Amino acid dipepetide frequency for Limnohabitans sp. 2KL-17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.068AlaAla: 14.068 ± 0.24
1.331AlaCys: 1.331 ± 0.039
6.098AlaAsp: 6.098 ± 0.098
6.024AlaGlu: 6.024 ± 0.094
3.816AlaPhe: 3.816 ± 0.058
9.039AlaGly: 9.039 ± 0.126
2.684AlaHis: 2.684 ± 0.056
5.059AlaIle: 5.059 ± 0.087
4.835AlaLys: 4.835 ± 0.105
14.053AlaLeu: 14.053 ± 0.141
3.644AlaMet: 3.644 ± 0.068
3.194AlaAsn: 3.194 ± 0.078
5.055AlaPro: 5.055 ± 0.086
6.445AlaGln: 6.445 ± 0.106
6.533AlaArg: 6.533 ± 0.099
6.779AlaSer: 6.779 ± 0.092
5.707AlaThr: 5.707 ± 0.101
8.259AlaVal: 8.259 ± 0.096
1.985AlaTrp: 1.985 ± 0.051
2.445AlaTyr: 2.445 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
1.12CysAla: 1.12 ± 0.037
0.129CysCys: 0.129 ± 0.011
0.539CysAsp: 0.539 ± 0.022
0.572CysGlu: 0.572 ± 0.024
0.323CysPhe: 0.323 ± 0.018
0.998CysGly: 0.998 ± 0.036
0.298CysHis: 0.298 ± 0.017
0.453CysIle: 0.453 ± 0.023
0.302CysLys: 0.302 ± 0.017
0.918CysLeu: 0.918 ± 0.032
0.266CysMet: 0.266 ± 0.017
0.282CysAsn: 0.282 ± 0.018
0.517CysPro: 0.517 ± 0.025
0.349CysGln: 0.349 ± 0.019
0.483CysArg: 0.483 ± 0.019
0.535CysSer: 0.535 ± 0.021
0.552CysThr: 0.552 ± 0.024
0.758CysVal: 0.758 ± 0.033
0.137CysTrp: 0.137 ± 0.012
0.186CysTyr: 0.186 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
6.348AspAla: 6.348 ± 0.093
0.471AspCys: 0.471 ± 0.024
2.368AspAsp: 2.368 ± 0.058
2.923AspGlu: 2.923 ± 0.057
2.087AspPhe: 2.087 ± 0.047
4.004AspGly: 4.004 ± 0.085
1.166AspHis: 1.166 ± 0.031
2.587AspIle: 2.587 ± 0.064
2.195AspLys: 2.195 ± 0.051
5.55AspLeu: 5.55 ± 0.081
1.479AspMet: 1.479 ± 0.039
1.412AspAsn: 1.412 ± 0.046
2.579AspPro: 2.579 ± 0.06
1.863AspGln: 1.863 ± 0.044
2.843AspArg: 2.843 ± 0.057
2.372AspSer: 2.372 ± 0.064
2.58AspThr: 2.58 ± 0.061
3.995AspVal: 3.995 ± 0.061
0.957AspTrp: 0.957 ± 0.029
1.302AspTyr: 1.302 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
6.193GluAla: 6.193 ± 0.096
0.41GluCys: 0.41 ± 0.02
2.269GluAsp: 2.269 ± 0.047
2.394GluGlu: 2.394 ± 0.055
1.825GluPhe: 1.825 ± 0.043
3.754GluGly: 3.754 ± 0.076
1.323GluHis: 1.323 ± 0.038
2.775GluIle: 2.775 ± 0.063
2.414GluLys: 2.414 ± 0.059
5.383GluLeu: 5.383 ± 0.092
1.355GluMet: 1.355 ± 0.037
1.439GluAsn: 1.439 ± 0.038
2.255GluPro: 2.255 ± 0.055
2.555GluGln: 2.555 ± 0.056
3.807GluArg: 3.807 ± 0.072
2.657GluSer: 2.657 ± 0.051
2.592GluThr: 2.592 ± 0.045
4.075GluVal: 4.075 ± 0.071
0.767GluTrp: 0.767 ± 0.028
0.933GluTyr: 0.933 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.858PheAla: 3.858 ± 0.07
0.397PheCys: 0.397 ± 0.021
2.394PheAsp: 2.394 ± 0.052
2.241PheGlu: 2.241 ± 0.052
1.392PhePhe: 1.392 ± 0.046
3.179PheGly: 3.179 ± 0.062
0.778PheHis: 0.778 ± 0.024
1.593PheIle: 1.593 ± 0.046
1.657PheLys: 1.657 ± 0.042
3.0PheLeu: 3.0 ± 0.066
0.994PheMet: 0.994 ± 0.031
1.276PheAsn: 1.276 ± 0.032
1.447PhePro: 1.447 ± 0.041
1.158PheGln: 1.158 ± 0.041
1.619PheArg: 1.619 ± 0.04
2.306PheSer: 2.306 ± 0.051
2.061PheThr: 2.061 ± 0.055
2.757PheVal: 2.757 ± 0.066
0.613PheTrp: 0.613 ± 0.025
0.878PheTyr: 0.878 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
8.223GlyAla: 8.223 ± 0.164
0.908GlyCys: 0.908 ± 0.031
3.662GlyAsp: 3.662 ± 0.067
4.011GlyGlu: 4.011 ± 0.075
3.226GlyPhe: 3.226 ± 0.058
6.603GlyGly: 6.603 ± 0.153
2.065GlyHis: 2.065 ± 0.048
3.988GlyIle: 3.988 ± 0.073
3.561GlyLys: 3.561 ± 0.077
9.248GlyLeu: 9.248 ± 0.1
2.489GlyMet: 2.489 ± 0.054
2.253GlyAsn: 2.253 ± 0.065
2.917GlyPro: 2.917 ± 0.055
4.306GlyGln: 4.306 ± 0.075
4.452GlyArg: 4.452 ± 0.088
4.614GlySer: 4.614 ± 0.093
4.353GlyThr: 4.353 ± 0.124
6.375GlyVal: 6.375 ± 0.091
1.445GlyTrp: 1.445 ± 0.04
2.136GlyTyr: 2.136 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
2.838HisAla: 2.838 ± 0.056
0.317HisCys: 0.317 ± 0.017
1.144HisAsp: 1.144 ± 0.034
1.195HisGlu: 1.195 ± 0.042
0.938HisPhe: 0.938 ± 0.029
2.101HisGly: 2.101 ± 0.054
0.664HisHis: 0.664 ± 0.03
1.156HisIle: 1.156 ± 0.032
0.736HisLys: 0.736 ± 0.027
2.441HisLeu: 2.441 ± 0.048
0.637HisMet: 0.637 ± 0.026
0.594HisAsn: 0.594 ± 0.025
1.459HisPro: 1.459 ± 0.037
0.963HisGln: 0.963 ± 0.03
1.38HisArg: 1.38 ± 0.038
1.144HisSer: 1.144 ± 0.031
1.172HisThr: 1.172 ± 0.035
1.686HisVal: 1.686 ± 0.043
0.462HisTrp: 0.462 ± 0.021
0.617HisTyr: 0.617 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.355IleAla: 5.355 ± 0.075
0.475IleCys: 0.475 ± 0.024
3.086IleAsp: 3.086 ± 0.061
3.312IleGlu: 3.312 ± 0.069
1.419IlePhe: 1.419 ± 0.039
4.056IleGly: 4.056 ± 0.061
0.939IleHis: 0.939 ± 0.03
1.703IleIle: 1.703 ± 0.046
1.944IleLys: 1.944 ± 0.048
3.652IleLeu: 3.652 ± 0.069
0.956IleMet: 0.956 ± 0.034
1.723IleAsn: 1.723 ± 0.056
2.039IlePro: 2.039 ± 0.048
1.796IleGln: 1.796 ± 0.036
2.56IleArg: 2.56 ± 0.059
2.875IleSer: 2.875 ± 0.06
2.964IleThr: 2.964 ± 0.099
3.323IleVal: 3.323 ± 0.059
0.587IleTrp: 0.587 ± 0.023
1.054IleTyr: 1.054 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
5.135LysAla: 5.135 ± 0.111
0.237LysCys: 0.237 ± 0.017
2.122LysAsp: 2.122 ± 0.052
1.859LysGlu: 1.859 ± 0.053
1.237LysPhe: 1.237 ± 0.042
2.931LysGly: 2.931 ± 0.062
0.835LysHis: 0.835 ± 0.028
2.011LysIle: 2.011 ± 0.053
1.988LysLys: 1.988 ± 0.062
4.203LysLeu: 4.203 ± 0.072
1.041LysMet: 1.041 ± 0.034
1.368LysAsn: 1.368 ± 0.037
2.535LysPro: 2.535 ± 0.062
1.499LysGln: 1.499 ± 0.044
2.307LysArg: 2.307 ± 0.051
2.379LysSer: 2.379 ± 0.053
2.574LysThr: 2.574 ± 0.058
3.056LysVal: 3.056 ± 0.058
0.432LysTrp: 0.432 ± 0.019
0.784LysTyr: 0.784 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
13.478LeuAla: 13.478 ± 0.151
1.053LeuCys: 1.053 ± 0.028
5.525LeuAsp: 5.525 ± 0.08
4.864LeuGlu: 4.864 ± 0.088
3.407LeuPhe: 3.407 ± 0.062
8.465LeuGly: 8.465 ± 0.107
2.464LeuHis: 2.464 ± 0.055
4.637LeuIle: 4.637 ± 0.083
4.562LeuLys: 4.562 ± 0.07
10.658LeuLeu: 10.658 ± 0.146
3.045LeuMet: 3.045 ± 0.062
3.433LeuAsn: 3.433 ± 0.059
5.92LeuPro: 5.92 ± 0.097
5.221LeuGln: 5.221 ± 0.08
6.353LeuArg: 6.353 ± 0.105
7.008LeuSer: 7.008 ± 0.09
5.809LeuThr: 5.809 ± 0.109
7.681LeuVal: 7.681 ± 0.112
1.455LeuTrp: 1.455 ± 0.044
1.96LeuTyr: 1.96 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
3.639MetAla: 3.639 ± 0.058
0.208MetCys: 0.208 ± 0.014
1.335MetAsp: 1.335 ± 0.038
1.069MetGlu: 1.069 ± 0.032
0.777MetPhe: 0.777 ± 0.028
2.488MetGly: 2.488 ± 0.053
0.626MetHis: 0.626 ± 0.028
1.084MetIle: 1.084 ± 0.035
1.254MetLys: 1.254 ± 0.036
2.869MetLeu: 2.869 ± 0.057
0.693MetMet: 0.693 ± 0.028
1.054MetAsn: 1.054 ± 0.032
1.542MetPro: 1.542 ± 0.037
1.302MetGln: 1.302 ± 0.034
1.693MetArg: 1.693 ± 0.042
1.887MetSer: 1.887 ± 0.047
1.735MetThr: 1.735 ± 0.043
2.059MetVal: 2.059 ± 0.056
0.245MetTrp: 0.245 ± 0.016
0.397MetTyr: 0.397 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.643AsnAla: 3.643 ± 0.07
0.295AsnCys: 0.295 ± 0.017
1.448AsnAsp: 1.448 ± 0.04
1.404AsnGlu: 1.404 ± 0.036
1.114AsnPhe: 1.114 ± 0.034
2.493AsnGly: 2.493 ± 0.073
0.628AsnHis: 0.628 ± 0.03
1.508AsnIle: 1.508 ± 0.058
1.144AsnLys: 1.144 ± 0.037
3.152AsnLeu: 3.152 ± 0.06
0.762AsnMet: 0.762 ± 0.029
0.968AsnAsn: 0.968 ± 0.037
1.994AsnPro: 1.994 ± 0.043
1.154AsnGln: 1.154 ± 0.036
1.595AsnArg: 1.595 ± 0.039
1.477AsnSer: 1.477 ± 0.05
1.922AsnThr: 1.922 ± 0.058
2.088AsnVal: 2.088 ± 0.055
0.474AsnTrp: 0.474 ± 0.021
0.727AsnTyr: 0.727 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
5.769ProAla: 5.769 ± 0.098
0.383ProCys: 0.383 ± 0.02
2.914ProAsp: 2.914 ± 0.057
3.383ProGlu: 3.383 ± 0.059
1.789ProPhe: 1.789 ± 0.052
4.199ProGly: 4.199 ± 0.073
1.167ProHis: 1.167 ± 0.035
1.989ProIle: 1.989 ± 0.043
1.852ProLys: 1.852 ± 0.048
4.942ProLeu: 4.942 ± 0.075
1.507ProMet: 1.507 ± 0.041
1.378ProAsn: 1.378 ± 0.035
2.114ProPro: 2.114 ± 0.052
2.235ProGln: 2.235 ± 0.044
2.289ProArg: 2.289 ± 0.051
2.878ProSer: 2.878 ± 0.051
2.683ProThr: 2.683 ± 0.057
4.166ProVal: 4.166 ± 0.073
0.74ProTrp: 0.74 ± 0.027
1.127ProTyr: 1.127 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
6.648GlnAla: 6.648 ± 0.105
0.327GlnCys: 0.327 ± 0.015
2.034GlnAsp: 2.034 ± 0.048
1.863GlnGlu: 1.863 ± 0.045
1.447GlnPhe: 1.447 ± 0.038
3.74GlnGly: 3.74 ± 0.067
1.111GlnHis: 1.111 ± 0.035
2.22GlnIle: 2.22 ± 0.047
1.778GlnLys: 1.778 ± 0.045
4.636GlnLeu: 4.636 ± 0.078
1.218GlnMet: 1.218 ± 0.034
1.257GlnAsn: 1.257 ± 0.041
2.159GlnPro: 2.159 ± 0.049
2.199GlnGln: 2.199 ± 0.06
3.225GlnArg: 3.225 ± 0.071
2.706GlnSer: 2.706 ± 0.061
2.727GlnThr: 2.727 ± 0.059
3.621GlnVal: 3.621 ± 0.063
0.808GlnTrp: 0.808 ± 0.028
0.811GlnTyr: 0.811 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
5.653ArgAla: 5.653 ± 0.088
0.56ArgCys: 0.56 ± 0.027
2.914ArgAsp: 2.914 ± 0.055
3.451ArgGlu: 3.451 ± 0.068
2.335ArgPhe: 2.335 ± 0.049
3.622ArgGly: 3.622 ± 0.069
1.599ArgHis: 1.599 ± 0.04
3.088ArgIle: 3.088 ± 0.057
2.173ArgLys: 2.173 ± 0.059
6.701ArgLeu: 6.701 ± 0.106
1.873ArgMet: 1.873 ± 0.04
1.651ArgAsn: 1.651 ± 0.044
2.629ArgPro: 2.629 ± 0.056
3.15ArgGln: 3.15 ± 0.071
3.33ArgArg: 3.33 ± 0.073
3.1ArgSer: 3.1 ± 0.059
2.749ArgThr: 2.749 ± 0.058
4.4ArgVal: 4.4 ± 0.08
1.151ArgTrp: 1.151 ± 0.035
1.564ArgTyr: 1.564 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
6.385SerAla: 6.385 ± 0.095
0.496SerCys: 0.496 ± 0.025
2.787SerAsp: 2.787 ± 0.072
2.768SerGlu: 2.768 ± 0.055
2.205SerPhe: 2.205 ± 0.048
5.54SerGly: 5.54 ± 0.129
1.352SerHis: 1.352 ± 0.034
2.56SerIle: 2.56 ± 0.051
2.041SerLys: 2.041 ± 0.052
6.34SerLeu: 6.34 ± 0.091
1.566SerMet: 1.566 ± 0.047
1.694SerAsn: 1.694 ± 0.055
3.075SerPro: 3.075 ± 0.05
2.529SerGln: 2.529 ± 0.056
3.261SerArg: 3.261 ± 0.063
3.373SerSer: 3.373 ± 0.08
3.149SerThr: 3.149 ± 0.082
4.457SerVal: 4.457 ± 0.072
0.817SerTrp: 0.817 ± 0.03
1.28SerTyr: 1.28 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
6.327ThrAla: 6.327 ± 0.126
0.453ThrCys: 0.453 ± 0.021
2.881ThrAsp: 2.881 ± 0.071
2.705ThrGlu: 2.705 ± 0.051
1.814ThrPhe: 1.814 ± 0.048
4.995ThrGly: 4.995 ± 0.138
1.337ThrHis: 1.337 ± 0.038
2.263ThrIle: 2.263 ± 0.068
1.578ThrLys: 1.578 ± 0.049
6.458ThrLeu: 6.458 ± 0.124
1.134ThrMet: 1.134 ± 0.031
1.454ThrAsn: 1.454 ± 0.049
3.625ThrPro: 3.625 ± 0.064
2.419ThrGln: 2.419 ± 0.055
3.055ThrArg: 3.055 ± 0.061
3.061ThrSer: 3.061 ± 0.084
2.958ThrThr: 2.958 ± 0.108
4.378ThrVal: 4.378 ± 0.082
0.784ThrTrp: 0.784 ± 0.032
1.12ThrTyr: 1.12 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
8.459ValAla: 8.459 ± 0.104
0.807ValCys: 0.807 ± 0.031
3.852ValAsp: 3.852 ± 0.061
3.558ValGlu: 3.558 ± 0.065
2.872ValPhe: 2.872 ± 0.056
5.512ValGly: 5.512 ± 0.076
1.752ValHis: 1.752 ± 0.038
3.645ValIle: 3.645 ± 0.066
3.09ValLys: 3.09 ± 0.069
8.317ValLeu: 8.317 ± 0.111
2.296ValMet: 2.296 ± 0.047
2.526ValAsn: 2.526 ± 0.056
3.81ValPro: 3.81 ± 0.064
3.538ValGln: 3.538 ± 0.064
4.333ValArg: 4.333 ± 0.071
4.463ValSer: 4.463 ± 0.082
4.322ValThr: 4.322 ± 0.113
6.325ValVal: 6.325 ± 0.096
1.109ValTrp: 1.109 ± 0.033
1.548ValTyr: 1.548 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.538TrpAla: 1.538 ± 0.044
0.217TrpCys: 0.217 ± 0.013
0.632TrpAsp: 0.632 ± 0.025
0.494TrpGlu: 0.494 ± 0.02
0.58TrpPhe: 0.58 ± 0.025
1.175TrpGly: 1.175 ± 0.038
0.428TrpHis: 0.428 ± 0.023
0.663TrpIle: 0.663 ± 0.023
0.468TrpLys: 0.468 ± 0.02
2.22TrpLeu: 2.22 ± 0.057
0.519TrpMet: 0.519 ± 0.022
0.379TrpAsn: 0.379 ± 0.02
0.792TrpPro: 0.792 ± 0.031
0.932TrpGln: 0.932 ± 0.03
1.193TrpArg: 1.193 ± 0.039
0.808TrpSer: 0.808 ± 0.027
0.84TrpThr: 0.84 ± 0.031
1.169TrpVal: 1.169 ± 0.038
0.308TrpTrp: 0.308 ± 0.02
0.27TrpTyr: 0.27 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.376TyrAla: 2.376 ± 0.053
0.243TyrCys: 0.243 ± 0.016
1.078TyrAsp: 1.078 ± 0.036
1.086TyrGlu: 1.086 ± 0.04
0.995TyrPhe: 0.995 ± 0.034
1.943TyrGly: 1.943 ± 0.051
0.427TyrHis: 0.427 ± 0.021
0.838TyrIle: 0.838 ± 0.032
0.963TyrLys: 0.963 ± 0.033
2.256TyrLeu: 2.256 ± 0.053
0.483TyrMet: 0.483 ± 0.023
0.654TyrAsn: 0.654 ± 0.029
1.041TyrPro: 1.041 ± 0.029
0.921TyrGln: 0.921 ± 0.029
1.38TyrArg: 1.38 ± 0.033
1.249TyrSer: 1.249 ± 0.044
1.352TyrThr: 1.352 ± 0.048
1.505TyrVal: 1.505 ± 0.041
0.349TyrTrp: 0.349 ± 0.02
0.508TyrTyr: 0.508 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3184 proteins (1042381 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski