Amino acid dipepetide frequency for Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.381AlaAla: 4.381 ± 0.15
0.537AlaCys: 0.537 ± 0.041
3.059AlaAsp: 3.059 ± 0.085
3.748AlaGlu: 3.748 ± 0.097
3.167AlaPhe: 3.167 ± 0.087
4.052AlaGly: 4.052 ± 0.117
1.045AlaHis: 1.045 ± 0.044
5.755AlaIle: 5.755 ± 0.116
6.913AlaLys: 6.913 ± 0.125
6.596AlaLeu: 6.596 ± 0.125
1.668AlaMet: 1.668 ± 0.063
3.017AlaAsn: 3.017 ± 0.086
1.778AlaPro: 1.778 ± 0.065
1.493AlaGln: 1.493 ± 0.054
2.018AlaArg: 2.018 ± 0.065
2.888AlaSer: 2.888 ± 0.091
2.79AlaThr: 2.79 ± 0.076
4.51AlaVal: 4.51 ± 0.117
0.383AlaTrp: 0.383 ± 0.028
2.611AlaTyr: 2.611 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.471CysAla: 0.471 ± 0.035
0.108CysCys: 0.108 ± 0.016
0.554CysAsp: 0.554 ± 0.037
0.687CysGlu: 0.687 ± 0.035
0.389CysPhe: 0.389 ± 0.026
0.748CysGly: 0.748 ± 0.042
0.204CysHis: 0.204 ± 0.029
0.548CysIle: 0.548 ± 0.035
0.8CysLys: 0.8 ± 0.044
0.508CysLeu: 0.508 ± 0.03
0.204CysMet: 0.204 ± 0.021
0.437CysAsn: 0.437 ± 0.029
0.433CysPro: 0.433 ± 0.034
0.142CysGln: 0.142 ± 0.017
0.266CysArg: 0.266 ± 0.023
0.446CysSer: 0.446 ± 0.032
0.306CysThr: 0.306 ± 0.023
0.487CysVal: 0.487 ± 0.031
0.056CysTrp: 0.056 ± 0.012
0.296CysTyr: 0.296 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.034AspAla: 3.034 ± 0.092
0.358AspCys: 0.358 ± 0.025
2.644AspAsp: 2.644 ± 0.085
5.293AspGlu: 5.293 ± 0.106
3.488AspPhe: 3.488 ± 0.086
2.761AspGly: 2.761 ± 0.08
0.568AspHis: 0.568 ± 0.035
6.02AspIle: 6.02 ± 0.12
5.468AspLys: 5.468 ± 0.103
5.514AspLeu: 5.514 ± 0.108
1.272AspMet: 1.272 ± 0.05
2.678AspAsn: 2.678 ± 0.088
1.574AspPro: 1.574 ± 0.058
0.695AspGln: 0.695 ± 0.042
1.505AspArg: 1.505 ± 0.059
2.38AspSer: 2.38 ± 0.07
2.413AspThr: 2.413 ± 0.08
3.706AspVal: 3.706 ± 0.089
0.342AspTrp: 0.342 ± 0.027
2.505AspTyr: 2.505 ± 0.078
0.0AspXaa: 0.0 ± 0.0
Glu
4.606GluAla: 4.606 ± 0.103
0.737GluCys: 0.737 ± 0.039
3.8GluAsp: 3.8 ± 0.088
6.642GluGlu: 6.642 ± 0.138
4.344GluPhe: 4.344 ± 0.091
3.65GluGly: 3.65 ± 0.102
1.102GluHis: 1.102 ± 0.042
8.639GluIle: 8.639 ± 0.153
8.799GluLys: 8.799 ± 0.16
7.277GluLeu: 7.277 ± 0.141
1.907GluMet: 1.907 ± 0.072
5.014GluAsn: 5.014 ± 0.104
1.659GluPro: 1.659 ± 0.06
1.353GluGln: 1.353 ± 0.052
2.351GluArg: 2.351 ± 0.079
2.851GluSer: 2.851 ± 0.082
2.751GluThr: 2.751 ± 0.082
5.037GluVal: 5.037 ± 0.117
0.687GluTrp: 0.687 ± 0.033
3.371GluTyr: 3.371 ± 0.093
0.0GluXaa: 0.0 ± 0.0
Phe
3.486PheAla: 3.486 ± 0.103
0.45PheCys: 0.45 ± 0.03
3.359PheAsp: 3.359 ± 0.088
4.298PheGlu: 4.298 ± 0.094
3.115PhePhe: 3.115 ± 0.099
3.3PheGly: 3.3 ± 0.085
0.798PheHis: 0.798 ± 0.033
4.824PheIle: 4.824 ± 0.13
4.829PheLys: 4.829 ± 0.103
5.672PheLeu: 5.672 ± 0.129
1.276PheMet: 1.276 ± 0.051
3.04PheAsn: 3.04 ± 0.081
1.472PhePro: 1.472 ± 0.056
0.943PheGln: 0.943 ± 0.046
1.495PheArg: 1.495 ± 0.049
3.213PheSer: 3.213 ± 0.087
2.442PheThr: 2.442 ± 0.067
3.386PheVal: 3.386 ± 0.083
0.498PheTrp: 0.498 ± 0.032
2.343PheTyr: 2.343 ± 0.074
0.0PheXaa: 0.0 ± 0.0
Gly
3.948GlyAla: 3.948 ± 0.122
0.704GlyCys: 0.704 ± 0.043
3.057GlyAsp: 3.057 ± 0.086
4.139GlyGlu: 4.139 ± 0.095
3.456GlyPhe: 3.456 ± 0.088
3.763GlyGly: 3.763 ± 0.127
1.051GlyHis: 1.051 ± 0.046
5.693GlyIle: 5.693 ± 0.126
4.947GlyLys: 4.947 ± 0.112
4.612GlyLeu: 4.612 ± 0.091
1.587GlyMet: 1.587 ± 0.056
2.574GlyAsn: 2.574 ± 0.079
1.074GlyPro: 1.074 ± 0.055
1.081GlyGln: 1.081 ± 0.051
1.978GlyArg: 1.978 ± 0.066
3.082GlySer: 3.082 ± 0.081
2.253GlyThr: 2.253 ± 0.082
4.652GlyVal: 4.652 ± 0.123
0.494GlyTrp: 0.494 ± 0.03
2.811GlyTyr: 2.811 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
0.895HisAla: 0.895 ± 0.048
0.14HisCys: 0.14 ± 0.016
0.625HisAsp: 0.625 ± 0.031
0.831HisGlu: 0.831 ± 0.039
0.956HisPhe: 0.956 ± 0.046
0.983HisGly: 0.983 ± 0.044
0.337HisHis: 0.337 ± 0.026
1.601HisIle: 1.601 ± 0.052
1.424HisLys: 1.424 ± 0.048
1.507HisLeu: 1.507 ± 0.055
0.36HisMet: 0.36 ± 0.029
0.779HisAsn: 0.779 ± 0.044
0.877HisPro: 0.877 ± 0.04
0.452HisGln: 0.452 ± 0.03
0.577HisArg: 0.577 ± 0.031
0.941HisSer: 0.941 ± 0.04
0.891HisThr: 0.891 ± 0.043
0.7HisVal: 0.7 ± 0.033
0.121HisTrp: 0.121 ± 0.018
0.66HisTyr: 0.66 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.378IleAla: 6.378 ± 0.131
0.637IleCys: 0.637 ± 0.035
6.067IleAsp: 6.067 ± 0.144
7.637IleGlu: 7.637 ± 0.143
4.61IlePhe: 4.61 ± 0.12
5.351IleGly: 5.351 ± 0.123
1.305IleHis: 1.305 ± 0.052
8.4IleIle: 8.4 ± 0.16
10.082IleLys: 10.082 ± 0.168
8.71IleLeu: 8.71 ± 0.164
1.928IleMet: 1.928 ± 0.056
5.886IleAsn: 5.886 ± 0.128
3.294IlePro: 3.294 ± 0.079
2.082IleGln: 2.082 ± 0.065
2.709IleArg: 2.709 ± 0.08
5.36IleSer: 5.36 ± 0.11
4.648IleThr: 4.648 ± 0.094
5.889IleVal: 5.889 ± 0.116
0.552IleTrp: 0.552 ± 0.032
3.888IleTyr: 3.888 ± 0.095
0.0IleXaa: 0.0 ± 0.0
Lys
5.943LysAla: 5.943 ± 0.117
0.697LysCys: 0.697 ± 0.042
5.936LysAsp: 5.936 ± 0.116
9.942LysGlu: 9.942 ± 0.156
4.31LysPhe: 4.31 ± 0.097
4.697LysGly: 4.697 ± 0.087
1.657LysHis: 1.657 ± 0.054
10.022LysIle: 10.022 ± 0.181
11.388LysLys: 11.388 ± 0.205
8.999LysLeu: 8.999 ± 0.145
2.355LysMet: 2.355 ± 0.066
7.352LysAsn: 7.352 ± 0.153
3.198LysPro: 3.198 ± 0.076
2.524LysGln: 2.524 ± 0.076
3.7LysArg: 3.7 ± 0.078
4.5LysSer: 4.5 ± 0.091
5.145LysThr: 5.145 ± 0.107
5.701LysVal: 5.701 ± 0.115
0.756LysTrp: 0.756 ± 0.046
4.737LysTyr: 4.737 ± 0.102
0.0LysXaa: 0.0 ± 0.0
Leu
5.936LeuAla: 5.936 ± 0.12
0.643LeuCys: 0.643 ± 0.041
4.812LeuAsp: 4.812 ± 0.104
6.544LeuGlu: 6.544 ± 0.11
5.281LeuPhe: 5.281 ± 0.124
5.218LeuGly: 5.218 ± 0.108
1.372LeuHis: 1.372 ± 0.048
8.448LeuIle: 8.448 ± 0.146
11.173LeuLys: 11.173 ± 0.164
8.408LeuLeu: 8.408 ± 0.142
2.08LeuMet: 2.08 ± 0.065
6.288LeuAsn: 6.288 ± 0.135
3.554LeuPro: 3.554 ± 0.072
2.569LeuGln: 2.569 ± 0.075
2.984LeuArg: 2.984 ± 0.08
5.884LeuSer: 5.884 ± 0.117
4.523LeuThr: 4.523 ± 0.087
4.762LeuVal: 4.762 ± 0.113
0.648LeuTrp: 0.648 ± 0.036
3.452LeuTyr: 3.452 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
1.585MetAla: 1.585 ± 0.053
0.185MetCys: 0.185 ± 0.02
1.21MetAsp: 1.21 ± 0.055
1.445MetGlu: 1.445 ± 0.051
1.241MetPhe: 1.241 ± 0.053
1.355MetGly: 1.355 ± 0.051
0.383MetHis: 0.383 ± 0.025
2.115MetIle: 2.115 ± 0.068
2.613MetLys: 2.613 ± 0.071
2.267MetLeu: 2.267 ± 0.069
0.527MetMet: 0.527 ± 0.03
1.214MetAsn: 1.214 ± 0.052
0.981MetPro: 0.981 ± 0.045
0.758MetGln: 0.758 ± 0.037
0.874MetArg: 0.874 ± 0.042
1.274MetSer: 1.274 ± 0.057
0.96MetThr: 0.96 ± 0.049
1.42MetVal: 1.42 ± 0.058
0.175MetTrp: 0.175 ± 0.02
0.714MetTyr: 0.714 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
3.352AsnAla: 3.352 ± 0.083
0.393AsnCys: 0.393 ± 0.03
2.884AsnAsp: 2.884 ± 0.094
4.725AsnGlu: 4.725 ± 0.094
2.911AsnPhe: 2.911 ± 0.088
3.273AsnGly: 3.273 ± 0.093
0.764AsnHis: 0.764 ± 0.04
6.226AsnIle: 6.226 ± 0.139
5.624AsnLys: 5.624 ± 0.131
5.422AsnLeu: 5.422 ± 0.117
1.231AsnMet: 1.231 ± 0.05
3.259AsnAsn: 3.259 ± 0.131
2.492AsnPro: 2.492 ± 0.068
1.405AsnGln: 1.405 ± 0.054
1.911AsnArg: 1.911 ± 0.066
3.215AsnSer: 3.215 ± 0.101
2.761AsnThr: 2.761 ± 0.083
3.257AsnVal: 3.257 ± 0.095
0.339AsnTrp: 0.339 ± 0.023
2.532AsnTyr: 2.532 ± 0.08
0.0AsnXaa: 0.0 ± 0.0
Pro
1.724ProAla: 1.724 ± 0.071
0.25ProCys: 0.25 ± 0.023
1.647ProAsp: 1.647 ± 0.055
2.724ProGlu: 2.724 ± 0.082
2.022ProPhe: 2.022 ± 0.061
1.739ProGly: 1.739 ± 0.066
0.656ProHis: 0.656 ± 0.032
2.647ProIle: 2.647 ± 0.066
3.309ProLys: 3.309 ± 0.077
3.057ProLeu: 3.057 ± 0.077
0.668ProMet: 0.668 ± 0.036
1.732ProAsn: 1.732 ± 0.067
0.914ProPro: 0.914 ± 0.046
0.931ProGln: 0.931 ± 0.039
0.874ProArg: 0.874 ± 0.05
1.585ProSer: 1.585 ± 0.053
1.739ProThr: 1.739 ± 0.055
2.476ProVal: 2.476 ± 0.072
0.258ProTrp: 0.258 ± 0.023
1.478ProTyr: 1.478 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
1.42GlnAla: 1.42 ± 0.052
0.165GlnCys: 0.165 ± 0.018
0.962GlnAsp: 0.962 ± 0.041
1.58GlnGlu: 1.58 ± 0.058
1.014GlnPhe: 1.014 ± 0.057
1.097GlnGly: 1.097 ± 0.052
0.331GlnHis: 0.331 ± 0.026
2.445GlnIle: 2.445 ± 0.074
3.173GlnLys: 3.173 ± 0.091
1.786GlnLeu: 1.786 ± 0.05
0.67GlnMet: 0.67 ± 0.035
2.032GlnAsn: 2.032 ± 0.073
0.571GlnPro: 0.571 ± 0.033
0.706GlnGln: 0.706 ± 0.054
0.86GlnArg: 0.86 ± 0.039
0.999GlnSer: 0.999 ± 0.046
1.293GlnThr: 1.293 ± 0.054
1.122GlnVal: 1.122 ± 0.048
0.156GlnTrp: 0.156 ± 0.017
0.741GlnTyr: 0.741 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
1.991ArgAla: 1.991 ± 0.071
0.264ArgCys: 0.264 ± 0.023
1.866ArgAsp: 1.866 ± 0.06
2.395ArgGlu: 2.395 ± 0.079
1.891ArgPhe: 1.891 ± 0.063
2.057ArgGly: 2.057 ± 0.066
0.566ArgHis: 0.566 ± 0.034
2.994ArgIle: 2.994 ± 0.078
2.882ArgLys: 2.882 ± 0.074
2.821ArgLeu: 2.821 ± 0.079
0.77ArgMet: 0.77 ± 0.042
1.655ArgAsn: 1.655 ± 0.057
0.904ArgPro: 0.904 ± 0.044
0.697ArgGln: 0.697 ± 0.036
1.272ArgArg: 1.272 ± 0.056
1.458ArgSer: 1.458 ± 0.054
1.056ArgThr: 1.056 ± 0.046
2.272ArgVal: 2.272 ± 0.068
0.262ArgTrp: 0.262 ± 0.026
1.439ArgTyr: 1.439 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
3.28SerAla: 3.28 ± 0.077
0.389SerCys: 0.389 ± 0.03
2.601SerAsp: 2.601 ± 0.092
3.388SerGlu: 3.388 ± 0.085
3.204SerPhe: 3.204 ± 0.082
3.338SerGly: 3.338 ± 0.098
0.885SerHis: 0.885 ± 0.039
4.849SerIle: 4.849 ± 0.116
4.877SerLys: 4.877 ± 0.092
5.433SerLeu: 5.433 ± 0.096
1.274SerMet: 1.274 ± 0.06
2.698SerAsn: 2.698 ± 0.083
1.685SerPro: 1.685 ± 0.065
1.393SerGln: 1.393 ± 0.066
1.526SerArg: 1.526 ± 0.051
2.948SerSer: 2.948 ± 0.077
2.267SerThr: 2.267 ± 0.073
3.296SerVal: 3.296 ± 0.077
0.339SerTrp: 0.339 ± 0.026
2.138SerTyr: 2.138 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
2.921ThrAla: 2.921 ± 0.076
0.369ThrCys: 0.369 ± 0.026
2.594ThrAsp: 2.594 ± 0.081
2.33ThrGlu: 2.33 ± 0.074
2.42ThrPhe: 2.42 ± 0.075
3.057ThrGly: 3.057 ± 0.089
0.935ThrHis: 0.935 ± 0.045
3.971ThrIle: 3.971 ± 0.101
4.081ThrLys: 4.081 ± 0.085
5.006ThrLeu: 5.006 ± 0.102
0.879ThrMet: 0.879 ± 0.041
2.213ThrAsn: 2.213 ± 0.076
2.349ThrPro: 2.349 ± 0.066
1.364ThrGln: 1.364 ± 0.052
1.135ThrArg: 1.135 ± 0.051
2.54ThrSer: 2.54 ± 0.077
2.463ThrThr: 2.463 ± 0.082
2.799ThrVal: 2.799 ± 0.08
0.283ThrTrp: 0.283 ± 0.025
1.988ThrTyr: 1.988 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
4.254ValAla: 4.254 ± 0.101
0.641ValCys: 0.641 ± 0.039
3.736ValAsp: 3.736 ± 0.093
4.468ValGlu: 4.468 ± 0.102
3.357ValPhe: 3.357 ± 0.073
3.727ValGly: 3.727 ± 0.096
0.812ValHis: 0.812 ± 0.043
5.859ValIle: 5.859 ± 0.107
6.178ValLys: 6.178 ± 0.108
6.028ValLeu: 6.028 ± 0.129
1.53ValMet: 1.53 ± 0.059
3.292ValAsn: 3.292 ± 0.081
1.893ValPro: 1.893 ± 0.066
1.172ValGln: 1.172 ± 0.047
1.957ValArg: 1.957 ± 0.065
3.529ValSer: 3.529 ± 0.085
2.848ValThr: 2.848 ± 0.082
4.36ValVal: 4.36 ± 0.106
0.421ValTrp: 0.421 ± 0.025
2.624ValTyr: 2.624 ± 0.076
0.0ValXaa: 0.0 ± 0.0
Trp
0.444TrpAla: 0.444 ± 0.03
0.096TrpCys: 0.096 ± 0.015
0.423TrpAsp: 0.423 ± 0.027
0.491TrpGlu: 0.491 ± 0.032
0.427TrpPhe: 0.427 ± 0.029
0.5TrpGly: 0.5 ± 0.031
0.187TrpHis: 0.187 ± 0.019
0.658TrpIle: 0.658 ± 0.035
0.554TrpLys: 0.554 ± 0.032
0.693TrpLeu: 0.693 ± 0.039
0.241TrpMet: 0.241 ± 0.024
0.319TrpAsn: 0.319 ± 0.026
0.173TrpPro: 0.173 ± 0.019
0.306TrpGln: 0.306 ± 0.023
0.223TrpArg: 0.223 ± 0.023
0.308TrpSer: 0.308 ± 0.027
0.215TrpThr: 0.215 ± 0.023
0.483TrpVal: 0.483 ± 0.032
0.09TrpTrp: 0.09 ± 0.014
0.325TrpTyr: 0.325 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.359TyrAla: 2.359 ± 0.067
0.329TyrCys: 0.329 ± 0.026
2.38TyrAsp: 2.38 ± 0.073
3.271TyrGlu: 3.271 ± 0.084
2.636TyrPhe: 2.636 ± 0.074
2.292TyrGly: 2.292 ± 0.065
0.702TyrHis: 0.702 ± 0.034
3.698TyrIle: 3.698 ± 0.085
4.443TyrLys: 4.443 ± 0.105
4.264TyrLeu: 4.264 ± 0.105
0.868TyrMet: 0.868 ± 0.04
2.497TyrAsn: 2.497 ± 0.083
1.557TyrPro: 1.557 ± 0.059
1.056TyrGln: 1.056 ± 0.048
1.299TyrArg: 1.299 ± 0.051
2.405TyrSer: 2.405 ± 0.068
1.934TyrThr: 1.934 ± 0.067
2.368TyrVal: 2.368 ± 0.063
0.296TyrTrp: 0.296 ± 0.027
1.966TyrTyr: 1.966 ± 0.082
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1730 proteins (519740 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski