr: 2.468 ± 0.054	3.784AspVal: 3.784 ± 0.066	0.425AspTrp: 0.425 ± 0.021	2.885AspTyr: 2.885 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	5.192GluAla: 5.192 ± 0.083	0.643GluCys: 0.643 ± 0.025	4.299GluAsp: 4.299 ± 0.06	6.809GluGlu: 6.809 ± 0.112	2.594GluPhe: 2.594 ± 0.051	4.37GluGly: 4.37 ± 0.071	1.066GluHis: 1.066 ± 0.032	7.104GluIle: 7.104 ± 0.076	7.345GluLys: 7.345 ± 0.104	6.77GluLeu: 6.77 ± 0.093	2.15GluMet: 2.15 ± 0.054	4.453GluAsn: 4.453 ± 0.079	1.7GluPro: 1.7 ± 0.044	1.959GluGln: 1.959 ± 0.047	3.064GluArg: 3.064 ± 0.057	3.654GluSer: 3.654 ± 0.069	3.009GluThr: 3.009 ± 0.062	4.77GluVal: 4.77 ± 0.088	0.49GluTrp: 0.49 ± 0.025	3.205GluTyr: 3.205 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	2.59PheAla: 2.59 ± 0.053	0.503PheCys: 0.503 ± 0.022	2.543PheAsp: 2.543 ± 0.05	2.562PheGlu: 2.562 ± 0.051	1.866PhePhe: 1.866 ± 0.051	2.81PheGly: 2.81 ± 0.057	0.652PheHis: 0.652 ± 0.024	4.156PheIle: 4.156 ± 0.076	2.853PheLys: 2.853 ± 0.061	3.615PheLeu: 3.615 ± 0.069	1.243PheMet: 1.243 ± 0.03	2.284PheAsn: 2.284 ± 0.046	1.229PhePro: 1.229 ± 0.035	0.967PheGln: 0.967 ± 0.032	1.479PheArg: 1.479 ± 0.041	2.934PheSer: 2.934 ± 0.063	2.171PheThr: 2.171 ± 0.051	2.503PheVal: 2.503 ± 0.046	0.328PheTrp: 0.328 ± 0.017	1.847PheTyr: 1.847 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.162GlyAla: 4.162 ± 0.078	0.927GlyCys: 0.927 ± 0.035	3.329GlyAsp: 3.329 ± 0.065	4.233GlyGlu: 4.233 ± 0.066	3.074GlyPhe: 3.074 ± 0.056	4.261GlyGly: 4.261 ± 0.085	1.059GlyHis: 1.059 ± 0.036	6.831GlyIle: 6.831 ± 0.093	5.604GlyLys: 5.604 ± 0.076	5.805GlyLeu: 5.805 ± 0.086	1.897GlyMet: 1.897 ± 0.045	3.198GlyAsn: 3.198 ± 0.05	1.358GlyPro: 1.358 ± 0.041	1.77GlyGln: 1.77 ± 0.042	2.672GlyArg: 2.672 ± 0.055	3.811GlySer: 3.811 ± 0.067	3.508GlyThr: 3.508 ± 0.056	4.476GlyVal: 4.476 ± 0.069	0.528GlyTrp: 0.528 ± 0.026	3.166GlyTyr: 3.166 ± 0.069	0.0GlyXaa: 0.0 ± 0.0
His	0.769HisAla: 0.769 ± 0.026	0.213HisCys: 0.213 ± 0.012	0.831HisAsp: 0.831 ± 0.029	0.987HisGlu: 0.987 ± 0.031	0.631HisPhe: 0.631 ± 0.026	1.075HisGly: 1.075 ± 0.036	0.314HisHis: 0.314 ± 0.018	1.503HisIle: 1.503 ± 0.044	1.063HisLys: 1.063 ± 0.033	1.249HisLeu: 1.249 ± 0.036	0.479HisMet: 0.479 ± 0.023	0.779HisAsn: 0.779 ± 0.027	0.707HisPro: 0.707 ± 0.029	0.426HisGln: 0.426 ± 0.02	0.627HisArg: 0.627 ± 0.026	0.893HisSer: 0.893 ± 0.032	0.676HisThr: 0.676 ± 0.031	0.897HisVal: 0.897 ± 0.032	0.151HisTrp: 0.151 ± 0.014	0.64HisTyr: 0.64 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.423IleAla: 6.423 ± 0.096	1.23IleCys: 1.23 ± 0.036	5.948IleAsp: 5.948 ± 0.077	7.157IleGlu: 7.157 ± 0.093	3.707IlePhe: 3.707 ± 0.074	6.201IleGly: 6.201 ± 0.082	1.339IleHis: 1.339 ± 0.042	9.143IleIle: 9.143 ± 0.126	7.855IleLys: 7.855 ± 0.089	8.251IleLeu: 8.251 ± 0.106	2.662IleMet: 2.662 ± 0.05	5.469IleAsn: 5.469 ± 0.073	3.491IlePro: 3.491 ± 0.062	2.29IleGln: 2.29 ± 0.054	3.804IleArg: 3.804 ± 0.059	6.682IleSer: 6.682 ± 0.112	4.821IleThr: 4.821 ± 0.068	5.868IleVal: 5.868 ± 0.083	0.619IleTrp: 0.619 ± 0.024	3.583IleTyr: 3.583 ± 0.073	0.0IleXaa: 0.0 ± 0.0
Lys	5.506LysAla: 5.506 ± 0.086	0.763LysCys: 0.763 ± 0.032	5.345LysAsp: 5.345 ± 0.078	7.529LysGlu: 7.529 ± 0.106	2.478LysPhe: 2.478 ± 0.048	5.006LysGly: 5.006 ± 0.07	1.21LysHis: 1.21 ± 0.035	6.944LysIle: 6.944 ± 0.08	6.98LysLys: 6.98 ± 0.094	7.194LysLeu: 7.194 ± 0.095	2.274LysMet: 2.274 ± 0.047	5.01LysAsn: 5.01 ± 0.075	2.496LysPro: 2.496 ± 0.048	2.149LysGln: 2.149 ± 0.051	3.288LysArg: 3.288 ± 0.061	4.494LysSer: 4.494 ± 0.072	3.903LysThr: 3.903 ± 0.059	5.389LysVal: 5.389 ± 0.086	0.617LysTrp: 0.617 ± 0.02	3.782LysTyr: 3.782 ± 0.066	0.0LysXaa: 0.0 ± 0.0
Leu	5.674LeuAla: 5.674 ± 0.083	1.114LeuCys: 1.114 ± 0.036	5.105LeuAsp: 5.105 ± 0.077	6.494LeuGlu: 6.494 ± 0.087	3.751LeuPhe: 3.751 ± 0.083	5.877LeuGly: 5.877 ± 0.08	1.269LeuHis: 1.269 ± 0.043	7.77LeuIle: 7.77 ± 0.093	7.889LeuLys: 7.889 ± 0.095	8.339LeuLeu: 8.339 ± 0.115	2.613LeuMet: 2.613 ± 0.054	4.88LeuAsn: 4.88 ± 0.071	3.11LeuPro: 3.11 ± 0.056	2.262LeuGln: 2.262 ± 0.048	3.531LeuArg: 3.531 ± 0.067	6.501LeuSer: 6.501 ± 0.091	4.327LeuThr: 4.327 ± 0.064	5.297LeuVal: 5.297 ± 0.077	0.667LeuTrp: 0.667 ± 0.025	3.44LeuTyr: 3.44 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.163MetAla: 2.163 ± 0.051	0.228MetCys: 0.228 ± 0.014	1.913MetAsp: 1.913 ± 0.047	2.368MetGlu: 2.368 ± 0.048	1.01MetPhe: 1.01 ± 0.031	2.005MetGly: 2.005 ± 0.049	0.364MetHis: 0.364 ± 0.021	2.377MetIle: 2.377 ± 0.043	2.653MetLys: 2.653 ± 0.051	2.759MetLeu: 2.759 ± 0.057	0.905MetMet: 0.905 ± 0.029	1.616MetAsn: 1.616 ± 0.035	1.094MetPro: 1.094 ± 0.031	0.744MetGln: 0.744 ± 0.028	1.2MetArg: 1.2 ± 0.039	1.754MetSer: 1.754 ± 0.039	1.445MetThr: 1.445 ± 0.035	1.828MetVal: 1.828 ± 0.038	0.14MetTrp: 0.14 ± 0.012	0.848MetTyr: 0.848 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	2.971AsnAla: 2.971 ± 0.051	0.624AsnCys: 0.624 ± 0.025	2.664AsnAsp: 2.664 ± 0.048	3.712AsnGlu: 3.712 ± 0.065	2.058AsnPhe: 2.058 ± 0.045	3.321AsnGly: 3.321 ± 0.059	0.795AsnHis: 0.795 ± 0.032	6.212AsnIle: 6.212 ± 0.095	4.41AsnLys: 4.41 ± 0.074	4.647AsnLeu: 4.647 ± 0.069	1.743AsnMet: 1.743 ± 0.041	3.114AsnAsn: 3.114 ± 0.071	2.232AsnPro: 2.232 ± 0.052	1.392AsnGln: 1.392 ± 0.034	2.183AsnArg: 2.183 ± 0.054	3.172AsnSer: 3.172 ± 0.053	2.563AsnThr: 2.563 ± 0.047	3.347AsnVal: 3.347 ± 0.059	0.424AsnTrp: 0.424 ± 0.021	2.261AsnTyr: 2.261 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	1.767ProAla: 1.767 ± 0.043	0.339ProCys: 0.339 ± 0.02	2.008ProAsp: 2.008 ± 0.045	2.609ProGlu: 2.609 ± 0.052	1.532ProPhe: 1.532 ± 0.04	2.057ProGly: 2.057 ± 0.05	0.547ProHis: 0.547 ± 0.024	2.775ProIle: 2.775 ± 0.056	2.222ProLys: 2.222 ± 0.048	2.652ProLeu: 2.652 ± 0.055	0.82ProMet: 0.82 ± 0.029	1.414ProAsn: 1.414 ± 0.039	0.791ProPro: 0.791 ± 0.029	0.975ProGln: 0.975 ± 0.031	0.989ProArg: 0.989 ± 0.028	1.816ProSer: 1.816 ± 0.045	1.455ProThr: 1.455 ± 0.039	2.522ProVal: 2.522 ± 0.056	0.277ProTrp: 0.277 ± 0.017	1.444ProTyr: 1.444 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	1.622GlnAla: 1.622 ± 0.042	0.311GlnCys: 0.311 ± 0.017	1.247GlnAsp: 1.247 ± 0.039	1.968GlnGlu: 1.968 ± 0.05	0.932GlnPhe: 0.932 ± 0.029	1.665GlnGly: 1.665 ± 0.041	0.376GlnHis: 0.376 ± 0.023	2.262GlnIle: 2.262 ± 0.05	2.096GlnLys: 2.096 ± 0.055	2.519GlnLeu: 2.519 ± 0.053	0.778GlnMet: 0.778 ± 0.027	1.466GlnAsn: 1.466 ± 0.036	0.733GlnPro: 0.733 ± 0.029	0.934GlnGln: 0.934 ± 0.034	1.188GlnArg: 1.188 ± 0.035	1.509GlnSer: 1.509 ± 0.04	1.045GlnThr: 1.045 ± 0.036	1.614GlnVal: 1.614 ± 0.039	0.295GlnTrp: 0.295 ± 0.016	1.24GlnTyr: 1.24 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.206ArgAla: 2.206 ± 0.047	0.429ArgCys: 0.429 ± 0.021	2.18ArgAsp: 2.18 ± 0.043	3.27ArgGlu: 3.27 ± 0.058	1.667ArgPhe: 1.667 ± 0.037	2.368ArgGly: 2.368 ± 0.053	0.6ArgHis: 0.6 ± 0.023	3.892ArgIle: 3.892 ± 0.067	3.53ArgLys: 3.53 ± 0.061	3.656ArgLeu: 3.656 ± 0.064	1.215ArgMet: 1.215 ± 0.034	2.231ArgAsn: 2.231 ± 0.051	1.046ArgPro: 1.046 ± 0.034	1.238ArgGln: 1.238 ± 0.037	1.813ArgArg: 1.813 ± 0.047	1.929ArgSer: 1.929 ± 0.044	1.817ArgThr: 1.817 ± 0.046	2.523ArgVal: 2.523 ± 0.046	0.291ArgTrp: 0.291 ± 0.018	1.729ArgTyr: 1.729 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.429SerAla: 3.429 ± 0.063	0.702SerCys: 0.702 ± 0.027	3.178SerAsp: 3.178 ± 0.057	3.68SerGlu: 3.68 ± 0.066	2.925SerPhe: 2.925 ± 0.058	4.257SerGly: 4.257 ± 0.067	0.964SerHis: 0.964 ± 0.032	6.437SerIle: 6.437 ± 0.09	4.968SerLys: 4.968 ± 0.076	5.731SerLeu: 5.731 ± 0.086	1.807SerMet: 1.807 ± 0.048	3.216SerAsn: 3.216 ± 0.063	1.801SerPro: 1.801 ± 0.054	1.773SerGln: 1.773 ± 0.045	2.325SerArg: 2.325 ± 0.05	3.908SerSer: 3.908 ± 0.082	2.749SerThr: 2.749 ± 0.059	3.74SerVal: 3.74 ± 0.063	0.473SerTrp: 0.473 ± 0.023	2.523SerTyr: 2.523 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	3.426ThrAla: 3.426 ± 0.072	0.453ThrCys: 0.453 ± 0.022	2.564ThrAsp: 2.564 ± 0.053	2.909ThrGlu: 2.909 ± 0.056	1.933ThrPhe: 1.933 ± 0.046	3.83ThrGly: 3.83 ± 0.065	0.755ThrHis: 0.755 ± 0.031	4.654ThrIle: 4.654 ± 0.07	3.134ThrLys: 3.134 ± 0.049	4.309ThrLeu: 4.309 ± 0.069	1.249ThrMet: 1.249 ± 0.039	2.151ThrAsn: 2.151 ± 0.052	1.937ThrPro: 1.937 ± 0.048	1.152ThrGln: 1.152 ± 0.034	1.769ThrArg: 1.769 ± 0.034	2.843ThrSer: 2.843 ± 0.06	2.37ThrThr: 2.37 ± 0.056	3.564ThrVal: 3.564 ± 0.067	0.355ThrTrp: 0.355 ± 0.021	1.94ThrTyr: 1.94 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	4.164ValAla: 4.164 ± 0.072	0.714ValCys: 0.714 ± 0.031	3.94ValAsp: 3.94 ± 0.067	4.775ValGlu: 4.775 ± 0.077	2.828ValPhe: 2.828 ± 0.052	4.013ValGly: 4.013 ± 0.072	0.938ValHis: 0.938 ± 0.034	6.111ValIle: 6.111 ± 0.076	5.123ValLys: 5.123 ± 0.085	6.101ValLeu: 6.101 ± 0.08	1.894ValMet: 1.894 ± 0.04	3.205ValAsn: 3.205 ± 0.06	2.131ValPro: 2.131 ± 0.049	1.504ValGln: 1.504 ± 0.041	2.472ValArg: 2.472 ± 0.062	4.178ValSer: 4.178 ± 0.062	3.348ValThr: 3.348 ± 0.07	4.588ValVal: 4.588 ± 0.08	0.453ValTrp: 0.453 ± 0.022	2.475ValTyr: 2.475 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.513TrpAla: 0.513 ± 0.026	0.099TrpCys: 0.099 ± 0.011	0.477TrpAsp: 0.477 ± 0.022	0.511TrpGlu: 0.511 ± 0.023	0.325TrpPhe: 0.325 ± 0.016	0.531TrpGly: 0.531 ± 0.026	0.153TrpHis: 0.153 ± 0.013	0.658TrpIle: 0.658 ± 0.026	0.586TrpLys: 0.586 ± 0.024	0.672TrpLeu: 0.672 ± 0.027	0.201TrpMet: 0.201 ± 0.014	0.444TrpAsn: 0.444 ± 0.019	0.203TrpPro: 0.203 ± 0.013	0.228TrpGln: 0.228 ± 0.015	0.305TrpArg: 0.305 ± 0.016	0.425TrpSer: 0.425 ± 0.022	0.335TrpThr: 0.335 ± 0.018	0.419TrpVal: 0.419 ± 0.018	0.088TrpTrp: 0.088 ± 0.012	0.33TrpTyr: 0.33 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.275TyrAla: 2.275 ± 0.049	0.556TyrCys: 0.556 ± 0.024	2.722TyrAsp: 2.722 ± 0.054	3.122TyrGlu: 3.122 ± 0.057	1.957TyrPhe: 1.957 ± 0.051	2.845TyrGly: 2.845 ± 0.057	0.635TyrHis: 0.635 ± 0.025	4.053TyrIle: 4.053 ± 0.068	3.244TyrLys: 3.244 ± 0.068	3.679TyrLeu: 3.679 ± 0.062	1.148TyrMet: 1.148 ± 0.035	2.55TyrAsn: 2.55 ± 0.054	1.324TyrPro: 1.324 ± 0.038	0.976TyrGln: 0.976 ± 0.036	1.789TyrArg: 1.789 ± 0.043	2.628TyrSer: 2.628 ± 0.048	1.987TyrThr: 1.987 ± 0.046	2.412TyrVal: 2.412 ± 0.048	0.335TyrTrp: 0.335 ± 0.017	2.067TyrTyr: 2.067 ± 0.062	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3409 proteins (1016382 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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