Amino acid dipepetide frequency for Candidatus Syntrophocurvum alkaliphilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.644AlaAla: 4.644 ± 0.109
0.706AlaCys: 0.706 ± 0.034
3.257AlaAsp: 3.257 ± 0.079
4.224AlaGlu: 4.224 ± 0.087
2.602AlaPhe: 2.602 ± 0.071
4.61AlaGly: 4.61 ± 0.094
1.011AlaHis: 1.011 ± 0.039
6.157AlaIle: 6.157 ± 0.095
4.42AlaLys: 4.42 ± 0.087
6.543AlaLeu: 6.543 ± 0.117
1.71AlaMet: 1.71 ± 0.052
3.082AlaAsn: 3.082 ± 0.07
1.604AlaPro: 1.604 ± 0.05
2.076AlaGln: 2.076 ± 0.062
2.677AlaArg: 2.677 ± 0.063
3.548AlaSer: 3.548 ± 0.064
3.347AlaThr: 3.347 ± 0.159
4.825AlaVal: 4.825 ± 0.096
0.445AlaTrp: 0.445 ± 0.032
2.186AlaTyr: 2.186 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.594CysAla: 0.594 ± 0.026
0.138CysCys: 0.138 ± 0.015
0.523CysAsp: 0.523 ± 0.03
0.648CysGlu: 0.648 ± 0.034
0.405CysPhe: 0.405 ± 0.026
0.888CysGly: 0.888 ± 0.046
0.178CysHis: 0.178 ± 0.016
0.784CysIle: 0.784 ± 0.033
0.588CysLys: 0.588 ± 0.03
0.925CysLeu: 0.925 ± 0.032
0.215CysMet: 0.215 ± 0.019
0.567CysAsn: 0.567 ± 0.033
0.539CysPro: 0.539 ± 0.031
0.308CysGln: 0.308 ± 0.02
0.414CysArg: 0.414 ± 0.024
0.717CysSer: 0.717 ± 0.032
0.498CysThr: 0.498 ± 0.027
0.526CysVal: 0.526 ± 0.032
0.074CysTrp: 0.074 ± 0.01
0.348CysTyr: 0.348 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
2.861AspAla: 2.861 ± 0.075
0.491AspCys: 0.491 ± 0.029
2.882AspAsp: 2.882 ± 0.096
4.841AspGlu: 4.841 ± 0.098
2.674AspPhe: 2.674 ± 0.07
3.433AspGly: 3.433 ± 0.146
0.771AspHis: 0.771 ± 0.035
6.177AspIle: 6.177 ± 0.094
4.216AspLys: 4.216 ± 0.084
5.61AspLeu: 5.61 ± 0.091
1.428AspMet: 1.428 ± 0.046
3.204AspAsn: 3.204 ± 0.093
1.744AspPro: 1.744 ± 0.05
1.298AspGln: 1.298 ± 0.045
2.04AspArg: 2.04 ± 0.062
2.87AspSer: 2.87 ± 0.069
2.581AspThr: 2.581 ± 0.066
3.727AspVal: 3.727 ± 0.093
0.555AspTrp: 0.555 ± 0.033
2.693AspTyr: 2.693 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
4.787GluAla: 4.787 ± 0.098
0.58GluCys: 0.58 ± 0.034
4.188GluAsp: 4.188 ± 0.125
7.007GluGlu: 7.007 ± 0.137
2.733GluPhe: 2.733 ± 0.067
4.081GluGly: 4.081 ± 0.085
1.255GluHis: 1.255 ± 0.046
7.097GluIle: 7.097 ± 0.111
6.879GluLys: 6.879 ± 0.128
7.767GluLeu: 7.767 ± 0.116
1.93GluMet: 1.93 ± 0.052
4.617GluAsn: 4.617 ± 0.097
1.918GluPro: 1.918 ± 0.061
2.955GluGln: 2.955 ± 0.068
2.935GluArg: 2.935 ± 0.072
3.439GluSer: 3.439 ± 0.069
3.568GluThr: 3.568 ± 0.082
5.349GluVal: 5.349 ± 0.099
0.566GluTrp: 0.566 ± 0.03
2.643GluTyr: 2.643 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
2.516PheAla: 2.516 ± 0.064
0.492PheCys: 0.492 ± 0.025
2.351PheAsp: 2.351 ± 0.059
2.652PheGlu: 2.652 ± 0.064
1.989PhePhe: 1.989 ± 0.062
2.593PheGly: 2.593 ± 0.065
0.576PheHis: 0.576 ± 0.03
3.957PheIle: 3.957 ± 0.083
2.835PheLys: 2.835 ± 0.08
3.901PheLeu: 3.901 ± 0.091
1.039PheMet: 1.039 ± 0.038
2.44PheAsn: 2.44 ± 0.056
1.373PhePro: 1.373 ± 0.046
0.981PheGln: 0.981 ± 0.042
1.385PheArg: 1.385 ± 0.045
2.827PheSer: 2.827 ± 0.068
2.188PheThr: 2.188 ± 0.058
2.41PheVal: 2.41 ± 0.065
0.385PheTrp: 0.385 ± 0.024
1.677PheTyr: 1.677 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.555GlyAla: 4.555 ± 0.167
0.825GlyCys: 0.825 ± 0.04
3.387GlyAsp: 3.387 ± 0.084
4.516GlyGlu: 4.516 ± 0.189
2.908GlyPhe: 2.908 ± 0.07
4.443GlyGly: 4.443 ± 0.121
1.214GlyHis: 1.214 ± 0.043
6.353GlyIle: 6.353 ± 0.108
4.567GlyLys: 4.567 ± 0.093
6.177GlyLeu: 6.177 ± 0.101
1.7GlyMet: 1.7 ± 0.052
3.004GlyAsn: 3.004 ± 0.086
1.622GlyPro: 1.622 ± 0.051
1.964GlyGln: 1.964 ± 0.062
2.581GlyArg: 2.581 ± 0.06
3.598GlySer: 3.598 ± 0.073
3.475GlyThr: 3.475 ± 0.082
4.937GlyVal: 4.937 ± 0.097
0.563GlyTrp: 0.563 ± 0.029
2.746GlyTyr: 2.746 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
0.86HisAla: 0.86 ± 0.034
0.211HisCys: 0.211 ± 0.019
0.825HisAsp: 0.825 ± 0.033
1.099HisGlu: 1.099 ± 0.036
0.738HisPhe: 0.738 ± 0.035
1.129HisGly: 1.129 ± 0.042
0.393HisHis: 0.393 ± 0.025
1.51HisIle: 1.51 ± 0.044
0.989HisLys: 0.989 ± 0.038
1.696HisLeu: 1.696 ± 0.051
0.386HisMet: 0.386 ± 0.024
0.908HisAsn: 0.908 ± 0.037
0.841HisPro: 0.841 ± 0.04
0.514HisGln: 0.514 ± 0.027
0.698HisArg: 0.698 ± 0.029
1.021HisSer: 1.021 ± 0.039
0.809HisThr: 0.809 ± 0.033
0.868HisVal: 0.868 ± 0.035
0.137HisTrp: 0.137 ± 0.013
0.659HisTyr: 0.659 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.493IleAla: 6.493 ± 0.108
0.89IleCys: 0.89 ± 0.036
5.796IleAsp: 5.796 ± 0.095
7.104IleGlu: 7.104 ± 0.113
3.405IlePhe: 3.405 ± 0.087
5.836IleGly: 5.836 ± 0.104
1.283IleHis: 1.283 ± 0.05
8.938IleIle: 8.938 ± 0.13
7.198IleLys: 7.198 ± 0.116
8.21IleLeu: 8.21 ± 0.129
2.06IleMet: 2.06 ± 0.054
6.233IleAsn: 6.233 ± 0.101
3.683IlePro: 3.683 ± 0.078
2.438IleGln: 2.438 ± 0.064
3.316IleArg: 3.316 ± 0.076
5.802IleSer: 5.802 ± 0.094
5.067IleThr: 5.067 ± 0.095
5.896IleVal: 5.896 ± 0.087
0.603IleTrp: 0.603 ± 0.033
3.181IleTyr: 3.181 ± 0.069
0.0IleXaa: 0.0 ± 0.0
Lys
4.691LysAla: 4.691 ± 0.088
0.57LysCys: 0.57 ± 0.031
4.521LysAsp: 4.521 ± 0.093
6.806LysGlu: 6.806 ± 0.123
2.127LysPhe: 2.127 ± 0.061
4.465LysGly: 4.465 ± 0.092
1.333LysHis: 1.333 ± 0.045
6.419LysIle: 6.419 ± 0.11
6.176LysLys: 6.176 ± 0.129
6.388LysLeu: 6.388 ± 0.109
1.906LysMet: 1.906 ± 0.05
4.831LysAsn: 4.831 ± 0.092
2.419LysPro: 2.419 ± 0.054
2.653LysGln: 2.653 ± 0.077
2.935LysArg: 2.935 ± 0.07
3.847LysSer: 3.847 ± 0.086
3.91LysThr: 3.91 ± 0.078
4.952LysVal: 4.952 ± 0.091
0.594LysTrp: 0.594 ± 0.031
2.594LysTyr: 2.594 ± 0.074
0.0LysXaa: 0.0 ± 0.0
Leu
6.664LeuAla: 6.664 ± 0.112
0.928LeuCys: 0.928 ± 0.038
5.43LeuAsp: 5.43 ± 0.112
7.229LeuGlu: 7.229 ± 0.113
3.829LeuPhe: 3.829 ± 0.09
6.406LeuGly: 6.406 ± 0.118
1.291LeuHis: 1.291 ± 0.044
8.264LeuIle: 8.264 ± 0.122
7.248LeuLys: 7.248 ± 0.139
9.177LeuLeu: 9.177 ± 0.178
2.164LeuMet: 2.164 ± 0.06
5.713LeuAsn: 5.713 ± 0.105
3.54LeuPro: 3.54 ± 0.071
2.896LeuGln: 2.896 ± 0.071
3.761LeuArg: 3.761 ± 0.072
6.166LeuSer: 6.166 ± 0.099
4.958LeuThr: 4.958 ± 0.092
6.169LeuVal: 6.169 ± 0.097
0.704LeuTrp: 0.704 ± 0.036
3.145LeuTyr: 3.145 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
1.84MetAla: 1.84 ± 0.056
0.217MetCys: 0.217 ± 0.019
1.369MetAsp: 1.369 ± 0.044
1.646MetGlu: 1.646 ± 0.053
0.915MetPhe: 0.915 ± 0.036
1.85MetGly: 1.85 ± 0.061
0.442MetHis: 0.442 ± 0.024
1.923MetIle: 1.923 ± 0.051
1.741MetLys: 1.741 ± 0.048
2.397MetLeu: 2.397 ± 0.062
0.601MetMet: 0.601 ± 0.033
1.232MetAsn: 1.232 ± 0.044
0.953MetPro: 0.953 ± 0.037
0.984MetGln: 0.984 ± 0.043
1.031MetArg: 1.031 ± 0.04
1.569MetSer: 1.569 ± 0.048
1.211MetThr: 1.211 ± 0.046
1.763MetVal: 1.763 ± 0.048
0.164MetTrp: 0.164 ± 0.016
0.697MetTyr: 0.697 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
2.893AsnAla: 2.893 ± 0.068
0.614AsnCys: 0.614 ± 0.034
2.955AsnAsp: 2.955 ± 0.069
4.3AsnGlu: 4.3 ± 0.081
2.123AsnPhe: 2.123 ± 0.055
2.888AsnGly: 2.888 ± 0.089
0.906AsnHis: 0.906 ± 0.041
6.149AsnIle: 6.149 ± 0.103
4.787AsnLys: 4.787 ± 0.093
5.587AsnLeu: 5.587 ± 0.101
1.453AsnMet: 1.453 ± 0.051
4.265AsnAsn: 4.265 ± 0.092
2.326AsnPro: 2.326 ± 0.062
2.049AsnGln: 2.049 ± 0.061
2.456AsnArg: 2.456 ± 0.057
3.299AsnSer: 3.299 ± 0.079
2.929AsnThr: 2.929 ± 0.083
3.213AsnVal: 3.213 ± 0.074
0.505AsnTrp: 0.505 ± 0.029
2.466AsnTyr: 2.466 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
1.962ProAla: 1.962 ± 0.05
0.326ProCys: 0.326 ± 0.022
2.155ProAsp: 2.155 ± 0.056
3.169ProGlu: 3.169 ± 0.068
1.531ProPhe: 1.531 ± 0.05
2.398ProGly: 2.398 ± 0.067
0.657ProHis: 0.657 ± 0.032
2.932ProIle: 2.932 ± 0.062
1.926ProLys: 1.926 ± 0.055
3.094ProLeu: 3.094 ± 0.072
0.738ProMet: 0.738 ± 0.031
1.731ProAsn: 1.731 ± 0.046
1.077ProPro: 1.077 ± 0.042
1.136ProGln: 1.136 ± 0.041
1.212ProArg: 1.212 ± 0.042
2.023ProSer: 2.023 ± 0.051
1.794ProThr: 1.794 ± 0.054
2.671ProVal: 2.671 ± 0.063
0.321ProTrp: 0.321 ± 0.023
1.348ProTyr: 1.348 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
2.211GlnAla: 2.211 ± 0.06
0.259GlnCys: 0.259 ± 0.02
1.612GlnAsp: 1.612 ± 0.053
2.751GlnGlu: 2.751 ± 0.057
1.108GlnPhe: 1.108 ± 0.04
1.971GlnGly: 1.971 ± 0.055
0.499GlnHis: 0.499 ± 0.028
2.836GlnIle: 2.836 ± 0.062
2.463GlnLys: 2.463 ± 0.065
3.091GlnLeu: 3.091 ± 0.07
0.896GlnMet: 0.896 ± 0.037
1.817GlnAsn: 1.817 ± 0.054
0.933GlnPro: 0.933 ± 0.036
1.248GlnGln: 1.248 ± 0.053
1.316GlnArg: 1.316 ± 0.047
1.51GlnSer: 1.51 ± 0.049
1.6GlnThr: 1.6 ± 0.058
2.116GlnVal: 2.116 ± 0.057
0.25GlnTrp: 0.25 ± 0.019
0.989GlnTyr: 0.989 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.309ArgAla: 2.309 ± 0.058
0.359ArgCys: 0.359 ± 0.026
2.121ArgAsp: 2.121 ± 0.067
2.982ArgGlu: 2.982 ± 0.062
1.705ArgPhe: 1.705 ± 0.051
2.516ArgGly: 2.516 ± 0.07
0.638ArgHis: 0.638 ± 0.028
3.309ArgIle: 3.309 ± 0.071
2.966ArgLys: 2.966 ± 0.065
3.774ArgLeu: 3.774 ± 0.075
1.134ArgMet: 1.134 ± 0.046
2.119ArgAsn: 2.119 ± 0.056
1.342ArgPro: 1.342 ± 0.045
1.367ArgGln: 1.367 ± 0.045
1.678ArgArg: 1.678 ± 0.053
2.055ArgSer: 2.055 ± 0.058
1.986ArgThr: 1.986 ± 0.056
2.73ArgVal: 2.73 ± 0.06
0.355ArgTrp: 0.355 ± 0.024
1.507ArgTyr: 1.507 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
3.271SerAla: 3.271 ± 0.076
0.56SerCys: 0.56 ± 0.03
3.193SerAsp: 3.193 ± 0.078
3.833SerGlu: 3.833 ± 0.073
2.602SerPhe: 2.602 ± 0.06
3.984SerGly: 3.984 ± 0.086
1.03SerHis: 1.03 ± 0.037
5.52SerIle: 5.52 ± 0.091
4.115SerLys: 4.115 ± 0.084
5.853SerLeu: 5.853 ± 0.09
1.352SerMet: 1.352 ± 0.047
3.365SerAsn: 3.365 ± 0.076
2.064SerPro: 2.064 ± 0.053
1.794SerGln: 1.794 ± 0.053
2.387SerArg: 2.387 ± 0.056
3.727SerSer: 3.727 ± 0.091
3.007SerThr: 3.007 ± 0.072
3.601SerVal: 3.601 ± 0.076
0.492SerTrp: 0.492 ± 0.024
2.267SerTyr: 2.267 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
3.428ThrAla: 3.428 ± 0.076
0.446ThrCys: 0.446 ± 0.026
2.749ThrAsp: 2.749 ± 0.06
3.213ThrGlu: 3.213 ± 0.069
2.116ThrPhe: 2.116 ± 0.058
4.317ThrGly: 4.317 ± 0.275
0.887ThrHis: 0.887 ± 0.034
4.906ThrIle: 4.906 ± 0.088
3.253ThrLys: 3.253 ± 0.064
4.51ThrLeu: 4.51 ± 0.077
1.148ThrMet: 1.148 ± 0.049
2.873ThrAsn: 2.873 ± 0.069
2.21ThrPro: 2.21 ± 0.054
1.451ThrGln: 1.451 ± 0.049
1.936ThrArg: 1.936 ± 0.054
3.066ThrSer: 3.066 ± 0.067
2.914ThrThr: 2.914 ± 0.076
3.702ThrVal: 3.702 ± 0.09
0.373ThrTrp: 0.373 ± 0.022
1.803ThrTyr: 1.803 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
4.588ValAla: 4.588 ± 0.091
0.703ValCys: 0.703 ± 0.032
4.1ValAsp: 4.1 ± 0.08
5.034ValGlu: 5.034 ± 0.096
2.945ValPhe: 2.945 ± 0.068
4.351ValGly: 4.351 ± 0.085
1.089ValHis: 1.089 ± 0.042
6.185ValIle: 6.185 ± 0.092
4.685ValLys: 4.685 ± 0.085
6.359ValLeu: 6.359 ± 0.099
1.619ValMet: 1.619 ± 0.052
3.568ValAsn: 3.568 ± 0.077
2.362ValPro: 2.362 ± 0.059
1.74ValGln: 1.74 ± 0.049
2.4ValArg: 2.4 ± 0.063
4.106ValSer: 4.106 ± 0.076
3.35ValThr: 3.35 ± 0.078
5.1ValVal: 5.1 ± 0.103
0.429ValTrp: 0.429 ± 0.026
2.298ValTyr: 2.298 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.523TrpAla: 0.523 ± 0.034
0.093TrpCys: 0.093 ± 0.011
0.514TrpAsp: 0.514 ± 0.029
0.657TrpGlu: 0.657 ± 0.032
0.368TrpPhe: 0.368 ± 0.022
0.582TrpGly: 0.582 ± 0.029
0.165TrpHis: 0.165 ± 0.016
0.607TrpIle: 0.607 ± 0.031
0.443TrpLys: 0.443 ± 0.027
0.846TrpLeu: 0.846 ± 0.033
0.228TrpMet: 0.228 ± 0.018
0.414TrpAsn: 0.414 ± 0.028
0.252TrpPro: 0.252 ± 0.019
0.326TrpGln: 0.326 ± 0.021
0.283TrpArg: 0.283 ± 0.02
0.423TrpSer: 0.423 ± 0.028
0.301TrpThr: 0.301 ± 0.024
0.513TrpVal: 0.513 ± 0.027
0.102TrpTrp: 0.102 ± 0.012
0.324TrpTyr: 0.324 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.983TyrAla: 1.983 ± 0.052
0.47TyrCys: 0.47 ± 0.03
2.167TyrAsp: 2.167 ± 0.065
2.584TyrGlu: 2.584 ± 0.067
1.744TyrPhe: 1.744 ± 0.052
2.396TyrGly: 2.396 ± 0.059
0.672TyrHis: 0.672 ± 0.032
3.409TyrIle: 3.409 ± 0.072
2.645TyrLys: 2.645 ± 0.06
3.777TyrLeu: 3.777 ± 0.089
0.835TyrMet: 0.835 ± 0.04
2.182TyrAsn: 2.182 ± 0.068
1.398TyrPro: 1.398 ± 0.046
1.295TyrGln: 1.295 ± 0.042
1.512TyrArg: 1.512 ± 0.048
2.406TyrSer: 2.406 ± 0.069
1.808TyrThr: 1.808 ± 0.053
1.942TyrVal: 1.942 ± 0.051
0.348TyrTrp: 0.348 ± 0.025
1.612TyrTyr: 1.612 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2290 proteins (678767 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski