Amino acid dipepetide frequency for Schaalia canis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.405AlaAla: 15.405 ± 0.233
1.072AlaCys: 1.072 ± 0.044
6.975AlaAsp: 6.975 ± 0.115
7.087AlaGlu: 7.087 ± 0.139
3.679AlaPhe: 3.679 ± 0.093
9.914AlaGly: 9.914 ± 0.125
2.928AlaHis: 2.928 ± 0.063
5.403AlaIle: 5.403 ± 0.104
3.015AlaLys: 3.015 ± 0.093
13.311AlaLeu: 13.311 ± 0.198
2.703AlaMet: 2.703 ± 0.068
2.746AlaAsn: 2.746 ± 0.068
5.892AlaPro: 5.892 ± 0.124
5.179AlaGln: 5.179 ± 0.106
7.821AlaArg: 7.821 ± 0.126
7.4AlaSer: 7.4 ± 0.107
7.038AlaThr: 7.038 ± 0.111
8.938AlaVal: 8.938 ± 0.139
1.805AlaTrp: 1.805 ± 0.055
2.291AlaTyr: 2.291 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
1.058CysAla: 1.058 ± 0.036
0.073CysCys: 0.073 ± 0.011
0.515CysAsp: 0.515 ± 0.028
0.645CysGlu: 0.645 ± 0.031
0.247CysPhe: 0.247 ± 0.018
0.843CysGly: 0.843 ± 0.035
0.185CysHis: 0.185 ± 0.016
0.258CysIle: 0.258 ± 0.018
0.106CysLys: 0.106 ± 0.011
0.618CysLeu: 0.618 ± 0.031
0.14CysMet: 0.14 ± 0.015
0.126CysAsn: 0.126 ± 0.013
0.455CysPro: 0.455 ± 0.028
0.263CysGln: 0.263 ± 0.019
0.414CysArg: 0.414 ± 0.023
0.49CysSer: 0.49 ± 0.027
0.475CysThr: 0.475 ± 0.028
0.744CysVal: 0.744 ± 0.031
0.088CysTrp: 0.088 ± 0.012
0.145CysTyr: 0.145 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.142AspAla: 7.142 ± 0.114
0.451AspCys: 0.451 ± 0.025
3.288AspAsp: 3.288 ± 0.087
4.25AspGlu: 4.25 ± 0.086
1.926AspPhe: 1.926 ± 0.052
5.06AspGly: 5.06 ± 0.101
1.281AspHis: 1.281 ± 0.047
2.886AspIle: 2.886 ± 0.063
1.376AspLys: 1.376 ± 0.049
5.962AspLeu: 5.962 ± 0.092
1.158AspMet: 1.158 ± 0.04
1.378AspAsn: 1.378 ± 0.048
3.706AspPro: 3.706 ± 0.077
1.677AspGln: 1.677 ± 0.046
3.177AspArg: 3.177 ± 0.074
3.155AspSer: 3.155 ± 0.069
3.2AspThr: 3.2 ± 0.078
4.555AspVal: 4.555 ± 0.103
0.747AspTrp: 0.747 ± 0.036
1.471AspTyr: 1.471 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
8.024GluAla: 8.024 ± 0.133
0.555GluCys: 0.555 ± 0.034
3.736GluAsp: 3.736 ± 0.086
4.388GluGlu: 4.388 ± 0.099
1.605GluPhe: 1.605 ± 0.047
5.38GluGly: 5.38 ± 0.101
1.638GluHis: 1.638 ± 0.054
2.967GluIle: 2.967 ± 0.069
1.922GluLys: 1.922 ± 0.062
5.927GluLeu: 5.927 ± 0.104
1.179GluMet: 1.179 ± 0.048
1.721GluAsn: 1.721 ± 0.05
2.533GluPro: 2.533 ± 0.065
2.325GluGln: 2.325 ± 0.064
4.736GluArg: 4.736 ± 0.096
3.015GluSer: 3.015 ± 0.07
2.768GluThr: 2.768 ± 0.068
5.041GluVal: 5.041 ± 0.086
0.951GluTrp: 0.951 ± 0.039
1.387GluTyr: 1.387 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.485PheAla: 3.485 ± 0.071
0.22PheCys: 0.22 ± 0.018
2.192PheAsp: 2.192 ± 0.057
1.836PheGlu: 1.836 ± 0.059
1.287PhePhe: 1.287 ± 0.047
2.739PheGly: 2.739 ± 0.065
0.684PheHis: 0.684 ± 0.028
1.578PheIle: 1.578 ± 0.058
0.636PheLys: 0.636 ± 0.038
2.866PheLeu: 2.866 ± 0.078
0.63PheMet: 0.63 ± 0.032
0.865PheAsn: 0.865 ± 0.033
1.566PhePro: 1.566 ± 0.046
0.759PheGln: 0.759 ± 0.034
1.525PheArg: 1.525 ± 0.047
2.219PheSer: 2.219 ± 0.054
2.265PheThr: 2.265 ± 0.057
2.546PheVal: 2.546 ± 0.062
0.382PheTrp: 0.382 ± 0.021
0.72PheTyr: 0.72 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
9.37GlyAla: 9.37 ± 0.153
0.604GlyCys: 0.604 ± 0.026
4.233GlyAsp: 4.233 ± 0.098
5.016GlyGlu: 5.016 ± 0.099
2.703GlyPhe: 2.703 ± 0.066
6.649GlyGly: 6.649 ± 0.136
1.859GlyHis: 1.859 ± 0.053
4.563GlyIle: 4.563 ± 0.084
2.768GlyLys: 2.768 ± 0.078
7.414GlyLeu: 7.414 ± 0.123
2.2GlyMet: 2.2 ± 0.063
2.18GlyAsn: 2.18 ± 0.067
3.326GlyPro: 3.326 ± 0.07
3.181GlyGln: 3.181 ± 0.077
5.523GlyArg: 5.523 ± 0.115
4.81GlySer: 4.81 ± 0.09
5.336GlyThr: 5.336 ± 0.103
7.19GlyVal: 7.19 ± 0.101
1.377GlyTrp: 1.377 ± 0.051
2.09GlyTyr: 2.09 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
2.67HisAla: 2.67 ± 0.067
0.225HisCys: 0.225 ± 0.02
1.415HisAsp: 1.415 ± 0.049
1.422HisGlu: 1.422 ± 0.045
0.665HisPhe: 0.665 ± 0.035
1.855HisGly: 1.855 ± 0.052
0.629HisHis: 0.629 ± 0.031
1.116HisIle: 1.116 ± 0.038
0.425HisLys: 0.425 ± 0.023
2.309HisLeu: 2.309 ± 0.063
0.549HisMet: 0.549 ± 0.025
0.592HisAsn: 0.592 ± 0.028
1.506HisPro: 1.506 ± 0.04
0.686HisGln: 0.686 ± 0.027
1.442HisArg: 1.442 ± 0.05
1.499HisSer: 1.499 ± 0.041
1.362HisThr: 1.362 ± 0.043
1.772HisVal: 1.772 ± 0.05
0.341HisTrp: 0.341 ± 0.019
0.619HisTyr: 0.619 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.353IleAla: 6.353 ± 0.102
0.379IleCys: 0.379 ± 0.024
3.575IleAsp: 3.575 ± 0.072
3.145IleGlu: 3.145 ± 0.069
1.48IlePhe: 1.48 ± 0.054
4.282IleGly: 4.282 ± 0.088
1.076IleHis: 1.076 ± 0.036
2.487IleIle: 2.487 ± 0.072
0.985IleLys: 0.985 ± 0.041
4.559IleLeu: 4.559 ± 0.094
0.898IleMet: 0.898 ± 0.037
1.327IleAsn: 1.327 ± 0.044
2.9IlePro: 2.9 ± 0.067
1.292IleGln: 1.292 ± 0.044
2.805IleArg: 2.805 ± 0.061
2.924IleSer: 2.924 ± 0.068
3.223IleThr: 3.223 ± 0.073
4.411IleVal: 4.411 ± 0.089
0.516IleTrp: 0.516 ± 0.025
0.982IleTyr: 0.982 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
3.251LysAla: 3.251 ± 0.092
0.128LysCys: 0.128 ± 0.012
1.745LysAsp: 1.745 ± 0.057
1.616LysGlu: 1.616 ± 0.047
0.534LysPhe: 0.534 ± 0.029
2.155LysGly: 2.155 ± 0.067
0.497LysHis: 0.497 ± 0.03
1.247LysIle: 1.247 ± 0.049
1.259LysLys: 1.259 ± 0.063
1.999LysLeu: 1.999 ± 0.056
0.6LysMet: 0.6 ± 0.028
0.816LysAsn: 0.816 ± 0.039
1.3LysPro: 1.3 ± 0.049
0.82LysGln: 0.82 ± 0.038
1.679LysArg: 1.679 ± 0.055
1.364LysSer: 1.364 ± 0.046
1.56LysThr: 1.56 ± 0.051
2.249LysVal: 2.249 ± 0.066
0.373LysTrp: 0.373 ± 0.026
0.553LysTyr: 0.553 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
12.17LeuAla: 12.17 ± 0.17
0.782LeuCys: 0.782 ± 0.033
5.412LeuAsp: 5.412 ± 0.095
5.195LeuGlu: 5.195 ± 0.107
2.756LeuPhe: 2.756 ± 0.064
7.732LeuGly: 7.732 ± 0.124
2.083LeuHis: 2.083 ± 0.055
4.85LeuIle: 4.85 ± 0.112
2.313LeuLys: 2.313 ± 0.063
9.253LeuLeu: 9.253 ± 0.173
2.111LeuMet: 2.111 ± 0.056
2.527LeuAsn: 2.527 ± 0.054
5.859LeuPro: 5.859 ± 0.111
2.496LeuGln: 2.496 ± 0.065
6.579LeuArg: 6.579 ± 0.106
6.748LeuSer: 6.748 ± 0.122
6.628LeuThr: 6.628 ± 0.095
7.766LeuVal: 7.766 ± 0.126
1.296LeuTrp: 1.296 ± 0.046
1.79LeuTyr: 1.79 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.508MetAla: 2.508 ± 0.059
0.179MetCys: 0.179 ± 0.016
1.081MetAsp: 1.081 ± 0.038
1.119MetGlu: 1.119 ± 0.042
0.564MetPhe: 0.564 ± 0.027
1.806MetGly: 1.806 ± 0.051
0.403MetHis: 0.403 ± 0.024
1.076MetIle: 1.076 ± 0.041
0.626MetLys: 0.626 ± 0.032
2.096MetLeu: 2.096 ± 0.052
0.588MetMet: 0.588 ± 0.03
0.693MetAsn: 0.693 ± 0.031
1.281MetPro: 1.281 ± 0.042
0.574MetGln: 0.574 ± 0.027
1.694MetArg: 1.694 ± 0.058
1.81MetSer: 1.81 ± 0.052
1.835MetThr: 1.835 ± 0.051
1.699MetVal: 1.699 ± 0.049
0.341MetTrp: 0.341 ± 0.021
0.346MetTyr: 0.346 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.207AsnAla: 3.207 ± 0.082
0.204AsnCys: 0.204 ± 0.017
1.51AsnAsp: 1.51 ± 0.053
1.425AsnGlu: 1.425 ± 0.044
0.75AsnPhe: 0.75 ± 0.035
2.396AsnGly: 2.396 ± 0.075
0.498AsnHis: 0.498 ± 0.024
1.274AsnIle: 1.274 ± 0.049
0.632AsnLys: 0.632 ± 0.035
2.354AsnLeu: 2.354 ± 0.057
0.508AsnMet: 0.508 ± 0.024
0.706AsnAsn: 0.706 ± 0.036
1.958AsnPro: 1.958 ± 0.051
0.759AsnGln: 0.759 ± 0.034
1.355AsnArg: 1.355 ± 0.044
1.412AsnSer: 1.412 ± 0.044
1.609AsnThr: 1.609 ± 0.056
1.95AsnVal: 1.95 ± 0.056
0.364AsnTrp: 0.364 ± 0.023
0.68AsnTyr: 0.68 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
6.554ProAla: 6.554 ± 0.114
0.333ProCys: 0.333 ± 0.022
3.197ProAsp: 3.197 ± 0.073
4.015ProGlu: 4.015 ± 0.081
1.604ProPhe: 1.604 ± 0.045
4.422ProGly: 4.422 ± 0.087
1.406ProHis: 1.406 ± 0.049
2.2ProIle: 2.2 ± 0.052
1.211ProLys: 1.211 ± 0.05
5.077ProLeu: 5.077 ± 0.094
1.002ProMet: 1.002 ± 0.035
1.287ProAsn: 1.287 ± 0.039
2.233ProPro: 2.233 ± 0.081
2.166ProGln: 2.166 ± 0.061
2.896ProArg: 2.896 ± 0.068
3.747ProSer: 3.747 ± 0.098
3.747ProThr: 3.747 ± 0.078
4.436ProVal: 4.436 ± 0.075
0.811ProTrp: 0.811 ± 0.036
1.175ProTyr: 1.175 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
4.373GlnAla: 4.373 ± 0.094
0.234GlnCys: 0.234 ± 0.018
1.41GlnAsp: 1.41 ± 0.044
1.96GlnGlu: 1.96 ± 0.065
0.839GlnPhe: 0.839 ± 0.035
2.704GlnGly: 2.704 ± 0.056
0.774GlnHis: 0.774 ± 0.035
1.755GlnIle: 1.755 ± 0.047
0.96GlnLys: 0.96 ± 0.038
2.943GlnLeu: 2.943 ± 0.067
0.94GlnMet: 0.94 ± 0.033
0.716GlnAsn: 0.716 ± 0.035
1.653GlnPro: 1.653 ± 0.055
1.305GlnGln: 1.305 ± 0.048
2.78GlnArg: 2.78 ± 0.066
2.049GlnSer: 2.049 ± 0.058
1.742GlnThr: 1.742 ± 0.055
2.912GlnVal: 2.912 ± 0.063
0.754GlnTrp: 0.754 ± 0.032
0.698GlnTyr: 0.698 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
7.171ArgAla: 7.171 ± 0.124
0.456ArgCys: 0.456 ± 0.023
3.447ArgAsp: 3.447 ± 0.075
4.376ArgGlu: 4.376 ± 0.068
2.158ArgPhe: 2.158 ± 0.05
4.502ArgGly: 4.502 ± 0.074
1.623ArgHis: 1.623 ± 0.049
3.534ArgIle: 3.534 ± 0.073
1.669ArgLys: 1.669 ± 0.057
6.025ArgLeu: 6.025 ± 0.107
1.656ArgMet: 1.656 ± 0.048
1.537ArgAsn: 1.537 ± 0.045
3.253ArgPro: 3.253 ± 0.083
2.47ArgGln: 2.47 ± 0.063
4.953ArgArg: 4.953 ± 0.121
4.112ArgSer: 4.112 ± 0.086
3.648ArgThr: 3.648 ± 0.073
5.06ArgVal: 5.06 ± 0.112
1.114ArgTrp: 1.114 ± 0.042
1.624ArgTyr: 1.624 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
7.623SerAla: 7.623 ± 0.125
0.481SerCys: 0.481 ± 0.026
3.34SerAsp: 3.34 ± 0.08
3.501SerGlu: 3.501 ± 0.071
2.271SerPhe: 2.271 ± 0.062
5.64SerGly: 5.64 ± 0.097
1.381SerHis: 1.381 ± 0.047
2.991SerIle: 2.991 ± 0.061
1.342SerLys: 1.342 ± 0.041
5.874SerLeu: 5.874 ± 0.098
1.501SerMet: 1.501 ± 0.039
1.396SerAsn: 1.396 ± 0.043
3.398SerPro: 3.398 ± 0.08
2.064SerGln: 2.064 ± 0.055
3.7SerArg: 3.7 ± 0.079
4.32SerSer: 4.32 ± 0.113
4.153SerThr: 4.153 ± 0.085
5.149SerVal: 5.149 ± 0.094
0.948SerTrp: 0.948 ± 0.037
1.547SerTyr: 1.547 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
6.537ThrAla: 6.537 ± 0.105
0.46ThrCys: 0.46 ± 0.025
3.278ThrAsp: 3.278 ± 0.07
3.041ThrGlu: 3.041 ± 0.069
2.131ThrPhe: 2.131 ± 0.059
4.941ThrGly: 4.941 ± 0.101
1.637ThrHis: 1.637 ± 0.047
3.383ThrIle: 3.383 ± 0.08
1.425ThrLys: 1.425 ± 0.055
6.395ThrLeu: 6.395 ± 0.1
1.26ThrMet: 1.26 ± 0.042
1.584ThrAsn: 1.584 ± 0.058
4.745ThrPro: 4.745 ± 0.103
2.162ThrGln: 2.162 ± 0.058
3.504ThrArg: 3.504 ± 0.069
3.985ThrSer: 3.985 ± 0.073
4.165ThrThr: 4.165 ± 0.085
5.56ThrVal: 5.56 ± 0.109
0.972ThrTrp: 0.972 ± 0.035
1.566ThrTyr: 1.566 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
9.552ValAla: 9.552 ± 0.133
0.716ValCys: 0.716 ± 0.028
5.225ValAsp: 5.225 ± 0.094
5.472ValGlu: 5.472 ± 0.102
2.496ValPhe: 2.496 ± 0.066
6.34ValGly: 6.34 ± 0.115
1.728ValHis: 1.728 ± 0.049
4.493ValIle: 4.493 ± 0.098
2.136ValLys: 2.136 ± 0.059
7.711ValLeu: 7.711 ± 0.136
1.775ValMet: 1.775 ± 0.057
2.256ValAsn: 2.256 ± 0.066
4.284ValPro: 4.284 ± 0.086
2.015ValGln: 2.015 ± 0.056
5.261ValArg: 5.261 ± 0.102
5.225ValSer: 5.225 ± 0.099
5.638ValThr: 5.638 ± 0.109
7.045ValVal: 7.045 ± 0.127
1.11ValTrp: 1.11 ± 0.042
1.528ValTyr: 1.528 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
1.571TrpAla: 1.571 ± 0.056
0.141TrpCys: 0.141 ± 0.014
0.887TrpAsp: 0.887 ± 0.038
0.921TrpGlu: 0.921 ± 0.036
0.492TrpPhe: 0.492 ± 0.029
1.08TrpGly: 1.08 ± 0.043
0.348TrpHis: 0.348 ± 0.024
0.708TrpIle: 0.708 ± 0.032
0.485TrpLys: 0.485 ± 0.025
1.422TrpLeu: 1.422 ± 0.047
0.479TrpMet: 0.479 ± 0.025
0.519TrpAsn: 0.519 ± 0.026
0.576TrpPro: 0.576 ± 0.027
0.573TrpGln: 0.573 ± 0.028
1.015TrpArg: 1.015 ± 0.039
0.917TrpSer: 0.917 ± 0.037
0.928TrpThr: 0.928 ± 0.041
1.281TrpVal: 1.281 ± 0.046
0.348TrpTrp: 0.348 ± 0.023
0.296TrpTyr: 0.296 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.576TyrAla: 2.576 ± 0.062
0.197TyrCys: 0.197 ± 0.018
1.385TyrAsp: 1.385 ± 0.08
1.369TyrGlu: 1.369 ± 0.047
0.815TyrPhe: 0.815 ± 0.035
1.952TyrGly: 1.952 ± 0.057
0.444TyrHis: 0.444 ± 0.025
0.83TyrIle: 0.83 ± 0.038
0.456TyrLys: 0.456 ± 0.025
2.231TyrLeu: 2.231 ± 0.059
0.441TyrMet: 0.441 ± 0.024
0.579TyrAsn: 0.579 ± 0.034
1.096TyrPro: 1.096 ± 0.042
0.732TyrGln: 0.732 ± 0.028
1.531TyrArg: 1.531 ± 0.048
1.415TyrSer: 1.415 ± 0.045
1.411TyrThr: 1.411 ± 0.055
1.7TyrVal: 1.7 ± 0.056
0.348TyrTrp: 0.348 ± 0.023
0.557TyrTyr: 0.557 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1993 proteins (736314 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski