Amino acid dipepetide frequency for Carnation etched ring virus (CERV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.651AlaAla: 2.651 ± 1.01
0.0AlaCys: 0.0 ± 0.0
0.884AlaAsp: 0.884 ± 0.356
3.535AlaGlu: 3.535 ± 0.9
3.093AlaPhe: 3.093 ± 1.136
1.326AlaGly: 1.326 ± 0.603
1.326AlaHis: 1.326 ± 0.46
5.303AlaIle: 5.303 ± 1.394
3.535AlaLys: 3.535 ± 1.576
1.768AlaLeu: 1.768 ± 1.074
0.884AlaMet: 0.884 ± 0.383
2.209AlaAsn: 2.209 ± 0.855
0.884AlaPro: 0.884 ± 0.383
1.768AlaGln: 1.768 ± 0.565
1.768AlaArg: 1.768 ± 0.757
4.861AlaSer: 4.861 ± 1.205
3.093AlaThr: 3.093 ± 0.869
1.326AlaVal: 1.326 ± 0.603
0.0AlaTrp: 0.0 ± 0.0
1.768AlaTyr: 1.768 ± 0.671
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.884CysCys: 0.884 ± 0.383
1.768CysAsp: 1.768 ± 0.757
1.326CysGlu: 1.326 ± 0.648
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.442CysHis: 0.442 ± 0.706
0.442CysIle: 0.442 ± 0.336
1.768CysLys: 1.768 ± 0.472
0.442CysLeu: 0.442 ± 0.349
0.442CysMet: 0.442 ± 0.341
1.326CysAsn: 1.326 ± 0.878
2.209CysPro: 2.209 ± 0.636
0.442CysGln: 0.442 ± 0.341
0.884CysArg: 0.884 ± 0.383
2.209CysSer: 2.209 ± 0.698
0.0CysThr: 0.0 ± 0.0
0.884CysVal: 0.884 ± 0.383
0.884CysTrp: 0.884 ± 0.435
0.884CysTyr: 0.884 ± 0.534
0.0CysXaa: 0.0 ± 0.0
Asp
1.768AspAla: 1.768 ± 0.927
0.884AspCys: 0.884 ± 0.383
3.535AspAsp: 3.535 ± 1.164
2.209AspGlu: 2.209 ± 0.936
1.768AspPhe: 1.768 ± 0.712
0.0AspGly: 0.0 ± 0.0
0.884AspHis: 0.884 ± 0.673
4.861AspIle: 4.861 ± 1.379
6.186AspLys: 6.186 ± 1.166
3.977AspLeu: 3.977 ± 0.671
0.442AspMet: 0.442 ± 0.336
1.768AspAsn: 1.768 ± 0.506
2.209AspPro: 2.209 ± 0.619
2.209AspGln: 2.209 ± 0.784
5.745AspArg: 5.745 ± 1.011
3.535AspSer: 3.535 ± 0.494
3.093AspThr: 3.093 ± 0.644
2.209AspVal: 2.209 ± 0.583
0.0AspTrp: 0.0 ± 0.0
2.209AspTyr: 2.209 ± 0.551
0.0AspXaa: 0.0 ± 0.0
Glu
2.651GluAla: 2.651 ± 0.956
1.326GluCys: 1.326 ± 0.739
5.303GluAsp: 5.303 ± 1.744
9.28GluGlu: 9.28 ± 2.324
3.977GluPhe: 3.977 ± 1.355
2.651GluGly: 2.651 ± 0.704
2.651GluHis: 2.651 ± 0.837
7.07GluIle: 7.07 ± 2.531
9.28GluLys: 9.28 ± 1.162
7.954GluLeu: 7.954 ± 1.166
2.209GluMet: 2.209 ± 0.802
2.651GluAsn: 2.651 ± 0.903
4.419GluPro: 4.419 ± 0.929
4.419GluGln: 4.419 ± 1.803
3.977GluArg: 3.977 ± 0.816
6.628GluSer: 6.628 ± 2.13
1.326GluThr: 1.326 ± 0.589
3.093GluVal: 3.093 ± 1.436
0.442GluTrp: 0.442 ± 0.349
1.768GluTyr: 1.768 ± 0.765
0.0GluXaa: 0.0 ± 0.0
Phe
1.326PheAla: 1.326 ± 0.335
0.884PheCys: 0.884 ± 0.383
2.651PheAsp: 2.651 ± 0.909
1.768PheGlu: 1.768 ± 1.069
2.209PhePhe: 2.209 ± 1.509
2.209PheGly: 2.209 ± 0.428
0.884PheHis: 0.884 ± 0.356
2.651PheIle: 2.651 ± 0.765
3.535PheLys: 3.535 ± 0.422
7.512PheLeu: 7.512 ± 1.77
0.442PheMet: 0.442 ± 0.445
1.768PheAsn: 1.768 ± 0.757
2.209PhePro: 2.209 ± 1.411
1.768PheGln: 1.768 ± 0.573
1.326PheArg: 1.326 ± 0.718
5.303PheSer: 5.303 ± 1.747
3.093PheThr: 3.093 ± 1.073
1.768PheVal: 1.768 ± 0.551
0.442PheTrp: 0.442 ± 0.341
0.442PheTyr: 0.442 ± 0.336
0.0PheXaa: 0.0 ± 0.0
Gly
1.326GlyAla: 1.326 ± 0.879
0.442GlyCys: 0.442 ± 0.349
2.651GlyAsp: 2.651 ± 0.626
2.651GlyGlu: 2.651 ± 1.235
2.651GlyPhe: 2.651 ± 0.749
2.209GlyGly: 2.209 ± 1.248
0.884GlyHis: 0.884 ± 0.383
7.954GlyIle: 7.954 ± 2.094
6.628GlyLys: 6.628 ± 1.112
4.419GlyLeu: 4.419 ± 0.995
0.442GlyMet: 0.442 ± 0.706
2.651GlyAsn: 2.651 ± 0.774
0.884GlyPro: 0.884 ± 0.673
0.0GlyGln: 0.0 ± 0.0
1.768GlyArg: 1.768 ± 0.699
2.651GlySer: 2.651 ± 1.33
1.768GlyThr: 1.768 ± 0.699
1.326GlyVal: 1.326 ± 0.603
0.0GlyTrp: 0.0 ± 0.0
0.442GlyTyr: 0.442 ± 0.341
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
1.768HisCys: 1.768 ± 0.974
0.0HisAsp: 0.0 ± 0.0
0.884HisGlu: 0.884 ± 0.356
1.768HisPhe: 1.768 ± 0.766
0.884HisGly: 0.884 ± 0.891
0.884HisHis: 0.884 ± 0.891
2.209HisIle: 2.209 ± 0.955
1.768HisLys: 1.768 ± 0.584
0.884HisLeu: 0.884 ± 0.682
0.442HisMet: 0.442 ± 0.341
1.326HisAsn: 1.326 ± 0.635
0.442HisPro: 0.442 ± 0.341
0.442HisGln: 0.442 ± 0.445
0.0HisArg: 0.0 ± 0.0
2.651HisSer: 2.651 ± 0.816
0.0HisThr: 0.0 ± 0.0
1.326HisVal: 1.326 ± 0.681
0.442HisTrp: 0.442 ± 0.336
1.326HisTyr: 1.326 ± 0.635
0.0HisXaa: 0.0 ± 0.0
Ile
3.093IleAla: 3.093 ± 0.53
3.093IleCys: 3.093 ± 0.8
6.186IleAsp: 6.186 ± 1.706
7.07IleGlu: 7.07 ± 1.676
1.768IlePhe: 1.768 ± 0.768
3.535IleGly: 3.535 ± 0.926
2.209IleHis: 2.209 ± 1.114
3.977IleIle: 3.977 ± 1.593
7.07IleLys: 7.07 ± 1.541
10.605IleLeu: 10.605 ± 1.578
0.0IleMet: 0.0 ± 0.0
3.093IleAsn: 3.093 ± 0.78
6.186IlePro: 6.186 ± 1.138
3.977IleGln: 3.977 ± 0.496
2.651IleArg: 2.651 ± 1.27
4.861IleSer: 4.861 ± 1.64
2.209IleThr: 2.209 ± 0.796
1.326IleVal: 1.326 ± 0.891
0.0IleTrp: 0.0 ± 0.0
5.303IleTyr: 5.303 ± 1.711
0.0IleXaa: 0.0 ± 0.0
Lys
8.838LysAla: 8.838 ± 1.201
0.442LysCys: 0.442 ± 0.336
4.419LysAsp: 4.419 ± 1.271
11.489LysGlu: 11.489 ± 3.289
4.419LysPhe: 4.419 ± 0.659
5.303LysGly: 5.303 ± 1.197
0.442LysHis: 0.442 ± 0.336
11.047LysIle: 11.047 ± 1.681
14.582LysLys: 14.582 ± 2.407
7.954LysLeu: 7.954 ± 1.638
0.884LysMet: 0.884 ± 0.494
5.303LysAsn: 5.303 ± 1.172
5.745LysPro: 5.745 ± 0.814
4.419LysGln: 4.419 ± 1.49
3.093LysArg: 3.093 ± 1.274
7.954LysSer: 7.954 ± 0.889
4.419LysThr: 4.419 ± 1.254
3.977LysVal: 3.977 ± 1.249
0.884LysTrp: 0.884 ± 0.724
4.861LysTyr: 4.861 ± 1.705
0.0LysXaa: 0.0 ± 0.0
Leu
3.977LeuAla: 3.977 ± 1.455
0.884LeuCys: 0.884 ± 0.383
3.977LeuAsp: 3.977 ± 1.497
9.28LeuGlu: 9.28 ± 1.386
1.768LeuPhe: 1.768 ± 0.945
6.186LeuGly: 6.186 ± 1.024
0.442LeuHis: 0.442 ± 0.341
4.419LeuIle: 4.419 ± 1.145
9.722LeuLys: 9.722 ± 2.313
4.861LeuLeu: 4.861 ± 1.934
1.326LeuMet: 1.326 ± 0.718
6.628LeuAsn: 6.628 ± 1.069
3.535LeuPro: 3.535 ± 0.854
3.535LeuGln: 3.535 ± 0.728
3.093LeuArg: 3.093 ± 0.66
8.396LeuSer: 8.396 ± 2.759
5.303LeuThr: 5.303 ± 1.666
6.186LeuVal: 6.186 ± 1.422
0.884LeuTrp: 0.884 ± 0.383
2.651LeuTyr: 2.651 ± 0.837
0.0LeuXaa: 0.0 ± 0.0
Met
2.209MetAla: 2.209 ± 0.61
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
1.768MetGlu: 1.768 ± 0.871
0.884MetPhe: 0.884 ± 0.535
0.442MetGly: 0.442 ± 0.706
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
1.326MetLys: 1.326 ± 0.698
1.326MetLeu: 1.326 ± 0.611
0.0MetMet: 0.0 ± 0.0
2.651MetAsn: 2.651 ± 1.01
0.0MetPro: 0.0 ± 0.0
0.442MetGln: 0.442 ± 0.336
0.884MetArg: 0.884 ± 0.535
1.768MetSer: 1.768 ± 1.025
0.442MetThr: 0.442 ± 0.341
0.442MetVal: 0.442 ± 0.341
0.442MetTrp: 0.442 ± 0.341
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.768AsnAla: 1.768 ± 0.906
0.442AsnCys: 0.442 ± 0.349
3.093AsnAsp: 3.093 ± 0.827
4.419AsnGlu: 4.419 ± 0.614
3.535AsnPhe: 3.535 ± 0.612
2.209AsnGly: 2.209 ± 0.666
1.326AsnHis: 1.326 ± 0.681
4.419AsnIle: 4.419 ± 1.112
6.186AsnLys: 6.186 ± 1.073
6.628AsnLeu: 6.628 ± 1.225
0.442AsnMet: 0.442 ± 0.336
2.651AsnAsn: 2.651 ± 0.735
3.977AsnPro: 3.977 ± 0.95
2.209AsnGln: 2.209 ± 0.665
2.651AsnArg: 2.651 ± 1.296
6.628AsnSer: 6.628 ± 2.096
1.326AsnThr: 1.326 ± 0.743
1.768AsnVal: 1.768 ± 0.765
0.0AsnTrp: 0.0 ± 0.0
3.535AsnTyr: 3.535 ± 0.707
0.0AsnXaa: 0.0 ± 0.0
Pro
0.442ProAla: 0.442 ± 0.341
0.442ProCys: 0.442 ± 0.336
2.209ProAsp: 2.209 ± 1.029
5.745ProGlu: 5.745 ± 0.395
1.326ProPhe: 1.326 ± 0.611
2.209ProGly: 2.209 ± 0.666
0.884ProHis: 0.884 ± 0.627
3.093ProIle: 3.093 ± 1.022
7.954ProLys: 7.954 ± 1.875
2.209ProLeu: 2.209 ± 0.619
0.884ProMet: 0.884 ± 0.356
4.861ProAsn: 4.861 ± 1.077
0.884ProPro: 0.884 ± 1.411
2.651ProGln: 2.651 ± 1.27
0.442ProArg: 0.442 ± 0.706
8.396ProSer: 8.396 ± 1.395
1.768ProThr: 1.768 ± 1.023
0.0ProVal: 0.0 ± 0.0
0.442ProTrp: 0.442 ± 0.706
1.768ProTyr: 1.768 ± 0.871
0.0ProXaa: 0.0 ± 0.0
Gln
0.884GlnAla: 0.884 ± 0.356
0.0GlnCys: 0.0 ± 0.0
1.768GlnAsp: 1.768 ± 1.216
3.093GlnGlu: 3.093 ± 1.186
0.442GlnPhe: 0.442 ± 0.336
3.093GlnGly: 3.093 ± 0.9
0.442GlnHis: 0.442 ± 0.341
4.861GlnIle: 4.861 ± 1.116
3.535GlnLys: 3.535 ± 1.647
3.093GlnLeu: 3.093 ± 1.574
0.884GlnMet: 0.884 ± 0.383
2.209GlnAsn: 2.209 ± 0.551
1.768GlnPro: 1.768 ± 0.78
0.884GlnGln: 0.884 ± 0.383
1.326GlnArg: 1.326 ± 0.398
2.209GlnSer: 2.209 ± 0.597
2.651GlnThr: 2.651 ± 0.909
1.326GlnVal: 1.326 ± 0.978
1.768GlnTrp: 1.768 ± 0.517
3.093GlnTyr: 3.093 ± 1.586
0.0GlnXaa: 0.0 ± 0.0
Arg
1.326ArgAla: 1.326 ± 0.714
1.326ArgCys: 1.326 ± 0.478
0.0ArgAsp: 0.0 ± 0.0
3.093ArgGlu: 3.093 ± 1.621
4.419ArgPhe: 4.419 ± 0.78
1.326ArgGly: 1.326 ± 0.635
0.442ArgHis: 0.442 ± 0.336
2.209ArgIle: 2.209 ± 0.619
3.977ArgLys: 3.977 ± 0.64
3.977ArgLeu: 3.977 ± 0.508
0.884ArgMet: 0.884 ± 0.608
1.768ArgAsn: 1.768 ± 0.552
2.651ArgPro: 2.651 ± 1.169
1.326ArgGln: 1.326 ± 0.46
1.326ArgArg: 1.326 ± 1.022
1.326ArgSer: 1.326 ± 0.536
2.209ArgThr: 2.209 ± 0.61
0.884ArgVal: 0.884 ± 0.682
0.442ArgTrp: 0.442 ± 0.341
0.442ArgTyr: 0.442 ± 0.341
0.0ArgXaa: 0.0 ± 0.0
Ser
2.209SerAla: 2.209 ± 0.85
0.884SerCys: 0.884 ± 0.673
5.303SerAsp: 5.303 ± 0.734
9.28SerGlu: 9.28 ± 2.444
5.303SerPhe: 5.303 ± 0.842
3.535SerGly: 3.535 ± 0.728
2.209SerHis: 2.209 ± 0.934
4.419SerIle: 4.419 ± 1.719
10.163SerLys: 10.163 ± 2.316
7.512SerLeu: 7.512 ± 2.559
1.768SerMet: 1.768 ± 0.663
5.303SerAsn: 5.303 ± 0.56
5.745SerPro: 5.745 ± 0.753
2.651SerGln: 2.651 ± 0.673
1.326SerArg: 1.326 ± 0.589
11.489SerSer: 11.489 ± 2.626
4.419SerThr: 4.419 ± 1.167
5.303SerVal: 5.303 ± 2.141
0.442SerTrp: 0.442 ± 0.445
3.093SerTyr: 3.093 ± 1.208
0.0SerXaa: 0.0 ± 0.0
Thr
2.651ThrAla: 2.651 ± 0.801
1.326ThrCys: 1.326 ± 0.648
3.093ThrAsp: 3.093 ± 1.099
1.326ThrGlu: 1.326 ± 0.813
1.768ThrPhe: 1.768 ± 1.086
1.326ThrGly: 1.326 ± 0.635
1.768ThrHis: 1.768 ± 0.972
2.651ThrIle: 2.651 ± 1.372
3.977ThrLys: 3.977 ± 0.915
4.861ThrLeu: 4.861 ± 1.501
0.442ThrMet: 0.442 ± 0.349
4.861ThrAsn: 4.861 ± 1.19
1.326ThrPro: 1.326 ± 0.698
1.768ThrGln: 1.768 ± 1.069
0.442ThrArg: 0.442 ± 0.336
3.977ThrSer: 3.977 ± 1.109
3.093ThrThr: 3.093 ± 1.605
1.768ThrVal: 1.768 ± 0.766
0.884ThrTrp: 0.884 ± 0.682
2.209ThrTyr: 2.209 ± 1.033
0.0ThrXaa: 0.0 ± 0.0
Val
1.326ValAla: 1.326 ± 0.808
0.884ValCys: 0.884 ± 0.383
1.768ValAsp: 1.768 ± 0.972
2.651ValGlu: 2.651 ± 0.552
2.209ValPhe: 2.209 ± 0.855
2.209ValGly: 2.209 ± 0.987
0.0ValHis: 0.0 ± 0.0
3.977ValIle: 3.977 ± 1.705
4.861ValLys: 4.861 ± 1.111
3.093ValLeu: 3.093 ± 0.495
0.442ValMet: 0.442 ± 0.317
4.419ValAsn: 4.419 ± 1.001
0.884ValPro: 0.884 ± 0.356
0.884ValGln: 0.884 ± 0.673
2.209ValArg: 2.209 ± 0.61
3.535ValSer: 3.535 ± 0.856
0.442ValThr: 0.442 ± 0.445
3.977ValVal: 3.977 ± 0.496
0.0ValTrp: 0.0 ± 0.0
2.209ValTyr: 2.209 ± 0.843
0.0ValXaa: 0.0 ± 0.0
Trp
0.884TrpAla: 0.884 ± 0.535
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.442TrpGlu: 0.442 ± 0.336
0.0TrpPhe: 0.0 ± 0.0
0.884TrpGly: 0.884 ± 0.356
0.0TrpHis: 0.0 ± 0.0
0.442TrpIle: 0.442 ± 0.349
0.442TrpLys: 0.442 ± 0.349
0.442TrpLeu: 0.442 ± 0.341
0.442TrpMet: 0.442 ± 0.341
0.884TrpAsn: 0.884 ± 0.682
0.884TrpPro: 0.884 ± 1.411
1.768TrpGln: 1.768 ± 0.923
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
0.884TrpThr: 0.884 ± 0.383
0.442TrpVal: 0.442 ± 0.349
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.651TyrAla: 2.651 ± 0.673
1.326TyrCys: 1.326 ± 0.335
0.884TyrAsp: 0.884 ± 0.356
2.209TyrGlu: 2.209 ± 0.918
0.884TyrPhe: 0.884 ± 0.383
2.209TyrGly: 2.209 ± 0.551
1.326TyrHis: 1.326 ± 0.681
2.209TyrIle: 2.209 ± 0.94
3.977TyrLys: 3.977 ± 0.962
3.535TyrLeu: 3.535 ± 0.969
0.884TyrMet: 0.884 ± 0.383
0.884TyrAsn: 0.884 ± 0.673
1.768TyrPro: 1.768 ± 0.665
1.768TyrGln: 1.768 ± 0.923
0.442TyrArg: 0.442 ± 0.336
3.977TyrSer: 3.977 ± 1.105
3.977TyrThr: 3.977 ± 1.123
2.651TyrVal: 2.651 ± 1.583
0.442TyrTrp: 0.442 ± 0.341
0.884TyrTyr: 0.884 ± 0.494
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2264 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski