Amino acid dipepetide frequency for Sulfurospirillum sp. UBA12182

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.897AlaAla: 3.897 ± 0.114	0.71AlaCys: 0.71 ± 0.041	2.785AlaAsp: 2.785 ± 0.066	2.852AlaGlu: 2.852 ± 0.07	3.229AlaPhe: 3.229 ± 0.069	3.88AlaGly: 3.88 ± 0.098	1.306AlaHis: 1.306 ± 0.043	5.929AlaIle: 5.929 ± 0.109	6.643AlaLys: 6.643 ± 0.109	8.134AlaLeu: 8.134 ± 0.132	1.959AlaMet: 1.959 ± 0.059	3.31AlaAsn: 3.31 ± 0.075	1.698AlaPro: 1.698 ± 0.069	2.381AlaGln: 2.381 ± 0.06	2.272AlaArg: 2.272 ± 0.061	4.31AlaSer: 4.31 ± 0.084	3.518AlaThr: 3.518 ± 0.08	3.664AlaVal: 3.664 ± 0.083	0.444AlaTrp: 0.444 ± 0.03	2.682AlaTyr: 2.682 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	0.666CysAla: 0.666 ± 0.031	0.137CysCys: 0.137 ± 0.015	0.643CysAsp: 0.643 ± 0.035	0.852CysGlu: 0.852 ± 0.035	0.421CysPhe: 0.421 ± 0.026	0.875CysGly: 0.875 ± 0.04	0.265CysHis: 0.265 ± 0.021	0.785CysIle: 0.785 ± 0.036	0.959CysLys: 0.959 ± 0.041	0.712CysLeu: 0.712 ± 0.035	0.226CysMet: 0.226 ± 0.016	0.424CysAsn: 0.424 ± 0.023	0.452CysPro: 0.452 ± 0.033	0.285CysGln: 0.285 ± 0.022	0.281CysArg: 0.281 ± 0.021	0.717CysSer: 0.717 ± 0.03	0.451CysThr: 0.451 ± 0.028	0.637CysVal: 0.637 ± 0.031	0.064CysTrp: 0.064 ± 0.01	0.305CysTyr: 0.305 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.564AspAla: 3.564 ± 0.076	0.454AspCys: 0.454 ± 0.028	2.626AspAsp: 2.626 ± 0.072	4.884AspGlu: 4.884 ± 0.097	3.674AspPhe: 3.674 ± 0.075	3.289AspGly: 3.289 ± 0.066	0.55AspHis: 0.55 ± 0.036	5.587AspIle: 5.587 ± 0.093	4.632AspLys: 4.632 ± 0.078	4.892AspLeu: 4.892 ± 0.087	1.362AspMet: 1.362 ± 0.045	2.218AspAsn: 2.218 ± 0.059	1.304AspPro: 1.304 ± 0.042	0.929AspGln: 0.929 ± 0.042	1.664AspArg: 1.664 ± 0.049	2.891AspSer: 2.891 ± 0.07	2.836AspThr: 2.836 ± 0.07	3.439AspVal: 3.439 ± 0.066	0.365AspTrp: 0.365 ± 0.024	1.929AspTyr: 1.929 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	5.146GluAla: 5.146 ± 0.094	0.674GluCys: 0.674 ± 0.031	4.132GluAsp: 4.132 ± 0.08	6.698GluGlu: 6.698 ± 0.136	3.78GluPhe: 3.78 ± 0.081	3.624GluGly: 3.624 ± 0.078	1.402GluHis: 1.402 ± 0.05	6.669GluIle: 6.669 ± 0.112	7.499GluLys: 7.499 ± 0.116	7.638GluLeu: 7.638 ± 0.121	1.725GluMet: 1.725 ± 0.046	4.552GluAsn: 4.552 ± 0.087	1.658GluPro: 1.658 ± 0.049	2.362GluGln: 2.362 ± 0.067	2.322GluArg: 2.322 ± 0.064	3.861GluSer: 3.861 ± 0.081	2.929GluThr: 2.929 ± 0.067	4.895GluVal: 4.895 ± 0.099	0.513GluTrp: 0.513 ± 0.027	2.991GluTyr: 2.991 ± 0.075	0.0GluXaa: 0.0 ± 0.0
Phe	3.694PheAla: 3.694 ± 0.083	0.707PheCys: 0.707 ± 0.032	3.3PheAsp: 3.3 ± 0.071	4.348PheGlu: 4.348 ± 0.076	3.357PhePhe: 3.357 ± 0.084	3.614PheGly: 3.614 ± 0.081	0.901PheHis: 0.901 ± 0.036	4.517PheIle: 4.517 ± 0.088	3.526PheLys: 3.526 ± 0.071	5.671PheLeu: 5.671 ± 0.11	1.194PheMet: 1.194 ± 0.039	2.211PheAsn: 2.211 ± 0.054	1.333PhePro: 1.333 ± 0.046	1.39PheGln: 1.39 ± 0.048	1.372PheArg: 1.372 ± 0.05	4.112PheSer: 4.112 ± 0.078	2.504PheThr: 2.504 ± 0.059	3.41PheVal: 3.41 ± 0.079	0.481PheTrp: 0.481 ± 0.028	2.249PheTyr: 2.249 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	4.141GlyAla: 4.141 ± 0.092	0.775GlyCys: 0.775 ± 0.04	2.938GlyAsp: 2.938 ± 0.075	3.869GlyGlu: 3.869 ± 0.077	3.569GlyPhe: 3.569 ± 0.073	4.03GlyGly: 4.03 ± 0.105	1.051GlyHis: 1.051 ± 0.038	5.29GlyIle: 5.29 ± 0.089	4.576GlyLys: 4.576 ± 0.086	5.642GlyLeu: 5.642 ± 0.1	1.652GlyMet: 1.652 ± 0.063	2.212GlyAsn: 2.212 ± 0.06	0.982GlyPro: 0.982 ± 0.038	1.301GlyGln: 1.301 ± 0.046	2.014GlyArg: 2.014 ± 0.065	3.556GlySer: 3.556 ± 0.082	2.846GlyThr: 2.846 ± 0.083	4.834GlyVal: 4.834 ± 0.091	0.52GlyTrp: 0.52 ± 0.029	2.739GlyTyr: 2.739 ± 0.069	0.001GlyXaa: 0.001 ± 0.001
His	1.048HisAla: 1.048 ± 0.044	0.185HisCys: 0.185 ± 0.016	0.879HisAsp: 0.879 ± 0.038	1.183HisGlu: 1.183 ± 0.046	1.118HisPhe: 1.118 ± 0.043	1.082HisGly: 1.082 ± 0.044	0.468HisHis: 0.468 ± 0.029	1.529HisIle: 1.529 ± 0.044	1.393HisLys: 1.393 ± 0.05	1.8HisLeu: 1.8 ± 0.048	0.442HisMet: 0.442 ± 0.026	0.846HisAsn: 0.846 ± 0.039	0.825HisPro: 0.825 ± 0.034	0.626HisGln: 0.626 ± 0.027	0.587HisArg: 0.587 ± 0.027	1.213HisSer: 1.213 ± 0.037	0.955HisThr: 0.955 ± 0.037	1.506HisVal: 1.506 ± 0.046	0.163HisTrp: 0.163 ± 0.016	0.723HisTyr: 0.723 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.261IleAla: 6.261 ± 0.097	0.892IleCys: 0.892 ± 0.044	5.193IleAsp: 5.193 ± 0.098	6.597IleGlu: 6.597 ± 0.117	4.278IlePhe: 4.278 ± 0.095	5.24IleGly: 5.24 ± 0.086	1.349IleHis: 1.349 ± 0.048	6.367IleIle: 6.367 ± 0.11	7.408IleLys: 7.408 ± 0.114	8.36IleLeu: 8.36 ± 0.135	1.615IleMet: 1.615 ± 0.047	4.234IleAsn: 4.234 ± 0.079	2.843IlePro: 2.843 ± 0.064	2.619IleGln: 2.619 ± 0.063	2.609IleArg: 2.609 ± 0.065	6.192IleSer: 6.192 ± 0.099	4.112IleThr: 4.112 ± 0.08	5.31IleVal: 5.31 ± 0.092	0.513IleTrp: 0.513 ± 0.034	3.091IleTyr: 3.091 ± 0.072	0.0IleXaa: 0.0 ± 0.0
Lys	5.456LysAla: 5.456 ± 0.098	0.594LysCys: 0.594 ± 0.029	5.03LysAsp: 5.03 ± 0.088	9.341LysGlu: 9.341 ± 0.155	3.197LysPhe: 3.197 ± 0.068	4.006LysGly: 4.006 ± 0.081	1.44LysHis: 1.44 ± 0.054	7.657LysIle: 7.657 ± 0.118	8.513LysLys: 8.513 ± 0.131	7.797LysLeu: 7.797 ± 0.121	2.192LysMet: 2.192 ± 0.057	5.611LysAsn: 5.611 ± 0.114	2.483LysPro: 2.483 ± 0.065	2.78LysGln: 2.78 ± 0.073	3.419LysArg: 3.419 ± 0.061	5.441LysSer: 5.441 ± 0.091	4.257LysThr: 4.257 ± 0.076	5.118LysVal: 5.118 ± 0.099	0.505LysTrp: 0.505 ± 0.029	3.06LysTyr: 3.06 ± 0.074	0.0LysXaa: 0.0 ± 0.0
Leu	6.696LeuAla: 6.696 ± 0.118	1.034LeuCys: 1.034 ± 0.041	5.504LeuAsp: 5.504 ± 0.099	8.046LeuGlu: 8.046 ± 0.11	5.64LeuPhe: 5.64 ± 0.131	6.134LeuGly: 6.134 ± 0.105	2.45LeuHis: 2.45 ± 0.058	7.438LeuIle: 7.438 ± 0.113	9.282LeuLys: 9.282 ± 0.128	10.142LeuLeu: 10.142 ± 0.141	2.358LeuMet: 2.358 ± 0.059	4.709LeuAsn: 4.709 ± 0.077	3.402LeuPro: 3.402 ± 0.075	3.685LeuGln: 3.685 ± 0.085	3.416LeuArg: 3.416 ± 0.075	7.952LeuSer: 7.952 ± 0.118	4.318LeuThr: 4.318 ± 0.077	5.813LeuVal: 5.813 ± 0.089	0.73LeuTrp: 0.73 ± 0.035	3.548LeuTyr: 3.548 ± 0.074	0.0LeuXaa: 0.0 ± 0.0
Met	1.654MetAla: 1.654 ± 0.05	0.199MetCys: 0.199 ± 0.017	1.227MetAsp: 1.227 ± 0.044	1.43MetGlu: 1.43 ± 0.045	1.138MetPhe: 1.138 ± 0.039	1.649MetGly: 1.649 ± 0.048	0.481MetHis: 0.481 ± 0.023	2.08MetIle: 2.08 ± 0.058	2.15MetLys: 2.15 ± 0.054	2.507MetLeu: 2.507 ± 0.06	0.756MetMet: 0.756 ± 0.031	1.143MetAsn: 1.143 ± 0.042	0.951MetPro: 0.951 ± 0.036	1.114MetGln: 1.114 ± 0.04	0.922MetArg: 0.922 ± 0.036	1.813MetSer: 1.813 ± 0.052	0.908MetThr: 0.908 ± 0.035	1.412MetVal: 1.412 ± 0.049	0.173MetTrp: 0.173 ± 0.014	0.756MetTyr: 0.756 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.436AsnAla: 3.436 ± 0.081	0.447AsnCys: 0.447 ± 0.028	2.524AsnAsp: 2.524 ± 0.058	3.733AsnGlu: 3.733 ± 0.076	2.654AsnPhe: 2.654 ± 0.064	2.633AsnGly: 2.633 ± 0.062	0.898AsnHis: 0.898 ± 0.039	4.695AsnIle: 4.695 ± 0.097	3.598AsnLys: 3.598 ± 0.077	5.335AsnLeu: 5.335 ± 0.102	1.057AsnMet: 1.057 ± 0.04	2.159AsnAsn: 2.159 ± 0.066	2.173AsnPro: 2.173 ± 0.059	1.717AsnGln: 1.717 ± 0.053	1.714AsnArg: 1.714 ± 0.051	3.473AsnSer: 3.473 ± 0.078	2.311AsnThr: 2.311 ± 0.072	2.821AsnVal: 2.821 ± 0.062	0.315AsnTrp: 0.315 ± 0.024	1.909AsnTyr: 1.909 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	1.509ProAla: 1.509 ± 0.052	0.283ProCys: 0.283 ± 0.022	1.455ProAsp: 1.455 ± 0.052	1.868ProGlu: 1.868 ± 0.056	1.846ProPhe: 1.846 ± 0.054	1.303ProGly: 1.303 ± 0.042	0.72ProHis: 0.72 ± 0.03	2.561ProIle: 2.561 ± 0.062	2.664ProLys: 2.664 ± 0.064	3.201ProLeu: 3.201 ± 0.077	0.743ProMet: 0.743 ± 0.036	1.642ProAsn: 1.642 ± 0.049	0.806ProPro: 0.806 ± 0.031	1.104ProGln: 1.104 ± 0.043	0.922ProArg: 0.922 ± 0.034	2.013ProSer: 2.013 ± 0.052	1.765ProThr: 1.765 ± 0.052	1.778ProVal: 1.778 ± 0.051	0.261ProTrp: 0.261 ± 0.02	1.258ProTyr: 1.258 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	1.984GlnAla: 1.984 ± 0.054	0.182GlnCys: 0.182 ± 0.016	1.466GlnAsp: 1.466 ± 0.045	2.955GlnGlu: 2.955 ± 0.081	1.16GlnPhe: 1.16 ± 0.04	1.483GlnGly: 1.483 ± 0.047	0.455GlnHis: 0.455 ± 0.026	2.964GlnIle: 2.964 ± 0.065	3.907GlnLys: 3.907 ± 0.086	2.351GlnLeu: 2.351 ± 0.059	0.974GlnMet: 0.974 ± 0.041	2.458GlnAsn: 2.458 ± 0.069	0.709GlnPro: 0.709 ± 0.034	0.815GlnGln: 0.815 ± 0.04	1.313GlnArg: 1.313 ± 0.045	2.062GlnSer: 2.062 ± 0.052	1.835GlnThr: 1.835 ± 0.053	1.626GlnVal: 1.626 ± 0.043	0.196GlnTrp: 0.196 ± 0.017	0.84GlnTyr: 0.84 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.238ArgAla: 2.238 ± 0.062	0.298ArgCys: 0.298 ± 0.021	1.909ArgAsp: 1.909 ± 0.051	2.647ArgGlu: 2.647 ± 0.064	1.992ArgPhe: 1.992 ± 0.052	1.994ArgGly: 1.994 ± 0.053	0.547ArgHis: 0.547 ± 0.028	2.58ArgIle: 2.58 ± 0.061	2.465ArgLys: 2.465 ± 0.059	3.231ArgLeu: 3.231 ± 0.071	0.825ArgMet: 0.825 ± 0.034	1.423ArgAsn: 1.423 ± 0.046	0.84ArgPro: 0.84 ± 0.038	1.001ArgGln: 1.001 ± 0.033	1.277ArgArg: 1.277 ± 0.047	1.709ArgSer: 1.709 ± 0.058	1.329ArgThr: 1.329 ± 0.045	2.652ArgVal: 2.652 ± 0.064	0.302ArgTrp: 0.302 ± 0.021	1.748ArgTyr: 1.748 ± 0.061	0.0ArgXaa: 0.0 ± 0.0
Ser	4.033SerAla: 4.033 ± 0.081	0.677SerCys: 0.677 ± 0.032	3.249SerAsp: 3.249 ± 0.071	3.985SerGlu: 3.985 ± 0.077	4.259SerPhe: 4.259 ± 0.083	4.036SerGly: 4.036 ± 0.091	1.314SerHis: 1.314 ± 0.041	5.67SerIle: 5.67 ± 0.085	5.535SerLys: 5.535 ± 0.087	7.89SerLeu: 7.89 ± 0.124	1.619SerMet: 1.619 ± 0.048	3.091SerAsn: 3.091 ± 0.07	1.748SerPro: 1.748 ± 0.047	2.193SerGln: 2.193 ± 0.053	2.029SerArg: 2.029 ± 0.059	4.831SerSer: 4.831 ± 0.088	2.898SerThr: 2.898 ± 0.071	4.052SerVal: 4.052 ± 0.078	0.541SerTrp: 0.541 ± 0.03	2.627SerTyr: 2.627 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	2.646ThrAla: 2.646 ± 0.068	0.747ThrCys: 0.747 ± 0.032	2.056ThrAsp: 2.056 ± 0.061	1.946ThrGlu: 1.946 ± 0.051	2.536ThrPhe: 2.536 ± 0.064	2.72ThrGly: 2.72 ± 0.079	1.055ThrHis: 1.055 ± 0.04	4.038ThrIle: 4.038 ± 0.077	4.175ThrLys: 4.175 ± 0.087	5.93ThrLeu: 5.93 ± 0.09	0.976ThrMet: 0.976 ± 0.036	2.514ThrAsn: 2.514 ± 0.061	2.186ThrPro: 2.186 ± 0.066	1.996ThrGln: 1.996 ± 0.048	1.387ThrArg: 1.387 ± 0.041	3.058ThrSer: 3.058 ± 0.075	2.626ThrThr: 2.626 ± 0.07	2.37ThrVal: 2.37 ± 0.05	0.348ThrTrp: 0.348 ± 0.023	1.909ThrTyr: 1.909 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	4.629ValAla: 4.629 ± 0.092	0.765ValCys: 0.765 ± 0.035	3.532ValAsp: 3.532 ± 0.083	4.199ValGlu: 4.199 ± 0.075	3.353ValPhe: 3.353 ± 0.07	4.161ValGly: 4.161 ± 0.084	1.052ValHis: 1.052 ± 0.043	5.03ValIle: 5.03 ± 0.094	5.008ValLys: 5.008 ± 0.087	6.357ValLeu: 6.357 ± 0.101	1.641ValMet: 1.641 ± 0.046	2.659ValAsn: 2.659 ± 0.054	1.853ValPro: 1.853 ± 0.05	1.92ValGln: 1.92 ± 0.057	1.93ValArg: 1.93 ± 0.055	4.275ValSer: 4.275 ± 0.081	2.695ValThr: 2.695 ± 0.063	4.554ValVal: 4.554 ± 0.089	0.45ValTrp: 0.45 ± 0.029	2.205ValTyr: 2.205 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.467TrpAla: 0.467 ± 0.03	0.077TrpCys: 0.077 ± 0.009	0.419TrpAsp: 0.419 ± 0.026	0.437TrpGlu: 0.437 ± 0.025	0.415TrpPhe: 0.415 ± 0.027	0.491TrpGly: 0.491 ± 0.029	0.149TrpHis: 0.149 ± 0.016	0.689TrpIle: 0.689 ± 0.029	0.47TrpLys: 0.47 ± 0.03	0.802TrpLeu: 0.802 ± 0.035	0.273TrpMet: 0.273 ± 0.021	0.301TrpAsn: 0.301 ± 0.02	0.165TrpPro: 0.165 ± 0.015	0.331TrpGln: 0.331 ± 0.023	0.263TrpArg: 0.263 ± 0.02	0.447TrpSer: 0.447 ± 0.028	0.241TrpThr: 0.241 ± 0.02	0.441TrpVal: 0.441 ± 0.027	0.079TrpTrp: 0.079 ± 0.012	0.308TrpTyr: 0.308 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.437TyrAla: 2.437 ± 0.065	0.319TyrCys: 0.319 ± 0.022	2.221TyrAsp: 2.221 ± 0.054	3.201TyrGlu: 3.201 ± 0.071	2.276TyrPhe: 2.276 ± 0.056	2.295TyrGly: 2.295 ± 0.055	0.719TyrHis: 0.719 ± 0.032	3.01TyrIle: 3.01 ± 0.06	3.492TyrLys: 3.492 ± 0.08	3.903TyrLeu: 3.903 ± 0.08	0.87TyrMet: 0.87 ± 0.034	1.886TyrAsn: 1.886 ± 0.055	1.293TyrPro: 1.293 ± 0.047	1.187TyrGln: 1.187 ± 0.046	1.294TyrArg: 1.294 ± 0.044	2.352TyrSer: 2.352 ± 0.061	1.886TyrThr: 1.886 ± 0.055	1.934TyrVal: 1.934 ± 0.053	0.301TyrTrp: 0.301 ± 0.022	1.393TyrTyr: 1.393 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2326 proteins (698452 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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