Amino acid dipepetide frequency for Cervus elaphus hippelaphus (European red deer)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.153AlaAla: 7.153 ± 0.065	1.512AlaCys: 1.512 ± 0.018	2.995AlaAsp: 2.995 ± 0.022	4.98AlaGlu: 4.98 ± 0.039	2.583AlaPhe: 2.583 ± 0.022	5.312AlaGly: 5.312 ± 0.038	1.679AlaHis: 1.679 ± 0.018	2.59AlaIle: 2.59 ± 0.021	3.318AlaLys: 3.318 ± 0.026	7.779AlaLeu: 7.779 ± 0.052	1.492AlaMet: 1.492 ± 0.014	1.903AlaAsn: 1.903 ± 0.02	4.837AlaPro: 4.837 ± 0.048	3.435AlaGln: 3.435 ± 0.031	4.081AlaArg: 4.081 ± 0.03	6.087AlaSer: 6.087 ± 0.034	3.564AlaThr: 3.564 ± 0.032	4.917AlaVal: 4.917 ± 0.031	0.929AlaTrp: 0.929 ± 0.013	1.523AlaTyr: 1.523 ± 0.015	0.001AlaXaa: 0.001 ± 0.0
Cys	1.331CysAla: 1.331 ± 0.017	0.645CysCys: 0.645 ± 0.014	0.945CysAsp: 0.945 ± 0.015	1.218CysGlu: 1.218 ± 0.017	0.864CysPhe: 0.864 ± 0.011	1.598CysGly: 1.598 ± 0.022	0.667CysHis: 0.667 ± 0.012	0.886CysIle: 0.886 ± 0.013	1.037CysLys: 1.037 ± 0.014	2.292CysLeu: 2.292 ± 0.022	0.394CysMet: 0.394 ± 0.008	0.703CysAsn: 0.703 ± 0.012	1.59CysPro: 1.59 ± 0.024	1.089CysGln: 1.089 ± 0.017	1.399CysArg: 1.399 ± 0.018	2.016CysSer: 2.016 ± 0.02	1.048CysThr: 1.048 ± 0.013	1.333CysVal: 1.333 ± 0.015	0.323CysTrp: 0.323 ± 0.007	0.56CysTyr: 0.56 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	2.937AspAla: 2.937 ± 0.026	1.01AspCys: 1.01 ± 0.014	2.494AspAsp: 2.494 ± 0.023	3.296AspGlu: 3.296 ± 0.029	2.071AspPhe: 2.071 ± 0.021	3.294AspGly: 3.294 ± 0.03	1.137AspHis: 1.137 ± 0.014	2.404AspIle: 2.404 ± 0.027	2.308AspLys: 2.308 ± 0.023	4.949AspLeu: 4.949 ± 0.029	1.067AspMet: 1.067 ± 0.014	1.542AspAsn: 1.542 ± 0.02	3.054AspPro: 3.054 ± 0.024	1.813AspGln: 1.813 ± 0.018	2.476AspArg: 2.476 ± 0.024	4.117AspSer: 4.117 ± 0.03	2.402AspThr: 2.402 ± 0.023	3.071AspVal: 3.071 ± 0.032	0.662AspTrp: 0.662 ± 0.01	1.369AspTyr: 1.369 ± 0.016	0.001AspXaa: 0.001 ± 0.0
Glu	5.588GluAla: 5.588 ± 0.043	1.154GluCys: 1.154 ± 0.019	4.31GluAsp: 4.31 ± 0.033	7.826GluGlu: 7.826 ± 0.075	2.001GluPhe: 2.001 ± 0.018	4.404GluGly: 4.404 ± 0.03	1.46GluHis: 1.46 ± 0.014	2.902GluIle: 2.902 ± 0.026	4.978GluLys: 4.978 ± 0.049	6.443GluLeu: 6.443 ± 0.041	1.642GluMet: 1.642 ± 0.018	2.905GluAsn: 2.905 ± 0.028	3.504GluPro: 3.504 ± 0.031	3.116GluGln: 3.116 ± 0.031	4.006GluArg: 4.006 ± 0.032	4.357GluSer: 4.357 ± 0.034	3.408GluThr: 3.408 ± 0.026	4.264GluVal: 4.264 ± 0.032	0.708GluTrp: 0.708 ± 0.011	1.454GluTyr: 1.454 ± 0.016	0.001GluXaa: 0.001 ± 0.0
Phe	1.973PheAla: 1.973 ± 0.019	0.92PheCys: 0.92 ± 0.013	1.579PheAsp: 1.579 ± 0.017	1.927PheGlu: 1.927 ± 0.015	1.518PhePhe: 1.518 ± 0.018	2.193PheGly: 2.193 ± 0.02	1.037PheHis: 1.037 ± 0.014	1.677PheIle: 1.677 ± 0.018	1.654PheLys: 1.654 ± 0.018	4.202PheLeu: 4.202 ± 0.032	0.725PheMet: 0.725 ± 0.011	1.217PheAsn: 1.217 ± 0.017	2.158PhePro: 2.158 ± 0.019	1.819PheGln: 1.819 ± 0.019	2.0PheArg: 2.0 ± 0.021	3.385PheSer: 3.385 ± 0.022	1.969PheThr: 1.969 ± 0.019	2.087PheVal: 2.087 ± 0.02	0.505PheTrp: 0.505 ± 0.01	1.135PheTyr: 1.135 ± 0.016	0.001PheXaa: 0.001 ± 0.0
Gly	5.083GlyAla: 5.083 ± 0.039	1.388GlyCys: 1.388 ± 0.016	3.157GlyAsp: 3.157 ± 0.026	4.073GlyGlu: 4.073 ± 0.03	2.384GlyPhe: 2.384 ± 0.023	5.475GlyGly: 5.475 ± 0.051	1.808GlyHis: 1.808 ± 0.02	2.622GlyIle: 2.622 ± 0.021	3.552GlyLys: 3.552 ± 0.028	6.416GlyLeu: 6.416 ± 0.043	1.311GlyMet: 1.311 ± 0.015	2.212GlyAsn: 2.212 ± 0.022	4.815GlyPro: 4.815 ± 0.051	2.929GlyGln: 2.929 ± 0.024	4.269GlyArg: 4.269 ± 0.032	6.008GlySer: 6.008 ± 0.034	3.686GlyThr: 3.686 ± 0.03	3.781GlyVal: 3.781 ± 0.024	0.927GlyTrp: 0.927 ± 0.012	1.66GlyTyr: 1.66 ± 0.019	0.001GlyXaa: 0.001 ± 0.0
His	1.38HisAla: 1.38 ± 0.015	0.748HisCys: 0.748 ± 0.011	0.865HisAsp: 0.865 ± 0.012	1.24HisGlu: 1.24 ± 0.014	1.099HisPhe: 1.099 ± 0.012	1.613HisGly: 1.613 ± 0.02	0.868HisHis: 0.868 ± 0.016	1.12HisIle: 1.12 ± 0.015	1.16HisLys: 1.16 ± 0.015	2.996HisLeu: 2.996 ± 0.026	0.571HisMet: 0.571 ± 0.009	0.798HisAsn: 0.798 ± 0.013	1.797HisPro: 1.797 ± 0.018	1.241HisGln: 1.241 ± 0.013	1.661HisArg: 1.661 ± 0.017	2.228HisSer: 2.228 ± 0.018	1.357HisThr: 1.357 ± 0.016	1.554HisVal: 1.554 ± 0.015	0.37HisTrp: 0.37 ± 0.008	0.754HisTyr: 0.754 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	2.388IleAla: 2.388 ± 0.021	0.982IleCys: 0.982 ± 0.012	1.828IleAsp: 1.828 ± 0.019	2.308IleGlu: 2.308 ± 0.021	1.739IlePhe: 1.739 ± 0.022	2.027IleGly: 2.027 ± 0.019	1.186IleHis: 1.186 ± 0.014	2.092IleIle: 2.092 ± 0.024	2.343IleLys: 2.343 ± 0.022	4.312IleLeu: 4.312 ± 0.03	0.886IleMet: 0.886 ± 0.012	1.622IleAsn: 1.622 ± 0.017	2.471IlePro: 2.471 ± 0.02	2.143IleGln: 2.143 ± 0.019	2.282IleArg: 2.282 ± 0.022	3.462IleSer: 3.462 ± 0.027	2.398IleThr: 2.398 ± 0.023	2.292IleVal: 2.292 ± 0.023	0.496IleTrp: 0.496 ± 0.009	1.261IleTyr: 1.261 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.896LysAla: 3.896 ± 0.029	1.005LysCys: 1.005 ± 0.015	2.967LysAsp: 2.967 ± 0.028	4.835LysGlu: 4.835 ± 0.046	1.626LysPhe: 1.626 ± 0.016	3.129LysGly: 3.129 ± 0.032	1.303LysHis: 1.303 ± 0.016	2.478LysIle: 2.478 ± 0.026	4.38LysLys: 4.38 ± 0.051	4.909LysLeu: 4.909 ± 0.037	1.411LysMet: 1.411 ± 0.018	2.161LysAsn: 2.161 ± 0.021	2.889LysPro: 2.889 ± 0.03	2.455LysGln: 2.455 ± 0.022	3.198LysArg: 3.198 ± 0.029	3.591LysSer: 3.591 ± 0.034	2.921LysThr: 2.921 ± 0.024	3.35LysVal: 3.35 ± 0.025	0.578LysTrp: 0.578 ± 0.009	1.447LysTyr: 1.447 ± 0.017	0.001LysXaa: 0.001 ± 0.0
Leu	7.294LeuAla: 7.294 ± 0.047	2.32LeuCys: 2.32 ± 0.023	4.768LeuAsp: 4.768 ± 0.032	7.23LeuGlu: 7.23 ± 0.053	3.4LeuPhe: 3.4 ± 0.029	6.53LeuGly: 6.53 ± 0.043	2.723LeuHis: 2.723 ± 0.022	3.595LeuIle: 3.595 ± 0.027	5.546LeuLys: 5.546 ± 0.041	11.179LeuLeu: 11.179 ± 0.067	1.985LeuMet: 1.985 ± 0.021	3.303LeuAsn: 3.303 ± 0.025	6.533LeuPro: 6.533 ± 0.043	5.904LeuGln: 5.904 ± 0.041	6.334LeuArg: 6.334 ± 0.04	8.262LeuSer: 8.262 ± 0.041	5.203LeuThr: 5.203 ± 0.031	5.723LeuVal: 5.723 ± 0.046	1.265LeuTrp: 1.265 ± 0.015	2.497LeuTyr: 2.497 ± 0.021	0.001LeuXaa: 0.001 ± 0.0
Met	1.882MetAla: 1.882 ± 0.018	0.384MetCys: 0.384 ± 0.008	1.183MetAsp: 1.183 ± 0.013	1.771MetGlu: 1.771 ± 0.018	0.705MetPhe: 0.705 ± 0.011	1.314MetGly: 1.314 ± 0.015	0.42MetHis: 0.42 ± 0.008	0.793MetIle: 0.793 ± 0.012	1.38MetLys: 1.38 ± 0.016	1.97MetLeu: 1.97 ± 0.02	0.57MetMet: 0.57 ± 0.013	0.827MetAsn: 0.827 ± 0.013	1.085MetPro: 1.085 ± 0.017	0.909MetGln: 0.909 ± 0.012	1.049MetArg: 1.049 ± 0.012	1.501MetSer: 1.501 ± 0.016	1.118MetThr: 1.118 ± 0.015	1.436MetVal: 1.436 ± 0.019	0.244MetTrp: 0.244 ± 0.006	0.518MetTyr: 0.518 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	1.926AsnAla: 1.926 ± 0.021	0.785AsnCys: 0.785 ± 0.011	1.373AsnAsp: 1.373 ± 0.02	1.98AsnGlu: 1.98 ± 0.022	1.401AsnPhe: 1.401 ± 0.016	2.214AsnGly: 2.214 ± 0.021	0.878AsnHis: 0.878 ± 0.012	1.895AsnIle: 1.895 ± 0.021	1.964AsnLys: 1.964 ± 0.024	3.521AsnLeu: 3.521 ± 0.028	0.838AsnMet: 0.838 ± 0.012	1.332AsnAsn: 1.332 ± 0.017	2.118AsnPro: 2.118 ± 0.02	1.523AsnGln: 1.523 ± 0.017	1.752AsnArg: 1.752 ± 0.019	2.838AsnSer: 2.838 ± 0.026	1.793AsnThr: 1.793 ± 0.018	2.056AsnVal: 2.056 ± 0.019	0.449AsnTrp: 0.449 ± 0.009	1.017AsnTyr: 1.017 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	5.526ProAla: 5.526 ± 0.052	1.298ProCys: 1.298 ± 0.023	2.92ProAsp: 2.92 ± 0.029	4.812ProGlu: 4.812 ± 0.038	1.96ProPhe: 1.96 ± 0.018	5.844ProGly: 5.844 ± 0.064	1.574ProHis: 1.574 ± 0.018	1.761ProIle: 1.761 ± 0.017	2.757ProLys: 2.757 ± 0.033	5.785ProLeu: 5.785 ± 0.037	1.027ProMet: 1.027 ± 0.015	1.732ProAsn: 1.732 ± 0.016	6.523ProPro: 6.523 ± 0.086	3.084ProGln: 3.084 ± 0.032	3.983ProArg: 3.983 ± 0.041	6.095ProSer: 6.095 ± 0.046	3.186ProThr: 3.186 ± 0.029	4.002ProVal: 4.002 ± 0.032	0.834ProTrp: 0.834 ± 0.012	1.302ProTyr: 1.302 ± 0.016	0.001ProXaa: 0.001 ± 0.0
Gln	3.768GlnAla: 3.768 ± 0.028	0.905GlnCys: 0.905 ± 0.015	2.372GlnAsp: 2.372 ± 0.023	3.98GlnGlu: 3.98 ± 0.032	1.328GlnPhe: 1.328 ± 0.014	3.065GlnGly: 3.065 ± 0.027	1.254GlnHis: 1.254 ± 0.016	1.858GlnIle: 1.858 ± 0.019	2.812GlnLys: 2.812 ± 0.024	4.832GlnLeu: 4.832 ± 0.037	1.07GlnMet: 1.07 ± 0.015	1.738GlnAsn: 1.738 ± 0.018	2.957GlnPro: 2.957 ± 0.03	2.836GlnGln: 2.836 ± 0.043	3.036GlnArg: 3.036 ± 0.028	3.073GlnSer: 3.073 ± 0.027	2.305GlnThr: 2.305 ± 0.021	2.955GlnVal: 2.955 ± 0.024	0.548GlnTrp: 0.548 ± 0.011	1.074GlnTyr: 1.074 ± 0.015	0.001GlnXaa: 0.001 ± 0.0
Arg	4.439ArgAla: 4.439 ± 0.033	1.299ArgCys: 1.299 ± 0.02	2.859ArgAsp: 2.859 ± 0.025	4.188ArgGlu: 4.188 ± 0.034	1.903ArgPhe: 1.903 ± 0.018	4.126ArgGly: 4.126 ± 0.033	1.548ArgHis: 1.548 ± 0.017	2.228ArgIle: 2.228 ± 0.02	3.619ArgLys: 3.619 ± 0.031	5.794ArgLeu: 5.794 ± 0.036	1.207ArgMet: 1.207 ± 0.016	1.986ArgAsn: 1.986 ± 0.018	3.719ArgPro: 3.719 ± 0.031	2.726ArgGln: 2.726 ± 0.025	4.69ArgArg: 4.69 ± 0.04	4.399ArgSer: 4.399 ± 0.035	2.817ArgThr: 2.817 ± 0.021	3.417ArgVal: 3.417 ± 0.027	0.767ArgTrp: 0.767 ± 0.013	1.42ArgTyr: 1.42 ± 0.014	0.001ArgXaa: 0.001 ± 0.0
Ser	5.549SerAla: 5.549 ± 0.033	1.929SerCys: 1.929 ± 0.023	3.72SerAsp: 3.72 ± 0.032	5.163SerGlu: 5.163 ± 0.042	3.005SerPhe: 3.005 ± 0.022	5.867SerGly: 5.867 ± 0.04	2.063SerHis: 2.063 ± 0.021	3.009SerIle: 3.009 ± 0.025	3.86SerLys: 3.86 ± 0.03	8.477SerLeu: 8.477 ± 0.042	1.54SerMet: 1.54 ± 0.015	2.418SerAsn: 2.418 ± 0.024	6.43SerPro: 6.43 ± 0.058	3.916SerGln: 3.916 ± 0.03	4.76SerArg: 4.76 ± 0.038	9.05SerSer: 9.05 ± 0.072	4.235SerThr: 4.235 ± 0.034	4.992SerVal: 4.992 ± 0.036	1.166SerTrp: 1.166 ± 0.014	1.932SerTyr: 1.932 ± 0.021	0.001SerXaa: 0.001 ± 0.0
Thr	3.84ThrAla: 3.84 ± 0.024	1.276ThrCys: 1.276 ± 0.019	2.375ThrAsp: 2.375 ± 0.02	3.364ThrGlu: 3.364 ± 0.025	2.05ThrPhe: 2.05 ± 0.021	3.456ThrGly: 3.456 ± 0.028	1.263ThrHis: 1.263 ± 0.015	2.151ThrIle: 2.151 ± 0.02	2.46ThrLys: 2.46 ± 0.02	5.358ThrLeu: 5.358 ± 0.033	1.099ThrMet: 1.099 ± 0.014	1.591ThrAsn: 1.591 ± 0.02	3.709ThrPro: 3.709 ± 0.037	2.306ThrGln: 2.306 ± 0.021	2.565ThrArg: 2.565 ± 0.02	4.525ThrSer: 4.525 ± 0.04	2.784ThrThr: 2.784 ± 0.032	3.815ThrVal: 3.815 ± 0.03	0.728ThrTrp: 0.728 ± 0.012	1.372ThrTyr: 1.372 ± 0.016	0.001ThrXaa: 0.001 ± 0.0
Val	4.419ValAla: 4.419 ± 0.03	1.482ValCys: 1.482 ± 0.016	2.89ValAsp: 2.89 ± 0.027	3.832ValGlu: 3.832 ± 0.033	2.398ValPhe: 2.398 ± 0.023	3.635ValGly: 3.635 ± 0.025	1.523ValHis: 1.523 ± 0.016	2.712ValIle: 2.712 ± 0.027	3.27ValLys: 3.27 ± 0.03	6.49ValLeu: 6.49 ± 0.041	1.351ValMet: 1.351 ± 0.018	2.154ValAsn: 2.154 ± 0.022	3.892ValPro: 3.892 ± 0.03	2.757ValGln: 2.757 ± 0.025	3.247ValArg: 3.247 ± 0.026	5.089ValSer: 5.089 ± 0.03	3.84ValThr: 3.84 ± 0.03	4.093ValVal: 4.093 ± 0.035	0.778ValTrp: 0.778 ± 0.011	1.579ValTyr: 1.579 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	0.95TrpAla: 0.95 ± 0.013	0.264TrpCys: 0.264 ± 0.007	0.688TrpAsp: 0.688 ± 0.012	0.871TrpGlu: 0.871 ± 0.012	0.476TrpPhe: 0.476 ± 0.011	0.884TrpGly: 0.884 ± 0.012	0.311TrpHis: 0.311 ± 0.007	0.526TrpIle: 0.526 ± 0.01	0.791TrpLys: 0.791 ± 0.012	1.273TrpLeu: 1.273 ± 0.018	0.321TrpMet: 0.321 ± 0.007	0.517TrpAsn: 0.517 ± 0.009	0.635TrpPro: 0.635 ± 0.011	0.552TrpGln: 0.552 ± 0.009	0.817TrpArg: 0.817 ± 0.012	0.929TrpSer: 0.929 ± 0.013	0.686TrpThr: 0.686 ± 0.011	0.79TrpVal: 0.79 ± 0.012	0.209TrpTrp: 0.209 ± 0.005	0.343TrpTyr: 0.343 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.345TyrAla: 1.345 ± 0.015	0.629TyrCys: 0.629 ± 0.012	1.188TyrAsp: 1.188 ± 0.014	1.535TyrGlu: 1.535 ± 0.017	1.171TyrPhe: 1.171 ± 0.015	1.574TyrGly: 1.574 ± 0.02	0.717TyrHis: 0.717 ± 0.01	1.219TyrIle: 1.219 ± 0.016	1.34TyrLys: 1.34 ± 0.022	2.617TyrLeu: 2.617 ± 0.024	0.551TyrMet: 0.551 ± 0.008	0.993TyrAsn: 0.993 ± 0.014	1.289TyrPro: 1.289 ± 0.015	1.215TyrGln: 1.215 ± 0.015	1.545TyrArg: 1.545 ± 0.018	2.071TyrSer: 2.071 ± 0.02	1.368TyrThr: 1.368 ± 0.016	1.5TyrVal: 1.5 ± 0.017	0.349TyrTrp: 0.349 ± 0.008	0.881TyrTyr: 0.881 ± 0.015	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.01XaaXaa: 0.01 ± 0.004

Statistics based on 19236 proteins (6944429 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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