Amino acid dipepetide frequency for Pelagivirga sediminicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.329AlaAla: 18.329 ± 0.199	1.194AlaCys: 1.194 ± 0.036	7.191AlaAsp: 7.191 ± 0.089	8.094AlaGlu: 8.094 ± 0.103	4.237AlaPhe: 4.237 ± 0.057	10.933AlaGly: 10.933 ± 0.121	2.59AlaHis: 2.59 ± 0.047	6.153AlaIle: 6.153 ± 0.075	3.581AlaLys: 3.581 ± 0.061	14.534AlaLeu: 14.534 ± 0.136	4.022AlaMet: 4.022 ± 0.052	2.592AlaAsn: 2.592 ± 0.048	6.584AlaPro: 6.584 ± 0.091	4.888AlaGln: 4.888 ± 0.082	9.874AlaArg: 9.874 ± 0.12	5.614AlaSer: 5.614 ± 0.069	5.662AlaThr: 5.662 ± 0.073	8.236AlaVal: 8.236 ± 0.091	1.552AlaTrp: 1.552 ± 0.04	2.541AlaTyr: 2.541 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.164CysAla: 1.164 ± 0.033	0.114CysCys: 0.114 ± 0.01	0.673CysAsp: 0.673 ± 0.026	0.433CysGlu: 0.433 ± 0.02	0.307CysPhe: 0.307 ± 0.016	0.966CysGly: 0.966 ± 0.031	0.303CysHis: 0.303 ± 0.019	0.459CysIle: 0.459 ± 0.018	0.219CysLys: 0.219 ± 0.015	0.78CysLeu: 0.78 ± 0.025	0.167CysMet: 0.167 ± 0.013	0.235CysAsn: 0.235 ± 0.016	0.515CysPro: 0.515 ± 0.023	0.214CysGln: 0.214 ± 0.013	0.594CysArg: 0.594 ± 0.024	0.432CysSer: 0.432 ± 0.019	0.482CysThr: 0.482 ± 0.021	0.639CysVal: 0.639 ± 0.028	0.114CysTrp: 0.114 ± 0.01	0.226CysTyr: 0.226 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.195AspAla: 8.195 ± 0.094	0.535AspCys: 0.535 ± 0.023	3.661AspAsp: 3.661 ± 0.073	3.657AspGlu: 3.657 ± 0.072	2.217AspPhe: 2.217 ± 0.047	5.581AspGly: 5.581 ± 0.076	1.313AspHis: 1.313 ± 0.033	3.383AspIle: 3.383 ± 0.056	1.7AspLys: 1.7 ± 0.043	6.65AspLeu: 6.65 ± 0.075	1.934AspMet: 1.934 ± 0.041	1.163AspAsn: 1.163 ± 0.032	3.562AspPro: 3.562 ± 0.064	1.836AspGln: 1.836 ± 0.038	4.18AspArg: 4.18 ± 0.062	2.15AspSer: 2.15 ± 0.046	3.091AspThr: 3.091 ± 0.05	4.31AspVal: 4.31 ± 0.068	1.139AspTrp: 1.139 ± 0.035	1.486AspTyr: 1.486 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.936GluAla: 7.936 ± 0.095	0.387GluCys: 0.387 ± 0.019	3.453GluAsp: 3.453 ± 0.066	3.28GluGlu: 3.28 ± 0.074	1.776GluPhe: 1.776 ± 0.037	4.919GluGly: 4.919 ± 0.075	1.079GluHis: 1.079 ± 0.032	3.416GluIle: 3.416 ± 0.056	2.019GluLys: 2.019 ± 0.057	4.694GluLeu: 4.694 ± 0.065	1.905GluMet: 1.905 ± 0.042	1.648GluAsn: 1.648 ± 0.042	2.422GluPro: 2.422 ± 0.047	1.867GluGln: 1.867 ± 0.042	4.448GluArg: 4.448 ± 0.076	1.973GluSer: 1.973 ± 0.042	3.419GluThr: 3.419 ± 0.065	4.013GluVal: 4.013 ± 0.058	0.782GluTrp: 0.782 ± 0.025	1.099GluTyr: 1.099 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.422PheAla: 4.422 ± 0.066	0.41PheCys: 0.41 ± 0.018	2.674PheAsp: 2.674 ± 0.051	2.104PheGlu: 2.104 ± 0.043	1.415PhePhe: 1.415 ± 0.036	3.609PheGly: 3.609 ± 0.058	0.754PheHis: 0.754 ± 0.026	1.673PheIle: 1.673 ± 0.045	0.863PheLys: 0.863 ± 0.03	3.283PheLeu: 3.283 ± 0.056	0.857PheMet: 0.857 ± 0.029	0.978PheAsn: 0.978 ± 0.031	1.466PhePro: 1.466 ± 0.041	1.051PheGln: 1.051 ± 0.031	2.08PheArg: 2.08 ± 0.047	2.0PheSer: 2.0 ± 0.045	1.949PheThr: 1.949 ± 0.044	2.496PheVal: 2.496 ± 0.049	0.561PheTrp: 0.561 ± 0.024	0.922PheTyr: 0.922 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	11.335GlyAla: 11.335 ± 0.126	0.862GlyCys: 0.862 ± 0.03	5.065GlyAsp: 5.065 ± 0.07	4.517GlyGlu: 4.517 ± 0.066	3.434GlyPhe: 3.434 ± 0.054	7.741GlyGly: 7.741 ± 0.106	1.918GlyHis: 1.918 ± 0.051	4.652GlyIle: 4.652 ± 0.079	3.052GlyLys: 3.052 ± 0.062	9.0GlyLeu: 9.0 ± 0.101	2.698GlyMet: 2.698 ± 0.052	1.992GlyAsn: 1.992 ± 0.042	3.732GlyPro: 3.732 ± 0.058	3.158GlyGln: 3.158 ± 0.055	6.172GlyArg: 6.172 ± 0.077	4.137GlySer: 4.137 ± 0.062	4.852GlyThr: 4.852 ± 0.068	6.047GlyVal: 6.047 ± 0.081	1.547GlyTrp: 1.547 ± 0.04	2.321GlyTyr: 2.321 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.468HisAla: 2.468 ± 0.049	0.24HisCys: 0.24 ± 0.014	1.37HisAsp: 1.37 ± 0.033	1.082HisGlu: 1.082 ± 0.034	0.799HisPhe: 0.799 ± 0.029	1.917HisGly: 1.917 ± 0.046	0.551HisHis: 0.551 ± 0.021	1.013HisIle: 1.013 ± 0.034	0.53HisLys: 0.53 ± 0.022	2.134HisLeu: 2.134 ± 0.047	0.582HisMet: 0.582 ± 0.018	0.433HisAsn: 0.433 ± 0.021	1.378HisPro: 1.378 ± 0.035	0.569HisGln: 0.569 ± 0.02	1.363HisArg: 1.363 ± 0.038	1.004HisSer: 1.004 ± 0.029	0.834HisThr: 0.834 ± 0.027	1.55HisVal: 1.55 ± 0.036	0.353HisTrp: 0.353 ± 0.019	0.569HisTyr: 0.569 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.563IleAla: 7.563 ± 0.101	0.671IleCys: 0.671 ± 0.024	3.634IleAsp: 3.634 ± 0.055	3.589IleGlu: 3.589 ± 0.054	1.804IlePhe: 1.804 ± 0.043	5.071IleGly: 5.071 ± 0.074	0.882IleHis: 0.882 ± 0.028	2.512IleIle: 2.512 ± 0.047	1.481IleLys: 1.481 ± 0.037	4.832IleLeu: 4.832 ± 0.077	1.167IleMet: 1.167 ± 0.033	1.343IleAsn: 1.343 ± 0.039	2.37IlePro: 2.37 ± 0.046	1.123IleGln: 1.123 ± 0.033	3.181IleArg: 3.181 ± 0.05	2.977IleSer: 2.977 ± 0.049	3.002IleThr: 3.002 ± 0.053	4.026IleVal: 4.026 ± 0.06	0.743IleTrp: 0.743 ± 0.028	1.194IleTyr: 1.194 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.612LysAla: 3.612 ± 0.062	0.18LysCys: 0.18 ± 0.012	1.848LysAsp: 1.848 ± 0.046	1.388LysGlu: 1.388 ± 0.042	0.929LysPhe: 0.929 ± 0.03	2.685LysGly: 2.685 ± 0.053	0.583LysHis: 0.583 ± 0.024	1.577LysIle: 1.577 ± 0.041	1.156LysLys: 1.156 ± 0.034	2.938LysLeu: 2.938 ± 0.057	0.882LysMet: 0.882 ± 0.028	0.774LysAsn: 0.774 ± 0.025	1.757LysPro: 1.757 ± 0.049	0.874LysGln: 0.874 ± 0.026	2.276LysArg: 2.276 ± 0.049	1.808LysSer: 1.808 ± 0.044	1.816LysThr: 1.816 ± 0.041	2.113LysVal: 2.113 ± 0.049	0.412LysTrp: 0.412 ± 0.021	0.621LysTyr: 0.621 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.122LeuAla: 13.122 ± 0.132	0.922LeuCys: 0.922 ± 0.032	6.128LeuAsp: 6.128 ± 0.081	5.287LeuGlu: 5.287 ± 0.07	3.364LeuPhe: 3.364 ± 0.061	8.612LeuGly: 8.612 ± 0.114	1.957LeuHis: 1.957 ± 0.043	5.565LeuIle: 5.565 ± 0.074	3.188LeuLys: 3.188 ± 0.058	9.048LeuLeu: 9.048 ± 0.117	2.786LeuMet: 2.786 ± 0.058	2.578LeuAsn: 2.578 ± 0.049	5.538LeuPro: 5.538 ± 0.088	2.747LeuGln: 2.747 ± 0.051	7.3LeuArg: 7.3 ± 0.097	6.313LeuSer: 6.313 ± 0.079	5.966LeuThr: 5.966 ± 0.08	6.512LeuVal: 6.512 ± 0.078	1.312LeuTrp: 1.312 ± 0.04	1.988LeuTyr: 1.988 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.66MetAla: 3.66 ± 0.058	0.195MetCys: 0.195 ± 0.012	1.594MetAsp: 1.594 ± 0.039	1.338MetGlu: 1.338 ± 0.036	0.82MetPhe: 0.82 ± 0.028	2.383MetGly: 2.383 ± 0.051	0.497MetHis: 0.497 ± 0.022	1.722MetIle: 1.722 ± 0.041	1.055MetLys: 1.055 ± 0.029	2.742MetLeu: 2.742 ± 0.043	0.877MetMet: 0.877 ± 0.03	0.82MetAsn: 0.82 ± 0.024	1.651MetPro: 1.651 ± 0.038	1.147MetGln: 1.147 ± 0.03	2.132MetArg: 2.132 ± 0.043	1.86MetSer: 1.86 ± 0.041	2.179MetThr: 2.179 ± 0.042	1.817MetVal: 1.817 ± 0.048	0.259MetTrp: 0.259 ± 0.015	0.351MetTyr: 0.351 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.025AsnAla: 3.025 ± 0.053	0.224AsnCys: 0.224 ± 0.012	1.352AsnAsp: 1.352 ± 0.039	1.122AsnGlu: 1.122 ± 0.034	0.928AsnPhe: 0.928 ± 0.028	2.158AsnGly: 2.158 ± 0.046	0.497AsnHis: 0.497 ± 0.023	1.359AsnIle: 1.359 ± 0.037	0.624AsnLys: 0.624 ± 0.023	2.396AsnLeu: 2.396 ± 0.045	0.704AsnMet: 0.704 ± 0.027	0.588AsnAsn: 0.588 ± 0.023	1.682AsnPro: 1.682 ± 0.04	0.645AsnGln: 0.645 ± 0.024	1.541AsnArg: 1.541 ± 0.042	1.138AsnSer: 1.138 ± 0.032	1.267AsnThr: 1.267 ± 0.033	1.794AsnVal: 1.794 ± 0.04	0.4AsnTrp: 0.4 ± 0.02	0.59AsnTyr: 0.59 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.994ProAla: 5.994 ± 0.085	0.386ProCys: 0.386 ± 0.019	4.091ProAsp: 4.091 ± 0.058	3.888ProGlu: 3.888 ± 0.062	1.901ProPhe: 1.901 ± 0.043	4.945ProGly: 4.945 ± 0.074	1.086ProHis: 1.086 ± 0.033	2.175ProIle: 2.175 ± 0.045	1.626ProLys: 1.626 ± 0.042	4.81ProLeu: 4.81 ± 0.079	1.349ProMet: 1.349 ± 0.035	1.176ProAsn: 1.176 ± 0.03	2.369ProPro: 2.369 ± 0.051	1.762ProGln: 1.762 ± 0.04	2.983ProArg: 2.983 ± 0.062	2.515ProSer: 2.515 ± 0.045	2.15ProThr: 2.15 ± 0.039	4.065ProVal: 4.065 ± 0.063	0.693ProTrp: 0.693 ± 0.029	1.151ProTyr: 1.151 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.932GlnAla: 3.932 ± 0.067	0.195GlnCys: 0.195 ± 0.013	1.831GlnAsp: 1.831 ± 0.04	1.539GlnGlu: 1.539 ± 0.038	1.027GlnPhe: 1.027 ± 0.03	2.691GlnGly: 2.691 ± 0.047	0.608GlnHis: 0.608 ± 0.023	2.211GlnIle: 2.211 ± 0.05	1.09GlnLys: 1.09 ± 0.034	2.827GlnLeu: 2.827 ± 0.046	1.222GlnMet: 1.222 ± 0.036	0.89GlnAsn: 0.89 ± 0.027	1.644GlnPro: 1.644 ± 0.043	1.115GlnGln: 1.115 ± 0.035	2.339GlnArg: 2.339 ± 0.057	1.874GlnSer: 1.874 ± 0.041	1.993GlnThr: 1.993 ± 0.044	2.203GlnVal: 2.203 ± 0.044	0.398GlnTrp: 0.398 ± 0.019	0.564GlnTyr: 0.564 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.022ArgAla: 9.022 ± 0.1	0.562ArgCys: 0.562 ± 0.024	4.444ArgAsp: 4.444 ± 0.056	3.891ArgGlu: 3.891 ± 0.069	2.534ArgPhe: 2.534 ± 0.049	5.046ArgGly: 5.046 ± 0.069	1.73ArgHis: 1.73 ± 0.045	4.161ArgIle: 4.161 ± 0.07	2.353ArgLys: 2.353 ± 0.05	7.326ArgLeu: 7.326 ± 0.09	2.076ArgMet: 2.076 ± 0.043	1.708ArgAsn: 1.708 ± 0.039	3.345ArgPro: 3.345 ± 0.059	2.456ArgGln: 2.456 ± 0.047	5.714ArgArg: 5.714 ± 0.099	3.451ArgSer: 3.451 ± 0.064	3.116ArgThr: 3.116 ± 0.05	4.711ArgVal: 4.711 ± 0.065	0.957ArgTrp: 0.957 ± 0.031	1.635ArgTyr: 1.635 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.18SerAla: 6.18 ± 0.074	0.475SerCys: 0.475 ± 0.02	3.304SerAsp: 3.304 ± 0.057	2.704SerGlu: 2.704 ± 0.052	2.004SerPhe: 2.004 ± 0.037	5.424SerGly: 5.424 ± 0.062	1.069SerHis: 1.069 ± 0.03	2.508SerIle: 2.508 ± 0.049	1.398SerLys: 1.398 ± 0.039	4.813SerLeu: 4.813 ± 0.076	1.306SerMet: 1.306 ± 0.038	1.236SerAsn: 1.236 ± 0.031	2.36SerPro: 2.36 ± 0.046	1.582SerGln: 1.582 ± 0.038	3.249SerArg: 3.249 ± 0.06	2.53SerSer: 2.53 ± 0.061	2.409SerThr: 2.409 ± 0.05	3.735SerVal: 3.735 ± 0.058	0.678SerTrp: 0.678 ± 0.023	1.316SerTyr: 1.316 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.219ThrAla: 6.219 ± 0.078	0.452ThrCys: 0.452 ± 0.021	3.174ThrAsp: 3.174 ± 0.055	2.786ThrGlu: 2.786 ± 0.051	1.927ThrPhe: 1.927 ± 0.038	5.419ThrGly: 5.419 ± 0.069	1.121ThrHis: 1.121 ± 0.033	2.71ThrIle: 2.71 ± 0.048	1.344ThrLys: 1.344 ± 0.039	6.042ThrLeu: 6.042 ± 0.082	1.32ThrMet: 1.32 ± 0.033	1.149ThrAsn: 1.149 ± 0.035	3.281ThrPro: 3.281 ± 0.054	1.561ThrGln: 1.561 ± 0.038	3.623ThrArg: 3.623 ± 0.057	2.696ThrSer: 2.696 ± 0.051	2.54ThrThr: 2.54 ± 0.048	3.975ThrVal: 3.975 ± 0.053	0.683ThrTrp: 0.683 ± 0.025	1.243ThrTyr: 1.243 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.218ValAla: 8.218 ± 0.1	0.628ValCys: 0.628 ± 0.023	3.907ValAsp: 3.907 ± 0.063	4.001ValGlu: 4.001 ± 0.065	2.714ValPhe: 2.714 ± 0.047	5.065ValGly: 5.065 ± 0.073	1.326ValHis: 1.326 ± 0.037	4.187ValIle: 4.187 ± 0.071	1.923ValLys: 1.923 ± 0.042	7.367ValLeu: 7.367 ± 0.085	2.271ValMet: 2.271 ± 0.048	1.741ValAsn: 1.741 ± 0.037	3.641ValPro: 3.641 ± 0.051	2.296ValGln: 2.296 ± 0.046	4.454ValArg: 4.454 ± 0.066	3.904ValSer: 3.904 ± 0.065	4.517ValThr: 4.517 ± 0.072	5.116ValVal: 5.116 ± 0.087	0.94ValTrp: 0.94 ± 0.032	1.448ValTyr: 1.448 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.433TrpAla: 1.433 ± 0.039	0.16TrpCys: 0.16 ± 0.012	0.781TrpAsp: 0.781 ± 0.026	0.605TrpGlu: 0.605 ± 0.027	0.57TrpPhe: 0.57 ± 0.023	0.973TrpGly: 0.973 ± 0.032	0.333TrpHis: 0.333 ± 0.016	0.751TrpIle: 0.751 ± 0.03	0.464TrpLys: 0.464 ± 0.024	1.729TrpLeu: 1.729 ± 0.043	0.442TrpMet: 0.442 ± 0.019	0.425TrpAsn: 0.425 ± 0.021	0.715TrpPro: 0.715 ± 0.027	0.623TrpGln: 0.623 ± 0.024	1.166TrpArg: 1.166 ± 0.031	0.795TrpSer: 0.795 ± 0.025	0.859TrpThr: 0.859 ± 0.027	0.779TrpVal: 0.779 ± 0.027	0.237TrpTrp: 0.237 ± 0.015	0.272TrpTyr: 0.272 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.574TyrAla: 2.574 ± 0.047	0.247TyrCys: 0.247 ± 0.015	1.568TyrAsp: 1.568 ± 0.04	1.226TyrGlu: 1.226 ± 0.039	0.863TyrPhe: 0.863 ± 0.027	2.094TyrGly: 2.094 ± 0.038	0.543TyrHis: 0.543 ± 0.023	0.977TyrIle: 0.977 ± 0.031	0.567TyrLys: 0.567 ± 0.023	2.287TyrLeu: 2.287 ± 0.042	0.529TyrMet: 0.529 ± 0.023	0.565TyrAsn: 0.565 ± 0.02	1.104TyrPro: 1.104 ± 0.033	0.677TyrGln: 0.677 ± 0.023	1.571TyrArg: 1.571 ± 0.038	1.111TyrSer: 1.111 ± 0.033	1.16TyrThr: 1.16 ± 0.033	1.527TyrVal: 1.527 ± 0.043	0.353TyrTrp: 0.353 ± 0.016	0.572TyrTyr: 0.572 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3729 proteins (1158833 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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