Amino acid dipepetide frequency for Salmonella phage 37

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.149AlaAla: 12.149 ± 1.044
0.718AlaCys: 0.718 ± 0.199
6.682AlaAsp: 6.682 ± 0.535
6.24AlaGlu: 6.24 ± 0.658
2.706AlaPhe: 2.706 ± 0.319
7.455AlaGly: 7.455 ± 0.589
1.602AlaHis: 1.602 ± 0.278
4.418AlaIle: 4.418 ± 0.505
5.025AlaLys: 5.025 ± 0.675
7.455AlaLeu: 7.455 ± 0.658
3.81AlaMet: 3.81 ± 0.383
3.093AlaAsn: 3.093 ± 0.358
3.313AlaPro: 3.313 ± 0.368
3.976AlaGln: 3.976 ± 0.677
6.24AlaArg: 6.24 ± 0.841
5.412AlaSer: 5.412 ± 0.528
5.522AlaThr: 5.522 ± 0.777
6.461AlaVal: 6.461 ± 0.633
1.27AlaTrp: 1.27 ± 0.234
3.369AlaTyr: 3.369 ± 0.418
0.0AlaXaa: 0.0 ± 0.0
Cys
0.718CysAla: 0.718 ± 0.224
0.331CysCys: 0.331 ± 0.134
0.884CysAsp: 0.884 ± 0.18
0.773CysGlu: 0.773 ± 0.196
0.331CysPhe: 0.331 ± 0.147
0.884CysGly: 0.884 ± 0.218
0.552CysHis: 0.552 ± 0.19
0.497CysIle: 0.497 ± 0.151
0.442CysLys: 0.442 ± 0.127
0.828CysLeu: 0.828 ± 0.203
0.221CysMet: 0.221 ± 0.119
0.331CysAsn: 0.331 ± 0.143
0.828CysPro: 0.828 ± 0.248
0.166CysGln: 0.166 ± 0.123
0.939CysArg: 0.939 ± 0.25
0.773CysSer: 0.773 ± 0.196
0.828CysThr: 0.828 ± 0.212
0.442CysVal: 0.442 ± 0.163
0.166CysTrp: 0.166 ± 0.089
0.276CysTyr: 0.276 ± 0.172
0.0CysXaa: 0.0 ± 0.0
Asp
6.24AspAla: 6.24 ± 0.574
0.552AspCys: 0.552 ± 0.2
4.307AspAsp: 4.307 ± 0.512
5.357AspGlu: 5.357 ± 0.717
2.43AspPhe: 2.43 ± 0.342
5.799AspGly: 5.799 ± 0.592
1.381AspHis: 1.381 ± 0.247
3.037AspIle: 3.037 ± 0.39
3.369AspLys: 3.369 ± 0.536
5.191AspLeu: 5.191 ± 0.581
2.319AspMet: 2.319 ± 0.309
2.154AspAsn: 2.154 ± 0.444
3.59AspPro: 3.59 ± 0.595
2.209AspGln: 2.209 ± 0.401
3.424AspArg: 3.424 ± 0.415
1.988AspSer: 1.988 ± 0.308
3.921AspThr: 3.921 ± 0.499
4.418AspVal: 4.418 ± 0.515
1.878AspTrp: 1.878 ± 0.349
1.767AspTyr: 1.767 ± 0.339
0.0AspXaa: 0.0 ± 0.0
Glu
5.357GluAla: 5.357 ± 0.575
0.497GluCys: 0.497 ± 0.143
3.976GluAsp: 3.976 ± 0.549
3.7GluGlu: 3.7 ± 0.664
1.988GluPhe: 1.988 ± 0.361
4.418GluGly: 4.418 ± 0.574
1.049GluHis: 1.049 ± 0.306
4.142GluIle: 4.142 ± 0.497
2.706GluLys: 2.706 ± 0.323
3.534GluLeu: 3.534 ± 0.483
1.878GluMet: 1.878 ± 0.272
2.651GluAsn: 2.651 ± 0.473
2.651GluPro: 2.651 ± 0.457
2.761GluGln: 2.761 ± 0.386
4.031GluArg: 4.031 ± 0.56
2.872GluSer: 2.872 ± 0.368
2.872GluThr: 2.872 ± 0.393
4.584GluVal: 4.584 ± 0.5
1.546GluTrp: 1.546 ± 0.243
1.988GluTyr: 1.988 ± 0.407
0.0GluXaa: 0.0 ± 0.0
Phe
3.203PheAla: 3.203 ± 0.446
0.442PheCys: 0.442 ± 0.155
3.369PheAsp: 3.369 ± 0.522
1.878PheGlu: 1.878 ± 0.37
1.16PhePhe: 1.16 ± 0.266
2.761PheGly: 2.761 ± 0.432
0.607PheHis: 0.607 ± 0.184
2.209PheIle: 2.209 ± 0.344
1.657PheLys: 1.657 ± 0.437
1.822PheLeu: 1.822 ± 0.303
0.773PheMet: 0.773 ± 0.206
1.767PheAsn: 1.767 ± 0.346
1.27PhePro: 1.27 ± 0.22
1.215PheGln: 1.215 ± 0.221
2.651PheArg: 2.651 ± 0.337
1.988PheSer: 1.988 ± 0.342
2.099PheThr: 2.099 ± 0.306
1.933PheVal: 1.933 ± 0.337
0.387PheTrp: 0.387 ± 0.179
1.104PheTyr: 1.104 ± 0.253
0.0PheXaa: 0.0 ± 0.0
Gly
6.24GlyAla: 6.24 ± 0.658
1.27GlyCys: 1.27 ± 0.327
4.197GlyAsp: 4.197 ± 0.478
4.694GlyGlu: 4.694 ± 0.538
2.54GlyPhe: 2.54 ± 0.336
5.743GlyGly: 5.743 ± 0.736
1.16GlyHis: 1.16 ± 0.356
4.031GlyIle: 4.031 ± 0.483
3.369GlyLys: 3.369 ± 0.41
5.909GlyLeu: 5.909 ± 0.659
1.602GlyMet: 1.602 ± 0.267
2.485GlyAsn: 2.485 ± 0.329
1.436GlyPro: 1.436 ± 0.309
2.872GlyGln: 2.872 ± 0.345
5.025GlyArg: 5.025 ± 0.608
3.81GlySer: 3.81 ± 0.448
5.136GlyThr: 5.136 ± 0.734
4.473GlyVal: 4.473 ± 0.42
1.657GlyTrp: 1.657 ± 0.29
3.534GlyTyr: 3.534 ± 0.549
0.0GlyXaa: 0.0 ± 0.0
His
1.712HisAla: 1.712 ± 0.318
0.166HisCys: 0.166 ± 0.091
1.602HisAsp: 1.602 ± 0.338
0.828HisGlu: 0.828 ± 0.21
0.607HisPhe: 0.607 ± 0.222
1.491HisGly: 1.491 ± 0.28
0.331HisHis: 0.331 ± 0.142
1.104HisIle: 1.104 ± 0.247
0.718HisLys: 0.718 ± 0.208
1.436HisLeu: 1.436 ± 0.254
0.497HisMet: 0.497 ± 0.183
0.828HisAsn: 0.828 ± 0.225
0.994HisPro: 0.994 ± 0.249
0.497HisGln: 0.497 ± 0.178
1.27HisArg: 1.27 ± 0.218
0.442HisSer: 0.442 ± 0.159
0.552HisThr: 0.552 ± 0.175
1.049HisVal: 1.049 ± 0.309
0.331HisTrp: 0.331 ± 0.158
0.663HisTyr: 0.663 ± 0.194
0.0HisXaa: 0.0 ± 0.0
Ile
5.136IleAla: 5.136 ± 0.531
0.552IleCys: 0.552 ± 0.206
3.645IleAsp: 3.645 ± 0.372
3.7IleGlu: 3.7 ± 0.382
1.491IlePhe: 1.491 ± 0.314
4.307IleGly: 4.307 ± 0.494
1.215IleHis: 1.215 ± 0.314
2.761IleIle: 2.761 ± 0.464
2.872IleLys: 2.872 ± 0.466
2.761IleLeu: 2.761 ± 0.401
1.822IleMet: 1.822 ± 0.351
2.761IleAsn: 2.761 ± 0.438
2.43IlePro: 2.43 ± 0.394
1.657IleGln: 1.657 ± 0.329
3.479IleArg: 3.479 ± 0.424
3.093IleSer: 3.093 ± 0.455
3.59IleThr: 3.59 ± 0.441
4.142IleVal: 4.142 ± 0.444
0.773IleTrp: 0.773 ± 0.244
1.767IleTyr: 1.767 ± 0.317
0.0IleXaa: 0.0 ± 0.0
Lys
4.805LysAla: 4.805 ± 0.428
0.663LysCys: 0.663 ± 0.209
3.037LysAsp: 3.037 ± 0.446
3.093LysGlu: 3.093 ± 0.488
1.767LysPhe: 1.767 ± 0.288
3.037LysGly: 3.037 ± 0.449
0.884LysHis: 0.884 ± 0.211
2.485LysIle: 2.485 ± 0.32
3.037LysLys: 3.037 ± 0.479
3.313LysLeu: 3.313 ± 0.385
1.988LysMet: 1.988 ± 0.362
1.491LysAsn: 1.491 ± 0.274
2.706LysPro: 2.706 ± 0.395
1.436LysGln: 1.436 ± 0.273
3.866LysArg: 3.866 ± 0.537
2.596LysSer: 2.596 ± 0.318
3.479LysThr: 3.479 ± 0.438
3.59LysVal: 3.59 ± 0.409
0.939LysTrp: 0.939 ± 0.268
2.209LysTyr: 2.209 ± 0.308
0.0LysXaa: 0.0 ± 0.0
Leu
6.737LeuAla: 6.737 ± 0.67
0.884LeuCys: 0.884 ± 0.247
5.191LeuAsp: 5.191 ± 0.6
4.639LeuGlu: 4.639 ± 0.474
2.43LeuPhe: 2.43 ± 0.4
3.7LeuGly: 3.7 ± 0.471
1.16LeuHis: 1.16 ± 0.249
4.087LeuIle: 4.087 ± 0.479
4.087LeuLys: 4.087 ± 0.423
4.749LeuLeu: 4.749 ± 0.575
1.767LeuMet: 1.767 ± 0.415
4.087LeuAsn: 4.087 ± 0.409
4.031LeuPro: 4.031 ± 0.545
2.43LeuGln: 2.43 ± 0.382
4.749LeuArg: 4.749 ± 0.501
5.522LeuSer: 5.522 ± 0.683
5.246LeuThr: 5.246 ± 0.454
4.307LeuVal: 4.307 ± 0.454
1.104LeuTrp: 1.104 ± 0.237
2.319LeuTyr: 2.319 ± 0.346
0.0LeuXaa: 0.0 ± 0.0
Met
3.369MetAla: 3.369 ± 0.413
0.331MetCys: 0.331 ± 0.131
1.657MetAsp: 1.657 ± 0.287
1.381MetGlu: 1.381 ± 0.257
1.104MetPhe: 1.104 ± 0.229
1.712MetGly: 1.712 ± 0.393
0.497MetHis: 0.497 ± 0.179
1.602MetIle: 1.602 ± 0.343
2.043MetLys: 2.043 ± 0.315
2.375MetLeu: 2.375 ± 0.347
0.663MetMet: 0.663 ± 0.167
1.712MetAsn: 1.712 ± 0.317
1.215MetPro: 1.215 ± 0.254
1.16MetGln: 1.16 ± 0.259
1.988MetArg: 1.988 ± 0.34
2.319MetSer: 2.319 ± 0.339
2.54MetThr: 2.54 ± 0.355
2.264MetVal: 2.264 ± 0.342
0.442MetTrp: 0.442 ± 0.151
1.325MetTyr: 1.325 ± 0.208
0.0MetXaa: 0.0 ± 0.0
Asn
4.363AsnAla: 4.363 ± 0.545
0.276AsnCys: 0.276 ± 0.139
2.596AsnAsp: 2.596 ± 0.415
1.602AsnGlu: 1.602 ± 0.292
1.215AsnPhe: 1.215 ± 0.253
3.755AsnGly: 3.755 ± 0.489
0.718AsnHis: 0.718 ± 0.181
1.988AsnIle: 1.988 ± 0.357
2.043AsnLys: 2.043 ± 0.419
2.651AsnLeu: 2.651 ± 0.382
0.994AsnMet: 0.994 ± 0.204
1.436AsnAsn: 1.436 ± 0.35
3.148AsnPro: 3.148 ± 0.456
1.491AsnGln: 1.491 ± 0.347
1.767AsnArg: 1.767 ± 0.292
2.651AsnSer: 2.651 ± 0.36
2.54AsnThr: 2.54 ± 0.436
3.203AsnVal: 3.203 ± 0.323
0.607AsnTrp: 0.607 ± 0.178
1.767AsnTyr: 1.767 ± 0.395
0.0AsnXaa: 0.0 ± 0.0
Pro
3.921ProAla: 3.921 ± 0.424
0.497ProCys: 0.497 ± 0.158
3.755ProAsp: 3.755 ± 0.661
2.761ProGlu: 2.761 ± 0.42
1.602ProPhe: 1.602 ± 0.27
3.59ProGly: 3.59 ± 0.585
0.884ProHis: 0.884 ± 0.2
2.651ProIle: 2.651 ± 0.448
2.54ProLys: 2.54 ± 0.37
3.645ProLeu: 3.645 ± 0.539
1.381ProMet: 1.381 ± 0.255
2.043ProAsn: 2.043 ± 0.317
3.037ProPro: 3.037 ± 0.642
1.381ProGln: 1.381 ± 0.296
1.712ProArg: 1.712 ± 0.344
3.148ProSer: 3.148 ± 0.463
3.037ProThr: 3.037 ± 0.494
3.424ProVal: 3.424 ± 0.543
0.552ProTrp: 0.552 ± 0.174
1.657ProTyr: 1.657 ± 0.3
0.0ProXaa: 0.0 ± 0.0
Gln
3.755GlnAla: 3.755 ± 0.734
0.276GlnCys: 0.276 ± 0.114
2.264GlnAsp: 2.264 ± 0.324
1.657GlnGlu: 1.657 ± 0.292
2.264GlnPhe: 2.264 ± 0.352
1.491GlnGly: 1.491 ± 0.32
0.552GlnHis: 0.552 ± 0.179
2.375GlnIle: 2.375 ± 0.32
2.043GlnLys: 2.043 ± 0.31
2.596GlnLeu: 2.596 ± 0.393
1.712GlnMet: 1.712 ± 0.365
1.546GlnAsn: 1.546 ± 0.303
1.988GlnPro: 1.988 ± 0.354
1.988GlnGln: 1.988 ± 0.523
2.927GlnArg: 2.927 ± 0.407
2.209GlnSer: 2.209 ± 0.368
1.988GlnThr: 1.988 ± 0.38
2.927GlnVal: 2.927 ± 0.615
0.663GlnTrp: 0.663 ± 0.194
1.27GlnTyr: 1.27 ± 0.229
0.0GlnXaa: 0.0 ± 0.0
Arg
6.572ArgAla: 6.572 ± 0.707
1.104ArgCys: 1.104 ± 0.311
3.81ArgAsp: 3.81 ± 0.495
3.203ArgGlu: 3.203 ± 0.509
2.319ArgPhe: 2.319 ± 0.314
3.755ArgGly: 3.755 ± 0.562
1.491ArgHis: 1.491 ± 0.292
3.645ArgIle: 3.645 ± 0.396
3.81ArgLys: 3.81 ± 0.519
6.296ArgLeu: 6.296 ± 0.54
2.485ArgMet: 2.485 ± 0.365
2.043ArgAsn: 2.043 ± 0.374
2.816ArgPro: 2.816 ± 0.417
2.375ArgGln: 2.375 ± 0.449
4.418ArgArg: 4.418 ± 0.567
3.424ArgSer: 3.424 ± 0.376
4.031ArgThr: 4.031 ± 0.417
5.081ArgVal: 5.081 ± 0.538
1.325ArgTrp: 1.325 ± 0.288
1.767ArgTyr: 1.767 ± 0.349
0.0ArgXaa: 0.0 ± 0.0
Ser
5.578SerAla: 5.578 ± 0.492
0.663SerCys: 0.663 ± 0.181
3.645SerAsp: 3.645 ± 0.422
2.264SerGlu: 2.264 ± 0.34
2.099SerPhe: 2.099 ± 0.341
4.86SerGly: 4.86 ± 0.46
0.607SerHis: 0.607 ± 0.169
3.313SerIle: 3.313 ± 0.488
2.54SerLys: 2.54 ± 0.362
3.866SerLeu: 3.866 ± 0.487
2.264SerMet: 2.264 ± 0.319
2.872SerAsn: 2.872 ± 0.357
2.651SerPro: 2.651 ± 0.372
2.651SerGln: 2.651 ± 0.43
4.252SerArg: 4.252 ± 0.653
3.313SerSer: 3.313 ± 0.47
3.479SerThr: 3.479 ± 0.458
4.197SerVal: 4.197 ± 0.465
0.718SerTrp: 0.718 ± 0.183
1.602SerTyr: 1.602 ± 0.321
0.0SerXaa: 0.0 ± 0.0
Thr
6.351ThrAla: 6.351 ± 0.572
0.773ThrCys: 0.773 ± 0.192
3.534ThrAsp: 3.534 ± 0.398
2.927ThrGlu: 2.927 ± 0.362
2.043ThrPhe: 2.043 ± 0.328
4.087ThrGly: 4.087 ± 0.534
0.773ThrHis: 0.773 ± 0.223
3.534ThrIle: 3.534 ± 0.427
2.872ThrLys: 2.872 ± 0.356
6.075ThrLeu: 6.075 ± 0.47
1.491ThrMet: 1.491 ± 0.239
2.319ThrAsn: 2.319 ± 0.375
3.7ThrPro: 3.7 ± 0.496
2.927ThrGln: 2.927 ± 0.442
3.81ThrArg: 3.81 ± 0.554
4.087ThrSer: 4.087 ± 0.498
4.252ThrThr: 4.252 ± 0.621
4.915ThrVal: 4.915 ± 0.567
1.16ThrTrp: 1.16 ± 0.245
1.988ThrTyr: 1.988 ± 0.354
0.0ThrXaa: 0.0 ± 0.0
Val
6.13ValAla: 6.13 ± 0.59
0.663ValCys: 0.663 ± 0.186
3.424ValAsp: 3.424 ± 0.355
4.915ValGlu: 4.915 ± 0.493
2.54ValPhe: 2.54 ± 0.336
4.528ValGly: 4.528 ± 0.535
0.663ValHis: 0.663 ± 0.189
3.866ValIle: 3.866 ± 0.47
3.755ValLys: 3.755 ± 0.434
5.136ValLeu: 5.136 ± 0.615
2.209ValMet: 2.209 ± 0.391
3.093ValAsn: 3.093 ± 0.394
2.982ValPro: 2.982 ± 0.414
2.816ValGln: 2.816 ± 0.447
5.633ValArg: 5.633 ± 0.556
4.197ValSer: 4.197 ± 0.521
4.97ValThr: 4.97 ± 0.538
5.025ValVal: 5.025 ± 0.539
0.939ValTrp: 0.939 ± 0.208
2.485ValTyr: 2.485 ± 0.383
0.0ValXaa: 0.0 ± 0.0
Trp
1.381TrpAla: 1.381 ± 0.36
0.221TrpCys: 0.221 ± 0.111
1.657TrpAsp: 1.657 ± 0.295
1.16TrpGlu: 1.16 ± 0.209
0.884TrpPhe: 0.884 ± 0.206
1.104TrpGly: 1.104 ± 0.252
0.387TrpHis: 0.387 ± 0.151
0.497TrpIle: 0.497 ± 0.176
0.663TrpLys: 0.663 ± 0.177
1.657TrpLeu: 1.657 ± 0.261
0.607TrpMet: 0.607 ± 0.186
0.994TrpAsn: 0.994 ± 0.232
0.442TrpPro: 0.442 ± 0.162
0.828TrpGln: 0.828 ± 0.242
0.939TrpArg: 0.939 ± 0.206
1.16TrpSer: 1.16 ± 0.271
0.939TrpThr: 0.939 ± 0.206
0.828TrpVal: 0.828 ± 0.222
0.497TrpTrp: 0.497 ± 0.155
0.663TrpTyr: 0.663 ± 0.184
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.203TyrAla: 3.203 ± 0.372
0.331TyrCys: 0.331 ± 0.144
2.099TyrAsp: 2.099 ± 0.319
2.43TyrGlu: 2.43 ± 0.36
0.773TyrPhe: 0.773 ± 0.204
2.706TyrGly: 2.706 ± 0.492
0.607TyrHis: 0.607 ± 0.182
1.712TyrIle: 1.712 ± 0.336
0.884TyrLys: 0.884 ± 0.2
1.933TyrLeu: 1.933 ± 0.411
1.16TyrMet: 1.16 ± 0.257
1.104TyrAsn: 1.104 ± 0.247
1.988TyrPro: 1.988 ± 0.398
1.657TyrGln: 1.657 ± 0.323
2.651TyrArg: 2.651 ± 0.384
2.43TyrSer: 2.43 ± 0.416
2.596TyrThr: 2.596 ± 0.443
2.706TyrVal: 2.706 ± 0.378
0.552TyrTrp: 0.552 ± 0.208
1.104TyrTyr: 1.104 ± 0.23
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 105 proteins (18109 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski