Amino acid dipepetide frequency for Salinivibrio sp. KP-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.492AlaAla: 9.492 ± 0.15
1.117AlaCys: 1.117 ± 0.034
5.594AlaAsp: 5.594 ± 0.092
5.615AlaGlu: 5.615 ± 0.087
3.834AlaPhe: 3.834 ± 0.064
6.775AlaGly: 6.775 ± 0.086
2.149AlaHis: 2.149 ± 0.048
6.092AlaIle: 6.092 ± 0.092
4.408AlaLys: 4.408 ± 0.072
11.756AlaLeu: 11.756 ± 0.128
3.31AlaMet: 3.31 ± 0.052
3.502AlaAsn: 3.502 ± 0.062
3.708AlaPro: 3.708 ± 0.067
4.759AlaGln: 4.759 ± 0.078
5.107AlaArg: 5.107 ± 0.083
6.08AlaSer: 6.08 ± 0.095
5.106AlaThr: 5.106 ± 0.077
6.894AlaVal: 6.894 ± 0.088
1.239AlaTrp: 1.239 ± 0.04
2.66AlaTyr: 2.66 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.928CysAla: 0.928 ± 0.031
0.134CysCys: 0.134 ± 0.012
0.68CysAsp: 0.68 ± 0.028
0.577CysGlu: 0.577 ± 0.026
0.43CysPhe: 0.43 ± 0.024
0.885CysGly: 0.885 ± 0.031
0.404CysHis: 0.404 ± 0.022
0.469CysIle: 0.469 ± 0.024
0.284CysLys: 0.284 ± 0.02
1.037CysLeu: 1.037 ± 0.032
0.184CysMet: 0.184 ± 0.015
0.266CysAsn: 0.266 ± 0.016
0.472CysPro: 0.472 ± 0.025
0.618CysGln: 0.618 ± 0.029
0.556CysArg: 0.556 ± 0.025
0.55CysSer: 0.55 ± 0.024
0.471CysThr: 0.471 ± 0.023
0.704CysVal: 0.704 ± 0.029
0.148CysTrp: 0.148 ± 0.012
0.34CysTyr: 0.34 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
5.956AspAla: 5.956 ± 0.085
0.548AspCys: 0.548 ± 0.022
3.812AspAsp: 3.812 ± 0.079
3.892AspGlu: 3.892 ± 0.073
2.238AspPhe: 2.238 ± 0.051
3.95AspGly: 3.95 ± 0.074
1.346AspHis: 1.346 ± 0.039
3.852AspIle: 3.852 ± 0.068
3.141AspLys: 3.141 ± 0.06
5.018AspLeu: 5.018 ± 0.071
1.577AspMet: 1.577 ± 0.038
2.568AspAsn: 2.568 ± 0.059
2.385AspPro: 2.385 ± 0.047
2.372AspGln: 2.372 ± 0.061
2.58AspArg: 2.58 ± 0.058
3.122AspSer: 3.122 ± 0.064
3.344AspThr: 3.344 ± 0.064
4.576AspVal: 4.576 ± 0.063
0.953AspTrp: 0.953 ± 0.034
2.2AspTyr: 2.2 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
5.861GluAla: 5.861 ± 0.088
0.465GluCys: 0.465 ± 0.024
2.673GluAsp: 2.673 ± 0.055
3.086GluGlu: 3.086 ± 0.065
1.822GluPhe: 1.822 ± 0.042
3.63GluGly: 3.63 ± 0.069
1.712GluHis: 1.712 ± 0.044
3.121GluIle: 3.121 ± 0.059
3.248GluLys: 3.248 ± 0.06
5.806GluLeu: 5.806 ± 0.081
1.655GluMet: 1.655 ± 0.04
2.027GluAsn: 2.027 ± 0.045
2.233GluPro: 2.233 ± 0.071
4.356GluGln: 4.356 ± 0.075
3.851GluArg: 3.851 ± 0.074
3.263GluSer: 3.263 ± 0.058
3.136GluThr: 3.136 ± 0.065
4.001GluVal: 4.001 ± 0.066
0.731GluTrp: 0.731 ± 0.029
1.44GluTyr: 1.44 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.648PheAla: 3.648 ± 0.066
0.438PheCys: 0.438 ± 0.022
2.719PheAsp: 2.719 ± 0.054
2.178PheGlu: 2.178 ± 0.055
1.544PhePhe: 1.544 ± 0.05
2.984PheGly: 2.984 ± 0.059
0.8PheHis: 0.8 ± 0.031
2.33PheIle: 2.33 ± 0.056
1.423PheLys: 1.423 ± 0.039
3.062PheLeu: 3.062 ± 0.066
0.925PheMet: 0.925 ± 0.03
1.677PheAsn: 1.677 ± 0.039
1.338PhePro: 1.338 ± 0.038
1.175PheGln: 1.175 ± 0.034
1.685PheArg: 1.685 ± 0.043
2.931PheSer: 2.931 ± 0.057
2.17PheThr: 2.17 ± 0.05
2.604PheVal: 2.604 ± 0.059
0.527PheTrp: 0.527 ± 0.023
1.19PheTyr: 1.19 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
5.921GlyAla: 5.921 ± 0.101
0.855GlyCys: 0.855 ± 0.031
4.096GlyAsp: 4.096 ± 0.086
4.689GlyGlu: 4.689 ± 0.07
3.121GlyPhe: 3.121 ± 0.062
4.92GlyGly: 4.92 ± 0.087
1.774GlyHis: 1.774 ± 0.043
4.343GlyIle: 4.343 ± 0.067
3.518GlyLys: 3.518 ± 0.067
7.333GlyLeu: 7.333 ± 0.08
2.224GlyMet: 2.224 ± 0.052
2.306GlyAsn: 2.306 ± 0.054
1.935GlyPro: 1.935 ± 0.041
3.326GlyGln: 3.326 ± 0.055
3.506GlyArg: 3.506 ± 0.071
3.756GlySer: 3.756 ± 0.078
3.521GlyThr: 3.521 ± 0.074
5.55GlyVal: 5.55 ± 0.086
1.064GlyTrp: 1.064 ± 0.033
2.465GlyTyr: 2.465 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
2.367HisAla: 2.367 ± 0.046
0.363HisCys: 0.363 ± 0.019
1.32HisAsp: 1.32 ± 0.043
1.085HisGlu: 1.085 ± 0.027
1.094HisPhe: 1.094 ± 0.037
1.803HisGly: 1.803 ± 0.04
0.945HisHis: 0.945 ± 0.035
1.413HisIle: 1.413 ± 0.036
0.835HisLys: 0.835 ± 0.032
2.478HisLeu: 2.478 ± 0.05
0.545HisMet: 0.545 ± 0.021
0.769HisAsn: 0.769 ± 0.025
1.436HisPro: 1.436 ± 0.038
1.752HisGln: 1.752 ± 0.047
1.394HisArg: 1.394 ± 0.037
1.345HisSer: 1.345 ± 0.036
1.322HisThr: 1.322 ± 0.042
1.5HisVal: 1.5 ± 0.042
0.482HisTrp: 0.482 ± 0.025
0.965HisTyr: 0.965 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.37IleAla: 6.37 ± 0.094
0.585IleCys: 0.585 ± 0.023
4.26IleAsp: 4.26 ± 0.068
3.939IleGlu: 3.939 ± 0.058
1.768IlePhe: 1.768 ± 0.047
4.471IleGly: 4.471 ± 0.078
1.225IleHis: 1.225 ± 0.038
2.832IleIle: 2.832 ± 0.062
2.493IleLys: 2.493 ± 0.057
4.283IleLeu: 4.283 ± 0.086
1.17IleMet: 1.17 ± 0.038
2.463IleAsn: 2.463 ± 0.053
2.323IlePro: 2.323 ± 0.055
2.009IleGln: 2.009 ± 0.049
2.871IleArg: 2.871 ± 0.058
3.565IleSer: 3.565 ± 0.07
3.329IleThr: 3.329 ± 0.076
3.628IleVal: 3.628 ± 0.069
0.56IleTrp: 0.56 ± 0.027
1.407IleTyr: 1.407 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
4.744LysAla: 4.744 ± 0.081
0.236LysCys: 0.236 ± 0.017
2.307LysAsp: 2.307 ± 0.056
2.487LysGlu: 2.487 ± 0.061
1.077LysPhe: 1.077 ± 0.03
2.973LysGly: 2.973 ± 0.063
1.087LysHis: 1.087 ± 0.038
1.983LysIle: 1.983 ± 0.053
2.331LysLys: 2.331 ± 0.062
4.275LysLeu: 4.275 ± 0.071
1.094LysMet: 1.094 ± 0.034
1.467LysAsn: 1.467 ± 0.037
2.173LysPro: 2.173 ± 0.047
2.527LysGln: 2.527 ± 0.052
2.83LysArg: 2.83 ± 0.059
2.222LysSer: 2.222 ± 0.05
2.452LysThr: 2.452 ± 0.049
3.204LysVal: 3.204 ± 0.061
0.479LysTrp: 0.479 ± 0.023
1.026LysTyr: 1.026 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
11.331LeuAla: 11.331 ± 0.132
1.098LeuCys: 1.098 ± 0.037
6.343LeuAsp: 6.343 ± 0.086
5.545LeuGlu: 5.545 ± 0.083
3.863LeuPhe: 3.863 ± 0.074
7.301LeuGly: 7.301 ± 0.1
2.228LeuHis: 2.228 ± 0.053
5.502LeuIle: 5.502 ± 0.094
4.388LeuLys: 4.388 ± 0.075
10.346LeuLeu: 10.346 ± 0.16
2.772LeuMet: 2.772 ± 0.056
3.954LeuAsn: 3.954 ± 0.058
5.045LeuPro: 5.045 ± 0.076
3.502LeuGln: 3.502 ± 0.064
4.986LeuArg: 4.986 ± 0.087
7.857LeuSer: 7.857 ± 0.11
6.458LeuThr: 6.458 ± 0.094
7.484LeuVal: 7.484 ± 0.099
1.106LeuTrp: 1.106 ± 0.041
2.51LeuTyr: 2.51 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
3.131MetAla: 3.131 ± 0.064
0.203MetCys: 0.203 ± 0.014
1.338MetAsp: 1.338 ± 0.036
1.304MetGlu: 1.304 ± 0.038
0.792MetPhe: 0.792 ± 0.029
1.842MetGly: 1.842 ± 0.046
0.524MetHis: 0.524 ± 0.023
1.431MetIle: 1.431 ± 0.044
1.313MetLys: 1.313 ± 0.039
2.872MetLeu: 2.872 ± 0.061
0.854MetMet: 0.854 ± 0.034
0.919MetAsn: 0.919 ± 0.032
1.361MetPro: 1.361 ± 0.038
1.235MetGln: 1.235 ± 0.036
1.453MetArg: 1.453 ± 0.037
1.768MetSer: 1.768 ± 0.046
1.89MetThr: 1.89 ± 0.041
2.054MetVal: 2.054 ± 0.045
0.24MetTrp: 0.24 ± 0.017
0.522MetTyr: 0.522 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.605AsnAla: 3.605 ± 0.06
0.287AsnCys: 0.287 ± 0.015
2.034AsnAsp: 2.034 ± 0.055
1.859AsnGlu: 1.859 ± 0.042
1.068AsnPhe: 1.068 ± 0.034
2.654AsnGly: 2.654 ± 0.057
0.952AsnHis: 0.952 ± 0.031
2.053AsnIle: 2.053 ± 0.055
1.54AsnLys: 1.54 ± 0.04
3.25AsnLeu: 3.25 ± 0.066
0.847AsnMet: 0.847 ± 0.028
1.297AsnAsn: 1.297 ± 0.041
2.025AsnPro: 2.025 ± 0.047
2.175AsnGln: 2.175 ± 0.047
1.916AsnArg: 1.916 ± 0.04
1.665AsnSer: 1.665 ± 0.042
2.055AsnThr: 2.055 ± 0.053
2.402AsnVal: 2.402 ± 0.049
0.535AsnTrp: 0.535 ± 0.025
1.035AsnTyr: 1.035 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
3.898ProAla: 3.898 ± 0.066
0.34ProCys: 0.34 ± 0.021
3.026ProAsp: 3.026 ± 0.057
3.25ProGlu: 3.25 ± 0.072
1.739ProPhe: 1.739 ± 0.046
2.708ProGly: 2.708 ± 0.06
1.124ProHis: 1.124 ± 0.032
2.203ProIle: 2.203 ± 0.051
1.74ProLys: 1.74 ± 0.049
4.539ProLeu: 4.539 ± 0.07
1.144ProMet: 1.144 ± 0.036
1.557ProAsn: 1.557 ± 0.042
1.335ProPro: 1.335 ± 0.036
1.805ProGln: 1.805 ± 0.037
1.759ProArg: 1.759 ± 0.047
2.732ProSer: 2.732 ± 0.047
2.309ProThr: 2.309 ± 0.058
3.485ProVal: 3.485 ± 0.06
0.577ProTrp: 0.577 ± 0.026
1.303ProTyr: 1.303 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
5.894GlnAla: 5.894 ± 0.091
0.508GlnCys: 0.508 ± 0.023
2.403GlnAsp: 2.403 ± 0.054
2.212GlnGlu: 2.212 ± 0.051
1.731GlnPhe: 1.731 ± 0.044
3.52GlnGly: 3.52 ± 0.064
1.483GlnHis: 1.483 ± 0.042
2.226GlnIle: 2.226 ± 0.044
1.776GlnLys: 1.776 ± 0.047
5.627GlnLeu: 5.627 ± 0.087
1.255GlnMet: 1.255 ± 0.033
1.258GlnAsn: 1.258 ± 0.038
2.232GlnPro: 2.232 ± 0.047
3.676GlnGln: 3.676 ± 0.08
3.13GlnArg: 3.13 ± 0.056
3.049GlnSer: 3.049 ± 0.057
2.799GlnThr: 2.799 ± 0.059
3.424GlnVal: 3.424 ± 0.058
0.88GlnTrp: 0.88 ± 0.036
1.422GlnTyr: 1.422 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
4.807ArgAla: 4.807 ± 0.077
0.601ArgCys: 0.601 ± 0.025
3.249ArgAsp: 3.249 ± 0.068
3.539ArgGlu: 3.539 ± 0.07
2.467ArgPhe: 2.467 ± 0.052
3.14ArgGly: 3.14 ± 0.061
1.602ArgHis: 1.602 ± 0.042
2.97ArgIle: 2.97 ± 0.052
2.143ArgLys: 2.143 ± 0.048
5.795ArgLeu: 5.795 ± 0.087
1.328ArgMet: 1.328 ± 0.035
1.698ArgAsn: 1.698 ± 0.041
1.969ArgPro: 1.969 ± 0.047
3.16ArgGln: 3.16 ± 0.066
3.218ArgArg: 3.218 ± 0.067
2.443ArgSer: 2.443 ± 0.054
2.333ArgThr: 2.333 ± 0.054
3.821ArgVal: 3.821 ± 0.067
0.8ArgTrp: 0.8 ± 0.029
1.998ArgTyr: 1.998 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
5.621SerAla: 5.621 ± 0.084
0.489SerCys: 0.489 ± 0.025
3.664SerAsp: 3.664 ± 0.072
3.674SerGlu: 3.674 ± 0.07
2.317SerPhe: 2.317 ± 0.051
4.655SerGly: 4.655 ± 0.074
1.622SerHis: 1.622 ± 0.044
3.088SerIle: 3.088 ± 0.06
2.181SerLys: 2.181 ± 0.048
6.87SerLeu: 6.87 ± 0.091
1.612SerMet: 1.612 ± 0.041
1.883SerAsn: 1.883 ± 0.049
2.621SerPro: 2.621 ± 0.048
3.205SerGln: 3.205 ± 0.059
3.152SerArg: 3.152 ± 0.058
3.419SerSer: 3.419 ± 0.069
3.017SerThr: 3.017 ± 0.057
4.542SerVal: 4.542 ± 0.078
0.753SerTrp: 0.753 ± 0.028
1.746SerTyr: 1.746 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
4.977ThrAla: 4.977 ± 0.08
0.511ThrCys: 0.511 ± 0.024
3.28ThrAsp: 3.28 ± 0.061
3.05ThrGlu: 3.05 ± 0.064
1.995ThrPhe: 1.995 ± 0.052
4.203ThrGly: 4.203 ± 0.083
1.472ThrHis: 1.472 ± 0.036
3.033ThrIle: 3.033 ± 0.066
1.709ThrLys: 1.709 ± 0.045
7.122ThrLeu: 7.122 ± 0.095
1.224ThrMet: 1.224 ± 0.04
1.612ThrAsn: 1.612 ± 0.043
3.061ThrPro: 3.061 ± 0.052
2.993ThrGln: 2.993 ± 0.063
2.806ThrArg: 2.806 ± 0.056
2.998ThrSer: 2.998 ± 0.065
2.833ThrThr: 2.833 ± 0.065
4.135ThrVal: 4.135 ± 0.078
0.639ThrTrp: 0.639 ± 0.027
1.426ThrTyr: 1.426 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
7.318ValAla: 7.318 ± 0.099
0.809ValCys: 0.809 ± 0.03
4.424ValAsp: 4.424 ± 0.063
4.335ValGlu: 4.335 ± 0.068
2.684ValPhe: 2.684 ± 0.056
5.04ValGly: 5.04 ± 0.083
1.38ValHis: 1.38 ± 0.042
4.631ValIle: 4.631 ± 0.072
3.175ValLys: 3.175 ± 0.06
6.923ValLeu: 6.923 ± 0.104
2.332ValMet: 2.332 ± 0.056
2.796ValAsn: 2.796 ± 0.052
2.93ValPro: 2.93 ± 0.059
2.213ValGln: 2.213 ± 0.047
3.453ValArg: 3.453 ± 0.069
5.123ValSer: 5.123 ± 0.07
4.562ValThr: 4.562 ± 0.098
5.734ValVal: 5.734 ± 0.081
0.803ValTrp: 0.803 ± 0.033
1.824ValTyr: 1.824 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.945TrpAla: 0.945 ± 0.035
0.163TrpCys: 0.163 ± 0.012
0.571TrpAsp: 0.571 ± 0.025
0.5TrpGlu: 0.5 ± 0.022
0.57TrpPhe: 0.57 ± 0.024
0.802TrpGly: 0.802 ± 0.03
0.441TrpHis: 0.441 ± 0.02
0.609TrpIle: 0.609 ± 0.026
0.381TrpLys: 0.381 ± 0.02
2.018TrpLeu: 2.018 ± 0.058
0.364TrpMet: 0.364 ± 0.018
0.352TrpAsn: 0.352 ± 0.018
0.569TrpPro: 0.569 ± 0.027
1.299TrpGln: 1.299 ± 0.044
0.867TrpArg: 0.867 ± 0.032
0.676TrpSer: 0.676 ± 0.025
0.508TrpThr: 0.508 ± 0.025
0.991TrpVal: 0.991 ± 0.031
0.237TrpTrp: 0.237 ± 0.016
0.378TrpTyr: 0.378 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.381TyrAla: 2.381 ± 0.041
0.387TyrCys: 0.387 ± 0.022
1.638TyrAsp: 1.638 ± 0.04
1.301TyrGlu: 1.301 ± 0.035
1.198TyrPhe: 1.198 ± 0.039
1.967TyrGly: 1.967 ± 0.046
0.942TyrHis: 0.942 ± 0.029
1.372TyrIle: 1.372 ± 0.037
0.948TyrLys: 0.948 ± 0.035
3.209TyrLeu: 3.209 ± 0.06
0.628TyrMet: 0.628 ± 0.024
0.882TyrAsn: 0.882 ± 0.027
1.422TyrPro: 1.422 ± 0.038
2.353TyrGln: 2.353 ± 0.057
1.961TyrArg: 1.961 ± 0.051
1.565TyrSer: 1.565 ± 0.042
1.463TyrThr: 1.463 ± 0.046
1.754TyrVal: 1.754 ± 0.044
0.486TyrTrp: 0.486 ± 0.025
0.936TyrTyr: 0.936 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3027 proteins (976084 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski