Amino acid dipepetide frequency for Gleimia hominis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.124AlaAla: 13.124 ± 0.203
1.024AlaCys: 1.024 ± 0.042
6.619AlaAsp: 6.619 ± 0.107
5.212AlaGlu: 5.212 ± 0.113
3.594AlaPhe: 3.594 ± 0.067
9.539AlaGly: 9.539 ± 0.125
2.659AlaHis: 2.659 ± 0.072
5.306AlaIle: 5.306 ± 0.107
4.205AlaLys: 4.205 ± 0.094
11.802AlaLeu: 11.802 ± 0.172
2.557AlaMet: 2.557 ± 0.061
3.142AlaAsn: 3.142 ± 0.07
4.524AlaPro: 4.524 ± 0.086
5.89AlaGln: 5.89 ± 0.119
7.659AlaArg: 7.659 ± 0.123
6.102AlaSer: 6.102 ± 0.097
5.893AlaThr: 5.893 ± 0.112
9.068AlaVal: 9.068 ± 0.151
1.572AlaTrp: 1.572 ± 0.062
2.374AlaTyr: 2.374 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
1.046CysAla: 1.046 ± 0.042
0.1CysCys: 0.1 ± 0.014
0.452CysAsp: 0.452 ± 0.03
0.5CysGlu: 0.5 ± 0.029
0.218CysPhe: 0.218 ± 0.019
0.865CysGly: 0.865 ± 0.04
0.186CysHis: 0.186 ± 0.023
0.341CysIle: 0.341 ± 0.02
0.226CysLys: 0.226 ± 0.019
0.734CysLeu: 0.734 ± 0.033
0.164CysMet: 0.164 ± 0.015
0.197CysAsn: 0.197 ± 0.019
0.447CysPro: 0.447 ± 0.03
0.197CysGln: 0.197 ± 0.02
0.416CysArg: 0.416 ± 0.027
0.557CysSer: 0.557 ± 0.029
0.519CysThr: 0.519 ± 0.031
0.705CysVal: 0.705 ± 0.04
0.105CysTrp: 0.105 ± 0.014
0.169CysTyr: 0.169 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
6.495AspAla: 6.495 ± 0.118
0.369AspCys: 0.369 ± 0.024
2.861AspAsp: 2.861 ± 0.077
4.24AspGlu: 4.24 ± 0.104
1.874AspPhe: 1.874 ± 0.06
4.573AspGly: 4.573 ± 0.105
1.231AspHis: 1.231 ± 0.05
2.535AspIle: 2.535 ± 0.057
2.033AspLys: 2.033 ± 0.067
5.656AspLeu: 5.656 ± 0.108
1.116AspMet: 1.116 ± 0.045
1.443AspAsn: 1.443 ± 0.044
3.634AspPro: 3.634 ± 0.072
2.052AspGln: 2.052 ± 0.064
3.294AspArg: 3.294 ± 0.084
3.092AspSer: 3.092 ± 0.088
3.158AspThr: 3.158 ± 0.074
4.654AspVal: 4.654 ± 0.102
0.771AspTrp: 0.771 ± 0.036
1.474AspTyr: 1.474 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
6.407GluAla: 6.407 ± 0.12
0.425GluCys: 0.425 ± 0.028
3.431GluAsp: 3.431 ± 0.085
3.836GluGlu: 3.836 ± 0.113
1.712GluPhe: 1.712 ± 0.061
4.392GluGly: 4.392 ± 0.104
1.441GluHis: 1.441 ± 0.058
2.766GluIle: 2.766 ± 0.077
2.245GluLys: 2.245 ± 0.073
5.826GluLeu: 5.826 ± 0.107
1.178GluMet: 1.178 ± 0.048
1.893GluAsn: 1.893 ± 0.055
2.938GluPro: 2.938 ± 0.089
3.041GluGln: 3.041 ± 0.078
4.099GluArg: 4.099 ± 0.089
3.081GluSer: 3.081 ± 0.082
3.175GluThr: 3.175 ± 0.083
4.957GluVal: 4.957 ± 0.111
0.707GluTrp: 0.707 ± 0.037
1.455GluTyr: 1.455 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.65PheAla: 3.65 ± 0.082
0.282PheCys: 0.282 ± 0.024
2.218PheAsp: 2.218 ± 0.064
2.124PheGlu: 2.124 ± 0.064
1.304PhePhe: 1.304 ± 0.047
2.955PheGly: 2.955 ± 0.078
0.653PheHis: 0.653 ± 0.03
1.597PheIle: 1.597 ± 0.066
1.169PheLys: 1.169 ± 0.045
2.908PheLeu: 2.908 ± 0.079
0.624PheMet: 0.624 ± 0.033
1.072PheAsn: 1.072 ± 0.042
1.36PhePro: 1.36 ± 0.046
0.896PheGln: 0.896 ± 0.038
1.385PheArg: 1.385 ± 0.054
2.064PheSer: 2.064 ± 0.058
2.398PheThr: 2.398 ± 0.069
2.521PheVal: 2.521 ± 0.077
0.443PheTrp: 0.443 ± 0.026
0.893PheTyr: 0.893 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
8.453GlyAla: 8.453 ± 0.143
0.661GlyCys: 0.661 ± 0.037
3.973GlyAsp: 3.973 ± 0.089
4.691GlyGlu: 4.691 ± 0.091
3.032GlyPhe: 3.032 ± 0.082
6.422GlyGly: 6.422 ± 0.137
1.767GlyHis: 1.767 ± 0.061
4.191GlyIle: 4.191 ± 0.096
3.831GlyLys: 3.831 ± 0.103
7.578GlyLeu: 7.578 ± 0.134
2.154GlyMet: 2.154 ± 0.06
2.357GlyAsn: 2.357 ± 0.069
3.107GlyPro: 3.107 ± 0.08
3.202GlyGln: 3.202 ± 0.073
5.005GlyArg: 5.005 ± 0.103
5.013GlySer: 5.013 ± 0.111
4.898GlyThr: 4.898 ± 0.093
6.982GlyVal: 6.982 ± 0.121
1.414GlyTrp: 1.414 ± 0.05
2.239GlyTyr: 2.239 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
2.541HisAla: 2.541 ± 0.085
0.185HisCys: 0.185 ± 0.019
1.177HisAsp: 1.177 ± 0.041
1.438HisGlu: 1.438 ± 0.052
0.607HisPhe: 0.607 ± 0.033
1.702HisGly: 1.702 ± 0.055
0.535HisHis: 0.535 ± 0.03
0.914HisIle: 0.914 ± 0.039
0.642HisLys: 0.642 ± 0.035
2.11HisLeu: 2.11 ± 0.063
0.498HisMet: 0.498 ± 0.03
0.588HisAsn: 0.588 ± 0.03
1.47HisPro: 1.47 ± 0.048
0.654HisGln: 0.654 ± 0.029
1.412HisArg: 1.412 ± 0.053
1.18HisSer: 1.18 ± 0.045
1.248HisThr: 1.248 ± 0.048
1.88HisVal: 1.88 ± 0.065
0.352HisTrp: 0.352 ± 0.022
0.573HisTyr: 0.573 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.915IleAla: 5.915 ± 0.108
0.447IleCys: 0.447 ± 0.028
3.158IleAsp: 3.158 ± 0.078
2.987IleGlu: 2.987 ± 0.071
1.451IlePhe: 1.451 ± 0.061
4.264IleGly: 4.264 ± 0.096
0.965IleHis: 0.965 ± 0.038
2.452IleIle: 2.452 ± 0.092
1.47IleLys: 1.47 ± 0.059
4.161IleLeu: 4.161 ± 0.09
0.976IleMet: 0.976 ± 0.042
1.419IleAsn: 1.419 ± 0.052
2.767IlePro: 2.767 ± 0.078
1.261IleGln: 1.261 ± 0.052
2.611IleArg: 2.611 ± 0.071
2.984IleSer: 2.984 ± 0.081
3.277IleThr: 3.277 ± 0.083
4.396IleVal: 4.396 ± 0.091
0.58IleTrp: 0.58 ± 0.031
1.113IleTyr: 1.113 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
3.758LysAla: 3.758 ± 0.101
0.217LysCys: 0.217 ± 0.021
2.188LysAsp: 2.188 ± 0.074
2.113LysGlu: 2.113 ± 0.065
0.882LysPhe: 0.882 ± 0.038
2.325LysGly: 2.325 ± 0.064
0.914LysHis: 0.914 ± 0.037
1.767LysIle: 1.767 ± 0.056
1.863LysLys: 1.863 ± 0.071
3.465LysLeu: 3.465 ± 0.09
0.974LysMet: 0.974 ± 0.043
1.424LysAsn: 1.424 ± 0.051
2.427LysPro: 2.427 ± 0.098
1.747LysGln: 1.747 ± 0.056
2.686LysArg: 2.686 ± 0.066
1.978LysSer: 1.978 ± 0.062
2.659LysThr: 2.659 ± 0.079
2.683LysVal: 2.683 ± 0.067
0.522LysTrp: 0.522 ± 0.028
0.987LysTyr: 0.987 ± 0.043
0.0LysXaa: 0.0 ± 0.0
Leu
11.222LeuAla: 11.222 ± 0.15
0.828LeuCys: 0.828 ± 0.036
5.678LeuAsp: 5.678 ± 0.11
5.727LeuGlu: 5.727 ± 0.1
2.901LeuPhe: 2.901 ± 0.076
7.903LeuGly: 7.903 ± 0.132
1.868LeuHis: 1.868 ± 0.058
4.662LeuIle: 4.662 ± 0.098
3.548LeuLys: 3.548 ± 0.093
8.946LeuLeu: 8.946 ± 0.148
2.153LeuMet: 2.153 ± 0.068
2.724LeuAsn: 2.724 ± 0.071
5.035LeuPro: 5.035 ± 0.101
3.099LeuGln: 3.099 ± 0.07
5.954LeuArg: 5.954 ± 0.101
5.672LeuSer: 5.672 ± 0.116
6.208LeuThr: 6.208 ± 0.105
8.294LeuVal: 8.294 ± 0.158
1.156LeuTrp: 1.156 ± 0.049
1.909LeuTyr: 1.909 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
2.387MetAla: 2.387 ± 0.064
0.188MetCys: 0.188 ± 0.016
1.202MetAsp: 1.202 ± 0.047
1.113MetGlu: 1.113 ± 0.04
0.728MetPhe: 0.728 ± 0.032
1.895MetGly: 1.895 ± 0.062
0.451MetHis: 0.451 ± 0.029
1.095MetIle: 1.095 ± 0.044
0.791MetLys: 0.791 ± 0.038
2.167MetLeu: 2.167 ± 0.07
0.513MetMet: 0.513 ± 0.032
0.828MetAsn: 0.828 ± 0.034
1.094MetPro: 1.094 ± 0.042
0.812MetGln: 0.812 ± 0.035
1.842MetArg: 1.842 ± 0.059
1.761MetSer: 1.761 ± 0.054
1.42MetThr: 1.42 ± 0.038
1.841MetVal: 1.841 ± 0.057
0.279MetTrp: 0.279 ± 0.02
0.425MetTyr: 0.425 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.476AsnAla: 3.476 ± 0.08
0.237AsnCys: 0.237 ± 0.018
1.419AsnAsp: 1.419 ± 0.051
1.748AsnGlu: 1.748 ± 0.058
0.844AsnPhe: 0.844 ± 0.039
2.223AsnGly: 2.223 ± 0.072
0.664AsnHis: 0.664 ± 0.037
1.349AsnIle: 1.349 ± 0.046
1.072AsnLys: 1.072 ± 0.055
2.941AsnLeu: 2.941 ± 0.066
0.675AsnMet: 0.675 ± 0.031
0.968AsnAsn: 0.968 ± 0.04
2.17AsnPro: 2.17 ± 0.07
1.26AsnGln: 1.26 ± 0.046
1.911AsnArg: 1.911 ± 0.056
1.495AsnSer: 1.495 ± 0.055
1.766AsnThr: 1.766 ± 0.054
2.336AsnVal: 2.336 ± 0.062
0.519AsnTrp: 0.519 ± 0.028
0.818AsnTyr: 0.818 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
5.404ProAla: 5.404 ± 0.112
0.299ProCys: 0.299 ± 0.025
2.903ProAsp: 2.903 ± 0.073
3.194ProGlu: 3.194 ± 0.077
1.611ProPhe: 1.611 ± 0.05
4.145ProGly: 4.145 ± 0.089
1.217ProHis: 1.217 ± 0.043
2.199ProIle: 2.199 ± 0.064
1.963ProLys: 1.963 ± 0.065
4.309ProLeu: 4.309 ± 0.098
1.068ProMet: 1.068 ± 0.049
1.586ProAsn: 1.586 ± 0.05
1.842ProPro: 1.842 ± 0.059
2.704ProGln: 2.704 ± 0.073
2.758ProArg: 2.758 ± 0.08
2.923ProSer: 2.923 ± 0.072
3.331ProThr: 3.331 ± 0.079
4.232ProVal: 4.232 ± 0.088
0.728ProTrp: 0.728 ± 0.039
1.119ProTyr: 1.119 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
4.915GlnAla: 4.915 ± 0.108
0.269GlnCys: 0.269 ± 0.022
1.732GlnAsp: 1.732 ± 0.058
2.127GlnGlu: 2.127 ± 0.069
1.169GlnPhe: 1.169 ± 0.04
2.376GlnGly: 2.376 ± 0.063
0.815GlnHis: 0.815 ± 0.039
2.355GlnIle: 2.355 ± 0.069
1.439GlnLys: 1.439 ± 0.045
4.113GlnLeu: 4.113 ± 0.094
1.244GlnMet: 1.244 ± 0.041
1.17GlnAsn: 1.17 ± 0.044
1.772GlnPro: 1.772 ± 0.058
1.839GlnGln: 1.839 ± 0.065
2.728GlnArg: 2.728 ± 0.071
1.931GlnSer: 1.931 ± 0.053
2.457GlnThr: 2.457 ± 0.066
3.688GlnVal: 3.688 ± 0.083
0.756GlnTrp: 0.756 ± 0.036
0.955GlnTyr: 0.955 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
6.88ArgAla: 6.88 ± 0.131
0.482ArgCys: 0.482 ± 0.029
3.309ArgAsp: 3.309 ± 0.083
4.264ArgGlu: 4.264 ± 0.097
2.089ArgPhe: 2.089 ± 0.063
4.793ArgGly: 4.793 ± 0.088
1.309ArgHis: 1.309 ± 0.042
3.379ArgIle: 3.379 ± 0.084
2.498ArgLys: 2.498 ± 0.065
5.591ArgLeu: 5.591 ± 0.11
1.575ArgMet: 1.575 ± 0.056
1.775ArgAsn: 1.775 ± 0.059
2.708ArgPro: 2.708 ± 0.076
2.317ArgGln: 2.317 ± 0.061
4.745ArgArg: 4.745 ± 0.117
3.737ArgSer: 3.737 ± 0.074
3.794ArgThr: 3.794 ± 0.079
5.355ArgVal: 5.355 ± 0.095
1.078ArgTrp: 1.078 ± 0.039
1.736ArgTyr: 1.736 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
6.665SerAla: 6.665 ± 0.118
0.368SerCys: 0.368 ± 0.025
3.175SerAsp: 3.175 ± 0.08
3.372SerGlu: 3.372 ± 0.077
2.121SerPhe: 2.121 ± 0.064
5.463SerGly: 5.463 ± 0.096
1.154SerHis: 1.154 ± 0.051
2.801SerIle: 2.801 ± 0.071
2.322SerLys: 2.322 ± 0.059
5.345SerLeu: 5.345 ± 0.093
1.414SerMet: 1.414 ± 0.048
1.845SerAsn: 1.845 ± 0.059
2.607SerPro: 2.607 ± 0.062
2.202SerGln: 2.202 ± 0.052
3.334SerArg: 3.334 ± 0.078
3.608SerSer: 3.608 ± 0.1
3.745SerThr: 3.745 ± 0.077
4.667SerVal: 4.667 ± 0.09
0.92SerTrp: 0.92 ± 0.039
1.312SerTyr: 1.312 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
6.227ThrAla: 6.227 ± 0.115
0.54ThrCys: 0.54 ± 0.031
3.382ThrAsp: 3.382 ± 0.085
2.893ThrGlu: 2.893 ± 0.07
1.973ThrPhe: 1.973 ± 0.055
5.38ThrGly: 5.38 ± 0.095
1.476ThrHis: 1.476 ± 0.056
3.161ThrIle: 3.161 ± 0.073
2.016ThrLys: 2.016 ± 0.058
5.911ThrLeu: 5.911 ± 0.098
1.244ThrMet: 1.244 ± 0.044
1.753ThrAsn: 1.753 ± 0.052
3.594ThrPro: 3.594 ± 0.08
2.463ThrGln: 2.463 ± 0.064
3.728ThrArg: 3.728 ± 0.086
3.654ThrSer: 3.654 ± 0.081
3.729ThrThr: 3.729 ± 0.087
5.25ThrVal: 5.25 ± 0.096
0.944ThrTrp: 0.944 ± 0.043
1.465ThrTyr: 1.465 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
9.216ValAla: 9.216 ± 0.149
0.855ValCys: 0.855 ± 0.04
5.457ValAsp: 5.457 ± 0.102
5.192ValGlu: 5.192 ± 0.108
2.933ValPhe: 2.933 ± 0.074
6.718ValGly: 6.718 ± 0.123
1.605ValHis: 1.605 ± 0.053
4.118ValIle: 4.118 ± 0.097
3.03ValLys: 3.03 ± 0.078
8.052ValLeu: 8.052 ± 0.14
1.798ValMet: 1.798 ± 0.056
2.527ValAsn: 2.527 ± 0.068
4.165ValPro: 4.165 ± 0.087
2.71ValGln: 2.71 ± 0.066
5.159ValArg: 5.159 ± 0.105
5.293ValSer: 5.293 ± 0.093
5.044ValThr: 5.044 ± 0.099
7.683ValVal: 7.683 ± 0.143
1.11ValTrp: 1.11 ± 0.042
1.678ValTyr: 1.678 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
1.42TrpAla: 1.42 ± 0.053
0.145TrpCys: 0.145 ± 0.015
0.861TrpAsp: 0.861 ± 0.04
0.753TrpGlu: 0.753 ± 0.037
0.613TrpPhe: 0.613 ± 0.032
1.029TrpGly: 1.029 ± 0.048
0.357TrpHis: 0.357 ± 0.025
0.756TrpIle: 0.756 ± 0.04
0.5TrpLys: 0.5 ± 0.028
1.494TrpLeu: 1.494 ± 0.053
0.43TrpMet: 0.43 ± 0.028
0.551TrpAsn: 0.551 ± 0.031
0.573TrpPro: 0.573 ± 0.028
0.67TrpGln: 0.67 ± 0.035
1.064TrpArg: 1.064 ± 0.043
0.796TrpSer: 0.796 ± 0.042
0.75TrpThr: 0.75 ± 0.035
1.267TrpVal: 1.267 ± 0.046
0.299TrpTrp: 0.299 ± 0.023
0.336TrpTyr: 0.336 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.659TyrAla: 2.659 ± 0.061
0.225TyrCys: 0.225 ± 0.018
1.363TyrAsp: 1.363 ± 0.051
1.479TyrGlu: 1.479 ± 0.051
0.86TyrPhe: 0.86 ± 0.038
2.008TyrGly: 2.008 ± 0.055
0.439TyrHis: 0.439 ± 0.027
0.911TyrIle: 0.911 ± 0.04
0.715TyrLys: 0.715 ± 0.034
2.38TyrLeu: 2.38 ± 0.058
0.475TyrMet: 0.475 ± 0.026
0.629TyrAsn: 0.629 ± 0.032
1.302TyrPro: 1.302 ± 0.053
0.834TyrGln: 0.834 ± 0.037
1.626TyrArg: 1.626 ± 0.05
1.521TyrSer: 1.521 ± 0.052
1.312TyrThr: 1.312 ± 0.052
1.884TyrVal: 1.884 ± 0.055
0.411TyrTrp: 0.411 ± 0.025
0.729TyrTyr: 0.729 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1778 proteins (628026 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski