Amino acid dipepetide frequency for Paraburkholderia sp. PDC91

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.467AlaAla: 18.467 ± 0.148	1.279AlaCys: 1.279 ± 0.026	6.877AlaAsp: 6.877 ± 0.06	5.448AlaGlu: 5.448 ± 0.057	4.421AlaPhe: 4.421 ± 0.046	11.314AlaGly: 11.314 ± 0.103	2.916AlaHis: 2.916 ± 0.042	5.935AlaIle: 5.935 ± 0.059	3.417AlaLys: 3.417 ± 0.047	14.599AlaLeu: 14.599 ± 0.104	3.231AlaMet: 3.231 ± 0.039	3.359AlaAsn: 3.359 ± 0.046	6.067AlaPro: 6.067 ± 0.073	5.375AlaGln: 5.375 ± 0.058	9.484AlaArg: 9.484 ± 0.088	7.635AlaSer: 7.635 ± 0.072	6.683AlaThr: 6.683 ± 0.066	8.875AlaVal: 8.875 ± 0.068	1.75AlaTrp: 1.75 ± 0.028	2.649AlaTyr: 2.649 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.246CysAla: 1.246 ± 0.024	0.128CysCys: 0.128 ± 0.008	0.535CysAsp: 0.535 ± 0.016	0.486CysGlu: 0.486 ± 0.014	0.33CysPhe: 0.33 ± 0.013	0.968CysGly: 0.968 ± 0.022	0.244CysHis: 0.244 ± 0.011	0.397CysIle: 0.397 ± 0.015	0.15CysLys: 0.15 ± 0.01	0.714CysLeu: 0.714 ± 0.017	0.191CysMet: 0.191 ± 0.009	0.248CysAsn: 0.248 ± 0.011	0.421CysPro: 0.421 ± 0.016	0.196CysGln: 0.196 ± 0.009	0.63CysArg: 0.63 ± 0.017	0.514CysSer: 0.514 ± 0.015	0.475CysThr: 0.475 ± 0.015	0.833CysVal: 0.833 ± 0.022	0.111CysTrp: 0.111 ± 0.006	0.239CysTyr: 0.239 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.715AspAla: 8.715 ± 0.085	0.449AspCys: 0.449 ± 0.014	3.496AspAsp: 3.496 ± 0.046	3.531AspGlu: 3.531 ± 0.041	1.9AspPhe: 1.9 ± 0.031	5.029AspGly: 5.029 ± 0.057	1.2AspHis: 1.2 ± 0.026	2.439AspIle: 2.439 ± 0.033	1.236AspLys: 1.236 ± 0.026	5.162AspLeu: 5.162 ± 0.049	1.096AspMet: 1.096 ± 0.022	1.293AspAsn: 1.293 ± 0.027	3.143AspPro: 3.143 ± 0.04	1.453AspGln: 1.453 ± 0.023	3.541AspArg: 3.541 ± 0.039	2.377AspSer: 2.377 ± 0.032	2.909AspThr: 2.909 ± 0.04	4.64AspVal: 4.64 ± 0.046	0.922AspTrp: 0.922 ± 0.019	1.461AspTyr: 1.461 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	5.96GluAla: 5.96 ± 0.056	0.384GluCys: 0.384 ± 0.014	1.94GluAsp: 1.94 ± 0.03	2.125GluGlu: 2.125 ± 0.036	1.603GluPhe: 1.603 ± 0.027	3.199GluGly: 3.199 ± 0.043	1.389GluHis: 1.389 ± 0.024	2.662GluIle: 2.662 ± 0.035	1.51GluLys: 1.51 ± 0.03	5.236GluLeu: 5.236 ± 0.053	1.146GluMet: 1.146 ± 0.024	1.286GluAsn: 1.286 ± 0.022	2.666GluPro: 2.666 ± 0.033	2.209GluGln: 2.209 ± 0.04	4.949GluArg: 4.949 ± 0.05	2.519GluSer: 2.519 ± 0.035	2.684GluThr: 2.684 ± 0.04	3.356GluVal: 3.356 ± 0.046	0.662GluTrp: 0.662 ± 0.016	1.134GluTyr: 1.134 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.768PheAla: 4.768 ± 0.052	0.403PheCys: 0.403 ± 0.014	2.759PheAsp: 2.759 ± 0.038	1.911PheGlu: 1.911 ± 0.029	1.399PhePhe: 1.399 ± 0.029	3.814PheGly: 3.814 ± 0.048	0.757PheHis: 0.757 ± 0.02	1.516PheIle: 1.516 ± 0.029	0.747PheLys: 0.747 ± 0.018	2.912PheLeu: 2.912 ± 0.039	0.767PheMet: 0.767 ± 0.018	1.036PheAsn: 1.036 ± 0.021	1.593PhePro: 1.593 ± 0.028	0.925PheGln: 0.925 ± 0.019	2.101PheArg: 2.101 ± 0.028	2.221PheSer: 2.221 ± 0.035	1.952PheThr: 1.952 ± 0.032	3.351PheVal: 3.351 ± 0.043	0.508PheTrp: 0.508 ± 0.016	0.889PheTyr: 0.889 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.107GlyAla: 10.107 ± 0.091	0.87GlyCys: 0.87 ± 0.022	4.309GlyAsp: 4.309 ± 0.05	4.217GlyGlu: 4.217 ± 0.044	3.546GlyPhe: 3.546 ± 0.049	7.351GlyGly: 7.351 ± 0.127	1.965GlyHis: 1.965 ± 0.033	4.44GlyIle: 4.44 ± 0.044	2.84GlyLys: 2.84 ± 0.041	8.187GlyLeu: 8.187 ± 0.078	2.215GlyMet: 2.215 ± 0.035	2.431GlyAsn: 2.431 ± 0.046	3.209GlyPro: 3.209 ± 0.042	2.679GlyGln: 2.679 ± 0.034	5.721GlyArg: 5.721 ± 0.057	4.835GlySer: 4.835 ± 0.071	4.942GlyThr: 4.942 ± 0.111	6.986GlyVal: 6.986 ± 0.064	1.433GlyTrp: 1.433 ± 0.027	2.498GlyTyr: 2.498 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	3.233HisAla: 3.233 ± 0.043	0.256HisCys: 0.256 ± 0.011	1.452HisAsp: 1.452 ± 0.029	1.215HisGlu: 1.215 ± 0.022	0.885HisPhe: 0.885 ± 0.018	2.218HisGly: 2.218 ± 0.03	0.64HisHis: 0.64 ± 0.02	0.883HisIle: 0.883 ± 0.02	0.449HisLys: 0.449 ± 0.016	2.115HisLeu: 2.115 ± 0.032	0.488HisMet: 0.488 ± 0.015	0.545HisAsn: 0.545 ± 0.015	1.468HisPro: 1.468 ± 0.025	0.632HisGln: 0.632 ± 0.018	1.663HisArg: 1.663 ± 0.031	1.061HisSer: 1.061 ± 0.024	1.118HisThr: 1.118 ± 0.024	1.808HisVal: 1.808 ± 0.027	0.413HisTrp: 0.413 ± 0.014	0.673HisTyr: 0.673 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.194IleAla: 7.194 ± 0.057	0.434IleCys: 0.434 ± 0.014	3.586IleAsp: 3.586 ± 0.041	3.118IleGlu: 3.118 ± 0.04	1.388IlePhe: 1.388 ± 0.027	5.01IleGly: 5.01 ± 0.055	0.907IleHis: 0.907 ± 0.022	1.471IleIle: 1.471 ± 0.027	1.065IleLys: 1.065 ± 0.025	3.259IleLeu: 3.259 ± 0.043	0.684IleMet: 0.684 ± 0.019	1.275IleAsn: 1.275 ± 0.027	2.112IlePro: 2.112 ± 0.03	1.165IleGln: 1.165 ± 0.025	2.893IleArg: 2.893 ± 0.034	2.428IleSer: 2.428 ± 0.034	2.376IleThr: 2.376 ± 0.042	4.623IleVal: 4.623 ± 0.052	0.49IleTrp: 0.49 ± 0.013	0.998IleTyr: 0.998 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.053LysAla: 3.053 ± 0.038	0.147LysCys: 0.147 ± 0.009	1.263LysAsp: 1.263 ± 0.026	1.173LysGlu: 1.173 ± 0.032	0.768LysPhe: 0.768 ± 0.019	1.874LysGly: 1.874 ± 0.035	0.581LysHis: 0.581 ± 0.016	1.351LysIle: 1.351 ± 0.027	1.005LysLys: 1.005 ± 0.032	2.971LysLeu: 2.971 ± 0.043	0.654LysMet: 0.654 ± 0.019	0.746LysAsn: 0.746 ± 0.019	1.821LysPro: 1.821 ± 0.036	1.044LysGln: 1.044 ± 0.023	2.117LysArg: 2.117 ± 0.033	1.51LysSer: 1.51 ± 0.031	1.647LysThr: 1.647 ± 0.028	2.084LysVal: 2.084 ± 0.041	0.346LysTrp: 0.346 ± 0.013	0.563LysTyr: 0.563 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	14.175LeuAla: 14.175 ± 0.104	0.983LeuCys: 0.983 ± 0.025	6.2LeuAsp: 6.2 ± 0.057	4.71LeuGlu: 4.71 ± 0.053	3.612LeuPhe: 3.612 ± 0.047	8.239LeuGly: 8.239 ± 0.07	2.294LeuHis: 2.294 ± 0.034	4.664LeuIle: 4.664 ± 0.055	2.911LeuLys: 2.911 ± 0.035	10.11LeuLeu: 10.11 ± 0.098	2.212LeuMet: 2.212 ± 0.035	2.674LeuAsn: 2.674 ± 0.037	5.778LeuPro: 5.778 ± 0.056	3.197LeuGln: 3.197 ± 0.037	7.177LeuArg: 7.177 ± 0.063	6.106LeuSer: 6.106 ± 0.059	5.497LeuThr: 5.497 ± 0.056	7.781LeuVal: 7.781 ± 0.072	1.127LeuTrp: 1.127 ± 0.022	2.279LeuTyr: 2.279 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.35MetAla: 2.35 ± 0.032	0.175MetCys: 0.175 ± 0.01	0.892MetAsp: 0.892 ± 0.018	0.848MetGlu: 0.848 ± 0.021	0.769MetPhe: 0.769 ± 0.02	1.495MetGly: 1.495 ± 0.03	0.551MetHis: 0.551 ± 0.016	1.117MetIle: 1.117 ± 0.023	0.949MetLys: 0.949 ± 0.018	2.582MetLeu: 2.582 ± 0.038	0.563MetMet: 0.563 ± 0.016	0.912MetAsn: 0.912 ± 0.021	1.439MetPro: 1.439 ± 0.025	0.991MetGln: 0.991 ± 0.023	1.779MetArg: 1.779 ± 0.026	1.724MetSer: 1.724 ± 0.029	1.626MetThr: 1.626 ± 0.028	1.478MetVal: 1.478 ± 0.029	0.198MetTrp: 0.198 ± 0.009	0.428MetTyr: 0.428 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.667AsnAla: 3.667 ± 0.047	0.226AsnCys: 0.226 ± 0.011	1.445AsnAsp: 1.445 ± 0.027	1.256AsnGlu: 1.256 ± 0.024	0.929AsnPhe: 0.929 ± 0.021	2.641AsnGly: 2.641 ± 0.048	0.535AsnHis: 0.535 ± 0.016	1.129AsnIle: 1.129 ± 0.025	0.53AsnLys: 0.53 ± 0.018	2.651AsnLeu: 2.651 ± 0.038	0.53AsnMet: 0.53 ± 0.015	0.738AsnAsn: 0.738 ± 0.021	1.857AsnPro: 1.857 ± 0.027	0.879AsnGln: 0.879 ± 0.026	1.849AsnArg: 1.849 ± 0.026	1.251AsnSer: 1.251 ± 0.028	1.466AsnThr: 1.466 ± 0.031	2.318AsnVal: 2.318 ± 0.035	0.384AsnTrp: 0.384 ± 0.013	0.714AsnTyr: 0.714 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.965ProAla: 6.965 ± 0.08	0.339ProCys: 0.339 ± 0.012	3.58ProAsp: 3.58 ± 0.045	2.82ProGlu: 2.82 ± 0.04	1.925ProPhe: 1.925 ± 0.027	4.55ProGly: 4.55 ± 0.048	1.3ProHis: 1.3 ± 0.026	1.935ProIle: 1.935 ± 0.026	1.313ProLys: 1.313 ± 0.027	5.321ProLeu: 5.321 ± 0.048	1.081ProMet: 1.081 ± 0.023	1.335ProAsn: 1.335 ± 0.025	2.713ProPro: 2.713 ± 0.054	1.977ProGln: 1.977 ± 0.033	3.115ProArg: 3.115 ± 0.041	2.884ProSer: 2.884 ± 0.035	2.672ProThr: 2.672 ± 0.036	4.624ProVal: 4.624 ± 0.045	0.706ProTrp: 0.706 ± 0.017	1.317ProTyr: 1.317 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.071GlnAla: 4.071 ± 0.053	0.278GlnCys: 0.278 ± 0.011	1.303GlnAsp: 1.303 ± 0.023	1.222GlnGlu: 1.222 ± 0.028	1.245GlnPhe: 1.245 ± 0.025	2.251GlnGly: 2.251 ± 0.032	0.937GlnHis: 0.937 ± 0.023	1.977GlnIle: 1.977 ± 0.029	0.99GlnLys: 0.99 ± 0.023	3.687GlnLeu: 3.687 ± 0.042	1.014GlnMet: 1.014 ± 0.023	0.887GlnAsn: 0.887 ± 0.021	2.062GlnPro: 2.062 ± 0.038	1.921GlnGln: 1.921 ± 0.038	2.98GlnArg: 2.98 ± 0.037	1.975GlnSer: 1.975 ± 0.033	2.027GlnThr: 2.027 ± 0.034	2.419GlnVal: 2.419 ± 0.035	0.559GlnTrp: 0.559 ± 0.015	0.96GlnTyr: 0.96 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.615ArgAla: 8.615 ± 0.078	0.603ArgCys: 0.603 ± 0.019	4.181ArgAsp: 4.181 ± 0.045	4.341ArgGlu: 4.341 ± 0.045	2.965ArgPhe: 2.965 ± 0.035	4.946ArgGly: 4.946 ± 0.048	1.987ArgHis: 1.987 ± 0.034	3.792ArgIle: 3.792 ± 0.035	1.853ArgLys: 1.853 ± 0.028	7.316ArgLeu: 7.316 ± 0.076	1.846ArgMet: 1.846 ± 0.028	1.955ArgAsn: 1.955 ± 0.031	3.285ArgPro: 3.285 ± 0.04	2.526ArgGln: 2.526 ± 0.038	5.923ArgArg: 5.923 ± 0.068	3.593ArgSer: 3.593 ± 0.041	3.569ArgThr: 3.569 ± 0.038	5.633ArgVal: 5.633 ± 0.055	1.063ArgTrp: 1.063 ± 0.023	2.085ArgTyr: 2.085 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.847SerAla: 6.847 ± 0.065	0.451SerCys: 0.451 ± 0.014	2.826SerAsp: 2.826 ± 0.038	2.267SerGlu: 2.267 ± 0.031	2.151SerPhe: 2.151 ± 0.036	5.683SerGly: 5.683 ± 0.106	1.234SerHis: 1.234 ± 0.024	2.753SerIle: 2.753 ± 0.036	1.405SerLys: 1.405 ± 0.029	5.737SerLeu: 5.737 ± 0.058	1.366SerMet: 1.366 ± 0.023	1.57SerAsn: 1.57 ± 0.028	3.006SerPro: 3.006 ± 0.041	1.808SerGln: 1.808 ± 0.029	3.762SerArg: 3.762 ± 0.049	3.431SerSer: 3.431 ± 0.054	3.253SerThr: 3.253 ± 0.048	4.417SerVal: 4.417 ± 0.057	0.749SerTrp: 0.749 ± 0.021	1.362SerTyr: 1.362 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	6.045ThrAla: 6.045 ± 0.056	0.415ThrCys: 0.415 ± 0.013	2.802ThrAsp: 2.802 ± 0.04	2.15ThrGlu: 2.15 ± 0.031	1.994ThrPhe: 1.994 ± 0.031	5.068ThrGly: 5.068 ± 0.066	1.278ThrHis: 1.278 ± 0.023	2.653ThrIle: 2.653 ± 0.04	1.189ThrLys: 1.189 ± 0.023	6.633ThrLeu: 6.633 ± 0.073	1.191ThrMet: 1.191 ± 0.023	1.393ThrAsn: 1.393 ± 0.033	3.65ThrPro: 3.65 ± 0.044	1.886ThrGln: 1.886 ± 0.037	3.658ThrArg: 3.658 ± 0.04	3.027ThrSer: 3.027 ± 0.046	3.157ThrThr: 3.157 ± 0.063	4.556ThrVal: 4.556 ± 0.062	0.704ThrTrp: 0.704 ± 0.019	1.266ThrTyr: 1.266 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	10.232ValAla: 10.232 ± 0.076	0.83ValCys: 0.83 ± 0.017	4.485ValAsp: 4.485 ± 0.054	4.085ValGlu: 4.085 ± 0.05	2.943ValPhe: 2.943 ± 0.039	5.94ValGly: 5.94 ± 0.055	1.581ValHis: 1.581 ± 0.028	3.812ValIle: 3.812 ± 0.053	2.247ValLys: 2.247 ± 0.043	8.136ValLeu: 8.136 ± 0.078	1.79ValMet: 1.79 ± 0.03	2.246ValAsn: 2.246 ± 0.035	4.227ValPro: 4.227 ± 0.05	2.428ValGln: 2.428 ± 0.035	5.463ValArg: 5.463 ± 0.055	4.88ValSer: 4.88 ± 0.056	4.623ValThr: 4.623 ± 0.046	6.643ValVal: 6.643 ± 0.071	0.996ValTrp: 0.996 ± 0.023	1.748ValTyr: 1.748 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.185TrpAla: 1.185 ± 0.023	0.14TrpCys: 0.14 ± 0.008	0.587TrpAsp: 0.587 ± 0.017	0.472TrpGlu: 0.472 ± 0.014	0.563TrpPhe: 0.563 ± 0.015	0.93TrpGly: 0.93 ± 0.02	0.41TrpHis: 0.41 ± 0.013	0.717TrpIle: 0.717 ± 0.019	0.388TrpLys: 0.388 ± 0.013	1.899TrpLeu: 1.899 ± 0.031	0.353TrpMet: 0.353 ± 0.012	0.443TrpAsn: 0.443 ± 0.015	0.674TrpPro: 0.674 ± 0.019	0.641TrpGln: 0.641 ± 0.017	1.263TrpArg: 1.263 ± 0.024	0.854TrpSer: 0.854 ± 0.021	0.731TrpThr: 0.731 ± 0.021	0.928TrpVal: 0.928 ± 0.021	0.233TrpTrp: 0.233 ± 0.01	0.338TrpTyr: 0.338 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.885TyrAla: 2.885 ± 0.038	0.266TyrCys: 0.266 ± 0.011	1.477TyrAsp: 1.477 ± 0.029	1.223TyrGlu: 1.223 ± 0.021	0.992TyrPhe: 0.992 ± 0.022	2.262TyrGly: 2.262 ± 0.032	0.51TyrHis: 0.51 ± 0.017	0.832TyrIle: 0.832 ± 0.019	0.521TyrLys: 0.521 ± 0.015	2.497TyrLeu: 2.497 ± 0.032	0.446TyrMet: 0.446 ± 0.015	0.621TyrAsn: 0.621 ± 0.02	1.282TyrPro: 1.282 ± 0.024	0.833TyrGln: 0.833 ± 0.021	2.008TyrArg: 2.008 ± 0.031	1.254TyrSer: 1.254 ± 0.022	1.307TyrThr: 1.307 ± 0.027	1.986TyrVal: 1.986 ± 0.031	0.396TyrTrp: 0.396 ± 0.013	0.644TyrTyr: 0.644 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6876 proteins (2242271 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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