Amino acid dipepetide frequency for Oceanicoccus sagamiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.959AlaAla: 9.959 ± 0.14	1.009AlaCys: 1.009 ± 0.03	5.793AlaAsp: 5.793 ± 0.102	6.374AlaGlu: 6.374 ± 0.084	3.383AlaPhe: 3.383 ± 0.056	7.336AlaGly: 7.336 ± 0.151	1.568AlaHis: 1.568 ± 0.038	6.328AlaIle: 6.328 ± 0.073	4.44AlaLys: 4.44 ± 0.1	9.805AlaLeu: 9.805 ± 0.116	2.828AlaMet: 2.828 ± 0.05	3.662AlaAsn: 3.662 ± 0.085	3.361AlaPro: 3.361 ± 0.061	3.612AlaGln: 3.612 ± 0.053	3.794AlaArg: 3.794 ± 0.077	5.986AlaSer: 5.986 ± 0.076	4.894AlaThr: 4.894 ± 0.074	6.565AlaVal: 6.565 ± 0.075	0.955AlaTrp: 0.955 ± 0.03	2.643AlaTyr: 2.643 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.811CysAla: 0.811 ± 0.03	0.142CysCys: 0.142 ± 0.011	0.656CysAsp: 0.656 ± 0.029	0.577CysGlu: 0.577 ± 0.023	0.426CysPhe: 0.426 ± 0.018	0.832CysGly: 0.832 ± 0.032	0.335CysHis: 0.335 ± 0.021	0.52CysIle: 0.52 ± 0.024	0.369CysLys: 0.369 ± 0.019	0.938CysLeu: 0.938 ± 0.029	0.23CysMet: 0.23 ± 0.014	0.342CysAsn: 0.342 ± 0.018	0.424CysPro: 0.424 ± 0.023	0.43CysGln: 0.43 ± 0.019	0.483CysArg: 0.483 ± 0.02	0.68CysSer: 0.68 ± 0.026	0.427CysThr: 0.427 ± 0.02	0.571CysVal: 0.571 ± 0.023	0.13CysTrp: 0.13 ± 0.011	0.328CysTyr: 0.328 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.01AspAla: 5.01 ± 0.101	0.6AspCys: 0.6 ± 0.025	3.832AspAsp: 3.832 ± 0.13	3.782AspGlu: 3.782 ± 0.065	2.702AspPhe: 2.702 ± 0.068	4.636AspGly: 4.636 ± 0.121	1.231AspHis: 1.231 ± 0.035	4.618AspIle: 4.618 ± 0.073	2.999AspLys: 2.999 ± 0.055	5.422AspLeu: 5.422 ± 0.083	1.483AspMet: 1.483 ± 0.039	3.234AspAsn: 3.234 ± 0.112	2.537AspPro: 2.537 ± 0.053	2.636AspGln: 2.636 ± 0.043	2.688AspArg: 2.688 ± 0.05	3.895AspSer: 3.895 ± 0.067	3.293AspThr: 3.293 ± 0.115	3.72AspVal: 3.72 ± 0.063	0.886AspTrp: 0.886 ± 0.028	2.416AspTyr: 2.416 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.703GluAla: 5.703 ± 0.09	0.433GluCys: 0.433 ± 0.019	3.303GluAsp: 3.303 ± 0.064	3.887GluGlu: 3.887 ± 0.077	2.272GluPhe: 2.272 ± 0.043	4.2GluGly: 4.2 ± 0.057	1.28GluHis: 1.28 ± 0.033	3.689GluIle: 3.689 ± 0.052	3.295GluLys: 3.295 ± 0.074	6.516GluLeu: 6.516 ± 0.087	1.535GluMet: 1.535 ± 0.041	2.292GluAsn: 2.292 ± 0.048	2.179GluPro: 2.179 ± 0.051	4.258GluGln: 4.258 ± 0.074	3.181GluArg: 3.181 ± 0.066	3.445GluSer: 3.445 ± 0.061	3.19GluThr: 3.19 ± 0.05	4.264GluVal: 4.264 ± 0.059	0.769GluTrp: 0.769 ± 0.025	1.704GluTyr: 1.704 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.325PheAla: 3.325 ± 0.054	0.472PheCys: 0.472 ± 0.019	2.861PheAsp: 2.861 ± 0.051	2.313PheGlu: 2.313 ± 0.05	1.693PhePhe: 1.693 ± 0.047	2.997PheGly: 2.997 ± 0.056	0.708PheHis: 0.708 ± 0.029	2.466PheIle: 2.466 ± 0.054	1.727PheLys: 1.727 ± 0.039	3.247PheLeu: 3.247 ± 0.064	0.997PheMet: 0.997 ± 0.032	1.85PheAsn: 1.85 ± 0.042	1.451PhePro: 1.451 ± 0.04	1.308PheGln: 1.308 ± 0.034	1.479PheArg: 1.479 ± 0.038	3.263PheSer: 3.263 ± 0.055	2.345PheThr: 2.345 ± 0.058	2.46PheVal: 2.46 ± 0.051	0.494PheTrp: 0.494 ± 0.022	1.455PheTyr: 1.455 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	5.956GlyAla: 5.956 ± 0.115	0.807GlyCys: 0.807 ± 0.027	4.729GlyAsp: 4.729 ± 0.155	4.633GlyGlu: 4.633 ± 0.069	3.41GlyPhe: 3.41 ± 0.048	5.602GlyGly: 5.602 ± 0.119	1.549GlyHis: 1.549 ± 0.047	4.695GlyIle: 4.695 ± 0.075	3.609GlyLys: 3.609 ± 0.065	7.279GlyLeu: 7.279 ± 0.097	2.104GlyMet: 2.104 ± 0.046	2.833GlyAsn: 2.833 ± 0.089	2.235GlyPro: 2.235 ± 0.049	2.937GlyGln: 2.937 ± 0.056	3.404GlyArg: 3.404 ± 0.055	4.893GlySer: 4.893 ± 0.108	3.698GlyThr: 3.698 ± 0.099	5.356GlyVal: 5.356 ± 0.074	1.038GlyTrp: 1.038 ± 0.034	2.495GlyTyr: 2.495 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.445HisAla: 1.445 ± 0.037	0.325HisCys: 0.325 ± 0.017	0.96HisAsp: 0.96 ± 0.03	0.903HisGlu: 0.903 ± 0.029	0.951HisPhe: 0.951 ± 0.034	1.478HisGly: 1.478 ± 0.041	0.585HisHis: 0.585 ± 0.023	1.366HisIle: 1.366 ± 0.039	0.834HisLys: 0.834 ± 0.026	1.959HisLeu: 1.959 ± 0.048	0.48HisMet: 0.48 ± 0.023	0.806HisAsn: 0.806 ± 0.027	1.093HisPro: 1.093 ± 0.031	1.076HisGln: 1.076 ± 0.036	1.147HisArg: 1.147 ± 0.035	1.364HisSer: 1.364 ± 0.038	1.035HisThr: 1.035 ± 0.032	1.018HisVal: 1.018 ± 0.029	0.361HisTrp: 0.361 ± 0.017	0.882HisTyr: 0.882 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.648IleAla: 6.648 ± 0.082	0.611IleCys: 0.611 ± 0.027	4.766IleAsp: 4.766 ± 0.074	4.35IleGlu: 4.35 ± 0.063	2.025IlePhe: 2.025 ± 0.038	4.395IleGly: 4.395 ± 0.071	1.169IleHis: 1.169 ± 0.041	3.663IleIle: 3.663 ± 0.061	3.04IleLys: 3.04 ± 0.052	4.789IleLeu: 4.789 ± 0.066	1.221IleMet: 1.221 ± 0.033	3.32IleAsn: 3.32 ± 0.064	2.736IlePro: 2.736 ± 0.049	2.059IleGln: 2.059 ± 0.045	2.654IleArg: 2.654 ± 0.049	4.522IleSer: 4.522 ± 0.074	3.846IleThr: 3.846 ± 0.076	4.024IleVal: 4.024 ± 0.054	0.596IleTrp: 0.596 ± 0.023	1.817IleTyr: 1.817 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.853LysAla: 4.853 ± 0.091	0.23LysCys: 0.23 ± 0.015	2.529LysAsp: 2.529 ± 0.055	2.706LysGlu: 2.706 ± 0.055	1.18LysPhe: 1.18 ± 0.032	2.989LysGly: 2.989 ± 0.056	0.945LysHis: 0.945 ± 0.031	2.563LysIle: 2.563 ± 0.056	2.648LysLys: 2.648 ± 0.084	4.313LysLeu: 4.313 ± 0.074	1.141LysMet: 1.141 ± 0.039	1.826LysAsn: 1.826 ± 0.041	2.429LysPro: 2.429 ± 0.061	2.461LysGln: 2.461 ± 0.048	2.316LysArg: 2.316 ± 0.05	2.589LysSer: 2.589 ± 0.047	2.723LysThr: 2.723 ± 0.051	3.218LysVal: 3.218 ± 0.059	0.41LysTrp: 0.41 ± 0.019	1.098LysTyr: 1.098 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	10.417LeuAla: 10.417 ± 0.111	0.99LeuCys: 0.99 ± 0.032	5.946LeuAsp: 5.946 ± 0.081	5.943LeuGlu: 5.943 ± 0.085	3.829LeuPhe: 3.829 ± 0.072	6.862LeuGly: 6.862 ± 0.103	1.814LeuHis: 1.814 ± 0.046	5.731LeuIle: 5.731 ± 0.071	4.547LeuLys: 4.547 ± 0.072	10.766LeuLeu: 10.766 ± 0.147	2.568LeuMet: 2.568 ± 0.053	4.133LeuAsn: 4.133 ± 0.078	4.665LeuPro: 4.665 ± 0.075	4.292LeuGln: 4.292 ± 0.066	4.443LeuArg: 4.443 ± 0.078	7.559LeuSer: 7.559 ± 0.082	5.525LeuThr: 5.525 ± 0.09	6.601LeuVal: 6.601 ± 0.072	1.177LeuTrp: 1.177 ± 0.037	2.593LeuTyr: 2.593 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.746MetAla: 2.746 ± 0.054	0.166MetCys: 0.166 ± 0.012	1.478MetAsp: 1.478 ± 0.042	1.355MetGlu: 1.355 ± 0.035	0.778MetPhe: 0.778 ± 0.025	1.916MetGly: 1.916 ± 0.044	0.466MetHis: 0.466 ± 0.02	1.459MetIle: 1.459 ± 0.038	1.169MetLys: 1.169 ± 0.033	2.473MetLeu: 2.473 ± 0.062	0.765MetMet: 0.765 ± 0.026	0.948MetAsn: 0.948 ± 0.03	1.28MetPro: 1.28 ± 0.035	1.067MetGln: 1.067 ± 0.033	1.143MetArg: 1.143 ± 0.031	1.856MetSer: 1.856 ± 0.041	1.594MetThr: 1.594 ± 0.034	1.806MetVal: 1.806 ± 0.041	0.202MetTrp: 0.202 ± 0.014	0.494MetTyr: 0.494 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.579AsnAla: 3.579 ± 0.067	0.384AsnCys: 0.384 ± 0.021	2.426AsnAsp: 2.426 ± 0.094	2.028AsnGlu: 2.028 ± 0.04	1.563AsnPhe: 1.563 ± 0.037	3.129AsnGly: 3.129 ± 0.085	0.873AsnHis: 0.873 ± 0.028	2.749AsnIle: 2.749 ± 0.064	1.948AsnLys: 1.948 ± 0.045	3.6AsnLeu: 3.6 ± 0.066	0.868AsnMet: 0.868 ± 0.026	2.207AsnAsn: 2.207 ± 0.063	2.256AsnPro: 2.256 ± 0.043	1.767AsnGln: 1.767 ± 0.041	2.028AsnArg: 2.028 ± 0.044	2.745AsnSer: 2.745 ± 0.074	2.666AsnThr: 2.666 ± 0.083	2.324AsnVal: 2.324 ± 0.065	0.538AsnTrp: 0.538 ± 0.024	1.467AsnTyr: 1.467 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	4.066ProAla: 4.066 ± 0.066	0.325ProCys: 0.325 ± 0.018	2.77ProAsp: 2.77 ± 0.049	3.529ProGlu: 3.529 ± 0.061	1.647ProPhe: 1.647 ± 0.04	2.968ProGly: 2.968 ± 0.058	0.809ProHis: 0.809 ± 0.026	2.332ProIle: 2.332 ± 0.041	1.706ProLys: 1.706 ± 0.043	4.302ProLeu: 4.302 ± 0.064	1.064ProMet: 1.064 ± 0.031	1.611ProAsn: 1.611 ± 0.042	1.454ProPro: 1.454 ± 0.039	1.707ProGln: 1.707 ± 0.045	1.583ProArg: 1.583 ± 0.04	2.529ProSer: 2.529 ± 0.055	2.046ProThr: 2.046 ± 0.049	3.489ProVal: 3.489 ± 0.058	0.545ProTrp: 0.545 ± 0.022	1.263ProTyr: 1.263 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.647GlnAla: 4.647 ± 0.077	0.428GlnCys: 0.428 ± 0.022	1.995GlnAsp: 1.995 ± 0.045	2.299GlnGlu: 2.299 ± 0.051	1.591GlnPhe: 1.591 ± 0.037	3.169GlnGly: 3.169 ± 0.056	1.172GlnHis: 1.172 ± 0.033	2.238GlnIle: 2.238 ± 0.042	1.615GlnLys: 1.615 ± 0.041	5.503GlnLeu: 5.503 ± 0.076	1.007GlnMet: 1.007 ± 0.031	1.295GlnAsn: 1.295 ± 0.031	1.92GlnPro: 1.92 ± 0.043	4.078GlnGln: 4.078 ± 0.103	2.767GlnArg: 2.767 ± 0.058	2.833GlnSer: 2.833 ± 0.054	2.166GlnThr: 2.166 ± 0.04	2.861GlnVal: 2.861 ± 0.049	0.813GlnTrp: 0.813 ± 0.029	1.315GlnTyr: 1.315 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	3.558ArgAla: 3.558 ± 0.064	0.487ArgCys: 0.487 ± 0.023	2.632ArgAsp: 2.632 ± 0.047	2.982ArgGlu: 2.982 ± 0.057	2.213ArgPhe: 2.213 ± 0.05	2.937ArgGly: 2.937 ± 0.048	1.051ArgHis: 1.051 ± 0.035	2.917ArgIle: 2.917 ± 0.045	2.128ArgLys: 2.128 ± 0.05	5.12ArgLeu: 5.12 ± 0.074	1.212ArgMet: 1.212 ± 0.034	1.755ArgAsn: 1.755 ± 0.037	1.745ArgPro: 1.745 ± 0.047	2.306ArgGln: 2.306 ± 0.055	2.556ArgArg: 2.556 ± 0.053	2.854ArgSer: 2.854 ± 0.053	1.991ArgThr: 1.991 ± 0.043	3.192ArgVal: 3.192 ± 0.055	0.759ArgTrp: 0.759 ± 0.027	1.873ArgTyr: 1.873 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.126SerAla: 6.126 ± 0.073	0.681SerCys: 0.681 ± 0.028	4.094SerAsp: 4.094 ± 0.086	3.775SerGlu: 3.775 ± 0.057	2.697SerPhe: 2.697 ± 0.054	5.42SerGly: 5.42 ± 0.109	1.36SerHis: 1.36 ± 0.04	4.2SerIle: 4.2 ± 0.068	2.732SerLys: 2.732 ± 0.052	7.049SerLeu: 7.049 ± 0.095	1.635SerMet: 1.635 ± 0.037	2.67SerAsn: 2.67 ± 0.054	2.799SerPro: 2.799 ± 0.052	2.77SerGln: 2.77 ± 0.055	3.055SerArg: 3.055 ± 0.061	4.671SerSer: 4.671 ± 0.076	3.546SerThr: 3.546 ± 0.068	4.448SerVal: 4.448 ± 0.066	0.85SerTrp: 0.85 ± 0.034	2.216SerTyr: 2.216 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	5.48ThrAla: 5.48 ± 0.089	0.385ThrCys: 0.385 ± 0.017	3.517ThrAsp: 3.517 ± 0.097	3.361ThrGlu: 3.361 ± 0.059	1.913ThrPhe: 1.913 ± 0.041	4.635ThrGly: 4.635 ± 0.116	0.971ThrHis: 0.971 ± 0.03	3.69ThrIle: 3.69 ± 0.068	1.705ThrLys: 1.705 ± 0.045	6.086ThrLeu: 6.086 ± 0.088	1.217ThrMet: 1.217 ± 0.033	1.862ThrAsn: 1.862 ± 0.066	2.687ThrPro: 2.687 ± 0.054	1.999ThrGln: 1.999 ± 0.038	2.143ThrArg: 2.143 ± 0.048	3.268ThrSer: 3.268 ± 0.054	3.105ThrThr: 3.105 ± 0.074	4.499ThrVal: 4.499 ± 0.106	0.503ThrTrp: 0.503 ± 0.024	1.426ThrTyr: 1.426 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	6.807ValAla: 6.807 ± 0.074	0.657ValCys: 0.657 ± 0.025	4.713ValAsp: 4.713 ± 0.089	4.387ValGlu: 4.387 ± 0.058	2.73ValPhe: 2.73 ± 0.05	4.659ValGly: 4.659 ± 0.101	1.144ValHis: 1.144 ± 0.029	4.606ValIle: 4.606 ± 0.071	2.983ValLys: 2.983 ± 0.053	6.489ValLeu: 6.489 ± 0.084	1.819ValMet: 1.819 ± 0.042	2.872ValAsn: 2.872 ± 0.053	2.676ValPro: 2.676 ± 0.052	2.113ValGln: 2.113 ± 0.053	2.861ValArg: 2.861 ± 0.053	4.698ValSer: 4.698 ± 0.067	4.136ValThr: 4.136 ± 0.087	5.413ValVal: 5.413 ± 0.077	0.749ValTrp: 0.749 ± 0.027	1.879ValTyr: 1.879 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.848TrpAla: 0.848 ± 0.032	0.147TrpCys: 0.147 ± 0.011	0.699TrpAsp: 0.699 ± 0.028	0.598TrpGlu: 0.598 ± 0.023	0.571TrpPhe: 0.571 ± 0.02	0.809TrpGly: 0.809 ± 0.028	0.295TrpHis: 0.295 ± 0.018	0.641TrpIle: 0.641 ± 0.023	0.437TrpLys: 0.437 ± 0.021	1.619TrpLeu: 1.619 ± 0.043	0.335TrpMet: 0.335 ± 0.017	0.435TrpAsn: 0.435 ± 0.019	0.505TrpPro: 0.505 ± 0.023	0.89TrpGln: 0.89 ± 0.029	0.701TrpArg: 0.701 ± 0.026	0.875TrpSer: 0.875 ± 0.029	0.554TrpThr: 0.554 ± 0.021	0.907TrpVal: 0.907 ± 0.034	0.183TrpTrp: 0.183 ± 0.013	0.402TrpTyr: 0.402 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.312TyrAla: 2.312 ± 0.044	0.375TyrCys: 0.375 ± 0.017	1.922TyrAsp: 1.922 ± 0.046	1.614TyrGlu: 1.614 ± 0.04	1.336TyrPhe: 1.336 ± 0.038	2.291TyrGly: 2.291 ± 0.05	0.741TyrHis: 0.741 ± 0.034	1.781TyrIle: 1.781 ± 0.034	1.238TyrLys: 1.238 ± 0.037	3.125TyrLeu: 3.125 ± 0.054	0.65TyrMet: 0.65 ± 0.023	1.192TyrAsn: 1.192 ± 0.036	1.314TyrPro: 1.314 ± 0.04	1.945TyrGln: 1.945 ± 0.044	1.846TyrArg: 1.846 ± 0.044	2.267TyrSer: 2.267 ± 0.057	1.67TyrThr: 1.67 ± 0.039	1.656TyrVal: 1.656 ± 0.036	0.494TyrTrp: 0.494 ± 0.023	1.089TyrTyr: 1.089 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3870 proteins (1275952 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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