Amino acid dipepetide frequency for Halovirus HHTV-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.087AlaAla: 10.087 ± 1.434
0.642AlaCys: 0.642 ± 0.222
7.71AlaAsp: 7.71 ± 0.688
6.874AlaGlu: 6.874 ± 0.69
3.405AlaPhe: 3.405 ± 0.667
7.067AlaGly: 7.067 ± 0.73
1.542AlaHis: 1.542 ± 0.315
4.562AlaIle: 4.562 ± 0.668
1.992AlaLys: 1.992 ± 0.465
4.69AlaLeu: 4.69 ± 0.934
1.542AlaMet: 1.542 ± 0.333
2.441AlaAsn: 2.441 ± 0.429
3.341AlaPro: 3.341 ± 0.458
3.212AlaGln: 3.212 ± 0.375
3.405AlaArg: 3.405 ± 0.439
5.461AlaSer: 5.461 ± 0.724
5.075AlaThr: 5.075 ± 0.582
6.168AlaVal: 6.168 ± 0.666
1.156AlaTrp: 1.156 ± 0.235
1.863AlaTyr: 1.863 ± 0.331
0.0AlaXaa: 0.0 ± 0.0
Cys
0.257CysAla: 0.257 ± 0.131
0.321CysCys: 0.321 ± 0.139
0.642CysAsp: 0.642 ± 0.261
0.45CysGlu: 0.45 ± 0.2
0.128CysPhe: 0.128 ± 0.098
1.413CysGly: 1.413 ± 0.346
0.193CysHis: 0.193 ± 0.112
0.321CysIle: 0.321 ± 0.169
0.128CysLys: 0.128 ± 0.093
0.578CysLeu: 0.578 ± 0.189
0.0CysMet: 0.0 ± 0.068
0.193CysAsn: 0.193 ± 0.163
0.578CysPro: 0.578 ± 0.19
0.385CysGln: 0.385 ± 0.164
0.835CysArg: 0.835 ± 0.253
0.45CysSer: 0.45 ± 0.212
0.257CysThr: 0.257 ± 0.123
0.064CysVal: 0.064 ± 0.072
0.257CysTrp: 0.257 ± 0.133
0.321CysTyr: 0.321 ± 0.139
0.0CysXaa: 0.0 ± 0.0
Asp
8.288AspAla: 8.288 ± 0.695
0.321AspCys: 0.321 ± 0.154
6.36AspAsp: 6.36 ± 0.881
6.039AspGlu: 6.039 ± 0.541
3.02AspPhe: 3.02 ± 0.433
9.701AspGly: 9.701 ± 0.878
2.955AspHis: 2.955 ± 0.571
3.726AspIle: 3.726 ± 0.483
0.899AspLys: 0.899 ± 0.203
9.38AspLeu: 9.38 ± 0.799
1.542AspMet: 1.542 ± 0.313
2.698AspAsn: 2.698 ± 0.525
8.031AspPro: 8.031 ± 0.839
6.939AspGln: 6.939 ± 0.727
4.433AspArg: 4.433 ± 0.513
5.911AspSer: 5.911 ± 0.749
5.718AspThr: 5.718 ± 0.769
5.718AspVal: 5.718 ± 0.546
1.542AspTrp: 1.542 ± 0.319
2.313AspTyr: 2.313 ± 0.47
0.0AspXaa: 0.0 ± 0.0
Glu
9.38GluAla: 9.38 ± 1.036
0.0GluCys: 0.0 ± 0.0
6.682GluAsp: 6.682 ± 0.711
7.131GluGlu: 7.131 ± 0.893
2.313GluPhe: 2.313 ± 0.362
6.489GluGly: 6.489 ± 0.958
1.799GluHis: 1.799 ± 0.366
3.919GluIle: 3.919 ± 0.515
1.735GluLys: 1.735 ± 0.294
6.617GluLeu: 6.617 ± 0.61
1.799GluMet: 1.799 ± 0.414
2.056GluAsn: 2.056 ± 0.329
5.268GluPro: 5.268 ± 0.737
4.048GluGln: 4.048 ± 0.522
6.103GluArg: 6.103 ± 0.954
5.718GluSer: 5.718 ± 0.567
4.819GluThr: 4.819 ± 0.637
5.846GluVal: 5.846 ± 0.668
0.321GluTrp: 0.321 ± 0.145
2.184GluTyr: 2.184 ± 0.315
0.0GluXaa: 0.0 ± 0.0
Phe
1.349PheAla: 1.349 ± 0.339
0.321PheCys: 0.321 ± 0.153
3.919PheAsp: 3.919 ± 0.397
2.698PheGlu: 2.698 ± 0.529
0.899PhePhe: 0.899 ± 0.251
3.148PheGly: 3.148 ± 0.756
1.028PheHis: 1.028 ± 0.237
1.285PheIle: 1.285 ± 0.284
1.028PheLys: 1.028 ± 0.273
3.084PheLeu: 3.084 ± 0.588
0.321PheMet: 0.321 ± 0.139
0.835PheAsn: 0.835 ± 0.245
1.478PhePro: 1.478 ± 0.336
1.478PheGln: 1.478 ± 0.328
2.249PheArg: 2.249 ± 0.44
2.827PheSer: 2.827 ± 0.411
2.506PheThr: 2.506 ± 0.331
1.799PheVal: 1.799 ± 0.367
0.578PheTrp: 0.578 ± 0.179
1.028PheTyr: 1.028 ± 0.239
0.0PheXaa: 0.0 ± 0.0
Gly
5.461GlyAla: 5.461 ± 0.958
1.285GlyCys: 1.285 ± 0.445
7.838GlyAsp: 7.838 ± 0.648
6.874GlyGlu: 6.874 ± 0.621
4.497GlyPhe: 4.497 ± 0.419
7.774GlyGly: 7.774 ± 0.963
1.542GlyHis: 1.542 ± 0.303
4.112GlyIle: 4.112 ± 0.569
3.148GlyLys: 3.148 ± 0.463
4.883GlyLeu: 4.883 ± 0.845
3.212GlyMet: 3.212 ± 0.458
4.69GlyAsn: 4.69 ± 0.636
2.57GlyPro: 2.57 ± 0.511
3.726GlyGln: 3.726 ± 0.505
3.084GlyArg: 3.084 ± 0.4
6.81GlySer: 6.81 ± 0.63
6.489GlyThr: 6.489 ± 0.945
4.947GlyVal: 4.947 ± 0.645
1.542GlyTrp: 1.542 ± 0.357
1.927GlyTyr: 1.927 ± 0.369
0.0GlyXaa: 0.0 ± 0.0
His
1.156HisAla: 1.156 ± 0.31
0.321HisCys: 0.321 ± 0.14
1.799HisAsp: 1.799 ± 0.352
1.285HisGlu: 1.285 ± 0.325
0.642HisPhe: 0.642 ± 0.219
2.441HisGly: 2.441 ± 0.467
0.642HisHis: 0.642 ± 0.224
1.156HisIle: 1.156 ± 0.322
0.128HisLys: 0.128 ± 0.091
1.799HisLeu: 1.799 ± 0.356
0.128HisMet: 0.128 ± 0.087
0.193HisAsn: 0.193 ± 0.108
1.478HisPro: 1.478 ± 0.26
1.606HisGln: 1.606 ± 0.347
1.799HisArg: 1.799 ± 0.359
1.028HisSer: 1.028 ± 0.266
1.413HisThr: 1.413 ± 0.293
1.863HisVal: 1.863 ± 0.311
0.771HisTrp: 0.771 ± 0.239
0.771HisTyr: 0.771 ± 0.226
0.0HisXaa: 0.0 ± 0.0
Ile
2.763IleAla: 2.763 ± 0.422
0.578IleCys: 0.578 ± 0.266
4.69IleAsp: 4.69 ± 0.581
6.168IleGlu: 6.168 ± 0.72
0.771IlePhe: 0.771 ± 0.2
4.754IleGly: 4.754 ± 0.625
1.092IleHis: 1.092 ± 0.27
2.377IleIle: 2.377 ± 0.522
0.899IleLys: 0.899 ± 0.184
3.919IleLeu: 3.919 ± 0.556
0.514IleMet: 0.514 ± 0.172
0.707IleAsn: 0.707 ± 0.193
3.084IlePro: 3.084 ± 0.413
3.148IleGln: 3.148 ± 0.391
3.405IleArg: 3.405 ± 0.423
3.726IleSer: 3.726 ± 0.573
4.369IleThr: 4.369 ± 0.718
2.377IleVal: 2.377 ± 0.349
1.156IleTrp: 1.156 ± 0.271
0.899IleTyr: 0.899 ± 0.262
0.0IleXaa: 0.0 ± 0.0
Lys
2.827LysAla: 2.827 ± 0.504
0.0LysCys: 0.0 ± 0.0
1.992LysAsp: 1.992 ± 0.282
1.992LysGlu: 1.992 ± 0.34
0.964LysPhe: 0.964 ± 0.252
1.413LysGly: 1.413 ± 0.303
1.156LysHis: 1.156 ± 0.353
1.478LysIle: 1.478 ± 0.336
1.092LysLys: 1.092 ± 0.302
1.542LysLeu: 1.542 ± 0.267
0.771LysMet: 0.771 ± 0.2
1.028LysAsn: 1.028 ± 0.271
1.992LysPro: 1.992 ± 0.422
0.835LysGln: 0.835 ± 0.245
2.184LysArg: 2.184 ± 0.381
1.028LysSer: 1.028 ± 0.234
1.606LysThr: 1.606 ± 0.266
1.606LysVal: 1.606 ± 0.252
0.45LysTrp: 0.45 ± 0.137
0.45LysTyr: 0.45 ± 0.158
0.0LysXaa: 0.0 ± 0.0
Leu
6.168LeuAla: 6.168 ± 0.947
0.385LeuCys: 0.385 ± 0.203
9.252LeuAsp: 9.252 ± 0.764
5.718LeuGlu: 5.718 ± 0.6
1.863LeuPhe: 1.863 ± 0.392
6.103LeuGly: 6.103 ± 0.753
1.478LeuHis: 1.478 ± 0.287
4.433LeuIle: 4.433 ± 0.902
2.698LeuLys: 2.698 ± 0.529
3.662LeuLeu: 3.662 ± 0.642
1.349LeuMet: 1.349 ± 0.291
3.341LeuAsn: 3.341 ± 0.621
3.791LeuPro: 3.791 ± 0.39
2.955LeuGln: 2.955 ± 0.532
2.698LeuArg: 2.698 ± 0.419
3.855LeuSer: 3.855 ± 0.657
2.313LeuThr: 2.313 ± 0.55
5.397LeuVal: 5.397 ± 0.79
0.642LeuTrp: 0.642 ± 0.176
1.542LeuTyr: 1.542 ± 0.313
0.0LeuXaa: 0.0 ± 0.0
Met
3.534MetAla: 3.534 ± 0.423
0.257MetCys: 0.257 ± 0.151
1.992MetAsp: 1.992 ± 0.317
1.092MetGlu: 1.092 ± 0.344
0.835MetPhe: 0.835 ± 0.288
1.799MetGly: 1.799 ± 0.273
0.321MetHis: 0.321 ± 0.139
1.735MetIle: 1.735 ± 0.316
0.707MetLys: 0.707 ± 0.189
1.863MetLeu: 1.863 ± 0.322
1.413MetMet: 1.413 ± 0.282
0.771MetAsn: 0.771 ± 0.238
0.578MetPro: 0.578 ± 0.212
1.927MetGln: 1.927 ± 0.356
1.349MetArg: 1.349 ± 0.318
1.67MetSer: 1.67 ± 0.371
0.771MetThr: 0.771 ± 0.246
1.156MetVal: 1.156 ± 0.295
0.257MetTrp: 0.257 ± 0.111
0.193MetTyr: 0.193 ± 0.115
0.0MetXaa: 0.0 ± 0.0
Asn
2.634AsnAla: 2.634 ± 0.418
0.321AsnCys: 0.321 ± 0.162
2.506AsnAsp: 2.506 ± 0.425
2.184AsnGlu: 2.184 ± 0.315
1.478AsnPhe: 1.478 ± 0.349
4.048AsnGly: 4.048 ± 0.466
0.642AsnHis: 0.642 ± 0.249
2.249AsnIle: 2.249 ± 0.438
0.578AsnLys: 0.578 ± 0.25
2.441AsnLeu: 2.441 ± 0.305
0.45AsnMet: 0.45 ± 0.181
0.899AsnAsn: 0.899 ± 0.268
3.02AsnPro: 3.02 ± 0.445
1.028AsnGln: 1.028 ± 0.221
1.863AsnArg: 1.863 ± 0.289
2.57AsnSer: 2.57 ± 0.433
2.313AsnThr: 2.313 ± 0.424
2.313AsnVal: 2.313 ± 0.434
0.771AsnTrp: 0.771 ± 0.183
1.285AsnTyr: 1.285 ± 0.329
0.0AsnXaa: 0.0 ± 0.0
Pro
2.955ProAla: 2.955 ± 0.56
0.321ProCys: 0.321 ± 0.163
7.067ProAsp: 7.067 ± 0.794
7.967ProGlu: 7.967 ± 1.204
1.542ProPhe: 1.542 ± 0.323
4.433ProGly: 4.433 ± 0.477
1.349ProHis: 1.349 ± 0.297
1.478ProIle: 1.478 ± 0.298
1.285ProLys: 1.285 ± 0.309
2.249ProLeu: 2.249 ± 0.387
0.899ProMet: 0.899 ± 0.268
1.927ProAsn: 1.927 ± 0.372
2.57ProPro: 2.57 ± 0.506
1.927ProGln: 1.927 ± 0.339
3.212ProArg: 3.212 ± 0.499
3.148ProSer: 3.148 ± 0.426
2.634ProThr: 2.634 ± 0.363
3.277ProVal: 3.277 ± 0.439
0.514ProTrp: 0.514 ± 0.212
1.478ProTyr: 1.478 ± 0.309
0.0ProXaa: 0.0 ± 0.0
Gln
4.883GlnAla: 4.883 ± 0.741
0.321GlnCys: 0.321 ± 0.168
4.433GlnAsp: 4.433 ± 0.38
4.69GlnGlu: 4.69 ± 0.647
2.249GlnPhe: 2.249 ± 0.383
3.662GlnGly: 3.662 ± 0.437
1.221GlnHis: 1.221 ± 0.264
4.048GlnIle: 4.048 ± 0.571
1.028GlnLys: 1.028 ± 0.21
1.735GlnLeu: 1.735 ± 0.514
2.377GlnMet: 2.377 ± 0.488
3.084GlnAsn: 3.084 ± 0.35
2.184GlnPro: 2.184 ± 0.423
3.598GlnGln: 3.598 ± 0.543
2.056GlnArg: 2.056 ± 0.446
1.349GlnSer: 1.349 ± 0.314
1.413GlnThr: 1.413 ± 0.346
3.598GlnVal: 3.598 ± 0.422
0.899GlnTrp: 0.899 ± 0.253
1.156GlnTyr: 1.156 ± 0.269
0.0GlnXaa: 0.0 ± 0.0
Arg
3.148ArgAla: 3.148 ± 0.514
0.642ArgCys: 0.642 ± 0.28
5.011ArgAsp: 5.011 ± 0.48
4.626ArgGlu: 4.626 ± 0.691
2.249ArgPhe: 2.249 ± 0.41
3.02ArgGly: 3.02 ± 0.485
1.221ArgHis: 1.221 ± 0.302
3.02ArgIle: 3.02 ± 0.427
2.57ArgLys: 2.57 ± 0.392
3.726ArgLeu: 3.726 ± 0.612
2.441ArgMet: 2.441 ± 0.391
1.992ArgAsn: 1.992 ± 0.345
1.478ArgPro: 1.478 ± 0.32
3.148ArgGln: 3.148 ± 0.429
2.184ArgArg: 2.184 ± 0.517
3.726ArgSer: 3.726 ± 0.49
2.763ArgThr: 2.763 ± 0.395
3.405ArgVal: 3.405 ± 0.456
1.028ArgTrp: 1.028 ± 0.281
1.221ArgTyr: 1.221 ± 0.348
0.0ArgXaa: 0.0 ± 0.0
Ser
4.048SerAla: 4.048 ± 0.571
0.257SerCys: 0.257 ± 0.141
6.296SerAsp: 6.296 ± 0.777
5.589SerGlu: 5.589 ± 0.736
1.478SerPhe: 1.478 ± 0.231
6.168SerGly: 6.168 ± 0.604
1.349SerHis: 1.349 ± 0.259
2.763SerIle: 2.763 ± 0.435
1.092SerLys: 1.092 ± 0.312
5.589SerLeu: 5.589 ± 0.638
1.349SerMet: 1.349 ± 0.306
1.927SerAsn: 1.927 ± 0.348
3.084SerPro: 3.084 ± 0.445
2.698SerGln: 2.698 ± 0.478
2.891SerArg: 2.891 ± 0.488
4.369SerSer: 4.369 ± 0.532
4.69SerThr: 4.69 ± 0.565
4.819SerVal: 4.819 ± 0.51
0.771SerTrp: 0.771 ± 0.21
1.156SerTyr: 1.156 ± 0.278
0.0SerXaa: 0.0 ± 0.0
Thr
5.011ThrAla: 5.011 ± 0.732
0.578ThrCys: 0.578 ± 0.255
5.911ThrAsp: 5.911 ± 0.593
4.883ThrGlu: 4.883 ± 0.659
2.506ThrPhe: 2.506 ± 0.422
5.589ThrGly: 5.589 ± 0.709
1.028ThrHis: 1.028 ± 0.299
3.084ThrIle: 3.084 ± 0.436
0.835ThrLys: 0.835 ± 0.221
3.598ThrLeu: 3.598 ± 0.528
1.221ThrMet: 1.221 ± 0.21
2.056ThrAsn: 2.056 ± 0.35
2.763ThrPro: 2.763 ± 0.366
1.927ThrGln: 1.927 ± 0.399
2.377ThrArg: 2.377 ± 0.477
4.369ThrSer: 4.369 ± 0.746
3.598ThrThr: 3.598 ± 0.523
4.24ThrVal: 4.24 ± 0.584
1.221ThrTrp: 1.221 ± 0.309
1.285ThrTyr: 1.285 ± 0.361
0.0ThrXaa: 0.0 ± 0.0
Val
5.332ValAla: 5.332 ± 0.664
0.578ValCys: 0.578 ± 0.183
8.159ValAsp: 8.159 ± 0.937
4.819ValGlu: 4.819 ± 0.627
1.542ValPhe: 1.542 ± 0.331
4.497ValGly: 4.497 ± 0.716
1.092ValHis: 1.092 ± 0.278
3.469ValIle: 3.469 ± 0.369
3.084ValLys: 3.084 ± 0.343
4.626ValLeu: 4.626 ± 0.692
2.056ValMet: 2.056 ± 0.318
3.212ValAsn: 3.212 ± 0.496
2.891ValPro: 2.891 ± 0.42
3.598ValGln: 3.598 ± 0.535
3.726ValArg: 3.726 ± 0.432
3.148ValSer: 3.148 ± 0.471
3.405ValThr: 3.405 ± 0.623
5.397ValVal: 5.397 ± 0.568
0.642ValTrp: 0.642 ± 0.213
1.349ValTyr: 1.349 ± 0.332
0.0ValXaa: 0.0 ± 0.0
Trp
1.349TrpAla: 1.349 ± 0.259
0.128TrpCys: 0.128 ± 0.093
1.349TrpAsp: 1.349 ± 0.386
1.221TrpGlu: 1.221 ± 0.351
0.835TrpPhe: 0.835 ± 0.255
0.899TrpGly: 0.899 ± 0.319
0.578TrpHis: 0.578 ± 0.2
0.964TrpIle: 0.964 ± 0.282
1.092TrpLys: 1.092 ± 0.314
1.542TrpLeu: 1.542 ± 0.292
0.321TrpMet: 0.321 ± 0.15
0.835TrpAsn: 0.835 ± 0.3
0.578TrpPro: 0.578 ± 0.219
0.707TrpGln: 0.707 ± 0.208
0.642TrpArg: 0.642 ± 0.206
0.064TrpSer: 0.064 ± 0.065
0.514TrpThr: 0.514 ± 0.172
1.092TrpVal: 1.092 ± 0.238
0.193TrpTrp: 0.193 ± 0.113
0.321TrpTyr: 0.321 ± 0.144
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.606TyrAla: 1.606 ± 0.376
0.257TyrCys: 0.257 ± 0.107
1.927TyrAsp: 1.927 ± 0.377
1.927TyrGlu: 1.927 ± 0.353
0.642TyrPhe: 0.642 ± 0.202
1.992TyrGly: 1.992 ± 0.416
0.193TyrHis: 0.193 ± 0.106
1.221TyrIle: 1.221 ± 0.236
0.385TyrLys: 0.385 ± 0.129
2.12TyrLeu: 2.12 ± 0.412
0.45TyrMet: 0.45 ± 0.129
0.707TyrAsn: 0.707 ± 0.211
1.478TyrPro: 1.478 ± 0.332
1.092TyrGln: 1.092 ± 0.278
2.12TyrArg: 2.12 ± 0.342
1.156TyrSer: 1.156 ± 0.246
1.413TyrThr: 1.413 ± 0.345
1.542TyrVal: 1.542 ± 0.344
0.514TyrTrp: 0.514 ± 0.203
0.385TyrTyr: 0.385 ± 0.165
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 74 proteins (15566 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski