Amino acid dipepetide frequency for Salinimicrobium catena

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.45AlaAla: 5.45 ± 0.084	0.513AlaCys: 0.513 ± 0.028	3.436AlaAsp: 3.436 ± 0.069	5.33AlaGlu: 5.33 ± 0.088	3.38AlaPhe: 3.38 ± 0.062	4.99AlaGly: 4.99 ± 0.079	1.213AlaHis: 1.213 ± 0.036	4.85AlaIle: 4.85 ± 0.077	4.294AlaLys: 4.294 ± 0.069	6.366AlaLeu: 6.366 ± 0.09	1.647AlaMet: 1.647 ± 0.043	2.96AlaAsn: 2.96 ± 0.054	2.23AlaPro: 2.23 ± 0.051	2.404AlaGln: 2.404 ± 0.051	2.656AlaArg: 2.656 ± 0.05	3.976AlaSer: 3.976 ± 0.086	3.562AlaThr: 3.562 ± 0.072	4.897AlaVal: 4.897 ± 0.08	0.665AlaTrp: 0.665 ± 0.025	2.398AlaTyr: 2.398 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.383CysAla: 0.383 ± 0.022	0.099CysCys: 0.099 ± 0.011	0.395CysAsp: 0.395 ± 0.02	0.482CysGlu: 0.482 ± 0.031	0.341CysPhe: 0.341 ± 0.019	0.566CysGly: 0.566 ± 0.028	0.147CysHis: 0.147 ± 0.013	0.463CysIle: 0.463 ± 0.025	0.346CysLys: 0.346 ± 0.02	0.535CysLeu: 0.535 ± 0.025	0.138CysMet: 0.138 ± 0.013	0.292CysAsn: 0.292 ± 0.02	0.339CysPro: 0.339 ± 0.029	0.183CysGln: 0.183 ± 0.014	0.253CysArg: 0.253 ± 0.017	0.487CysSer: 0.487 ± 0.023	0.392CysThr: 0.392 ± 0.019	0.379CysVal: 0.379 ± 0.02	0.05CysTrp: 0.05 ± 0.007	0.262CysTyr: 0.262 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.437AspAla: 3.437 ± 0.068	0.363AspCys: 0.363 ± 0.02	2.64AspAsp: 2.64 ± 0.057	4.086AspGlu: 4.086 ± 0.07	3.479AspPhe: 3.479 ± 0.057	3.307AspGly: 3.307 ± 0.07	1.246AspHis: 1.246 ± 0.035	3.675AspIle: 3.675 ± 0.072	3.426AspLys: 3.426 ± 0.062	6.195AspLeu: 6.195 ± 0.091	1.122AspMet: 1.122 ± 0.034	2.37AspAsn: 2.37 ± 0.059	2.426AspPro: 2.426 ± 0.059	1.799AspGln: 1.799 ± 0.047	2.417AspArg: 2.417 ± 0.047	3.05AspSer: 3.05 ± 0.059	2.516AspThr: 2.516 ± 0.051	3.428AspVal: 3.428 ± 0.068	0.786AspTrp: 0.786 ± 0.029	2.625AspTyr: 2.625 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	5.39GluAla: 5.39 ± 0.093	0.339GluCys: 0.339 ± 0.021	4.495GluAsp: 4.495 ± 0.063	7.792GluGlu: 7.792 ± 0.111	3.48GluPhe: 3.48 ± 0.064	4.841GluGly: 4.841 ± 0.08	1.357GluHis: 1.357 ± 0.04	6.079GluIle: 6.079 ± 0.078	7.195GluLys: 7.195 ± 0.107	7.163GluLeu: 7.163 ± 0.106	2.051GluMet: 2.051 ± 0.051	4.899GluAsn: 4.899 ± 0.075	2.108GluPro: 2.108 ± 0.049	2.755GluGln: 2.755 ± 0.059	3.273GluArg: 3.273 ± 0.06	3.2GluSer: 3.2 ± 0.051	3.753GluThr: 3.753 ± 0.061	5.657GluVal: 5.657 ± 0.083	0.772GluTrp: 0.772 ± 0.026	2.682GluTyr: 2.682 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.126PheAla: 3.126 ± 0.065	0.405PheCys: 0.405 ± 0.019	3.041PheAsp: 3.041 ± 0.054	3.673PheGlu: 3.673 ± 0.051	2.951PhePhe: 2.951 ± 0.07	3.648PheGly: 3.648 ± 0.07	0.902PheHis: 0.902 ± 0.034	3.423PheIle: 3.423 ± 0.067	3.07PheLys: 3.07 ± 0.059	5.344PheLeu: 5.344 ± 0.087	1.166PheMet: 1.166 ± 0.037	2.537PheAsn: 2.537 ± 0.056	1.981PhePro: 1.981 ± 0.045	1.676PheGln: 1.676 ± 0.037	2.173PheArg: 2.173 ± 0.051	4.25PheSer: 4.25 ± 0.084	3.028PheThr: 3.028 ± 0.056	2.778PheVal: 2.778 ± 0.058	0.625PheTrp: 0.625 ± 0.025	2.094PheTyr: 2.094 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	4.434GlyAla: 4.434 ± 0.067	0.567GlyCys: 0.567 ± 0.027	3.472GlyAsp: 3.472 ± 0.069	4.741GlyGlu: 4.741 ± 0.077	3.558GlyPhe: 3.558 ± 0.069	4.672GlyGly: 4.672 ± 0.084	1.199GlyHis: 1.199 ± 0.031	5.413GlyIle: 5.413 ± 0.084	5.241GlyLys: 5.241 ± 0.075	5.916GlyLeu: 5.916 ± 0.091	1.872GlyMet: 1.872 ± 0.046	3.444GlyAsn: 3.444 ± 0.073	1.552GlyPro: 1.552 ± 0.043	1.962GlyGln: 1.962 ± 0.056	2.511GlyArg: 2.511 ± 0.056	4.091GlySer: 4.091 ± 0.074	3.829GlyThr: 3.829 ± 0.077	4.501GlyVal: 4.501 ± 0.067	0.805GlyTrp: 0.805 ± 0.033	2.747GlyTyr: 2.747 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	0.967HisAla: 0.967 ± 0.032	0.164HisCys: 0.164 ± 0.013	0.896HisAsp: 0.896 ± 0.029	1.168HisGlu: 1.168 ± 0.041	1.234HisPhe: 1.234 ± 0.035	1.169HisGly: 1.169 ± 0.037	0.495HisHis: 0.495 ± 0.023	1.271HisIle: 1.271 ± 0.035	1.126HisLys: 1.126 ± 0.041	2.057HisLeu: 2.057 ± 0.049	0.34HisMet: 0.34 ± 0.019	0.858HisAsn: 0.858 ± 0.031	1.016HisPro: 1.016 ± 0.032	0.717HisGln: 0.717 ± 0.027	0.851HisArg: 0.851 ± 0.029	1.169HisSer: 1.169 ± 0.039	0.96HisThr: 0.96 ± 0.029	1.008HisVal: 1.008 ± 0.031	0.217HisTrp: 0.217 ± 0.016	0.878HisTyr: 0.878 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.06IleAla: 5.06 ± 0.082	0.477IleCys: 0.477 ± 0.023	4.119IleAsp: 4.119 ± 0.065	4.971IleGlu: 4.971 ± 0.081	3.778IlePhe: 3.778 ± 0.068	4.537IleGly: 4.537 ± 0.082	1.252IleHis: 1.252 ± 0.035	4.881IleIle: 4.881 ± 0.085	4.697IleLys: 4.697 ± 0.085	6.869IleLeu: 6.869 ± 0.096	1.266IleMet: 1.266 ± 0.035	3.686IleAsn: 3.686 ± 0.062	3.186IlePro: 3.186 ± 0.06	2.153IleGln: 2.153 ± 0.047	2.893IleArg: 2.893 ± 0.061	5.232IleSer: 5.232 ± 0.074	3.973IleThr: 3.973 ± 0.076	4.068IleVal: 4.068 ± 0.075	0.676IleTrp: 0.676 ± 0.024	2.618IleTyr: 2.618 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	4.835LysAla: 4.835 ± 0.084	0.335LysCys: 0.335 ± 0.018	4.435LysAsp: 4.435 ± 0.072	6.989LysGlu: 6.989 ± 0.117	2.878LysPhe: 2.878 ± 0.054	4.422LysGly: 4.422 ± 0.073	1.179LysHis: 1.179 ± 0.032	5.291LysIle: 5.291 ± 0.087	6.794LysLys: 6.794 ± 0.108	6.141LysLeu: 6.141 ± 0.089	2.041LysMet: 2.041 ± 0.043	4.246LysAsn: 4.246 ± 0.069	2.39LysPro: 2.39 ± 0.047	2.402LysGln: 2.402 ± 0.049	3.085LysArg: 3.085 ± 0.056	3.543LysSer: 3.543 ± 0.062	3.759LysThr: 3.759 ± 0.06	4.683LysVal: 4.683 ± 0.072	0.728LysTrp: 0.728 ± 0.031	2.728LysTyr: 2.728 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	6.318LeuAla: 6.318 ± 0.092	0.594LeuCys: 0.594 ± 0.028	5.079LeuAsp: 5.079 ± 0.079	7.414LeuGlu: 7.414 ± 0.096	5.019LeuPhe: 5.019 ± 0.095	6.099LeuGly: 6.099 ± 0.089	1.774LeuHis: 1.774 ± 0.041	6.318LeuIle: 6.318 ± 0.085	7.617LeuLys: 7.617 ± 0.1	9.704LeuLeu: 9.704 ± 0.132	2.169LeuMet: 2.169 ± 0.043	4.967LeuAsn: 4.967 ± 0.072	3.921LeuPro: 3.921 ± 0.058	4.038LeuGln: 4.038 ± 0.086	3.909LeuArg: 3.909 ± 0.071	6.542LeuSer: 6.542 ± 0.09	4.781LeuThr: 4.781 ± 0.077	5.793LeuVal: 5.793 ± 0.064	0.885LeuTrp: 0.885 ± 0.034	3.131LeuTyr: 3.131 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.898MetAla: 1.898 ± 0.046	0.13MetCys: 0.13 ± 0.012	1.213MetAsp: 1.213 ± 0.036	1.821MetGlu: 1.821 ± 0.043	0.851MetPhe: 0.851 ± 0.031	1.611MetGly: 1.611 ± 0.039	0.419MetHis: 0.419 ± 0.023	1.545MetIle: 1.545 ± 0.047	2.264MetLys: 2.264 ± 0.054	2.08MetLeu: 2.08 ± 0.059	0.623MetMet: 0.623 ± 0.03	1.316MetAsn: 1.316 ± 0.035	0.901MetPro: 0.901 ± 0.034	0.826MetGln: 0.826 ± 0.027	1.045MetArg: 1.045 ± 0.03	1.247MetSer: 1.247 ± 0.037	1.136MetThr: 1.136 ± 0.029	1.475MetVal: 1.475 ± 0.038	0.176MetTrp: 0.176 ± 0.013	0.658MetTyr: 0.658 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.189AsnAla: 3.189 ± 0.061	0.37AsnCys: 0.37 ± 0.023	2.706AsnAsp: 2.706 ± 0.063	3.548AsnGlu: 3.548 ± 0.06	2.935AsnPhe: 2.935 ± 0.061	3.332AsnGly: 3.332 ± 0.074	0.94AsnHis: 0.94 ± 0.031	3.835AsnIle: 3.835 ± 0.061	3.286AsnLys: 3.286 ± 0.055	5.028AsnLeu: 5.028 ± 0.067	1.194AsnMet: 1.194 ± 0.033	2.636AsnAsn: 2.636 ± 0.062	2.455AsnPro: 2.455 ± 0.05	1.624AsnGln: 1.624 ± 0.044	2.343AsnArg: 2.343 ± 0.054	3.268AsnSer: 3.268 ± 0.058	2.803AsnThr: 2.803 ± 0.062	3.092AsnVal: 3.092 ± 0.058	0.709AsnTrp: 0.709 ± 0.028	2.383AsnTyr: 2.383 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	2.543ProAla: 2.543 ± 0.057	0.18ProCys: 0.18 ± 0.015	2.294ProAsp: 2.294 ± 0.054	3.827ProGlu: 3.827 ± 0.064	1.95ProPhe: 1.95 ± 0.051	2.519ProGly: 2.519 ± 0.055	0.737ProHis: 0.737 ± 0.029	2.184ProIle: 2.184 ± 0.046	2.426ProLys: 2.426 ± 0.052	3.286ProLeu: 3.286 ± 0.055	0.756ProMet: 0.756 ± 0.028	1.744ProAsn: 1.744 ± 0.043	0.997ProPro: 0.997 ± 0.035	1.538ProGln: 1.538 ± 0.039	1.154ProArg: 1.154 ± 0.038	2.147ProSer: 2.147 ± 0.054	1.768ProThr: 1.768 ± 0.044	3.153ProVal: 3.153 ± 0.057	0.368ProTrp: 0.368 ± 0.021	1.455ProTyr: 1.455 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.263GlnAla: 2.263 ± 0.052	0.138GlnCys: 0.138 ± 0.012	1.771GlnAsp: 1.771 ± 0.041	3.099GlnGlu: 3.099 ± 0.058	1.505GlnPhe: 1.505 ± 0.043	1.882GlnGly: 1.882 ± 0.05	0.611GlnHis: 0.611 ± 0.026	2.373GlnIle: 2.373 ± 0.05	3.176GlnLys: 3.176 ± 0.058	3.499GlnLeu: 3.499 ± 0.073	0.902GlnMet: 0.902 ± 0.029	1.945GlnAsn: 1.945 ± 0.047	1.258GlnPro: 1.258 ± 0.043	1.659GlnGln: 1.659 ± 0.048	1.483GlnArg: 1.483 ± 0.042	1.611GlnSer: 1.611 ± 0.044	1.68GlnThr: 1.68 ± 0.037	2.288GlnVal: 2.288 ± 0.048	0.366GlnTrp: 0.366 ± 0.02	1.255GlnTyr: 1.255 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.386ArgAla: 2.386 ± 0.053	0.181ArgCys: 0.181 ± 0.014	2.115ArgAsp: 2.115 ± 0.047	3.463ArgGlu: 3.463 ± 0.067	2.178ArgPhe: 2.178 ± 0.048	2.303ArgGly: 2.303 ± 0.048	0.832ArgHis: 0.832 ± 0.031	3.057ArgIle: 3.057 ± 0.063	3.586ArgLys: 3.586 ± 0.067	3.926ArgLeu: 3.926 ± 0.069	1.074ArgMet: 1.074 ± 0.035	2.448ArgAsn: 2.448 ± 0.054	1.357ArgPro: 1.357 ± 0.042	1.475ArgGln: 1.475 ± 0.039	1.847ArgArg: 1.847 ± 0.047	2.606ArgSer: 2.606 ± 0.058	2.105ArgThr: 2.105 ± 0.044	2.411ArgVal: 2.411 ± 0.056	0.464ArgTrp: 0.464 ± 0.027	1.706ArgTyr: 1.706 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	4.118SerAla: 4.118 ± 0.067	0.572SerCys: 0.572 ± 0.03	2.99SerAsp: 2.99 ± 0.06	4.906SerGlu: 4.906 ± 0.084	3.595SerPhe: 3.595 ± 0.064	4.772SerGly: 4.772 ± 0.085	1.103SerHis: 1.103 ± 0.033	4.246SerIle: 4.246 ± 0.07	3.897SerLys: 3.897 ± 0.068	5.985SerLeu: 5.985 ± 0.085	1.334SerMet: 1.334 ± 0.039	2.792SerAsn: 2.792 ± 0.053	2.233SerPro: 2.233 ± 0.05	1.968SerGln: 1.968 ± 0.042	2.701SerArg: 2.701 ± 0.059	4.083SerSer: 4.083 ± 0.076	3.176SerThr: 3.176 ± 0.057	3.873SerVal: 3.873 ± 0.06	0.711SerTrp: 0.711 ± 0.03	2.508SerTyr: 2.508 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	4.081ThrAla: 4.081 ± 0.06	0.312ThrCys: 0.312 ± 0.021	2.838ThrAsp: 2.838 ± 0.063	3.671ThrGlu: 3.671 ± 0.061	2.704ThrPhe: 2.704 ± 0.057	4.556ThrGly: 4.556 ± 0.079	0.955ThrHis: 0.955 ± 0.032	3.663ThrIle: 3.663 ± 0.072	2.668ThrLys: 2.668 ± 0.056	4.737ThrLeu: 4.737 ± 0.074	0.937ThrMet: 0.937 ± 0.035	2.35ThrAsn: 2.35 ± 0.051	2.384ThrPro: 2.384 ± 0.051	1.543ThrGln: 1.543 ± 0.043	2.161ThrArg: 2.161 ± 0.051	3.514ThrSer: 3.514 ± 0.063	3.028ThrThr: 3.028 ± 0.07	3.626ThrVal: 3.626 ± 0.074	0.562ThrTrp: 0.562 ± 0.029	2.069ThrTyr: 2.069 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	4.445ValAla: 4.445 ± 0.09	0.417ValCys: 0.417 ± 0.025	3.603ValAsp: 3.603 ± 0.06	4.823ValGlu: 4.823 ± 0.074	3.126ValPhe: 3.126 ± 0.058	3.952ValGly: 3.952 ± 0.061	1.147ValHis: 1.147 ± 0.036	4.817ValIle: 4.817 ± 0.079	4.447ValLys: 4.447 ± 0.072	6.273ValLeu: 6.273 ± 0.082	1.545ValMet: 1.545 ± 0.041	3.366ValAsn: 3.366 ± 0.066	2.461ValPro: 2.461 ± 0.056	2.182ValGln: 2.182 ± 0.045	2.404ValArg: 2.404 ± 0.056	4.24ValSer: 4.24 ± 0.064	3.534ValThr: 3.534 ± 0.072	4.538ValVal: 4.538 ± 0.076	0.659ValTrp: 0.659 ± 0.025	2.439ValTyr: 2.439 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.645TrpAla: 0.645 ± 0.03	0.078TrpCys: 0.078 ± 0.008	0.607TrpAsp: 0.607 ± 0.024	0.815TrpGlu: 0.815 ± 0.03	0.58TrpPhe: 0.58 ± 0.025	0.662TrpGly: 0.662 ± 0.024	0.238TrpHis: 0.238 ± 0.017	0.742TrpIle: 0.742 ± 0.03	0.842TrpLys: 0.842 ± 0.027	1.058TrpLeu: 1.058 ± 0.038	0.341TrpMet: 0.341 ± 0.017	0.69TrpAsn: 0.69 ± 0.029	0.3TrpPro: 0.3 ± 0.021	0.412TrpGln: 0.412 ± 0.021	0.463TrpArg: 0.463 ± 0.023	0.602TrpSer: 0.602 ± 0.023	0.501TrpThr: 0.501 ± 0.025	0.653TrpVal: 0.653 ± 0.026	0.179TrpTrp: 0.179 ± 0.014	0.482TrpTyr: 0.482 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.248TyrAla: 2.248 ± 0.044	0.3TyrCys: 0.3 ± 0.019	2.249TyrAsp: 2.249 ± 0.05	2.664TyrGlu: 2.664 ± 0.053	2.368TyrPhe: 2.368 ± 0.047	2.685TyrGly: 2.685 ± 0.055	0.815TyrHis: 0.815 ± 0.028	2.265TyrIle: 2.265 ± 0.044	2.504TyrLys: 2.504 ± 0.052	3.909TyrLeu: 3.909 ± 0.072	0.716TyrMet: 0.716 ± 0.031	2.129TyrAsn: 2.129 ± 0.051	1.532TyrPro: 1.532 ± 0.043	1.451TyrGln: 1.451 ± 0.038	1.9TyrArg: 1.9 ± 0.038	2.705TyrSer: 2.705 ± 0.061	2.069TyrThr: 2.069 ± 0.057	2.12TyrVal: 2.12 ± 0.046	0.489TyrTrp: 0.489 ± 0.021	1.656TyrTyr: 1.656 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2965 proteins (981291 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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