Amino acid dipepetide frequency for Roseivivax halodurans JCM 10272

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.43AlaAla: 17.43 ± 0.184	1.129AlaCys: 1.129 ± 0.038	6.83AlaAsp: 6.83 ± 0.081	9.263AlaGlu: 9.263 ± 0.106	4.31AlaPhe: 4.31 ± 0.066	11.096AlaGly: 11.096 ± 0.099	2.357AlaHis: 2.357 ± 0.049	5.844AlaIle: 5.844 ± 0.069	3.122AlaLys: 3.122 ± 0.054	14.297AlaLeu: 14.297 ± 0.138	3.785AlaMet: 3.785 ± 0.062	2.382AlaAsn: 2.382 ± 0.044	6.174AlaPro: 6.174 ± 0.073	4.125AlaGln: 4.125 ± 0.06	9.949AlaArg: 9.949 ± 0.126	6.132AlaSer: 6.132 ± 0.087	6.094AlaThr: 6.094 ± 0.058	8.218AlaVal: 8.218 ± 0.088	1.624AlaTrp: 1.624 ± 0.039	2.44AlaTyr: 2.44 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.059CysAla: 1.059 ± 0.025	0.127CysCys: 0.127 ± 0.009	0.593CysAsp: 0.593 ± 0.023	0.485CysGlu: 0.485 ± 0.021	0.305CysPhe: 0.305 ± 0.015	0.945CysGly: 0.945 ± 0.032	0.271CysHis: 0.271 ± 0.015	0.391CysIle: 0.391 ± 0.017	0.172CysLys: 0.172 ± 0.011	0.885CysLeu: 0.885 ± 0.028	0.171CysMet: 0.171 ± 0.011	0.193CysAsn: 0.193 ± 0.01	0.448CysPro: 0.448 ± 0.022	0.205CysGln: 0.205 ± 0.012	0.637CysArg: 0.637 ± 0.026	0.427CysSer: 0.427 ± 0.019	0.436CysThr: 0.436 ± 0.018	0.593CysVal: 0.593 ± 0.024	0.117CysTrp: 0.117 ± 0.01	0.194CysTyr: 0.194 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.826AspAla: 7.826 ± 0.084	0.454AspCys: 0.454 ± 0.021	3.487AspAsp: 3.487 ± 0.072	3.964AspGlu: 3.964 ± 0.06	2.238AspPhe: 2.238 ± 0.042	5.818AspGly: 5.818 ± 0.091	1.315AspHis: 1.315 ± 0.033	3.054AspIle: 3.054 ± 0.062	1.38AspLys: 1.38 ± 0.035	6.56AspLeu: 6.56 ± 0.076	1.612AspMet: 1.612 ± 0.035	1.146AspAsn: 1.146 ± 0.035	3.892AspPro: 3.892 ± 0.063	1.611AspGln: 1.611 ± 0.038	4.869AspArg: 4.869 ± 0.06	1.994AspSer: 1.994 ± 0.044	2.963AspThr: 2.963 ± 0.056	4.337AspVal: 4.337 ± 0.065	1.204AspTrp: 1.204 ± 0.031	1.484AspTyr: 1.484 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	9.479GluAla: 9.479 ± 0.11	0.405GluCys: 0.405 ± 0.017	3.908GluAsp: 3.908 ± 0.06	4.358GluGlu: 4.358 ± 0.073	1.78GluPhe: 1.78 ± 0.039	5.455GluGly: 5.455 ± 0.07	1.182GluHis: 1.182 ± 0.032	3.965GluIle: 3.965 ± 0.06	1.93GluLys: 1.93 ± 0.042	5.324GluLeu: 5.324 ± 0.068	2.011GluMet: 2.011 ± 0.042	1.672GluAsn: 1.672 ± 0.037	2.936GluPro: 2.936 ± 0.053	1.847GluGln: 1.847 ± 0.048	5.214GluArg: 5.214 ± 0.075	2.456GluSer: 2.456 ± 0.049	4.514GluThr: 4.514 ± 0.064	4.741GluVal: 4.741 ± 0.064	0.749GluTrp: 0.749 ± 0.023	1.049GluTyr: 1.049 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.373PheAla: 4.373 ± 0.058	0.372PheCys: 0.372 ± 0.017	2.779PheAsp: 2.779 ± 0.05	2.324PheGlu: 2.324 ± 0.044	1.359PhePhe: 1.359 ± 0.038	3.761PheGly: 3.761 ± 0.056	0.728PheHis: 0.728 ± 0.025	1.38PheIle: 1.38 ± 0.037	0.719PheLys: 0.719 ± 0.028	3.328PheLeu: 3.328 ± 0.056	0.79PheMet: 0.79 ± 0.026	0.863PheAsn: 0.863 ± 0.024	1.534PhePro: 1.534 ± 0.039	0.904PheGln: 0.904 ± 0.031	2.362PheArg: 2.362 ± 0.035	2.053PheSer: 2.053 ± 0.04	1.91PheThr: 1.91 ± 0.034	2.717PheVal: 2.717 ± 0.048	0.561PheTrp: 0.561 ± 0.021	0.856PheTyr: 0.856 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.689GlyAla: 10.689 ± 0.103	0.82GlyCys: 0.82 ± 0.027	5.0GlyAsp: 5.0 ± 0.088	5.449GlyGlu: 5.449 ± 0.074	3.471GlyPhe: 3.471 ± 0.049	7.818GlyGly: 7.818 ± 0.122	1.982GlyHis: 1.982 ± 0.042	4.786GlyIle: 4.786 ± 0.073	2.62GlyLys: 2.62 ± 0.057	9.282GlyLeu: 9.282 ± 0.094	2.524GlyMet: 2.524 ± 0.048	1.961GlyAsn: 1.961 ± 0.049	4.159GlyPro: 4.159 ± 0.061	2.894GlyGln: 2.894 ± 0.054	6.566GlyArg: 6.566 ± 0.086	4.534GlySer: 4.534 ± 0.064	5.082GlyThr: 5.082 ± 0.069	6.236GlyVal: 6.236 ± 0.073	1.533GlyTrp: 1.533 ± 0.039	2.192GlyTyr: 2.192 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.456HisAla: 2.456 ± 0.05	0.235HisCys: 0.235 ± 0.014	1.292HisAsp: 1.292 ± 0.034	1.175HisGlu: 1.175 ± 0.033	0.748HisPhe: 0.748 ± 0.023	1.957HisGly: 1.957 ± 0.044	0.543HisHis: 0.543 ± 0.024	0.821HisIle: 0.821 ± 0.028	0.393HisLys: 0.393 ± 0.015	2.095HisLeu: 2.095 ± 0.041	0.501HisMet: 0.501 ± 0.018	0.387HisAsn: 0.387 ± 0.018	1.339HisPro: 1.339 ± 0.031	0.525HisGln: 0.525 ± 0.022	1.431HisArg: 1.431 ± 0.034	0.917HisSer: 0.917 ± 0.029	0.785HisThr: 0.785 ± 0.022	1.67HisVal: 1.67 ± 0.04	0.302HisTrp: 0.302 ± 0.017	0.505HisTyr: 0.505 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.988IleAla: 6.988 ± 0.071	0.586IleCys: 0.586 ± 0.021	3.497IleAsp: 3.497 ± 0.059	3.621IleGlu: 3.621 ± 0.048	1.694IlePhe: 1.694 ± 0.043	4.777IleGly: 4.777 ± 0.071	0.844IleHis: 0.844 ± 0.027	1.727IleIle: 1.727 ± 0.047	0.973IleLys: 0.973 ± 0.029	4.758IleLeu: 4.758 ± 0.061	0.975IleMet: 0.975 ± 0.031	1.086IleAsn: 1.086 ± 0.028	2.234IlePro: 2.234 ± 0.046	0.999IleGln: 0.999 ± 0.029	3.327IleArg: 3.327 ± 0.052	2.666IleSer: 2.666 ± 0.049	2.508IleThr: 2.508 ± 0.046	4.044IleVal: 4.044 ± 0.066	0.687IleTrp: 0.687 ± 0.024	1.068IleTyr: 1.068 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.25LysAla: 3.25 ± 0.057	0.158LysCys: 0.158 ± 0.012	1.516LysAsp: 1.516 ± 0.034	1.372LysGlu: 1.372 ± 0.038	0.685LysPhe: 0.685 ± 0.026	2.207LysGly: 2.207 ± 0.043	0.518LysHis: 0.518 ± 0.021	1.336LysIle: 1.336 ± 0.037	0.934LysLys: 0.934 ± 0.032	2.464LysLeu: 2.464 ± 0.046	0.667LysMet: 0.667 ± 0.021	0.618LysAsn: 0.618 ± 0.021	1.477LysPro: 1.477 ± 0.034	0.692LysGln: 0.692 ± 0.024	2.117LysArg: 2.117 ± 0.042	1.562LysSer: 1.562 ± 0.034	1.684LysThr: 1.684 ± 0.045	1.937LysVal: 1.937 ± 0.042	0.325LysTrp: 0.325 ± 0.014	0.47LysTyr: 0.47 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.4LeuAla: 13.4 ± 0.141	0.957LeuCys: 0.957 ± 0.027	6.327LeuAsp: 6.327 ± 0.086	5.701LeuGlu: 5.701 ± 0.066	3.454LeuPhe: 3.454 ± 0.053	8.836LeuGly: 8.836 ± 0.094	1.856LeuHis: 1.856 ± 0.044	4.689LeuIle: 4.689 ± 0.065	2.789LeuLys: 2.789 ± 0.052	8.84LeuLeu: 8.84 ± 0.121	2.487LeuMet: 2.487 ± 0.049	2.173LeuAsn: 2.173 ± 0.043	5.521LeuPro: 5.521 ± 0.071	2.507LeuGln: 2.507 ± 0.043	7.428LeuArg: 7.428 ± 0.093	6.685LeuSer: 6.685 ± 0.075	5.856LeuThr: 5.856 ± 0.072	7.324LeuVal: 7.324 ± 0.085	1.373LeuTrp: 1.373 ± 0.035	1.947LeuTyr: 1.947 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.248MetAla: 3.248 ± 0.051	0.188MetCys: 0.188 ± 0.012	1.366MetAsp: 1.366 ± 0.032	1.39MetGlu: 1.39 ± 0.035	0.755MetPhe: 0.755 ± 0.025	2.107MetGly: 2.107 ± 0.042	0.447MetHis: 0.447 ± 0.017	1.454MetIle: 1.454 ± 0.034	0.898MetLys: 0.898 ± 0.027	2.524MetLeu: 2.524 ± 0.053	0.709MetMet: 0.709 ± 0.027	0.667MetAsn: 0.667 ± 0.025	1.568MetPro: 1.568 ± 0.036	0.883MetGln: 0.883 ± 0.025	2.078MetArg: 2.078 ± 0.042	1.871MetSer: 1.871 ± 0.042	2.106MetThr: 2.106 ± 0.043	1.716MetVal: 1.716 ± 0.039	0.24MetTrp: 0.24 ± 0.014	0.299MetTyr: 0.299 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.845AsnAla: 2.845 ± 0.048	0.205AsnCys: 0.205 ± 0.012	1.272AsnAsp: 1.272 ± 0.035	1.127AsnGlu: 1.127 ± 0.034	0.863AsnPhe: 0.863 ± 0.031	2.104AsnGly: 2.104 ± 0.05	0.431AsnHis: 0.431 ± 0.02	1.106AsnIle: 1.106 ± 0.032	0.454AsnLys: 0.454 ± 0.022	2.259AsnLeu: 2.259 ± 0.042	0.554AsnMet: 0.554 ± 0.019	0.503AsnAsn: 0.503 ± 0.023	1.549AsnPro: 1.549 ± 0.038	0.591AsnGln: 0.591 ± 0.023	1.626AsnArg: 1.626 ± 0.038	1.016AsnSer: 1.016 ± 0.027	1.133AsnThr: 1.133 ± 0.034	1.767AsnVal: 1.767 ± 0.042	0.37AsnTrp: 0.37 ± 0.018	0.56AsnTyr: 0.56 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	5.958ProAla: 5.958 ± 0.066	0.377ProCys: 0.377 ± 0.015	4.085ProAsp: 4.085 ± 0.055	4.699ProGlu: 4.699 ± 0.072	1.908ProPhe: 1.908 ± 0.039	4.939ProGly: 4.939 ± 0.066	1.104ProHis: 1.104 ± 0.031	2.121ProIle: 2.121 ± 0.042	1.427ProLys: 1.427 ± 0.038	4.585ProLeu: 4.585 ± 0.06	1.22ProMet: 1.22 ± 0.031	1.204ProAsn: 1.204 ± 0.029	2.377ProPro: 2.377 ± 0.051	1.552ProGln: 1.552 ± 0.037	3.151ProArg: 3.151 ± 0.056	2.645ProSer: 2.645 ± 0.047	2.257ProThr: 2.257 ± 0.043	4.272ProVal: 4.272 ± 0.063	0.708ProTrp: 0.708 ± 0.023	1.084ProTyr: 1.084 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.528GlnAla: 3.528 ± 0.059	0.169GlnCys: 0.169 ± 0.011	1.599GlnAsp: 1.599 ± 0.039	1.689GlnGlu: 1.689 ± 0.043	0.893GlnPhe: 0.893 ± 0.027	2.46GlnGly: 2.46 ± 0.046	0.513GlnHis: 0.513 ± 0.019	1.771GlnIle: 1.771 ± 0.034	0.937GlnLys: 0.937 ± 0.029	2.518GlnLeu: 2.518 ± 0.044	0.912GlnMet: 0.912 ± 0.028	0.789GlnAsn: 0.789 ± 0.027	1.427GlnPro: 1.427 ± 0.041	0.942GlnGln: 0.942 ± 0.033	2.1GlnArg: 2.1 ± 0.042	1.727GlnSer: 1.727 ± 0.048	1.629GlnThr: 1.629 ± 0.036	2.159GlnVal: 2.159 ± 0.038	0.336GlnTrp: 0.336 ± 0.017	0.529GlnTyr: 0.529 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.85ArgAla: 8.85 ± 0.111	0.495ArgCys: 0.495 ± 0.019	4.652ArgAsp: 4.652 ± 0.061	4.725ArgGlu: 4.725 ± 0.065	2.834ArgPhe: 2.834 ± 0.048	5.352ArgGly: 5.352 ± 0.061	1.711ArgHis: 1.711 ± 0.035	4.206ArgIle: 4.206 ± 0.063	2.045ArgLys: 2.045 ± 0.044	7.974ArgLeu: 7.974 ± 0.102	2.109ArgMet: 2.109 ± 0.037	1.713ArgAsn: 1.713 ± 0.032	3.738ArgPro: 3.738 ± 0.059	2.396ArgGln: 2.396 ± 0.053	6.145ArgArg: 6.145 ± 0.09	3.808ArgSer: 3.808 ± 0.058	3.526ArgThr: 3.526 ± 0.054	5.118ArgVal: 5.118 ± 0.065	0.989ArgTrp: 0.989 ± 0.029	1.605ArgTyr: 1.605 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.24SerAla: 6.24 ± 0.072	0.461SerCys: 0.461 ± 0.019	3.457SerAsp: 3.457 ± 0.06	3.464SerGlu: 3.464 ± 0.055	2.092SerPhe: 2.092 ± 0.04	5.753SerGly: 5.753 ± 0.078	1.035SerHis: 1.035 ± 0.028	2.343SerIle: 2.343 ± 0.05	1.294SerLys: 1.294 ± 0.035	5.019SerLeu: 5.019 ± 0.067	1.346SerMet: 1.346 ± 0.033	1.193SerAsn: 1.193 ± 0.032	2.56SerPro: 2.56 ± 0.041	1.449SerGln: 1.449 ± 0.039	3.669SerArg: 3.669 ± 0.057	2.791SerSer: 2.791 ± 0.061	2.415SerThr: 2.415 ± 0.046	3.913SerVal: 3.913 ± 0.061	0.674SerTrp: 0.674 ± 0.022	1.309SerTyr: 1.309 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.085ThrAla: 6.085 ± 0.07	0.516ThrCys: 0.516 ± 0.021	3.246ThrAsp: 3.246 ± 0.054	3.414ThrGlu: 3.414 ± 0.06	2.099ThrPhe: 2.099 ± 0.042	5.614ThrGly: 5.614 ± 0.079	1.107ThrHis: 1.107 ± 0.029	2.594ThrIle: 2.594 ± 0.052	1.24ThrLys: 1.24 ± 0.032	6.162ThrLeu: 6.162 ± 0.063	1.236ThrMet: 1.236 ± 0.031	1.11ThrAsn: 1.11 ± 0.029	3.16ThrPro: 3.16 ± 0.052	1.436ThrGln: 1.436 ± 0.041	3.751ThrArg: 3.751 ± 0.054	2.772ThrSer: 2.772 ± 0.044	2.686ThrThr: 2.686 ± 0.051	4.141ThrVal: 4.141 ± 0.063	0.754ThrTrp: 0.754 ± 0.025	1.203ThrTyr: 1.203 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.028ValAla: 9.028 ± 0.095	0.626ValCys: 0.626 ± 0.022	4.003ValAsp: 4.003 ± 0.063	4.694ValGlu: 4.694 ± 0.061	2.803ValPhe: 2.803 ± 0.053	5.533ValGly: 5.533 ± 0.08	1.341ValHis: 1.341 ± 0.035	3.918ValIle: 3.918 ± 0.066	1.793ValLys: 1.793 ± 0.042	7.468ValLeu: 7.468 ± 0.085	2.082ValMet: 2.082 ± 0.037	1.808ValAsn: 1.808 ± 0.047	3.865ValPro: 3.865 ± 0.062	1.929ValGln: 1.929 ± 0.048	4.734ValArg: 4.734 ± 0.068	4.369ValSer: 4.369 ± 0.056	4.847ValThr: 4.847 ± 0.065	5.667ValVal: 5.667 ± 0.077	0.991ValTrp: 0.991 ± 0.028	1.428ValTyr: 1.428 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.356TrpAla: 1.356 ± 0.036	0.15TrpCys: 0.15 ± 0.011	0.783TrpAsp: 0.783 ± 0.027	0.711TrpGlu: 0.711 ± 0.021	0.545TrpPhe: 0.545 ± 0.02	1.015TrpGly: 1.015 ± 0.031	0.334TrpHis: 0.334 ± 0.014	0.768TrpIle: 0.768 ± 0.026	0.402TrpLys: 0.402 ± 0.019	1.632TrpLeu: 1.632 ± 0.037	0.4TrpMet: 0.4 ± 0.02	0.385TrpAsn: 0.385 ± 0.018	0.726TrpPro: 0.726 ± 0.024	0.568TrpGln: 0.568 ± 0.022	1.224TrpArg: 1.224 ± 0.032	0.914TrpSer: 0.914 ± 0.03	0.847TrpThr: 0.847 ± 0.028	0.881TrpVal: 0.881 ± 0.027	0.239TrpTrp: 0.239 ± 0.014	0.244TrpTyr: 0.244 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.511TyrAla: 2.511 ± 0.048	0.223TyrCys: 0.223 ± 0.012	1.516TyrAsp: 1.516 ± 0.033	1.35TyrGlu: 1.35 ± 0.037	0.836TyrPhe: 0.836 ± 0.025	2.048TyrGly: 2.048 ± 0.045	0.458TyrHis: 0.458 ± 0.018	0.785TyrIle: 0.785 ± 0.024	0.469TyrLys: 0.469 ± 0.018	2.18TyrLeu: 2.18 ± 0.038	0.424TyrMet: 0.424 ± 0.019	0.483TyrAsn: 0.483 ± 0.019	0.99TyrPro: 0.99 ± 0.028	0.572TyrGln: 0.572 ± 0.025	1.609TyrArg: 1.609 ± 0.037	1.14TyrSer: 1.14 ± 0.032	1.049TyrThr: 1.049 ± 0.023	1.477TyrVal: 1.477 ± 0.038	0.346TyrTrp: 0.346 ± 0.016	0.556TyrTyr: 0.556 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4304 proteins (1296111 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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