Amino acid dipepetide frequency for Cavia porcellus (Guinea pig)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.823AlaAla: 6.823 ± 0.037	1.443AlaCys: 1.443 ± 0.014	2.927AlaAsp: 2.927 ± 0.016	4.817AlaGlu: 4.817 ± 0.026	2.7AlaPhe: 2.7 ± 0.017	4.683AlaGly: 4.683 ± 0.028	1.597AlaHis: 1.597 ± 0.01	2.844AlaIle: 2.844 ± 0.016	3.434AlaLys: 3.434 ± 0.022	7.375AlaLeu: 7.375 ± 0.029	1.536AlaMet: 1.536 ± 0.01	2.022AlaAsn: 2.022 ± 0.013	4.168AlaPro: 4.168 ± 0.03	3.336AlaGln: 3.336 ± 0.023	3.718AlaArg: 3.718 ± 0.023	5.818AlaSer: 5.818 ± 0.026	3.631AlaThr: 3.631 ± 0.021	4.889AlaVal: 4.889 ± 0.024	0.801AlaTrp: 0.801 ± 0.008	1.571AlaTyr: 1.571 ± 0.012	0.001AlaXaa: 0.001 ± 0.0
Cys	1.334CysAla: 1.334 ± 0.014	0.703CysCys: 0.703 ± 0.016	1.048CysAsp: 1.048 ± 0.013	1.272CysGlu: 1.272 ± 0.012	0.865CysPhe: 0.865 ± 0.008	1.718CysGly: 1.718 ± 0.024	0.691CysHis: 0.691 ± 0.009	0.972CysIle: 0.972 ± 0.01	1.164CysLys: 1.164 ± 0.013	2.196CysLeu: 2.196 ± 0.016	0.445CysMet: 0.445 ± 0.006	0.789CysAsn: 0.789 ± 0.01	1.386CysPro: 1.386 ± 0.022	1.077CysGln: 1.077 ± 0.014	1.305CysArg: 1.305 ± 0.014	2.051CysSer: 2.051 ± 0.016	1.127CysThr: 1.127 ± 0.011	1.368CysVal: 1.368 ± 0.013	0.288CysTrp: 0.288 ± 0.005	0.608CysTyr: 0.608 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	2.915AspAla: 2.915 ± 0.017	1.062AspCys: 1.062 ± 0.012	2.626AspAsp: 2.626 ± 0.02	3.365AspGlu: 3.365 ± 0.022	2.163AspPhe: 2.163 ± 0.014	3.242AspGly: 3.242 ± 0.021	1.143AspHis: 1.143 ± 0.01	2.579AspIle: 2.579 ± 0.017	2.489AspLys: 2.489 ± 0.016	5.06AspLeu: 5.06 ± 0.023	1.122AspMet: 1.122 ± 0.008	1.641AspAsn: 1.641 ± 0.012	2.932AspPro: 2.932 ± 0.015	1.824AspGln: 1.824 ± 0.012	2.479AspArg: 2.479 ± 0.016	4.235AspSer: 4.235 ± 0.025	2.543AspThr: 2.543 ± 0.014	3.02AspVal: 3.02 ± 0.018	0.624AspTrp: 0.624 ± 0.006	1.493AspTyr: 1.493 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	5.215GluAla: 5.215 ± 0.028	1.34GluCys: 1.34 ± 0.02	4.457GluAsp: 4.457 ± 0.022	7.826GluGlu: 7.826 ± 0.048	2.057GluPhe: 2.057 ± 0.013	4.116GluGly: 4.116 ± 0.02	1.521GluHis: 1.521 ± 0.011	3.098GluIle: 3.098 ± 0.019	5.177GluLys: 5.177 ± 0.033	6.49GluLeu: 6.49 ± 0.034	1.641GluMet: 1.641 ± 0.012	2.996GluAsn: 2.996 ± 0.019	3.226GluPro: 3.226 ± 0.019	3.176GluGln: 3.176 ± 0.023	3.978GluArg: 3.978 ± 0.027	4.268GluSer: 4.268 ± 0.022	3.285GluThr: 3.285 ± 0.021	4.185GluVal: 4.185 ± 0.019	0.689GluTrp: 0.689 ± 0.007	1.592GluTyr: 1.592 ± 0.011	0.0GluXaa: 0.0 ± 0.0
Phe	2.046PheAla: 2.046 ± 0.016	1.012PheCys: 1.012 ± 0.011	1.701PheAsp: 1.701 ± 0.011	1.992PheGlu: 1.992 ± 0.013	1.711PhePhe: 1.711 ± 0.016	2.246PheGly: 2.246 ± 0.015	1.065PheHis: 1.065 ± 0.01	1.891PheIle: 1.891 ± 0.014	1.762PheLys: 1.762 ± 0.013	4.269PheLeu: 4.269 ± 0.023	0.798PheMet: 0.798 ± 0.009	1.337PheAsn: 1.337 ± 0.01	2.012PhePro: 2.012 ± 0.012	1.802PheGln: 1.802 ± 0.011	1.973PheArg: 1.973 ± 0.013	3.43PheSer: 3.43 ± 0.019	2.064PheThr: 2.064 ± 0.015	2.24PheVal: 2.24 ± 0.014	0.503PheTrp: 0.503 ± 0.007	1.247PheTyr: 1.247 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	4.467GlyAla: 4.467 ± 0.026	1.319GlyCys: 1.319 ± 0.014	3.159GlyAsp: 3.159 ± 0.02	3.967GlyGlu: 3.967 ± 0.021	2.44GlyPhe: 2.44 ± 0.019	4.804GlyGly: 4.804 ± 0.033	1.7GlyHis: 1.7 ± 0.014	2.74GlyIle: 2.74 ± 0.017	3.642GlyLys: 3.642 ± 0.02	5.967GlyLeu: 5.967 ± 0.033	1.282GlyMet: 1.282 ± 0.011	2.359GlyAsn: 2.359 ± 0.014	4.196GlyPro: 4.196 ± 0.047	2.803GlyGln: 2.803 ± 0.017	3.71GlyArg: 3.71 ± 0.023	5.819GlySer: 5.819 ± 0.031	3.64GlyThr: 3.64 ± 0.021	3.549GlyVal: 3.549 ± 0.022	0.795GlyTrp: 0.795 ± 0.009	1.731GlyTyr: 1.731 ± 0.014	0.0GlyXaa: 0.0 ± 0.0
His	1.356HisAla: 1.356 ± 0.011	0.754HisCys: 0.754 ± 0.01	0.872HisAsp: 0.872 ± 0.007	1.342HisGlu: 1.342 ± 0.011	1.117HisPhe: 1.117 ± 0.009	1.551HisGly: 1.551 ± 0.012	0.878HisHis: 0.878 ± 0.011	1.274HisIle: 1.274 ± 0.01	1.248HisLys: 1.248 ± 0.011	2.961HisLeu: 2.961 ± 0.018	0.602HisMet: 0.602 ± 0.006	0.865HisAsn: 0.865 ± 0.008	1.634HisPro: 1.634 ± 0.012	1.306HisGln: 1.306 ± 0.014	1.62HisArg: 1.62 ± 0.011	2.3HisSer: 2.3 ± 0.015	1.509HisThr: 1.509 ± 0.013	1.51HisVal: 1.51 ± 0.011	0.351HisTrp: 0.351 ± 0.005	0.829HisTyr: 0.829 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	2.6IleAla: 2.6 ± 0.017	1.104IleCys: 1.104 ± 0.01	1.989IleAsp: 1.989 ± 0.015	2.532IleGlu: 2.532 ± 0.016	1.959IlePhe: 1.959 ± 0.015	2.226IleGly: 2.226 ± 0.014	1.315IleHis: 1.315 ± 0.012	2.394IleIle: 2.394 ± 0.02	2.564IleLys: 2.564 ± 0.014	4.682IleLeu: 4.682 ± 0.023	1.02IleMet: 1.02 ± 0.009	1.786IleAsn: 1.786 ± 0.014	2.586IlePro: 2.586 ± 0.019	2.251IleGln: 2.251 ± 0.013	2.388IleArg: 2.388 ± 0.017	3.647IleSer: 3.647 ± 0.018	2.55IleThr: 2.55 ± 0.016	2.544IleVal: 2.544 ± 0.018	0.508IleTrp: 0.508 ± 0.006	1.438IleTyr: 1.438 ± 0.012	0.001IleXaa: 0.001 ± 0.0
Lys	4.018LysAla: 4.018 ± 0.024	1.102LysCys: 1.102 ± 0.011	3.073LysAsp: 3.073 ± 0.02	4.923LysGlu: 4.923 ± 0.028	1.741LysPhe: 1.741 ± 0.013	3.173LysGly: 3.173 ± 0.026	1.393LysHis: 1.393 ± 0.012	2.708LysIle: 2.708 ± 0.017	4.611LysLys: 4.611 ± 0.036	5.137LysLeu: 5.137 ± 0.024	1.433LysMet: 1.433 ± 0.011	2.318LysAsn: 2.318 ± 0.018	3.018LysPro: 3.018 ± 0.018	2.592LysGln: 2.592 ± 0.018	3.244LysArg: 3.244 ± 0.019	3.776LysSer: 3.776 ± 0.021	3.0LysThr: 3.0 ± 0.019	3.443LysVal: 3.443 ± 0.017	0.591LysTrp: 0.591 ± 0.007	1.549LysTyr: 1.549 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	7.086LeuAla: 7.086 ± 0.029	2.262LeuCys: 2.262 ± 0.017	4.807LeuAsp: 4.807 ± 0.021	7.167LeuGlu: 7.167 ± 0.033	3.498LeuPhe: 3.498 ± 0.022	6.021LeuGly: 6.021 ± 0.029	2.832LeuHis: 2.832 ± 0.014	3.911LeuIle: 3.911 ± 0.023	5.725LeuLys: 5.725 ± 0.025	11.19LeuLeu: 11.19 ± 0.051	2.035LeuMet: 2.035 ± 0.013	3.465LeuAsn: 3.465 ± 0.018	6.019LeuPro: 6.019 ± 0.03	5.943LeuGln: 5.943 ± 0.034	6.065LeuArg: 6.065 ± 0.027	8.151LeuSer: 8.151 ± 0.028	5.126LeuThr: 5.126 ± 0.021	5.714LeuVal: 5.714 ± 0.023	1.156LeuTrp: 1.156 ± 0.01	2.609LeuTyr: 2.609 ± 0.017	0.0LeuXaa: 0.0 ± 0.0
Met	1.975MetAla: 1.975 ± 0.013	0.414MetCys: 0.414 ± 0.005	1.252MetAsp: 1.252 ± 0.009	1.85MetGlu: 1.85 ± 0.012	0.748MetPhe: 0.748 ± 0.008	1.303MetGly: 1.303 ± 0.011	0.474MetHis: 0.474 ± 0.006	0.855MetIle: 0.855 ± 0.009	1.421MetLys: 1.421 ± 0.01	2.036MetLeu: 2.036 ± 0.013	0.565MetMet: 0.565 ± 0.008	0.892MetAsn: 0.892 ± 0.009	1.062MetPro: 1.062 ± 0.011	0.943MetGln: 0.943 ± 0.009	1.039MetArg: 1.039 ± 0.01	1.582MetSer: 1.582 ± 0.011	1.124MetThr: 1.124 ± 0.009	1.429MetVal: 1.429 ± 0.011	0.237MetTrp: 0.237 ± 0.004	0.628MetTyr: 0.628 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.044AsnAla: 2.044 ± 0.015	0.822AsnCys: 0.822 ± 0.01	1.466AsnAsp: 1.466 ± 0.011	2.118AsnGlu: 2.118 ± 0.013	1.486AsnPhe: 1.486 ± 0.012	2.406AsnGly: 2.406 ± 0.019	0.938AsnHis: 0.938 ± 0.009	2.055AsnIle: 2.055 ± 0.015	2.137AsnLys: 2.137 ± 0.014	3.701AsnLeu: 3.701 ± 0.02	0.878AsnMet: 0.878 ± 0.01	1.452AsnAsn: 1.452 ± 0.012	2.182AsnPro: 2.182 ± 0.015	1.603AsnGln: 1.603 ± 0.013	1.824AsnArg: 1.824 ± 0.012	3.04AsnSer: 3.04 ± 0.018	1.926AsnThr: 1.926 ± 0.014	2.176AsnVal: 2.176 ± 0.014	0.434AsnTrp: 0.434 ± 0.006	1.097AsnTyr: 1.097 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	4.901ProAla: 4.901 ± 0.03	1.179ProCys: 1.179 ± 0.015	2.776ProAsp: 2.776 ± 0.016	4.432ProGlu: 4.432 ± 0.021	1.942ProPhe: 1.942 ± 0.013	5.219ProGly: 5.219 ± 0.063	1.43ProHis: 1.43 ± 0.011	1.838ProIle: 1.838 ± 0.014	2.77ProLys: 2.77 ± 0.019	5.311ProLeu: 5.311 ± 0.024	1.097ProMet: 1.097 ± 0.009	1.795ProAsn: 1.795 ± 0.014	5.905ProPro: 5.905 ± 0.054	2.816ProGln: 2.816 ± 0.023	3.315ProArg: 3.315 ± 0.021	5.606ProSer: 5.606 ± 0.032	3.056ProThr: 3.056 ± 0.019	3.839ProVal: 3.839 ± 0.022	0.68ProTrp: 0.68 ± 0.008	1.496ProTyr: 1.496 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	3.605GlnAla: 3.605 ± 0.023	0.963GlnCys: 0.963 ± 0.012	2.377GlnAsp: 2.377 ± 0.016	3.911GlnGlu: 3.911 ± 0.025	1.382GlnPhe: 1.382 ± 0.01	2.863GlnGly: 2.863 ± 0.018	1.318GlnHis: 1.318 ± 0.012	1.97GlnIle: 1.97 ± 0.014	2.906GlnLys: 2.906 ± 0.017	4.868GlnLeu: 4.868 ± 0.032	1.134GlnMet: 1.134 ± 0.01	1.799GlnAsn: 1.799 ± 0.013	2.81GlnPro: 2.81 ± 0.02	3.141GlnGln: 3.141 ± 0.041	2.96GlnArg: 2.96 ± 0.021	3.118GlnSer: 3.118 ± 0.018	2.261GlnThr: 2.261 ± 0.017	2.913GlnVal: 2.913 ± 0.016	0.539GlnTrp: 0.539 ± 0.007	1.162GlnTyr: 1.162 ± 0.01	0.0GlnXaa: 0.0 ± 0.0
Arg	3.911ArgAla: 3.911 ± 0.023	1.228ArgCys: 1.228 ± 0.015	2.773ArgAsp: 2.773 ± 0.018	3.937ArgGlu: 3.937 ± 0.024	1.899ArgPhe: 1.899 ± 0.012	3.566ArgGly: 3.566 ± 0.025	1.522ArgHis: 1.522 ± 0.012	2.434ArgIle: 2.434 ± 0.015	3.664ArgLys: 3.664 ± 0.019	5.46ArgLeu: 5.46 ± 0.024	1.213ArgMet: 1.213 ± 0.01	2.113ArgAsn: 2.113 ± 0.015	3.216ArgPro: 3.216 ± 0.017	2.644ArgGln: 2.644 ± 0.019	4.328ArgArg: 4.328 ± 0.026	4.222ArgSer: 4.222 ± 0.026	2.82ArgThr: 2.82 ± 0.016	3.205ArgVal: 3.205 ± 0.017	0.686ArgTrp: 0.686 ± 0.008	1.499ArgTyr: 1.499 ± 0.012	0.0ArgXaa: 0.0 ± 0.0
Ser	5.361SerAla: 5.361 ± 0.026	1.906SerCys: 1.906 ± 0.019	3.869SerAsp: 3.869 ± 0.023	5.094SerGlu: 5.094 ± 0.03	3.038SerPhe: 3.038 ± 0.016	5.602SerGly: 5.602 ± 0.03	2.115SerHis: 2.115 ± 0.014	3.215SerIle: 3.215 ± 0.016	3.97SerLys: 3.97 ± 0.023	8.278SerLeu: 8.278 ± 0.03	1.618SerMet: 1.618 ± 0.011	2.61SerAsn: 2.61 ± 0.015	5.955SerPro: 5.955 ± 0.034	3.828SerGln: 3.828 ± 0.021	4.519SerArg: 4.519 ± 0.028	9.237SerSer: 9.237 ± 0.054	4.446SerThr: 4.446 ± 0.026	4.954SerVal: 4.954 ± 0.019	1.074SerTrp: 1.074 ± 0.011	2.162SerTyr: 2.162 ± 0.014	0.0SerXaa: 0.0 ± 0.0
Thr	3.812ThrAla: 3.812 ± 0.019	1.345ThrCys: 1.345 ± 0.014	2.437ThrAsp: 2.437 ± 0.015	3.504ThrGlu: 3.504 ± 0.019	2.154ThrPhe: 2.154 ± 0.015	3.513ThrGly: 3.513 ± 0.02	1.283ThrHis: 1.283 ± 0.01	2.38ThrIle: 2.38 ± 0.017	2.595ThrLys: 2.595 ± 0.018	5.39ThrLeu: 5.39 ± 0.02	1.129ThrMet: 1.129 ± 0.01	1.696ThrAsn: 1.696 ± 0.012	3.559ThrPro: 3.559 ± 0.023	2.306ThrGln: 2.306 ± 0.015	2.467ThrArg: 2.467 ± 0.015	4.534ThrSer: 4.534 ± 0.022	2.886ThrThr: 2.886 ± 0.021	3.949ThrVal: 3.949 ± 0.023	0.678ThrTrp: 0.678 ± 0.008	1.438ThrTyr: 1.438 ± 0.013	0.0ThrXaa: 0.0 ± 0.0
Val	4.406ValAla: 4.406 ± 0.021	1.492ValCys: 1.492 ± 0.014	2.98ValAsp: 2.98 ± 0.017	3.834ValGlu: 3.834 ± 0.016	2.473ValPhe: 2.473 ± 0.016	3.406ValGly: 3.406 ± 0.02	1.594ValHis: 1.594 ± 0.01	2.993ValIle: 2.993 ± 0.017	3.335ValLys: 3.335 ± 0.018	6.462ValLeu: 6.462 ± 0.027	1.34ValMet: 1.34 ± 0.01	2.209ValAsn: 2.209 ± 0.015	3.712ValPro: 3.712 ± 0.019	2.803ValGln: 2.803 ± 0.016	3.077ValArg: 3.077 ± 0.017	4.918ValSer: 4.918 ± 0.023	3.868ValThr: 3.868 ± 0.024	4.092ValVal: 4.092 ± 0.023	0.725ValTrp: 0.725 ± 0.008	1.654ValTyr: 1.654 ± 0.011	0.0ValXaa: 0.0 ± 0.0
Trp	0.799TrpAla: 0.799 ± 0.009	0.245TrpCys: 0.245 ± 0.004	0.652TrpAsp: 0.652 ± 0.008	0.78TrpGlu: 0.78 ± 0.008	0.438TrpPhe: 0.438 ± 0.006	0.726TrpGly: 0.726 ± 0.01	0.303TrpHis: 0.303 ± 0.005	0.547TrpIle: 0.547 ± 0.007	0.787TrpLys: 0.787 ± 0.008	1.219TrpLeu: 1.219 ± 0.01	0.314TrpMet: 0.314 ± 0.005	0.537TrpAsn: 0.537 ± 0.006	0.524TrpPro: 0.524 ± 0.006	0.537TrpGln: 0.537 ± 0.007	0.726TrpArg: 0.726 ± 0.008	0.861TrpSer: 0.861 ± 0.01	0.673TrpThr: 0.673 ± 0.009	0.715TrpVal: 0.715 ± 0.008	0.198TrpTrp: 0.198 ± 0.004	0.34TrpTyr: 0.34 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.456TyrAla: 1.456 ± 0.013	0.712TyrCys: 0.712 ± 0.009	1.316TyrAsp: 1.316 ± 0.012	1.672TyrGlu: 1.672 ± 0.012	1.289TyrPhe: 1.289 ± 0.01	1.703TyrGly: 1.703 ± 0.014	0.767TyrHis: 0.767 ± 0.007	1.388TyrIle: 1.388 ± 0.012	1.444TyrLys: 1.444 ± 0.018	2.728TyrLeu: 2.728 ± 0.015	0.621TyrMet: 0.621 ± 0.007	1.106TyrAsn: 1.106 ± 0.008	1.302TyrPro: 1.302 ± 0.013	1.266TyrGln: 1.266 ± 0.011	1.604TyrArg: 1.604 ± 0.013	2.238TyrSer: 2.238 ± 0.014	1.523TyrThr: 1.523 ± 0.013	1.641TyrVal: 1.641 ± 0.012	0.367TyrTrp: 0.367 ± 0.007	0.962TyrTyr: 0.962 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.125XaaXaa: 0.125 ± 0.023

Statistics based on 25080 proteins (14117386 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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