Amino acid dipepetide frequency for Lysobacter maris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.953AlaAla: 18.953 ± 0.202	1.271AlaCys: 1.271 ± 0.038	8.042AlaAsp: 8.042 ± 0.096	7.387AlaGlu: 7.387 ± 0.099	4.182AlaPhe: 4.182 ± 0.064	12.021AlaGly: 12.021 ± 0.11	2.69AlaHis: 2.69 ± 0.053	5.528AlaIle: 5.528 ± 0.071	2.533AlaLys: 2.533 ± 0.079	15.597AlaLeu: 15.597 ± 0.167	3.326AlaMet: 3.326 ± 0.061	2.606AlaAsn: 2.606 ± 0.048	6.782AlaPro: 6.782 ± 0.107	4.519AlaGln: 4.519 ± 0.079	10.814AlaArg: 10.814 ± 0.126	6.79AlaSer: 6.79 ± 0.09	6.432AlaThr: 6.432 ± 0.136	8.989AlaVal: 8.989 ± 0.098	2.064AlaTrp: 2.064 ± 0.053	2.604AlaTyr: 2.604 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.069CysAla: 1.069 ± 0.036	0.099CysCys: 0.099 ± 0.01	0.506CysAsp: 0.506 ± 0.023	0.469CysGlu: 0.469 ± 0.023	0.263CysPhe: 0.263 ± 0.017	0.944CysGly: 0.944 ± 0.032	0.226CysHis: 0.226 ± 0.015	0.329CysIle: 0.329 ± 0.018	0.131CysLys: 0.131 ± 0.011	0.742CysLeu: 0.742 ± 0.031	0.156CysMet: 0.156 ± 0.014	0.213CysAsn: 0.213 ± 0.017	0.426CysPro: 0.426 ± 0.023	0.205CysGln: 0.205 ± 0.013	0.641CysArg: 0.641 ± 0.027	0.466CysSer: 0.466 ± 0.024	0.414CysThr: 0.414 ± 0.032	0.607CysVal: 0.607 ± 0.024	0.118CysTrp: 0.118 ± 0.011	0.191CysTyr: 0.191 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	9.535AspAla: 9.535 ± 0.11	0.464AspCys: 0.464 ± 0.023	4.098AspAsp: 4.098 ± 0.076	3.572AspGlu: 3.572 ± 0.06	2.05AspPhe: 2.05 ± 0.044	7.133AspGly: 7.133 ± 0.096	1.219AspHis: 1.219 ± 0.03	2.463AspIle: 2.463 ± 0.049	1.388AspLys: 1.388 ± 0.044	5.47AspLeu: 5.47 ± 0.07	1.16AspMet: 1.16 ± 0.035	1.55AspAsn: 1.55 ± 0.044	3.982AspPro: 3.982 ± 0.071	1.47AspGln: 1.47 ± 0.037	4.611AspArg: 4.611 ± 0.073	2.721AspSer: 2.721 ± 0.051	3.012AspThr: 3.012 ± 0.062	4.019AspVal: 4.019 ± 0.071	1.239AspTrp: 1.239 ± 0.035	1.772AspTyr: 1.772 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	8.007GluAla: 8.007 ± 0.115	0.383GluCys: 0.383 ± 0.019	2.812GluAsp: 2.812 ± 0.047	2.363GluGlu: 2.363 ± 0.061	1.705GluPhe: 1.705 ± 0.04	4.121GluGly: 4.121 ± 0.061	1.508GluHis: 1.508 ± 0.04	2.475GluIle: 2.475 ± 0.05	1.309GluLys: 1.309 ± 0.045	6.234GluLeu: 6.234 ± 0.084	1.083GluMet: 1.083 ± 0.038	1.176GluAsn: 1.176 ± 0.031	2.902GluPro: 2.902 ± 0.053	2.531GluGln: 2.531 ± 0.051	5.948GluArg: 5.948 ± 0.093	2.591GluSer: 2.591 ± 0.05	2.624GluThr: 2.624 ± 0.066	4.313GluVal: 4.313 ± 0.067	0.696GluTrp: 0.696 ± 0.026	1.235GluTyr: 1.235 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	4.231PheAla: 4.231 ± 0.066	0.295PheCys: 0.295 ± 0.016	2.88PheAsp: 2.88 ± 0.053	2.176PheGlu: 2.176 ± 0.046	1.133PhePhe: 1.133 ± 0.04	3.331PheGly: 3.331 ± 0.057	0.739PheHis: 0.739 ± 0.027	1.167PheIle: 1.167 ± 0.041	0.753PheLys: 0.753 ± 0.029	2.761PheLeu: 2.761 ± 0.058	0.632PheMet: 0.632 ± 0.024	1.007PheAsn: 1.007 ± 0.035	1.329PhePro: 1.329 ± 0.041	0.918PheGln: 0.918 ± 0.03	2.179PheArg: 2.179 ± 0.05	1.864PheSer: 1.864 ± 0.044	1.545PheThr: 1.545 ± 0.04	2.639PheVal: 2.639 ± 0.055	0.492PheTrp: 0.492 ± 0.028	0.793PheTyr: 0.793 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.395GlyAla: 9.395 ± 0.095	0.827GlyCys: 0.827 ± 0.029	5.618GlyAsp: 5.618 ± 0.085	5.601GlyGlu: 5.601 ± 0.083	3.488GlyPhe: 3.488 ± 0.058	8.005GlyGly: 8.005 ± 0.108	2.285GlyHis: 2.285 ± 0.05	4.009GlyIle: 4.009 ± 0.071	2.514GlyLys: 2.514 ± 0.058	9.089GlyLeu: 9.089 ± 0.123	2.29GlyMet: 2.29 ± 0.051	2.445GlyAsn: 2.445 ± 0.061	3.409GlyPro: 3.409 ± 0.066	3.102GlyGln: 3.102 ± 0.057	7.186GlyArg: 7.186 ± 0.095	5.038GlySer: 5.038 ± 0.091	4.355GlyThr: 4.355 ± 0.109	6.474GlyVal: 6.474 ± 0.091	1.707GlyTrp: 1.707 ± 0.042	2.614GlyTyr: 2.614 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	3.042HisAla: 3.042 ± 0.058	0.269HisCys: 0.269 ± 0.016	1.442HisAsp: 1.442 ± 0.039	1.168HisGlu: 1.168 ± 0.029	0.782HisPhe: 0.782 ± 0.028	2.385HisGly: 2.385 ± 0.059	0.634HisHis: 0.634 ± 0.027	0.682HisIle: 0.682 ± 0.025	0.434HisLys: 0.434 ± 0.024	2.145HisLeu: 2.145 ± 0.051	0.415HisMet: 0.415 ± 0.022	0.467HisAsn: 0.467 ± 0.02	1.513HisPro: 1.513 ± 0.041	0.632HisGln: 0.632 ± 0.023	1.838HisArg: 1.838 ± 0.044	0.964HisSer: 0.964 ± 0.028	0.976HisThr: 0.976 ± 0.032	1.56HisVal: 1.56 ± 0.041	0.417HisTrp: 0.417 ± 0.022	0.64HisTyr: 0.64 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.356IleAla: 6.356 ± 0.086	0.329IleCys: 0.329 ± 0.02	3.526IleAsp: 3.526 ± 0.071	3.385IleGlu: 3.385 ± 0.06	0.953IlePhe: 0.953 ± 0.034	4.521IleGly: 4.521 ± 0.066	0.828IleHis: 0.828 ± 0.03	1.052IleIle: 1.052 ± 0.039	0.991IleLys: 0.991 ± 0.035	2.795IleLeu: 2.795 ± 0.058	0.485IleMet: 0.485 ± 0.023	1.124IleAsn: 1.124 ± 0.034	1.874IlePro: 1.874 ± 0.046	1.038IleGln: 1.038 ± 0.036	2.737IleArg: 2.737 ± 0.055	1.995IleSer: 1.995 ± 0.047	1.935IleThr: 1.935 ± 0.063	3.225IleVal: 3.225 ± 0.067	0.424IleTrp: 0.424 ± 0.02	0.774IleTyr: 0.774 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.976LysAla: 2.976 ± 0.083	0.134LysCys: 0.134 ± 0.012	1.152LysAsp: 1.152 ± 0.038	0.964LysGlu: 0.964 ± 0.04	0.619LysPhe: 0.619 ± 0.026	1.749LysGly: 1.749 ± 0.052	0.479LysHis: 0.479 ± 0.022	0.919LysIle: 0.919 ± 0.032	0.794LysLys: 0.794 ± 0.063	2.54LysLeu: 2.54 ± 0.059	0.497LysMet: 0.497 ± 0.025	0.492LysAsn: 0.492 ± 0.022	1.462LysPro: 1.462 ± 0.041	0.91LysGln: 0.91 ± 0.036	1.905LysArg: 1.905 ± 0.042	1.189LysSer: 1.189 ± 0.038	1.267LysThr: 1.267 ± 0.046	1.842LysVal: 1.842 ± 0.052	0.255LysTrp: 0.255 ± 0.018	0.531LysTyr: 0.531 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	15.195LeuAla: 15.195 ± 0.17	0.89LeuCys: 0.89 ± 0.028	7.202LeuAsp: 7.202 ± 0.09	5.669LeuGlu: 5.669 ± 0.088	3.399LeuPhe: 3.399 ± 0.061	8.683LeuGly: 8.683 ± 0.094	2.323LeuHis: 2.323 ± 0.057	3.821LeuIle: 3.821 ± 0.075	2.639LeuLys: 2.639 ± 0.053	11.319LeuLeu: 11.319 ± 0.166	2.1LeuMet: 2.1 ± 0.049	2.206LeuAsn: 2.206 ± 0.05	6.494LeuPro: 6.494 ± 0.106	3.582LeuGln: 3.582 ± 0.064	8.969LeuArg: 8.969 ± 0.116	5.936LeuSer: 5.936 ± 0.085	4.576LeuThr: 4.576 ± 0.075	7.458LeuVal: 7.458 ± 0.094	1.372LeuTrp: 1.372 ± 0.041	2.193LeuTyr: 2.193 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.691MetAla: 2.691 ± 0.048	0.118MetCys: 0.118 ± 0.012	1.039MetAsp: 1.039 ± 0.03	0.903MetGlu: 0.903 ± 0.033	0.675MetPhe: 0.675 ± 0.024	1.461MetGly: 1.461 ± 0.041	0.442MetHis: 0.442 ± 0.02	0.84MetIle: 0.84 ± 0.032	0.666MetLys: 0.666 ± 0.027	2.416MetLeu: 2.416 ± 0.047	0.447MetMet: 0.447 ± 0.02	0.652MetAsn: 0.652 ± 0.024	1.493MetPro: 1.493 ± 0.046	0.838MetGln: 0.838 ± 0.028	1.812MetArg: 1.812 ± 0.045	1.561MetSer: 1.561 ± 0.036	1.324MetThr: 1.324 ± 0.038	1.513MetVal: 1.513 ± 0.038	0.195MetTrp: 0.195 ± 0.014	0.344MetTyr: 0.344 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.018AsnAla: 3.018 ± 0.053	0.206AsnCys: 0.206 ± 0.014	1.441AsnAsp: 1.441 ± 0.04	1.113AsnGlu: 1.113 ± 0.031	0.825AsnPhe: 0.825 ± 0.031	2.376AsnGly: 2.376 ± 0.057	0.468AsnHis: 0.468 ± 0.021	0.994AsnIle: 0.994 ± 0.032	0.529AsnLys: 0.529 ± 0.023	2.338AsnLeu: 2.338 ± 0.051	0.406AsnMet: 0.406 ± 0.019	0.634AsnAsn: 0.634 ± 0.03	1.65AsnPro: 1.65 ± 0.04	0.659AsnGln: 0.659 ± 0.026	1.789AsnArg: 1.789 ± 0.041	1.048AsnSer: 1.048 ± 0.037	1.264AsnThr: 1.264 ± 0.061	1.698AsnVal: 1.698 ± 0.049	0.355AsnTrp: 0.355 ± 0.02	0.624AsnTyr: 0.624 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.671ProAla: 7.671 ± 0.114	0.321ProCys: 0.321 ± 0.016	3.889ProAsp: 3.889 ± 0.078	3.493ProGlu: 3.493 ± 0.062	1.623ProPhe: 1.623 ± 0.046	5.228ProGly: 5.228 ± 0.075	1.04ProHis: 1.04 ± 0.031	1.837ProIle: 1.837 ± 0.042	1.104ProLys: 1.104 ± 0.037	5.482ProLeu: 5.482 ± 0.09	1.289ProMet: 1.289 ± 0.035	1.135ProAsn: 1.135 ± 0.034	3.026ProPro: 3.026 ± 0.082	1.976ProGln: 1.976 ± 0.046	3.803ProArg: 3.803 ± 0.069	2.764ProSer: 2.764 ± 0.055	2.406ProThr: 2.406 ± 0.069	4.329ProVal: 4.329 ± 0.067	0.839ProTrp: 0.839 ± 0.032	1.143ProTyr: 1.143 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	5.211GlnAla: 5.211 ± 0.088	0.224GlnCys: 0.224 ± 0.016	1.495GlnAsp: 1.495 ± 0.039	1.295GlnGlu: 1.295 ± 0.043	0.965GlnPhe: 0.965 ± 0.033	2.45GlnGly: 2.45 ± 0.05	0.696GlnHis: 0.696 ± 0.028	1.331GlnIle: 1.331 ± 0.04	0.728GlnLys: 0.728 ± 0.028	3.71GlnLeu: 3.71 ± 0.063	0.732GlnMet: 0.732 ± 0.027	0.636GlnAsn: 0.636 ± 0.027	2.035GlnPro: 2.035 ± 0.045	1.505GlnGln: 1.505 ± 0.043	3.405GlnArg: 3.405 ± 0.061	1.574GlnSer: 1.574 ± 0.043	1.468GlnThr: 1.468 ± 0.039	2.779GlnVal: 2.779 ± 0.052	0.571GlnTrp: 0.571 ± 0.024	0.738GlnTyr: 0.738 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	9.164ArgAla: 9.164 ± 0.117	0.575ArgCys: 0.575 ± 0.025	5.015ArgAsp: 5.015 ± 0.081	5.359ArgGlu: 5.359 ± 0.085	3.122ArgPhe: 3.122 ± 0.052	5.97ArgGly: 5.97 ± 0.083	2.214ArgHis: 2.214 ± 0.055	4.204ArgIle: 4.204 ± 0.07	1.787ArgLys: 1.787 ± 0.052	9.409ArgLeu: 9.409 ± 0.132	2.0ArgMet: 2.0 ± 0.044	1.895ArgAsn: 1.895 ± 0.044	4.01ArgPro: 4.01 ± 0.062	2.933ArgGln: 2.933 ± 0.057	6.994ArgArg: 6.994 ± 0.093	3.67ArgSer: 3.67 ± 0.054	3.253ArgThr: 3.253 ± 0.058	5.836ArgVal: 5.836 ± 0.087	1.546ArgTrp: 1.546 ± 0.038	2.333ArgTyr: 2.333 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	6.362SerAla: 6.362 ± 0.079	0.404SerCys: 0.404 ± 0.02	3.035SerAsp: 3.035 ± 0.06	2.581SerGlu: 2.581 ± 0.054	1.788SerPhe: 1.788 ± 0.04	5.63SerGly: 5.63 ± 0.102	1.162SerHis: 1.162 ± 0.034	2.048SerIle: 2.048 ± 0.045	1.172SerLys: 1.172 ± 0.042	5.308SerLeu: 5.308 ± 0.082	1.044SerMet: 1.044 ± 0.031	1.347SerAsn: 1.347 ± 0.038	2.881SerPro: 2.881 ± 0.06	1.692SerGln: 1.692 ± 0.044	3.819SerArg: 3.819 ± 0.064	2.72SerSer: 2.72 ± 0.07	2.61SerThr: 2.61 ± 0.056	3.679SerVal: 3.679 ± 0.071	0.782SerTrp: 0.782 ± 0.032	1.346SerTyr: 1.346 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.142ThrAla: 6.142 ± 0.131	0.418ThrCys: 0.418 ± 0.044	2.579ThrAsp: 2.579 ± 0.058	2.078ThrGlu: 2.078 ± 0.048	1.371ThrPhe: 1.371 ± 0.043	4.577ThrGly: 4.577 ± 0.081	1.019ThrHis: 1.019 ± 0.031	1.997ThrIle: 1.997 ± 0.065	0.712ThrLys: 0.712 ± 0.031	5.848ThrLeu: 5.848 ± 0.096	0.885ThrMet: 0.885 ± 0.027	0.854ThrAsn: 0.854 ± 0.044	3.281ThrPro: 3.281 ± 0.075	1.303ThrGln: 1.303 ± 0.041	3.63ThrArg: 3.63 ± 0.06	2.268ThrSer: 2.268 ± 0.058	2.501ThrThr: 2.501 ± 0.1	4.321ThrVal: 4.321 ± 0.11	0.655ThrTrp: 0.655 ± 0.024	1.127ThrTyr: 1.127 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	9.903ValAla: 9.903 ± 0.095	0.639ValCys: 0.639 ± 0.028	4.873ValAsp: 4.873 ± 0.071	4.697ValGlu: 4.697 ± 0.066	2.467ValPhe: 2.467 ± 0.048	5.756ValGly: 5.756 ± 0.069	1.61ValHis: 1.61 ± 0.043	3.249ValIle: 3.249 ± 0.057	1.624ValLys: 1.624 ± 0.053	8.08ValLeu: 8.08 ± 0.111	1.582ValMet: 1.582 ± 0.041	1.842ValAsn: 1.842 ± 0.048	3.862ValPro: 3.862 ± 0.061	2.172ValGln: 2.172 ± 0.047	5.432ValArg: 5.432 ± 0.07	4.037ValSer: 4.037 ± 0.07	3.666ValThr: 3.666 ± 0.118	6.017ValVal: 6.017 ± 0.095	0.891ValTrp: 0.891 ± 0.027	1.553ValTyr: 1.553 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.343TrpAla: 1.343 ± 0.039	0.129TrpCys: 0.129 ± 0.011	0.691TrpAsp: 0.691 ± 0.025	0.604TrpGlu: 0.604 ± 0.024	0.592TrpPhe: 0.592 ± 0.023	0.956TrpGly: 0.956 ± 0.032	0.361TrpHis: 0.361 ± 0.017	0.663TrpIle: 0.663 ± 0.026	0.394TrpLys: 0.394 ± 0.023	2.241TrpLeu: 2.241 ± 0.055	0.45TrpMet: 0.45 ± 0.019	0.501TrpAsn: 0.501 ± 0.022	0.796TrpPro: 0.796 ± 0.028	0.767TrpGln: 0.767 ± 0.031	1.549TrpArg: 1.549 ± 0.048	0.962TrpSer: 0.962 ± 0.036	0.743TrpThr: 0.743 ± 0.028	0.955TrpVal: 0.955 ± 0.032	0.33TrpTrp: 0.33 ± 0.022	0.344TrpTyr: 0.344 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.867TyrAla: 2.867 ± 0.054	0.218TyrCys: 0.218 ± 0.015	1.593TyrAsp: 1.593 ± 0.064	1.139TyrGlu: 1.139 ± 0.035	0.865TyrPhe: 0.865 ± 0.029	2.152TyrGly: 2.152 ± 0.048	0.462TyrHis: 0.462 ± 0.018	0.738TyrIle: 0.738 ± 0.025	0.472TyrLys: 0.472 ± 0.023	2.504TyrLeu: 2.504 ± 0.047	0.449TyrMet: 0.449 ± 0.022	0.654TyrAsn: 0.654 ± 0.027	1.189TyrPro: 1.189 ± 0.034	0.795TyrGln: 0.795 ± 0.028	2.229TyrArg: 2.229 ± 0.05	1.254TyrSer: 1.254 ± 0.042	1.197TyrThr: 1.197 ± 0.05	1.697TyrVal: 1.697 ± 0.045	0.424TyrTrp: 0.424 ± 0.021	0.638TyrTyr: 0.638 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3120 proteins (1080331 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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