Amino acid dipepetide frequency for Paracoccus solventivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.796AlaAla: 23.796 ± 0.314	1.077AlaCys: 1.077 ± 0.039	7.446AlaAsp: 7.446 ± 0.107	9.741AlaGlu: 9.741 ± 0.139	3.704AlaPhe: 3.704 ± 0.064	12.853AlaGly: 12.853 ± 0.14	2.426AlaHis: 2.426 ± 0.051	5.837AlaIle: 5.837 ± 0.095	2.528AlaLys: 2.528 ± 0.062	16.104AlaLeu: 16.104 ± 0.185	3.898AlaMet: 3.898 ± 0.063	2.329AlaAsn: 2.329 ± 0.053	7.78AlaPro: 7.78 ± 0.13	5.183AlaGln: 5.183 ± 0.094	11.365AlaArg: 11.365 ± 0.14	5.452AlaSer: 5.452 ± 0.083	6.318AlaThr: 6.318 ± 0.088	9.499AlaVal: 9.499 ± 0.1	1.646AlaTrp: 1.646 ± 0.042	2.237AlaTyr: 2.237 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.05CysAla: 1.05 ± 0.036	0.1CysCys: 0.1 ± 0.01	0.552CysAsp: 0.552 ± 0.022	0.407CysGlu: 0.407 ± 0.022	0.289CysPhe: 0.289 ± 0.018	0.932CysGly: 0.932 ± 0.037	0.279CysHis: 0.279 ± 0.018	0.36CysIle: 0.36 ± 0.022	0.149CysLys: 0.149 ± 0.014	0.727CysLeu: 0.727 ± 0.027	0.168CysMet: 0.168 ± 0.014	0.192CysAsn: 0.192 ± 0.014	0.529CysPro: 0.529 ± 0.025	0.207CysGln: 0.207 ± 0.014	0.602CysArg: 0.602 ± 0.028	0.401CysSer: 0.401 ± 0.018	0.398CysThr: 0.398 ± 0.021	0.553CysVal: 0.553 ± 0.029	0.109CysTrp: 0.109 ± 0.011	0.194CysTyr: 0.194 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.553AspAla: 7.553 ± 0.102	0.525AspCys: 0.525 ± 0.024	3.314AspAsp: 3.314 ± 0.071	3.533AspGlu: 3.533 ± 0.065	2.178AspPhe: 2.178 ± 0.046	5.251AspGly: 5.251 ± 0.089	1.383AspHis: 1.383 ± 0.042	2.615AspIle: 2.615 ± 0.05	1.207AspLys: 1.207 ± 0.036	5.873AspLeu: 5.873 ± 0.081	1.418AspMet: 1.418 ± 0.041	1.06AspAsn: 1.06 ± 0.036	4.304AspPro: 4.304 ± 0.071	1.707AspGln: 1.707 ± 0.04	5.145AspArg: 5.145 ± 0.075	2.446AspSer: 2.446 ± 0.056	2.524AspThr: 2.524 ± 0.055	3.439AspVal: 3.439 ± 0.056	1.243AspTrp: 1.243 ± 0.037	1.478AspTyr: 1.478 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.905GluAla: 7.905 ± 0.119	0.323GluCys: 0.323 ± 0.02	3.087GluAsp: 3.087 ± 0.066	2.649GluGlu: 2.649 ± 0.06	1.686GluPhe: 1.686 ± 0.043	4.791GluGly: 4.791 ± 0.078	1.026GluHis: 1.026 ± 0.032	3.488GluIle: 3.488 ± 0.062	1.453GluLys: 1.453 ± 0.044	5.746GluLeu: 5.746 ± 0.089	1.601GluMet: 1.601 ± 0.045	1.365GluAsn: 1.365 ± 0.04	2.854GluPro: 2.854 ± 0.061	2.025GluGln: 2.025 ± 0.05	4.738GluArg: 4.738 ± 0.069	2.363GluSer: 2.363 ± 0.045	3.271GluThr: 3.271 ± 0.055	3.997GluVal: 3.997 ± 0.067	0.78GluTrp: 0.78 ± 0.029	0.986GluTyr: 0.986 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.363PheAla: 4.363 ± 0.08	0.368PheCys: 0.368 ± 0.021	2.451PheAsp: 2.451 ± 0.049	1.686PheGlu: 1.686 ± 0.044	1.101PhePhe: 1.101 ± 0.035	3.415PheGly: 3.415 ± 0.068	0.753PheHis: 0.753 ± 0.025	1.323PheIle: 1.323 ± 0.039	0.618PheLys: 0.618 ± 0.025	3.154PheLeu: 3.154 ± 0.067	0.747PheMet: 0.747 ± 0.028	0.817PheAsn: 0.817 ± 0.034	1.524PhePro: 1.524 ± 0.04	0.96PheGln: 0.96 ± 0.028	2.306PheArg: 2.306 ± 0.05	1.708PheSer: 1.708 ± 0.042	1.761PheThr: 1.761 ± 0.041	2.387PheVal: 2.387 ± 0.051	0.529PheTrp: 0.529 ± 0.025	0.764PheTyr: 0.764 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	11.365GlyAla: 11.365 ± 0.117	0.837GlyCys: 0.837 ± 0.028	4.784GlyAsp: 4.784 ± 0.089	4.868GlyGlu: 4.868 ± 0.073	3.746GlyPhe: 3.746 ± 0.064	8.188GlyGly: 8.188 ± 0.137	1.908GlyHis: 1.908 ± 0.038	4.542GlyIle: 4.542 ± 0.069	2.523GlyLys: 2.523 ± 0.054	9.772GlyLeu: 9.772 ± 0.121	2.761GlyMet: 2.761 ± 0.058	1.963GlyAsn: 1.963 ± 0.061	4.223GlyPro: 4.223 ± 0.077	3.309GlyGln: 3.309 ± 0.066	7.413GlyArg: 7.413 ± 0.096	4.137GlySer: 4.137 ± 0.07	4.551GlyThr: 4.551 ± 0.07	6.421GlyVal: 6.421 ± 0.084	1.666GlyTrp: 1.666 ± 0.038	2.167GlyTyr: 2.167 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.477HisAla: 2.477 ± 0.054	0.213HisCys: 0.213 ± 0.016	1.36HisAsp: 1.36 ± 0.04	1.059HisGlu: 1.059 ± 0.032	0.745HisPhe: 0.745 ± 0.026	2.051HisGly: 2.051 ± 0.045	0.54HisHis: 0.54 ± 0.022	0.81HisIle: 0.81 ± 0.031	0.399HisLys: 0.399 ± 0.021	2.081HisLeu: 2.081 ± 0.047	0.508HisMet: 0.508 ± 0.024	0.396HisAsn: 0.396 ± 0.018	1.516HisPro: 1.516 ± 0.033	0.568HisGln: 0.568 ± 0.022	1.657HisArg: 1.657 ± 0.041	0.876HisSer: 0.876 ± 0.028	0.671HisThr: 0.671 ± 0.022	1.498HisVal: 1.498 ± 0.036	0.345HisTrp: 0.345 ± 0.018	0.548HisTyr: 0.548 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.349IleAla: 7.349 ± 0.099	0.516IleCys: 0.516 ± 0.02	3.095IleAsp: 3.095 ± 0.057	3.273IleGlu: 3.273 ± 0.054	1.458IlePhe: 1.458 ± 0.039	4.463IleGly: 4.463 ± 0.076	0.945IleHis: 0.945 ± 0.032	1.821IleIle: 1.821 ± 0.046	0.95IleLys: 0.95 ± 0.035	4.34IleLeu: 4.34 ± 0.064	0.939IleMet: 0.939 ± 0.034	1.108IleAsn: 1.108 ± 0.033	2.425IlePro: 2.425 ± 0.055	1.035IleGln: 1.035 ± 0.033	3.575IleArg: 3.575 ± 0.058	2.404IleSer: 2.404 ± 0.049	2.57IleThr: 2.57 ± 0.047	3.544IleVal: 3.544 ± 0.069	0.644IleTrp: 0.644 ± 0.023	0.985IleTyr: 0.985 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	2.767LysAla: 2.767 ± 0.063	0.121LysCys: 0.121 ± 0.011	1.18LysAsp: 1.18 ± 0.041	0.962LysGlu: 0.962 ± 0.037	0.615LysPhe: 0.615 ± 0.024	1.973LysGly: 1.973 ± 0.052	0.397LysHis: 0.397 ± 0.023	1.141LysIle: 1.141 ± 0.037	0.694LysLys: 0.694 ± 0.03	2.212LysLeu: 2.212 ± 0.052	0.588LysMet: 0.588 ± 0.026	0.522LysAsn: 0.522 ± 0.023	1.43LysPro: 1.43 ± 0.038	0.706LysGln: 0.706 ± 0.03	1.675LysArg: 1.675 ± 0.049	1.253LysSer: 1.253 ± 0.033	1.346LysThr: 1.346 ± 0.044	1.638LysVal: 1.638 ± 0.05	0.29LysTrp: 0.29 ± 0.018	0.505LysTyr: 0.505 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	16.098LeuAla: 16.098 ± 0.194	0.923LeuCys: 0.923 ± 0.034	6.387LeuAsp: 6.387 ± 0.08	4.699LeuGlu: 4.699 ± 0.066	3.17LeuPhe: 3.17 ± 0.07	9.144LeuGly: 9.144 ± 0.11	1.95LeuHis: 1.95 ± 0.043	4.891LeuIle: 4.891 ± 0.084	2.276LeuLys: 2.276 ± 0.048	9.59LeuLeu: 9.59 ± 0.152	2.52LeuMet: 2.52 ± 0.057	2.246LeuAsn: 2.246 ± 0.053	6.375LeuPro: 6.375 ± 0.089	2.589LeuGln: 2.589 ± 0.052	8.56LeuArg: 8.56 ± 0.113	6.31LeuSer: 6.31 ± 0.075	5.815LeuThr: 5.815 ± 0.082	7.358LeuVal: 7.358 ± 0.088	1.366LeuTrp: 1.366 ± 0.042	1.825LeuTyr: 1.825 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.613MetAla: 3.613 ± 0.06	0.16MetCys: 0.16 ± 0.013	1.298MetAsp: 1.298 ± 0.036	1.164MetGlu: 1.164 ± 0.034	0.782MetPhe: 0.782 ± 0.027	2.273MetGly: 2.273 ± 0.055	0.436MetHis: 0.436 ± 0.022	1.378MetIle: 1.378 ± 0.038	0.775MetLys: 0.775 ± 0.031	2.721MetLeu: 2.721 ± 0.053	0.68MetMet: 0.68 ± 0.032	0.768MetAsn: 0.768 ± 0.033	1.478MetPro: 1.478 ± 0.036	1.019MetGln: 1.019 ± 0.035	1.987MetArg: 1.987 ± 0.052	1.515MetSer: 1.515 ± 0.036	1.918MetThr: 1.918 ± 0.045	1.789MetVal: 1.789 ± 0.049	0.239MetTrp: 0.239 ± 0.017	0.301MetTyr: 0.301 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.748AsnAla: 2.748 ± 0.053	0.227AsnCys: 0.227 ± 0.014	1.146AsnAsp: 1.146 ± 0.041	0.893AsnGlu: 0.893 ± 0.032	0.767AsnPhe: 0.767 ± 0.026	1.986AsnGly: 1.986 ± 0.046	0.475AsnHis: 0.475 ± 0.025	1.162AsnIle: 1.162 ± 0.038	0.442AsnLys: 0.442 ± 0.024	2.21AsnLeu: 2.21 ± 0.05	0.545AsnMet: 0.545 ± 0.024	0.469AsnAsn: 0.469 ± 0.02	1.76AsnPro: 1.76 ± 0.043	0.592AsnGln: 0.592 ± 0.028	1.7AsnArg: 1.7 ± 0.039	0.9AsnSer: 0.9 ± 0.03	1.0AsnThr: 1.0 ± 0.033	1.466AsnVal: 1.466 ± 0.035	0.37AsnTrp: 0.37 ± 0.021	0.524AsnTyr: 0.524 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	8.608ProAla: 8.608 ± 0.157	0.37ProCys: 0.37 ± 0.017	4.181ProAsp: 4.181 ± 0.065	4.397ProGlu: 4.397 ± 0.083	1.746ProPhe: 1.746 ± 0.042	6.022ProGly: 6.022 ± 0.086	1.153ProHis: 1.153 ± 0.035	2.063ProIle: 2.063 ± 0.043	1.093ProLys: 1.093 ± 0.035	5.287ProLeu: 5.287 ± 0.081	1.369ProMet: 1.369 ± 0.037	1.046ProAsn: 1.046 ± 0.031	3.414ProPro: 3.414 ± 0.086	2.152ProGln: 2.152 ± 0.043	3.925ProArg: 3.925 ± 0.06	2.386ProSer: 2.386 ± 0.051	2.293ProThr: 2.293 ± 0.053	4.758ProVal: 4.758 ± 0.072	0.731ProTrp: 0.731 ± 0.028	1.031ProTyr: 1.031 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.79GlnAla: 4.79 ± 0.09	0.175GlnCys: 0.175 ± 0.014	1.624GlnAsp: 1.624 ± 0.038	1.348GlnGlu: 1.348 ± 0.037	0.954GlnPhe: 0.954 ± 0.03	3.054GlnGly: 3.054 ± 0.061	0.592GlnHis: 0.592 ± 0.025	1.741GlnIle: 1.741 ± 0.042	0.834GlnLys: 0.834 ± 0.029	3.172GlnLeu: 3.172 ± 0.061	1.036GlnMet: 1.036 ± 0.033	0.727GlnAsn: 0.727 ± 0.027	2.091GlnPro: 2.091 ± 0.048	1.144GlnGln: 1.144 ± 0.044	2.455GlnArg: 2.455 ± 0.056	1.492GlnSer: 1.492 ± 0.039	1.555GlnThr: 1.555 ± 0.045	2.51GlnVal: 2.51 ± 0.045	0.343GlnTrp: 0.343 ± 0.02	0.489GlnTyr: 0.489 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	10.416ArgAla: 10.416 ± 0.113	0.51ArgCys: 0.51 ± 0.021	4.761ArgAsp: 4.761 ± 0.082	4.336ArgGlu: 4.336 ± 0.064	2.832ArgPhe: 2.832 ± 0.063	5.903ArgGly: 5.903 ± 0.081	1.927ArgHis: 1.927 ± 0.045	4.49ArgIle: 4.49 ± 0.069	1.978ArgLys: 1.978 ± 0.056	9.127ArgLeu: 9.127 ± 0.126	2.256ArgMet: 2.256 ± 0.048	1.787ArgAsn: 1.787 ± 0.045	4.54ArgPro: 4.54 ± 0.085	2.724ArgGln: 2.724 ± 0.053	6.725ArgArg: 6.725 ± 0.112	3.424ArgSer: 3.424 ± 0.061	3.046ArgThr: 3.046 ± 0.051	5.271ArgVal: 5.271 ± 0.076	1.184ArgTrp: 1.184 ± 0.038	1.514ArgTyr: 1.514 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.915SerAla: 5.915 ± 0.078	0.428SerCys: 0.428 ± 0.022	2.846SerAsp: 2.846 ± 0.055	2.179SerGlu: 2.179 ± 0.048	1.904SerPhe: 1.904 ± 0.042	5.289SerGly: 5.289 ± 0.081	0.993SerHis: 0.993 ± 0.029	2.14SerIle: 2.14 ± 0.047	0.913SerLys: 0.913 ± 0.034	4.535SerLeu: 4.535 ± 0.073	1.187SerMet: 1.187 ± 0.029	1.026SerAsn: 1.026 ± 0.032	2.593SerPro: 2.593 ± 0.053	1.282SerGln: 1.282 ± 0.035	3.641SerArg: 3.641 ± 0.066	2.121SerSer: 2.121 ± 0.056	2.217SerThr: 2.217 ± 0.049	3.479SerVal: 3.479 ± 0.058	0.738SerTrp: 0.738 ± 0.03	1.089SerTyr: 1.089 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.537ThrAla: 6.537 ± 0.09	0.403ThrCys: 0.403 ± 0.02	2.799ThrAsp: 2.799 ± 0.051	2.806ThrGlu: 2.806 ± 0.064	1.3ThrPhe: 1.3 ± 0.041	5.32ThrGly: 5.32 ± 0.075	1.024ThrHis: 1.024 ± 0.033	2.328ThrIle: 2.328 ± 0.05	0.869ThrLys: 0.869 ± 0.028	5.533ThrLeu: 5.533 ± 0.084	1.172ThrMet: 1.172 ± 0.04	0.981ThrAsn: 0.981 ± 0.032	3.655ThrPro: 3.655 ± 0.06	1.394ThrGln: 1.394 ± 0.041	3.73ThrArg: 3.73 ± 0.057	2.248ThrSer: 2.248 ± 0.047	2.636ThrThr: 2.636 ± 0.061	3.821ThrVal: 3.821 ± 0.062	0.545ThrTrp: 0.545 ± 0.023	0.929ThrTyr: 0.929 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	10.089ValAla: 10.089 ± 0.106	0.585ValCys: 0.585 ± 0.026	3.659ValAsp: 3.659 ± 0.059	4.488ValGlu: 4.488 ± 0.06	2.479ValPhe: 2.479 ± 0.054	5.201ValGly: 5.201 ± 0.085	1.311ValHis: 1.311 ± 0.031	3.907ValIle: 3.907 ± 0.071	1.547ValLys: 1.547 ± 0.043	7.866ValLeu: 7.866 ± 0.093	2.116ValMet: 2.116 ± 0.05	1.732ValAsn: 1.732 ± 0.043	3.752ValPro: 3.752 ± 0.057	2.237ValGln: 2.237 ± 0.052	4.585ValArg: 4.585 ± 0.073	3.479ValSer: 3.479 ± 0.058	4.449ValThr: 4.449 ± 0.075	5.89ValVal: 5.89 ± 0.093	0.932ValTrp: 0.932 ± 0.035	1.262ValTyr: 1.262 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.473TrpAla: 1.473 ± 0.04	0.121TrpCys: 0.121 ± 0.011	0.801TrpAsp: 0.801 ± 0.03	0.57TrpGlu: 0.57 ± 0.023	0.558TrpPhe: 0.558 ± 0.025	1.085TrpGly: 1.085 ± 0.038	0.336TrpHis: 0.336 ± 0.019	0.669TrpIle: 0.669 ± 0.028	0.354TrpLys: 0.354 ± 0.019	1.897TrpLeu: 1.897 ± 0.047	0.366TrpMet: 0.366 ± 0.018	0.371TrpAsn: 0.371 ± 0.018	0.778TrpPro: 0.778 ± 0.028	0.696TrpGln: 0.696 ± 0.024	1.31TrpArg: 1.31 ± 0.039	0.693TrpSer: 0.693 ± 0.026	0.833TrpThr: 0.833 ± 0.029	0.889TrpVal: 0.889 ± 0.031	0.241TrpTrp: 0.241 ± 0.014	0.229TrpTyr: 0.229 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.308TyrAla: 2.308 ± 0.047	0.219TyrCys: 0.219 ± 0.014	1.425TyrAsp: 1.425 ± 0.038	1.077TyrGlu: 1.077 ± 0.037	0.72TyrPhe: 0.72 ± 0.03	1.945TyrGly: 1.945 ± 0.047	0.464TyrHis: 0.464 ± 0.024	0.734TyrIle: 0.734 ± 0.029	0.409TyrLys: 0.409 ± 0.02	2.146TyrLeu: 2.146 ± 0.051	0.42TyrMet: 0.42 ± 0.019	0.476TyrAsn: 0.476 ± 0.022	1.005TyrPro: 1.005 ± 0.033	0.599TyrGln: 0.599 ± 0.023	1.657TyrArg: 1.657 ± 0.045	0.906TyrSer: 0.906 ± 0.033	0.858TyrThr: 0.858 ± 0.028	1.361TyrVal: 1.361 ± 0.038	0.33TyrTrp: 0.33 ± 0.016	0.489TyrTyr: 0.489 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3193 proteins (1003777 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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