Amino acid dipepetide frequency for Human respirovirus 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.228AlaAla: 2.228 ± 0.322
0.557AlaCys: 0.557 ± 0.338
2.043AlaAsp: 2.043 ± 0.425
1.857AlaGlu: 1.857 ± 0.483
1.671AlaPhe: 1.671 ± 0.783
2.043AlaGly: 2.043 ± 0.742
0.371AlaHis: 0.371 ± 0.225
5.2AlaIle: 5.2 ± 0.867
3.157AlaLys: 3.157 ± 0.784
4.828AlaLeu: 4.828 ± 0.806
1.3AlaMet: 1.3 ± 0.413
1.857AlaAsn: 1.857 ± 0.462
0.743AlaPro: 0.743 ± 0.558
2.043AlaGln: 2.043 ± 0.378
1.486AlaArg: 1.486 ± 0.531
4.271AlaSer: 4.271 ± 0.692
3.157AlaThr: 3.157 ± 0.608
1.857AlaVal: 1.857 ± 0.415
0.371AlaTrp: 0.371 ± 0.369
1.3AlaTyr: 1.3 ± 0.439
0.0AlaXaa: 0.0 ± 0.0
Cys
0.186CysAla: 0.186 ± 0.113
0.371CysCys: 0.371 ± 0.225
0.743CysAsp: 0.743 ± 0.349
0.557CysGlu: 0.557 ± 0.238
0.557CysPhe: 0.557 ± 0.217
0.557CysGly: 0.557 ± 0.256
0.371CysHis: 0.371 ± 0.225
1.3CysIle: 1.3 ± 0.433
0.557CysLys: 0.557 ± 0.245
1.114CysLeu: 1.114 ± 0.277
0.186CysMet: 0.186 ± 0.165
1.3CysAsn: 1.3 ± 0.416
1.114CysPro: 1.114 ± 0.621
0.929CysGln: 0.929 ± 0.291
0.186CysArg: 0.186 ± 0.209
0.929CysSer: 0.929 ± 0.524
1.486CysThr: 1.486 ± 0.236
0.557CysVal: 0.557 ± 0.214
0.0CysTrp: 0.0 ± 0.0
0.557CysTyr: 0.557 ± 0.24
0.0CysXaa: 0.0 ± 0.0
Asp
1.857AspAla: 1.857 ± 0.596
0.371AspCys: 0.371 ± 0.175
3.9AspAsp: 3.9 ± 0.833
3.714AspGlu: 3.714 ± 0.801
0.371AspPhe: 0.371 ± 0.254
2.6AspGly: 2.6 ± 0.415
1.114AspHis: 1.114 ± 0.374
4.457AspIle: 4.457 ± 1.142
5.2AspLys: 5.2 ± 0.967
7.428AspLeu: 7.428 ± 0.535
1.671AspMet: 1.671 ± 0.699
3.714AspAsn: 3.714 ± 0.583
3.9AspPro: 3.9 ± 0.779
3.157AspGln: 3.157 ± 0.959
2.6AspArg: 2.6 ± 0.26
4.457AspSer: 4.457 ± 1.049
3.9AspThr: 3.9 ± 1.065
3.714AspVal: 3.714 ± 0.447
0.929AspTrp: 0.929 ± 0.31
2.228AspTyr: 2.228 ± 0.538
0.0AspXaa: 0.0 ± 0.0
Glu
3.157GluAla: 3.157 ± 1.096
1.671GluCys: 1.671 ± 0.328
3.343GluAsp: 3.343 ± 0.425
4.085GluGlu: 4.085 ± 1.311
2.6GluPhe: 2.6 ± 0.656
2.414GluGly: 2.414 ± 0.543
1.114GluHis: 1.114 ± 0.5
5.942GluIle: 5.942 ± 0.777
4.085GluLys: 4.085 ± 0.874
5.014GluLeu: 5.014 ± 0.586
1.671GluMet: 1.671 ± 0.431
3.157GluAsn: 3.157 ± 0.513
1.857GluPro: 1.857 ± 0.564
2.043GluGln: 2.043 ± 0.949
2.6GluArg: 2.6 ± 0.63
6.128GluSer: 6.128 ± 1.167
4.643GluThr: 4.643 ± 0.718
2.786GluVal: 2.786 ± 0.813
0.929GluTrp: 0.929 ± 0.415
0.743GluTyr: 0.743 ± 0.247
0.0GluXaa: 0.0 ± 0.0
Phe
0.929PheAla: 0.929 ± 0.407
0.371PheCys: 0.371 ± 0.225
1.857PheAsp: 1.857 ± 0.437
1.486PheGlu: 1.486 ± 0.415
1.3PhePhe: 1.3 ± 0.369
2.6PheGly: 2.6 ± 0.88
0.371PheHis: 0.371 ± 0.272
2.971PheIle: 2.971 ± 0.691
1.857PheLys: 1.857 ± 0.495
2.971PheLeu: 2.971 ± 0.723
0.557PheMet: 0.557 ± 0.253
2.414PheAsn: 2.414 ± 0.58
1.114PhePro: 1.114 ± 0.514
1.3PheGln: 1.3 ± 0.351
1.114PheArg: 1.114 ± 0.399
1.114PheSer: 1.114 ± 0.415
1.671PheThr: 1.671 ± 0.408
1.114PheVal: 1.114 ± 0.397
0.743PheTrp: 0.743 ± 0.299
0.371PheTyr: 0.371 ± 0.189
0.0PheXaa: 0.0 ± 0.0
Gly
1.671GlyAla: 1.671 ± 0.543
0.929GlyCys: 0.929 ± 0.798
1.486GlyAsp: 1.486 ± 0.512
2.043GlyGlu: 2.043 ± 0.512
1.671GlyPhe: 1.671 ± 0.522
4.457GlyGly: 4.457 ± 0.602
1.114GlyHis: 1.114 ± 0.366
4.828GlyIle: 4.828 ± 0.795
4.271GlyLys: 4.271 ± 1.137
5.014GlyLeu: 5.014 ± 0.638
1.114GlyMet: 1.114 ± 0.406
3.9GlyAsn: 3.9 ± 0.579
1.857GlyPro: 1.857 ± 0.552
1.3GlyGln: 1.3 ± 0.438
2.971GlyArg: 2.971 ± 0.535
5.942GlySer: 5.942 ± 1.568
1.671GlyThr: 1.671 ± 0.537
3.9GlyVal: 3.9 ± 0.856
0.0GlyTrp: 0.0 ± 0.0
2.043GlyTyr: 2.043 ± 0.664
0.0GlyXaa: 0.0 ± 0.0
His
0.929HisAla: 0.929 ± 0.31
0.743HisCys: 0.743 ± 0.247
0.929HisAsp: 0.929 ± 0.396
1.486HisGlu: 1.486 ± 0.294
0.0HisPhe: 0.0 ± 0.0
1.3HisGly: 1.3 ± 0.488
0.371HisHis: 0.371 ± 0.275
1.857HisIle: 1.857 ± 0.534
0.929HisLys: 0.929 ± 0.339
1.671HisLeu: 1.671 ± 0.603
0.186HisMet: 0.186 ± 0.113
0.743HisAsn: 0.743 ± 0.239
1.3HisPro: 1.3 ± 0.475
1.671HisGln: 1.671 ± 0.957
0.743HisArg: 0.743 ± 0.369
1.114HisSer: 1.114 ± 0.522
1.3HisThr: 1.3 ± 0.439
0.743HisVal: 0.743 ± 0.288
0.0HisTrp: 0.0 ± 0.0
0.743HisTyr: 0.743 ± 0.291
0.0HisXaa: 0.0 ± 0.0
Ile
3.528IleAla: 3.528 ± 1.353
1.857IleCys: 1.857 ± 0.147
4.271IleAsp: 4.271 ± 0.774
5.571IleGlu: 5.571 ± 0.718
3.528IlePhe: 3.528 ± 0.531
4.828IleGly: 4.828 ± 0.793
0.929IleHis: 0.929 ± 0.417
5.385IleIle: 5.385 ± 1.137
7.985IleLys: 7.985 ± 1.157
6.5IleLeu: 6.5 ± 0.98
2.6IleMet: 2.6 ± 0.502
5.942IleAsn: 5.942 ± 0.703
2.414IlePro: 2.414 ± 0.468
3.343IleGln: 3.343 ± 0.924
4.828IleArg: 4.828 ± 0.675
9.471IleSer: 9.471 ± 0.875
8.542IleThr: 8.542 ± 1.775
4.085IleVal: 4.085 ± 1.43
0.929IleTrp: 0.929 ± 0.364
3.528IleTyr: 3.528 ± 0.692
0.0IleXaa: 0.0 ± 0.0
Lys
2.971LysAla: 2.971 ± 0.475
0.371LysCys: 0.371 ± 0.275
5.385LysAsp: 5.385 ± 1.253
5.2LysGlu: 5.2 ± 1.568
1.857LysPhe: 1.857 ± 0.758
4.643LysGly: 4.643 ± 1.224
0.743LysHis: 0.743 ± 0.421
6.314LysIle: 6.314 ± 1.11
3.714LysLys: 3.714 ± 1.291
6.128LysLeu: 6.128 ± 1.401
2.414LysMet: 2.414 ± 0.513
3.714LysAsn: 3.714 ± 0.818
1.486LysPro: 1.486 ± 0.453
2.971LysGln: 2.971 ± 0.593
4.085LysArg: 4.085 ± 0.746
5.942LysSer: 5.942 ± 0.947
4.828LysThr: 4.828 ± 1.504
3.343LysVal: 3.343 ± 0.759
0.557LysTrp: 0.557 ± 0.217
2.414LysTyr: 2.414 ± 0.529
0.0LysXaa: 0.0 ± 0.0
Leu
4.643LeuAla: 4.643 ± 1.028
0.186LeuCys: 0.186 ± 0.198
5.942LeuAsp: 5.942 ± 1.239
4.643LeuGlu: 4.643 ± 0.98
3.714LeuPhe: 3.714 ± 0.81
5.2LeuGly: 5.2 ± 0.963
1.671LeuHis: 1.671 ± 0.567
7.799LeuIle: 7.799 ± 1.147
7.614LeuLys: 7.614 ± 2.343
8.171LeuLeu: 8.171 ± 1.45
2.6LeuMet: 2.6 ± 0.447
7.614LeuAsn: 7.614 ± 0.644
3.157LeuPro: 3.157 ± 1.001
3.714LeuGln: 3.714 ± 1.273
3.714LeuArg: 3.714 ± 0.754
10.028LeuSer: 10.028 ± 1.894
5.2LeuThr: 5.2 ± 0.669
5.2LeuVal: 5.2 ± 0.626
1.114LeuTrp: 1.114 ± 0.338
3.528LeuTyr: 3.528 ± 0.308
0.0LeuXaa: 0.0 ± 0.0
Met
1.486MetAla: 1.486 ± 0.608
0.186MetCys: 0.186 ± 0.113
2.228MetAsp: 2.228 ± 0.831
3.157MetGlu: 3.157 ± 0.54
0.929MetPhe: 0.929 ± 0.314
0.557MetGly: 0.557 ± 0.235
0.186MetHis: 0.186 ± 0.113
1.671MetIle: 1.671 ± 0.458
1.671MetLys: 1.671 ± 0.271
2.043MetLeu: 2.043 ± 0.315
0.186MetMet: 0.186 ± 0.201
0.743MetAsn: 0.743 ± 0.32
0.557MetPro: 0.557 ± 0.427
0.371MetGln: 0.371 ± 0.184
2.414MetArg: 2.414 ± 0.462
1.486MetSer: 1.486 ± 0.563
0.929MetThr: 0.929 ± 0.242
1.3MetVal: 1.3 ± 0.382
0.186MetTrp: 0.186 ± 0.113
0.929MetTyr: 0.929 ± 0.412
0.0MetXaa: 0.0 ± 0.0
Asn
2.043AsnAla: 2.043 ± 0.474
0.743AsnCys: 0.743 ± 0.281
4.457AsnAsp: 4.457 ± 0.405
4.643AsnGlu: 4.643 ± 1.043
0.743AsnPhe: 0.743 ± 0.257
2.971AsnGly: 2.971 ± 0.538
1.114AsnHis: 1.114 ± 0.375
7.985AsnIle: 7.985 ± 0.956
4.271AsnLys: 4.271 ± 0.931
5.385AsnLeu: 5.385 ± 1.358
0.929AsnMet: 0.929 ± 0.382
3.9AsnAsn: 3.9 ± 0.896
3.714AsnPro: 3.714 ± 0.819
3.714AsnGln: 3.714 ± 1.12
2.786AsnArg: 2.786 ± 1.108
5.014AsnSer: 5.014 ± 0.605
4.085AsnThr: 4.085 ± 1.395
1.3AsnVal: 1.3 ± 0.411
0.929AsnTrp: 0.929 ± 0.563
3.343AsnTyr: 3.343 ± 0.831
0.0AsnXaa: 0.0 ± 0.0
Pro
1.114ProAla: 1.114 ± 0.521
0.0ProCys: 0.0 ± 0.0
3.157ProAsp: 3.157 ± 0.637
3.157ProGlu: 3.157 ± 0.621
0.371ProPhe: 0.371 ± 0.184
2.6ProGly: 2.6 ± 0.883
0.557ProHis: 0.557 ± 0.398
2.414ProIle: 2.414 ± 0.256
2.786ProLys: 2.786 ± 1.024
3.528ProLeu: 3.528 ± 0.832
0.186ProMet: 0.186 ± 0.198
1.671ProAsn: 1.671 ± 0.727
1.486ProPro: 1.486 ± 0.251
1.857ProGln: 1.857 ± 0.281
2.414ProArg: 2.414 ± 0.432
3.9ProSer: 3.9 ± 0.972
2.786ProThr: 2.786 ± 0.975
0.929ProVal: 0.929 ± 0.396
0.557ProTrp: 0.557 ± 0.465
1.486ProTyr: 1.486 ± 0.545
0.0ProXaa: 0.0 ± 0.0
Gln
2.043GlnAla: 2.043 ± 0.602
0.371GlnCys: 0.371 ± 0.3
1.857GlnAsp: 1.857 ± 0.644
3.528GlnGlu: 3.528 ± 1.226
0.371GlnPhe: 0.371 ± 0.184
1.114GlnGly: 1.114 ± 0.373
0.929GlnHis: 0.929 ± 0.455
4.828GlnIle: 4.828 ± 0.533
4.828GlnLys: 4.828 ± 1.503
4.271GlnLeu: 4.271 ± 0.839
1.114GlnMet: 1.114 ± 0.578
3.528GlnAsn: 3.528 ± 0.938
1.857GlnPro: 1.857 ± 0.801
2.6GlnGln: 2.6 ± 1.228
2.414GlnArg: 2.414 ± 0.833
4.085GlnSer: 4.085 ± 1.184
1.671GlnThr: 1.671 ± 0.661
1.486GlnVal: 1.486 ± 0.475
0.371GlnTrp: 0.371 ± 0.198
1.486GlnTyr: 1.486 ± 0.508
0.0GlnXaa: 0.0 ± 0.0
Arg
2.228ArgAla: 2.228 ± 0.83
0.557ArgCys: 0.557 ± 0.217
2.414ArgAsp: 2.414 ± 0.618
2.043ArgGlu: 2.043 ± 0.246
1.671ArgPhe: 1.671 ± 0.443
2.414ArgGly: 2.414 ± 0.787
1.3ArgHis: 1.3 ± 0.375
3.528ArgIle: 3.528 ± 0.574
3.343ArgLys: 3.343 ± 0.965
6.5ArgLeu: 6.5 ± 0.929
1.114ArgMet: 1.114 ± 0.365
3.714ArgAsn: 3.714 ± 0.782
0.743ArgPro: 0.743 ± 0.381
2.971ArgGln: 2.971 ± 1.208
2.228ArgArg: 2.228 ± 0.279
4.085ArgSer: 4.085 ± 0.961
3.157ArgThr: 3.157 ± 0.38
3.157ArgVal: 3.157 ± 0.629
0.371ArgTrp: 0.371 ± 0.275
2.228ArgTyr: 2.228 ± 0.515
0.0ArgXaa: 0.0 ± 0.0
Ser
3.157SerAla: 3.157 ± 0.584
1.857SerCys: 1.857 ± 0.682
6.5SerAsp: 6.5 ± 1.049
4.457SerGlu: 4.457 ± 1.03
2.414SerPhe: 2.414 ± 0.767
4.457SerGly: 4.457 ± 0.652
2.6SerHis: 2.6 ± 0.403
8.171SerIle: 8.171 ± 1.057
5.385SerLys: 5.385 ± 1.409
10.028SerLeu: 10.028 ± 1.094
1.486SerMet: 1.486 ± 0.614
5.014SerAsn: 5.014 ± 1.014
2.228SerPro: 2.228 ± 0.55
2.786SerGln: 2.786 ± 0.27
4.643SerArg: 4.643 ± 0.963
5.571SerSer: 5.571 ± 1.292
8.171SerThr: 8.171 ± 1.775
4.457SerVal: 4.457 ± 1.002
1.3SerTrp: 1.3 ± 0.343
2.414SerTyr: 2.414 ± 0.391
0.0SerXaa: 0.0 ± 0.0
Thr
2.786ThrAla: 2.786 ± 0.479
0.557ThrCys: 0.557 ± 0.374
4.643ThrAsp: 4.643 ± 0.887
5.014ThrGlu: 5.014 ± 1.671
1.857ThrPhe: 1.857 ± 0.434
3.157ThrGly: 3.157 ± 0.681
1.857ThrHis: 1.857 ± 0.554
5.942ThrIle: 5.942 ± 0.622
2.414ThrLys: 2.414 ± 0.823
5.942ThrLeu: 5.942 ± 0.753
1.486ThrMet: 1.486 ± 0.404
5.014ThrAsn: 5.014 ± 1.146
2.971ThrPro: 2.971 ± 0.696
3.157ThrGln: 3.157 ± 0.902
4.457ThrArg: 4.457 ± 1.02
5.2ThrSer: 5.2 ± 1.225
6.128ThrThr: 6.128 ± 1.485
3.9ThrVal: 3.9 ± 0.438
0.929ThrTrp: 0.929 ± 0.396
2.043ThrTyr: 2.043 ± 0.741
0.0ThrXaa: 0.0 ± 0.0
Val
2.971ValAla: 2.971 ± 0.887
0.557ValCys: 0.557 ± 0.245
2.786ValAsp: 2.786 ± 0.744
1.671ValGlu: 1.671 ± 0.74
1.486ValPhe: 1.486 ± 0.501
2.228ValGly: 2.228 ± 0.614
1.3ValHis: 1.3 ± 0.458
5.014ValIle: 5.014 ± 0.658
2.786ValLys: 2.786 ± 0.541
5.2ValLeu: 5.2 ± 1.255
0.929ValMet: 0.929 ± 0.327
3.343ValAsn: 3.343 ± 1.443
2.228ValPro: 2.228 ± 0.635
2.971ValGln: 2.971 ± 1.028
1.857ValArg: 1.857 ± 0.498
4.085ValSer: 4.085 ± 1.029
2.971ValThr: 2.971 ± 0.558
2.786ValVal: 2.786 ± 0.561
0.186ValTrp: 0.186 ± 0.198
1.114ValTyr: 1.114 ± 0.379
0.0ValXaa: 0.0 ± 0.0
Trp
0.743TrpAla: 0.743 ± 0.239
0.0TrpCys: 0.0 ± 0.0
0.929TrpAsp: 0.929 ± 0.563
0.557TrpGlu: 0.557 ± 0.216
0.743TrpPhe: 0.743 ± 0.23
0.557TrpGly: 0.557 ± 0.356
0.557TrpHis: 0.557 ± 0.427
2.043TrpIle: 2.043 ± 0.639
0.371TrpLys: 0.371 ± 0.175
0.743TrpLeu: 0.743 ± 0.45
0.557TrpMet: 0.557 ± 0.338
0.557TrpAsn: 0.557 ± 0.345
0.186TrpPro: 0.186 ± 0.113
0.0TrpGln: 0.0 ± 0.0
0.371TrpArg: 0.371 ± 0.175
1.3TrpSer: 1.3 ± 0.327
0.743TrpThr: 0.743 ± 0.548
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.371TrpTyr: 0.371 ± 0.189
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.671TyrAla: 1.671 ± 0.692
1.3TyrCys: 1.3 ± 0.333
2.414TyrAsp: 2.414 ± 0.716
1.114TyrGlu: 1.114 ± 0.521
0.371TyrPhe: 0.371 ± 0.225
1.486TyrGly: 1.486 ± 0.379
0.186TyrHis: 0.186 ± 0.113
2.414TyrIle: 2.414 ± 0.449
1.857TyrLys: 1.857 ± 0.498
2.971TyrLeu: 2.971 ± 0.821
0.743TyrMet: 0.743 ± 0.32
2.414TyrAsn: 2.414 ± 0.934
2.043TyrPro: 2.043 ± 0.625
1.857TyrGln: 1.857 ± 0.452
1.857TyrArg: 1.857 ± 0.557
2.971TyrSer: 2.971 ± 0.73
2.414TyrThr: 2.414 ± 0.81
1.857TyrVal: 1.857 ± 0.605
0.929TyrTrp: 0.929 ± 0.378
1.114TyrTyr: 1.114 ± 0.26
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (5386 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski