Amino acid dipepetide frequency for Leishmania donovani

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.022AlaAla: 21.022 ± 0.187	1.789AlaCys: 1.789 ± 0.031	5.577AlaAsp: 5.577 ± 0.052	7.757AlaGlu: 7.757 ± 0.134	3.052AlaPhe: 3.052 ± 0.038	7.287AlaGly: 7.287 ± 0.061	2.761AlaHis: 2.761 ± 0.03	2.991AlaIle: 2.991 ± 0.026	3.831AlaLys: 3.831 ± 0.053	10.474AlaLeu: 10.474 ± 0.084	2.568AlaMet: 2.568 ± 0.027	2.735AlaAsn: 2.735 ± 0.038	7.104AlaPro: 7.104 ± 0.088	4.564AlaGln: 4.564 ± 0.059	7.116AlaArg: 7.116 ± 0.085	11.022AlaSer: 11.022 ± 0.092	7.873AlaThr: 7.873 ± 0.066	9.214AlaVal: 9.214 ± 0.363	1.031AlaTrp: 1.031 ± 0.016	2.284AlaTyr: 2.284 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	2.365CysAla: 2.365 ± 0.192	0.518CysCys: 0.518 ± 0.013	0.948CysAsp: 0.948 ± 0.02	0.919CysGlu: 0.919 ± 0.015	0.666CysPhe: 0.666 ± 0.012	1.64CysGly: 1.64 ± 0.041	0.438CysHis: 0.438 ± 0.01	0.715CysIle: 0.715 ± 0.013	0.486CysLys: 0.486 ± 0.011	1.532CysLeu: 1.532 ± 0.024	0.404CysMet: 0.404 ± 0.011	0.48CysAsn: 0.48 ± 0.009	0.881CysPro: 0.881 ± 0.016	0.488CysGln: 0.488 ± 0.012	1.276CysArg: 1.276 ± 0.017	1.542CysSer: 1.542 ± 0.022	1.187CysThr: 1.187 ± 0.023	1.631CysVal: 1.631 ± 0.027	0.213CysTrp: 0.213 ± 0.007	0.459CysTyr: 0.459 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.795AspAla: 6.795 ± 0.065	0.755AspCys: 0.755 ± 0.013	3.363AspAsp: 3.363 ± 0.037	3.544AspGlu: 3.544 ± 0.047	1.432AspPhe: 1.432 ± 0.019	4.234AspGly: 4.234 ± 0.04	0.947AspHis: 0.947 ± 0.014	1.727AspIle: 1.727 ± 0.02	1.496AspLys: 1.496 ± 0.027	3.654AspLeu: 3.654 ± 0.045	1.189AspMet: 1.189 ± 0.022	1.249AspAsn: 1.249 ± 0.022	2.382AspPro: 2.382 ± 0.04	1.094AspGln: 1.094 ± 0.015	2.787AspArg: 2.787 ± 0.047	3.512AspSer: 3.512 ± 0.036	2.739AspThr: 2.739 ± 0.031	4.202AspVal: 4.202 ± 0.038	0.488AspTrp: 0.488 ± 0.012	1.172AspTyr: 1.172 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	7.893GluAla: 7.893 ± 0.153	0.92GluCys: 0.92 ± 0.024	3.5GluAsp: 3.5 ± 0.048	5.777GluGlu: 5.777 ± 0.113	1.32GluPhe: 1.32 ± 0.021	3.707GluGly: 3.707 ± 0.041	1.465GluHis: 1.465 ± 0.022	1.452GluIle: 1.452 ± 0.023	2.691GluLys: 2.691 ± 0.058	5.779GluLeu: 5.779 ± 0.076	1.515GluMet: 1.515 ± 0.021	1.551GluAsn: 1.551 ± 0.023	2.255GluPro: 2.255 ± 0.042	2.689GluGln: 2.689 ± 0.05	4.78GluArg: 4.78 ± 0.081	3.797GluSer: 3.797 ± 0.035	2.799GluThr: 2.799 ± 0.049	4.448GluVal: 4.448 ± 0.038	0.744GluTrp: 0.744 ± 0.018	1.335GluTyr: 1.335 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	2.888PheAla: 2.888 ± 0.029	0.63PheCys: 0.63 ± 0.012	1.56PheAsp: 1.56 ± 0.024	1.455PheGlu: 1.455 ± 0.02	1.405PhePhe: 1.405 ± 0.023	1.934PheGly: 1.934 ± 0.031	0.82PheHis: 0.82 ± 0.015	1.09PheIle: 1.09 ± 0.021	0.856PheLys: 0.856 ± 0.017	2.956PheLeu: 2.956 ± 0.033	0.718PheMet: 0.718 ± 0.014	0.882PheAsn: 0.882 ± 0.014	1.454PhePro: 1.454 ± 0.021	1.026PheGln: 1.026 ± 0.018	1.766PheArg: 1.766 ± 0.026	2.619PheSer: 2.619 ± 0.028	1.866PheThr: 1.866 ± 0.024	2.331PheVal: 2.331 ± 0.034	0.3PheTrp: 0.3 ± 0.007	0.917PheTyr: 0.917 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	8.09GlyAla: 8.09 ± 0.071	1.3GlyCys: 1.3 ± 0.028	3.747GlyAsp: 3.747 ± 0.037	3.575GlyGlu: 3.575 ± 0.037	1.888GlyPhe: 1.888 ± 0.027	6.686GlyGly: 6.686 ± 0.073	1.559GlyHis: 1.559 ± 0.026	2.155GlyIle: 2.155 ± 0.031	2.33GlyLys: 2.33 ± 0.029	4.53GlyLeu: 4.53 ± 0.039	1.391GlyMet: 1.391 ± 0.017	1.959GlyAsn: 1.959 ± 0.023	2.532GlyPro: 2.532 ± 0.039	1.87GlyGln: 1.87 ± 0.028	4.169GlyArg: 4.169 ± 0.036	6.051GlySer: 6.051 ± 0.064	4.018GlyThr: 4.018 ± 0.036	5.054GlyVal: 5.054 ± 0.165	0.633GlyTrp: 0.633 ± 0.012	1.507GlyTyr: 1.507 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	2.79HisAla: 2.79 ± 0.03	0.544HisCys: 0.544 ± 0.011	1.203HisAsp: 1.203 ± 0.019	1.354HisGlu: 1.354 ± 0.019	0.827HisPhe: 0.827 ± 0.014	1.841HisGly: 1.841 ± 0.028	1.041HisHis: 1.041 ± 0.016	0.923HisIle: 0.923 ± 0.016	0.752HisLys: 0.752 ± 0.015	2.443HisLeu: 2.443 ± 0.029	0.552HisMet: 0.552 ± 0.011	0.768HisAsn: 0.768 ± 0.014	1.632HisPro: 1.632 ± 0.024	1.081HisGln: 1.081 ± 0.018	2.296HisArg: 2.296 ± 0.025	2.095HisSer: 2.095 ± 0.026	1.551HisThr: 1.551 ± 0.019	1.888HisVal: 1.888 ± 0.023	0.302HisTrp: 0.302 ± 0.009	0.749HisTyr: 0.749 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.303IleAla: 3.303 ± 0.036	0.564IleCys: 0.564 ± 0.013	1.691IleAsp: 1.691 ± 0.019	1.788IleGlu: 1.788 ± 0.023	1.142IlePhe: 1.142 ± 0.023	1.966IleGly: 1.966 ± 0.025	0.777IleHis: 0.777 ± 0.012	1.22IleIle: 1.22 ± 0.024	1.015IleLys: 1.015 ± 0.021	2.577IleLeu: 2.577 ± 0.033	0.718IleMet: 0.718 ± 0.013	0.883IleAsn: 0.883 ± 0.017	1.798IlePro: 1.798 ± 0.021	1.059IleGln: 1.059 ± 0.017	1.951IleArg: 1.951 ± 0.024	2.362IleSer: 2.362 ± 0.027	1.92IleThr: 1.92 ± 0.025	2.266IleVal: 2.266 ± 0.031	0.243IleTrp: 0.243 ± 0.006	0.741IleTyr: 0.741 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.684LysAla: 3.684 ± 0.039	0.5LysCys: 0.5 ± 0.012	1.856LysAsp: 1.856 ± 0.028	2.625LysGlu: 2.625 ± 0.059	0.71LysPhe: 0.71 ± 0.016	2.105LysGly: 2.105 ± 0.034	0.813LysHis: 0.813 ± 0.014	0.947LysIle: 0.947 ± 0.019	1.915LysLys: 1.915 ± 0.034	2.867LysLeu: 2.867 ± 0.037	0.864LysMet: 0.864 ± 0.017	0.958LysAsn: 0.958 ± 0.019	1.693LysPro: 1.693 ± 0.027	1.418LysGln: 1.418 ± 0.026	2.752LysArg: 2.752 ± 0.033	2.304LysSer: 2.304 ± 0.032	1.828LysThr: 1.828 ± 0.025	2.185LysVal: 2.185 ± 0.028	0.373LysTrp: 0.373 ± 0.013	0.85LysTyr: 0.85 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.706LeuAla: 8.706 ± 0.075	2.097LeuCys: 2.097 ± 0.026	4.075LeuAsp: 4.075 ± 0.039	5.43LeuGlu: 5.43 ± 0.11	3.116LeuPhe: 3.116 ± 0.037	4.53LeuGly: 4.53 ± 0.042	3.017LeuHis: 3.017 ± 0.036	2.593LeuIle: 2.593 ± 0.031	3.029LeuLys: 3.029 ± 0.036	10.227LeuLeu: 10.227 ± 0.079	2.021LeuMet: 2.021 ± 0.024	2.347LeuAsn: 2.347 ± 0.031	5.891LeuPro: 5.891 ± 0.05	4.953LeuGln: 4.953 ± 0.052	8.339LeuArg: 8.339 ± 0.194	7.792LeuSer: 7.792 ± 0.053	4.934LeuThr: 4.934 ± 0.043	5.915LeuVal: 5.915 ± 0.16	1.135LeuTrp: 1.135 ± 0.019	2.362LeuTyr: 2.362 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.291MetAla: 2.291 ± 0.026	0.409MetCys: 0.409 ± 0.009	1.122MetAsp: 1.122 ± 0.017	1.56MetGlu: 1.56 ± 0.024	0.597MetPhe: 0.597 ± 0.013	1.192MetGly: 1.192 ± 0.018	0.623MetHis: 0.623 ± 0.013	0.673MetIle: 0.673 ± 0.013	0.895MetLys: 0.895 ± 0.015	2.119MetLeu: 2.119 ± 0.026	0.649MetMet: 0.649 ± 0.016	0.744MetAsn: 0.744 ± 0.019	1.428MetPro: 1.428 ± 0.02	1.134MetGln: 1.134 ± 0.016	1.768MetArg: 1.768 ± 0.02	1.867MetSer: 1.867 ± 0.024	1.274MetThr: 1.274 ± 0.02	1.299MetVal: 1.299 ± 0.019	0.283MetTrp: 0.283 ± 0.008	0.553MetTyr: 0.553 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.289AsnAla: 3.289 ± 0.044	0.48AsnCys: 0.48 ± 0.01	1.389AsnAsp: 1.389 ± 0.021	1.486AsnGlu: 1.486 ± 0.023	0.822AsnPhe: 0.822 ± 0.016	2.22AsnGly: 2.22 ± 0.027	0.578AsnHis: 0.578 ± 0.011	1.049AsnIle: 1.049 ± 0.017	0.877AsnLys: 0.877 ± 0.018	1.91AsnLeu: 1.91 ± 0.026	0.619AsnMet: 0.619 ± 0.013	0.853AsnAsn: 0.853 ± 0.014	1.459AsnPro: 1.459 ± 0.02	0.708AsnGln: 0.708 ± 0.014	1.627AsnArg: 1.627 ± 0.02	2.123AsnSer: 2.123 ± 0.026	1.737AsnThr: 1.737 ± 0.021	1.987AsnVal: 1.987 ± 0.026	0.247AsnTrp: 0.247 ± 0.006	0.726AsnTyr: 0.726 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	6.776ProAla: 6.776 ± 0.07	0.904ProCys: 0.904 ± 0.015	2.048ProAsp: 2.048 ± 0.026	2.617ProGlu: 2.617 ± 0.037	1.82ProPhe: 1.82 ± 0.027	2.855ProGly: 2.855 ± 0.034	1.692ProHis: 1.692 ± 0.022	1.52ProIle: 1.52 ± 0.021	1.573ProLys: 1.573 ± 0.027	5.966ProLeu: 5.966 ± 0.073	1.11ProMet: 1.11 ± 0.018	1.362ProAsn: 1.362 ± 0.021	5.536ProPro: 5.536 ± 0.074	2.46ProGln: 2.46 ± 0.033	3.747ProArg: 3.747 ± 0.041	6.473ProSer: 6.473 ± 0.069	3.769ProThr: 3.769 ± 0.042	3.785ProVal: 3.785 ± 0.048	0.561ProTrp: 0.561 ± 0.011	1.321ProTyr: 1.321 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.745GlnAla: 3.745 ± 0.063	0.746GlnCys: 0.746 ± 0.018	1.465GlnAsp: 1.465 ± 0.023	2.516GlnGlu: 2.516 ± 0.047	0.931GlnPhe: 0.931 ± 0.017	1.832GlnGly: 1.832 ± 0.021	1.493GlnHis: 1.493 ± 0.02	0.935GlnIle: 0.935 ± 0.02	1.351GlnLys: 1.351 ± 0.024	5.104GlnLeu: 5.104 ± 0.203	0.881GlnMet: 0.881 ± 0.016	0.922GlnAsn: 0.922 ± 0.016	2.315GlnPro: 2.315 ± 0.033	3.919GlnGln: 3.919 ± 0.398	4.476GlnArg: 4.476 ± 0.043	2.659GlnSer: 2.659 ± 0.037	1.76GlnThr: 1.76 ± 0.017	2.297GlnVal: 2.297 ± 0.026	0.56GlnTrp: 0.56 ± 0.013	1.019GlnTyr: 1.019 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	7.574ArgAla: 7.574 ± 0.218	1.638ArgCys: 1.638 ± 0.026	3.507ArgAsp: 3.507 ± 0.043	4.494ArgGlu: 4.494 ± 0.061	2.009ArgPhe: 2.009 ± 0.022	4.669ArgGly: 4.669 ± 0.05	2.403ArgHis: 2.403 ± 0.028	2.275ArgIle: 2.275 ± 0.028	2.524ArgLys: 2.524 ± 0.029	6.965ArgLeu: 6.965 ± 0.066	1.57ArgMet: 1.57 ± 0.022	1.898ArgAsn: 1.898 ± 0.023	3.279ArgPro: 3.279 ± 0.03	3.527ArgGln: 3.527 ± 0.034	7.301ArgArg: 7.301 ± 0.068	5.682ArgSer: 5.682 ± 0.051	3.782ArgThr: 3.782 ± 0.034	4.835ArgVal: 4.835 ± 0.049	0.972ArgTrp: 0.972 ± 0.016	1.896ArgTyr: 1.896 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	11.009SerAla: 11.009 ± 0.101	1.501SerCys: 1.501 ± 0.024	3.741SerAsp: 3.741 ± 0.037	3.963SerGlu: 3.963 ± 0.084	2.562SerPhe: 2.562 ± 0.028	6.173SerGly: 6.173 ± 0.056	1.957SerHis: 1.957 ± 0.023	2.636SerIle: 2.636 ± 0.029	2.413SerLys: 2.413 ± 0.027	7.5SerLeu: 7.5 ± 0.052	1.851SerMet: 1.851 ± 0.025	2.149SerAsn: 2.149 ± 0.025	6.018SerPro: 6.018 ± 0.072	2.525SerGln: 2.525 ± 0.024	5.46SerArg: 5.46 ± 0.046	10.725SerSer: 10.725 ± 0.105	6.059SerThr: 6.059 ± 0.059	5.834SerVal: 5.834 ± 0.048	0.824SerTrp: 0.824 ± 0.015	1.659SerTyr: 1.659 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	8.239ThrAla: 8.239 ± 0.074	0.952ThrCys: 0.952 ± 0.017	2.52ThrAsp: 2.52 ± 0.028	3.184ThrGlu: 3.184 ± 0.037	1.718ThrPhe: 1.718 ± 0.025	3.674ThrGly: 3.674 ± 0.036	1.41ThrHis: 1.41 ± 0.018	1.812ThrIle: 1.812 ± 0.023	1.716ThrLys: 1.716 ± 0.024	5.393ThrLeu: 5.393 ± 0.048	1.239ThrMet: 1.239 ± 0.019	1.471ThrAsn: 1.471 ± 0.02	4.358ThrPro: 4.358 ± 0.049	2.025ThrGln: 2.025 ± 0.037	3.509ThrArg: 3.509 ± 0.034	5.755ThrSer: 5.755 ± 0.059	4.347ThrThr: 4.347 ± 0.054	4.365ThrVal: 4.365 ± 0.041	0.568ThrTrp: 0.568 ± 0.012	1.289ThrTyr: 1.289 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	8.204ValAla: 8.204 ± 0.06	1.741ValCys: 1.741 ± 0.189	3.689ValAsp: 3.689 ± 0.032	4.439ValGlu: 4.439 ± 0.06	2.28ValPhe: 2.28 ± 0.026	4.237ValGly: 4.237 ± 0.162	1.883ValHis: 1.883 ± 0.023	2.022ValIle: 2.022 ± 0.028	2.315ValLys: 2.315 ± 0.028	7.262ValLeu: 7.262 ± 0.151	1.672ValMet: 1.672 ± 0.021	1.814ValAsn: 1.814 ± 0.022	4.291ValPro: 4.291 ± 0.044	3.08ValGln: 3.08 ± 0.184	4.903ValArg: 4.903 ± 0.052	5.687ValSer: 5.687 ± 0.046	4.073ValThr: 4.073 ± 0.038	5.873ValVal: 5.873 ± 0.21	0.794ValTrp: 0.794 ± 0.013	1.821ValTyr: 1.821 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	0.987TrpAla: 0.987 ± 0.019	0.307TrpCys: 0.307 ± 0.008	0.486TrpAsp: 0.486 ± 0.01	0.573TrpGlu: 0.573 ± 0.011	0.289TrpPhe: 0.289 ± 0.008	0.627TrpGly: 0.627 ± 0.015	0.286TrpHis: 0.286 ± 0.008	0.357TrpIle: 0.357 ± 0.01	0.448TrpLys: 0.448 ± 0.01	1.045TrpLeu: 1.045 ± 0.016	0.341TrpMet: 0.341 ± 0.008	0.361TrpAsn: 0.361 ± 0.009	0.453TrpPro: 0.453 ± 0.01	0.468TrpGln: 0.468 ± 0.012	1.091TrpArg: 1.091 ± 0.019	0.856TrpSer: 0.856 ± 0.015	0.586TrpThr: 0.586 ± 0.012	0.686TrpVal: 0.686 ± 0.013	0.225TrpTrp: 0.225 ± 0.007	0.307TrpTyr: 0.307 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.403TyrAla: 2.403 ± 0.026	0.491TyrCys: 0.491 ± 0.011	1.274TyrAsp: 1.274 ± 0.02	1.36TyrGlu: 1.36 ± 0.024	0.891TyrPhe: 0.891 ± 0.018	1.636TyrGly: 1.636 ± 0.021	0.67TyrHis: 0.67 ± 0.012	0.892TyrIle: 0.892 ± 0.019	0.733TyrLys: 0.733 ± 0.013	2.205TyrLeu: 2.205 ± 0.029	0.608TyrMet: 0.608 ± 0.012	0.799TyrAsn: 0.799 ± 0.016	1.133TyrPro: 1.133 ± 0.018	0.838TyrGln: 0.838 ± 0.014	1.684TyrArg: 1.684 ± 0.02	1.637TyrSer: 1.637 ± 0.02	1.445TyrThr: 1.445 ± 0.02	1.987TyrVal: 1.987 ± 0.024	0.282TyrTrp: 0.282 ± 0.007	0.872TyrTyr: 0.872 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7554 proteins (5270428 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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