Amino acid dipepetide frequency for Streptococcus uberis (strain ATCC BAA-854 / 0140J)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.297AlaAla: 5.297 ± 0.147
0.489AlaCys: 0.489 ± 0.033
3.772AlaAsp: 3.772 ± 0.097
4.621AlaGlu: 4.621 ± 0.099
3.712AlaPhe: 3.712 ± 0.097
4.812AlaGly: 4.812 ± 0.103
1.202AlaHis: 1.202 ± 0.044
6.733AlaIle: 6.733 ± 0.114
5.398AlaLys: 5.398 ± 0.116
7.687AlaLeu: 7.687 ± 0.135
2.024AlaMet: 2.024 ± 0.065
3.232AlaAsn: 3.232 ± 0.076
1.936AlaPro: 1.936 ± 0.061
2.913AlaGln: 2.913 ± 0.091
2.659AlaArg: 2.659 ± 0.075
4.944AlaSer: 4.944 ± 0.101
3.942AlaThr: 3.942 ± 0.109
4.698AlaVal: 4.698 ± 0.116
0.56AlaTrp: 0.56 ± 0.032
2.724AlaTyr: 2.724 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
0.286CysAla: 0.286 ± 0.027
0.039CysCys: 0.039 ± 0.008
0.349CysAsp: 0.349 ± 0.027
0.237CysGlu: 0.237 ± 0.022
0.319CysPhe: 0.319 ± 0.03
0.504CysGly: 0.504 ± 0.039
0.215CysHis: 0.215 ± 0.022
0.392CysIle: 0.392 ± 0.024
0.202CysLys: 0.202 ± 0.019
0.609CysLeu: 0.609 ± 0.033
0.146CysMet: 0.146 ± 0.017
0.205CysAsn: 0.205 ± 0.017
0.265CysPro: 0.265 ± 0.022
0.457CysGln: 0.457 ± 0.035
0.239CysArg: 0.239 ± 0.02
0.327CysSer: 0.327 ± 0.028
0.194CysThr: 0.194 ± 0.018
0.314CysVal: 0.314 ± 0.029
0.034CysTrp: 0.034 ± 0.008
0.196CysTyr: 0.196 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.673AspAla: 3.673 ± 0.09
0.349AspCys: 0.349 ± 0.025
3.006AspAsp: 3.006 ± 0.086
3.419AspGlu: 3.419 ± 0.093
3.508AspPhe: 3.508 ± 0.087
3.613AspGly: 3.613 ± 0.102
1.262AspHis: 1.262 ± 0.054
5.039AspIle: 5.039 ± 0.101
4.037AspLys: 4.037 ± 0.081
5.964AspLeu: 5.964 ± 0.115
1.596AspMet: 1.596 ± 0.053
2.418AspAsn: 2.418 ± 0.063
1.776AspPro: 1.776 ± 0.064
2.409AspGln: 2.409 ± 0.068
2.011AspArg: 2.011 ± 0.064
3.17AspSer: 3.17 ± 0.076
2.653AspThr: 2.653 ± 0.072
3.404AspVal: 3.404 ± 0.086
0.603AspTrp: 0.603 ± 0.034
3.019AspTyr: 3.019 ± 0.082
0.0AspXaa: 0.0 ± 0.0
Glu
5.29GluAla: 5.29 ± 0.127
0.31GluCys: 0.31 ± 0.024
3.794GluAsp: 3.794 ± 0.086
5.889GluGlu: 5.889 ± 0.119
2.379GluPhe: 2.379 ± 0.059
3.725GluGly: 3.725 ± 0.089
1.285GluHis: 1.285 ± 0.05
5.094GluIle: 5.094 ± 0.111
6.505GluLys: 6.505 ± 0.117
6.451GluLeu: 6.451 ± 0.119
2.125GluMet: 2.125 ± 0.065
3.971GluAsn: 3.971 ± 0.096
1.49GluPro: 1.49 ± 0.06
2.3GluGln: 2.3 ± 0.062
2.844GluArg: 2.844 ± 0.093
3.658GluSer: 3.658 ± 0.092
3.693GluThr: 3.693 ± 0.092
4.435GluVal: 4.435 ± 0.102
0.519GluTrp: 0.519 ± 0.028
1.815GluTyr: 1.815 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.329PheAla: 3.329 ± 0.085
0.302PheCys: 0.302 ± 0.026
3.006PheAsp: 3.006 ± 0.076
3.124PheGlu: 3.124 ± 0.079
2.332PhePhe: 2.332 ± 0.082
3.441PheGly: 3.441 ± 0.092
0.913PheHis: 0.913 ± 0.045
3.622PheIle: 3.622 ± 0.091
2.898PheLys: 2.898 ± 0.073
4.782PheLeu: 4.782 ± 0.119
1.262PheMet: 1.262 ± 0.045
2.127PheAsn: 2.127 ± 0.065
1.71PhePro: 1.71 ± 0.055
1.682PheGln: 1.682 ± 0.058
1.445PheArg: 1.445 ± 0.058
3.505PheSer: 3.505 ± 0.089
2.489PheThr: 2.489 ± 0.072
3.111PheVal: 3.111 ± 0.084
0.428PheTrp: 0.428 ± 0.034
1.871PheTyr: 1.871 ± 0.068
0.0PheXaa: 0.0 ± 0.0
Gly
4.558GlyAla: 4.558 ± 0.112
0.383GlyCys: 0.383 ± 0.027
3.294GlyAsp: 3.294 ± 0.087
3.327GlyGlu: 3.327 ± 0.091
3.361GlyPhe: 3.361 ± 0.082
4.216GlyGly: 4.216 ± 0.129
1.455GlyHis: 1.455 ± 0.059
5.842GlyIle: 5.842 ± 0.11
4.746GlyLys: 4.746 ± 0.101
6.703GlyLeu: 6.703 ± 0.123
1.865GlyMet: 1.865 ± 0.065
2.836GlyAsn: 2.836 ± 0.084
1.57GlyPro: 1.57 ± 0.058
2.984GlyGln: 2.984 ± 0.088
2.551GlyArg: 2.551 ± 0.082
3.858GlySer: 3.858 ± 0.091
3.52GlyThr: 3.52 ± 0.091
4.459GlyVal: 4.459 ± 0.117
0.558GlyTrp: 0.558 ± 0.03
2.567GlyTyr: 2.567 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.146HisAla: 1.146 ± 0.048
0.127HisCys: 0.127 ± 0.013
1.057HisAsp: 1.057 ± 0.046
1.135HisGlu: 1.135 ± 0.043
1.412HisPhe: 1.412 ± 0.053
1.249HisGly: 1.249 ± 0.059
0.663HisHis: 0.663 ± 0.035
1.548HisIle: 1.548 ± 0.056
1.141HisLys: 1.141 ± 0.045
2.496HisLeu: 2.496 ± 0.067
0.504HisMet: 0.504 ± 0.03
0.747HisAsn: 0.747 ± 0.038
0.963HisPro: 0.963 ± 0.052
0.949HisGln: 0.949 ± 0.045
0.807HisArg: 0.807 ± 0.042
1.141HisSer: 1.141 ± 0.05
0.829HisThr: 0.829 ± 0.039
1.247HisVal: 1.247 ± 0.045
0.148HisTrp: 0.148 ± 0.018
1.053HisTyr: 1.053 ± 0.048
0.0HisXaa: 0.0 ± 0.0
Ile
6.544IleAla: 6.544 ± 0.116
0.605IleCys: 0.605 ± 0.035
4.877IleAsp: 4.877 ± 0.101
5.31IleGlu: 5.31 ± 0.097
3.535IlePhe: 3.535 ± 0.106
5.445IleGly: 5.445 ± 0.109
1.427IleHis: 1.427 ± 0.05
6.175IleIle: 6.175 ± 0.136
5.081IleLys: 5.081 ± 0.099
7.896IleLeu: 7.896 ± 0.159
1.964IleMet: 1.964 ± 0.062
3.559IleAsn: 3.559 ± 0.089
3.182IlePro: 3.182 ± 0.081
2.771IleGln: 2.771 ± 0.067
2.694IleArg: 2.694 ± 0.079
5.665IleSer: 5.665 ± 0.119
4.216IleThr: 4.216 ± 0.088
5.105IleVal: 5.105 ± 0.103
0.584IleTrp: 0.584 ± 0.03
2.595IleTyr: 2.595 ± 0.077
0.0IleXaa: 0.0 ± 0.0
Lys
5.939LysAla: 5.939 ± 0.123
0.246LysCys: 0.246 ± 0.022
4.448LysAsp: 4.448 ± 0.103
6.563LysGlu: 6.563 ± 0.136
1.897LysPhe: 1.897 ± 0.054
4.281LysGly: 4.281 ± 0.09
1.38LysHis: 1.38 ± 0.044
5.066LysIle: 5.066 ± 0.103
5.534LysLys: 5.534 ± 0.123
5.852LysLeu: 5.852 ± 0.108
2.321LysMet: 2.321 ± 0.06
3.648LysAsn: 3.648 ± 0.089
2.151LysPro: 2.151 ± 0.069
2.646LysGln: 2.646 ± 0.076
3.057LysArg: 3.057 ± 0.082
4.231LysSer: 4.231 ± 0.102
4.225LysThr: 4.225 ± 0.092
4.817LysVal: 4.817 ± 0.094
0.637LysTrp: 0.637 ± 0.035
2.175LysTyr: 2.175 ± 0.062
0.0LysXaa: 0.0 ± 0.0
Leu
8.397LeuAla: 8.397 ± 0.139
0.555LeuCys: 0.555 ± 0.034
5.714LeuAsp: 5.714 ± 0.111
7.024LeuGlu: 7.024 ± 0.135
4.901LeuPhe: 4.901 ± 0.13
6.279LeuGly: 6.279 ± 0.101
1.63LeuHis: 1.63 ± 0.055
7.424LeuIle: 7.424 ± 0.156
7.146LeuLys: 7.146 ± 0.125
10.424LeuLeu: 10.424 ± 0.196
2.646LeuMet: 2.646 ± 0.07
4.41LeuAsn: 4.41 ± 0.1
4.022LeuPro: 4.022 ± 0.089
3.301LeuGln: 3.301 ± 0.083
3.475LeuArg: 3.475 ± 0.09
7.588LeuSer: 7.588 ± 0.125
5.885LeuThr: 5.885 ± 0.121
6.707LeuVal: 6.707 ± 0.132
0.683LeuTrp: 0.683 ± 0.037
2.935LeuTyr: 2.935 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
2.267MetAla: 2.267 ± 0.069
0.129MetCys: 0.129 ± 0.018
1.428MetAsp: 1.428 ± 0.058
1.525MetGlu: 1.525 ± 0.052
0.887MetPhe: 0.887 ± 0.047
1.815MetGly: 1.815 ± 0.064
0.398MetHis: 0.398 ± 0.026
2.265MetIle: 2.265 ± 0.068
2.076MetLys: 2.076 ± 0.068
2.319MetLeu: 2.319 ± 0.067
0.855MetMet: 0.855 ± 0.045
1.247MetAsn: 1.247 ± 0.045
0.984MetPro: 0.984 ± 0.046
0.876MetGln: 0.876 ± 0.038
1.003MetArg: 1.003 ± 0.041
1.916MetSer: 1.916 ± 0.061
2.422MetThr: 2.422 ± 0.057
1.832MetVal: 1.832 ± 0.058
0.159MetTrp: 0.159 ± 0.018
0.612MetTyr: 0.612 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
3.165AsnAla: 3.165 ± 0.068
0.295AsnCys: 0.295 ± 0.025
2.618AsnAsp: 2.618 ± 0.074
2.663AsnGlu: 2.663 ± 0.075
1.893AsnPhe: 1.893 ± 0.058
3.477AsnGly: 3.477 ± 0.092
1.37AsnHis: 1.37 ± 0.048
3.264AsnIle: 3.264 ± 0.085
2.909AsnLys: 2.909 ± 0.077
4.403AsnLeu: 4.403 ± 0.103
1.223AsnMet: 1.223 ± 0.052
2.157AsnAsn: 2.157 ± 0.067
2.381AsnPro: 2.381 ± 0.065
2.579AsnGln: 2.579 ± 0.078
1.955AsnArg: 1.955 ± 0.064
2.491AsnSer: 2.491 ± 0.074
2.134AsnThr: 2.134 ± 0.069
2.732AsnVal: 2.732 ± 0.077
0.472AsnTrp: 0.472 ± 0.028
1.893AsnTyr: 1.893 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
2.022ProAla: 2.022 ± 0.067
0.125ProCys: 0.125 ± 0.016
2.005ProAsp: 2.005 ± 0.058
2.853ProGlu: 2.853 ± 0.076
1.865ProPhe: 1.865 ± 0.054
1.936ProGly: 1.936 ± 0.067
0.67ProHis: 0.67 ± 0.04
2.853ProIle: 2.853 ± 0.074
2.422ProLys: 2.422 ± 0.068
3.165ProLeu: 3.165 ± 0.076
0.838ProMet: 0.838 ± 0.039
1.764ProAsn: 1.764 ± 0.07
0.504ProPro: 0.504 ± 0.03
1.292ProGln: 1.292 ± 0.049
0.947ProArg: 0.947 ± 0.045
2.168ProSer: 2.168 ± 0.064
1.897ProThr: 1.897 ± 0.057
2.446ProVal: 2.446 ± 0.067
0.278ProTrp: 0.278 ± 0.023
1.374ProTyr: 1.374 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
3.365GlnAla: 3.365 ± 0.085
0.138GlnCys: 0.138 ± 0.014
1.998GlnAsp: 1.998 ± 0.073
3.329GlnGlu: 3.329 ± 0.08
1.817GlnPhe: 1.817 ± 0.055
2.115GlnGly: 2.115 ± 0.072
0.65GlnHis: 0.65 ± 0.032
2.786GlnIle: 2.786 ± 0.07
3.671GlnLys: 3.671 ± 0.094
4.638GlnLeu: 4.638 ± 0.105
1.219GlnMet: 1.219 ± 0.048
1.931GlnAsn: 1.931 ± 0.066
1.019GlnPro: 1.019 ± 0.045
1.3GlnGln: 1.3 ± 0.056
1.391GlnArg: 1.391 ± 0.052
2.358GlnSer: 2.358 ± 0.075
2.172GlnThr: 2.172 ± 0.075
2.862GlnVal: 2.862 ± 0.07
0.312GlnTrp: 0.312 ± 0.027
1.195GlnTyr: 1.195 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
2.298ArgAla: 2.298 ± 0.068
0.157ArgCys: 0.157 ± 0.018
2.282ArgAsp: 2.282 ± 0.069
2.678ArgGlu: 2.678 ± 0.08
1.811ArgPhe: 1.811 ± 0.061
2.175ArgGly: 2.175 ± 0.068
0.917ArgHis: 0.917 ± 0.042
2.913ArgIle: 2.913 ± 0.073
2.603ArgLys: 2.603 ± 0.072
3.843ArgLeu: 3.843 ± 0.091
1.059ArgMet: 1.059 ± 0.047
1.634ArgAsn: 1.634 ± 0.055
1.245ArgPro: 1.245 ± 0.05
2.054ArgGln: 2.054 ± 0.071
1.809ArgArg: 1.809 ± 0.078
1.886ArgSer: 1.886 ± 0.056
1.768ArgThr: 1.768 ± 0.069
2.478ArgVal: 2.478 ± 0.07
0.246ArgTrp: 0.246 ± 0.022
1.494ArgTyr: 1.494 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
3.983SerAla: 3.983 ± 0.083
0.308SerCys: 0.308 ± 0.025
3.714SerAsp: 3.714 ± 0.094
3.878SerGlu: 3.878 ± 0.097
3.366SerPhe: 3.366 ± 0.095
4.631SerGly: 4.631 ± 0.101
1.567SerHis: 1.567 ± 0.054
4.963SerIle: 4.963 ± 0.105
4.378SerLys: 4.378 ± 0.086
6.849SerLeu: 6.849 ± 0.129
1.456SerMet: 1.456 ± 0.052
2.724SerAsn: 2.724 ± 0.074
2.086SerPro: 2.086 ± 0.063
3.241SerGln: 3.241 ± 0.087
2.468SerArg: 2.468 ± 0.063
4.07SerSer: 4.07 ± 0.112
3.105SerThr: 3.105 ± 0.08
3.945SerVal: 3.945 ± 0.076
0.541SerTrp: 0.541 ± 0.035
2.597SerTyr: 2.597 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
3.76ThrAla: 3.76 ± 0.09
0.306ThrCys: 0.306 ± 0.026
3.025ThrAsp: 3.025 ± 0.08
3.292ThrGlu: 3.292 ± 0.079
2.89ThrPhe: 2.89 ± 0.078
3.813ThrGly: 3.813 ± 0.097
0.99ThrHis: 0.99 ± 0.049
4.931ThrIle: 4.931 ± 0.106
3.467ThrLys: 3.467 ± 0.08
5.512ThrLeu: 5.512 ± 0.115
1.167ThrMet: 1.167 ± 0.045
2.386ThrAsn: 2.386 ± 0.07
2.172ThrPro: 2.172 ± 0.064
1.761ThrGln: 1.761 ± 0.058
1.785ThrArg: 1.785 ± 0.065
3.544ThrSer: 3.544 ± 0.086
2.821ThrThr: 2.821 ± 0.074
4.225ThrVal: 4.225 ± 0.097
0.446ThrTrp: 0.446 ± 0.03
2.214ThrTyr: 2.214 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
5.206ValAla: 5.206 ± 0.117
0.407ValCys: 0.407 ± 0.021
3.852ValAsp: 3.852 ± 0.086
4.218ValGlu: 4.218 ± 0.097
2.986ValPhe: 2.986 ± 0.083
4.276ValGly: 4.276 ± 0.086
1.124ValHis: 1.124 ± 0.048
5.228ValIle: 5.228 ± 0.098
4.38ValLys: 4.38 ± 0.092
6.406ValLeu: 6.406 ± 0.116
1.729ValMet: 1.729 ± 0.059
3.062ValAsn: 3.062 ± 0.077
2.364ValPro: 2.364 ± 0.069
2.017ValGln: 2.017 ± 0.063
2.364ValArg: 2.364 ± 0.072
4.698ValSer: 4.698 ± 0.094
4.358ValThr: 4.358 ± 0.102
4.229ValVal: 4.229 ± 0.113
0.493ValTrp: 0.493 ± 0.031
2.2ValTyr: 2.2 ± 0.064
0.0ValXaa: 0.0 ± 0.0
Trp
0.527TrpAla: 0.527 ± 0.03
0.037TrpCys: 0.037 ± 0.008
0.484TrpAsp: 0.484 ± 0.031
0.478TrpGlu: 0.478 ± 0.03
0.431TrpPhe: 0.431 ± 0.031
0.556TrpGly: 0.556 ± 0.034
0.192TrpHis: 0.192 ± 0.018
0.611TrpIle: 0.611 ± 0.037
0.457TrpLys: 0.457 ± 0.027
0.911TrpLeu: 0.911 ± 0.04
0.213TrpMet: 0.213 ± 0.022
0.407TrpAsn: 0.407 ± 0.029
0.185TrpPro: 0.185 ± 0.02
0.443TrpGln: 0.443 ± 0.031
0.332TrpArg: 0.332 ± 0.026
0.519TrpSer: 0.519 ± 0.034
0.463TrpThr: 0.463 ± 0.031
0.485TrpVal: 0.485 ± 0.027
0.097TrpTrp: 0.097 ± 0.015
0.314TrpTyr: 0.314 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.304TyrAla: 2.304 ± 0.07
0.22TyrCys: 0.22 ± 0.02
2.209TyrAsp: 2.209 ± 0.061
2.007TyrGlu: 2.007 ± 0.065
2.076TyrPhe: 2.076 ± 0.068
2.293TyrGly: 2.293 ± 0.072
1.053TyrHis: 1.053 ± 0.049
2.481TyrIle: 2.481 ± 0.075
2.063TyrLys: 2.063 ± 0.07
4.237TyrLeu: 4.237 ± 0.093
0.799TyrMet: 0.799 ± 0.039
1.608TyrAsn: 1.608 ± 0.06
1.421TyrPro: 1.421 ± 0.055
2.293TyrGln: 2.293 ± 0.071
1.514TyrArg: 1.514 ± 0.053
2.136TyrSer: 2.136 ± 0.064
1.722TyrThr: 1.722 ± 0.061
2.065TyrVal: 2.065 ± 0.053
0.344TyrTrp: 0.344 ± 0.027
1.643TyrTyr: 1.643 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1760 proteins (535573 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski